Navigation Links
Munich researchers discover key allergy gene

This press release is available in German.

Together with colleagues from the Department of Dermatology and Allergy and the Center for Allergy and Environment of the Technische Universitt Mnchen, scientists at the Helmholtz Zentrum Mnchen have pinpointed a major gene for allergic diseases. The gene was localized using cutting edge technologies for examining the whole human genome at the Helmholtz Zentrum Mnchen.

The newly discovered FCER1A gene encodes the alpha chain of high affinity IgE receptor, which plays a major role in controlling allergic responses. The team of scientists led by Dr. Stephan Weidinger from the Technische Universitt Mnchen and Dr. Thomas Illig from the Helmholtz Zentrum Mnchen found that certain variations of the FCER1A gene decisively influence the production of immunoglobulin E (IgE) antibodies. IgE antibodies are a particular type of antibody that is normally used to protect against parasites. In Western lifestyle countries with less contact, however, elevated IgE levels are associated with allergic disorders.

In genetically susceptible individuals the immune system becomes biased and produces IgE antibodies against harmless agents such as pollen, dust mites or animal hair. These IgE antibodies then work in conjunction with certain cells to get rid of the allergens, a process that gives rise to the symptoms of allergy such as allergic rhinitis (hay fever), atopic dermatitis or asthma.

"Most people with allergies are atopic - meaning they have a genetic tendency to develop allergies. To detect the genetic factors we examined the genomes of more than 10,000 adults and children from the whole of Germany" explained Stephan Weidinger.

Most of the persons examined for the study come from the population studies of the KORA (co-operative health research in the Augsburg region) research platform, which is led by Prof. Dr. H.-Erich Wichmann, the Director of the Institute of Epidemiology at the Helmholtz Zentrum Mnchen. The allergological examinations were carried by the Department for Dermatology and Allergy of the Technische Universitt Mnchen headed by Prof. Dr. Dr. Johannes Ring.

Although in its early stages, the new knowledge on the regulation of IgE production does have the potential to guide the development of new drugs.


Contact: Heinz Joerg Haury
Helmholtz Zentrum Mnchen - German Research Center for Environmental Health

Related biology news :

1. Rapid test for pathogens developed by K-State researchers
2. OU researchers isolate microorganisms that convert hydrocarbons to natural gas
3. UH researchers win top prize for research with humanitarian applications
4. Caltech researchers awarded $10M for molecular programming project
5. Researchers study facial structures, brain abnormalities to reveal formula for detection of autism
6. Mount Sinai researchers discover technology that silences genes
7. Researchers link cocoa flavanols to improved brain blood flow
8. Researchers create safer alternative to heparin
9. Researchers to study lyme-like illness in Texas
10. UNC researchers find MSG use linked to obesity
11. Monash researchers uncover cancer survival secrets
Post Your Comments:
(Date:4/28/2016)... BANGALORE, India , April 28, 2016 ... subsidiary of Infosys (NYSE: INFY ), and Samsung ... global partnership that will provide end customers with a ... and payment services.      (Logo: ... for financial services, but it also plays a fundamental part ...
(Date:4/15/2016)... 15, 2016  A new partnership announced today ... underwriting decisions in a fraction of the time ... and high-value life insurance policies to consumers without ... With Force Diagnostics, rapid testing (A1C, Cotinine and ... (blood pressure, weight, pulse, BMI, and activity data) ...
(Date:3/31/2016)... 2016  Genomics firm Nabsys has completed a financial ... Bready , M.D., who returned to the company in ... leadership team, including Chief Technology Officer, John Oliver ... Nurnberg and Vice President of Software and Informatics, ... Dr. Bready served as CEO of Nabsys from ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... PHILADELPHIA , June 27, 2016  Liquid ... today announced the funding of a Sponsored Research ... study circulating tumor cells (CTCs) from cancer patients.  ... changes in CTC levels correlate with clinical outcomes ... therapies. These data will then be employed to ...
(Date:6/24/2016)... Epic Sciences unveiled a liquid biopsy ... PARP inhibitors by targeting homologous recombination deficiency (HRD) ... test has already been incorporated into numerous clinical ... Over 230 clinical trials are investigating ... PARP, ATM, ATR, DNA-PK and WEE-1. Drugs targeting ...
(Date:6/23/2016)... , ... June 23, 2016 , ... ... release of its second eBook, “Clinical Trials Patient Recruitment and Retention Tips.” Partnering ... retention in this eBook by providing practical tips, tools, and strategies for clinical ...
(Date:6/23/2016)... TORONTO , June 23, 2016 /PRNewswire/ - ... Ontario biotechnology company, Propellon ... the development and commercialization of a portfolio of ... cancers. Epigenetic targets such as WDR5 represent an ... contribute significantly in precision medicine for cancer patients. ...
Breaking Biology Technology: