Navigation Links
Munich researchers discover key allergy gene
Date:8/22/2008

This press release is available in German.

Together with colleagues from the Department of Dermatology and Allergy and the Center for Allergy and Environment of the Technische Universitt Mnchen, scientists at the Helmholtz Zentrum Mnchen have pinpointed a major gene for allergic diseases. The gene was localized using cutting edge technologies for examining the whole human genome at the Helmholtz Zentrum Mnchen.

The newly discovered FCER1A gene encodes the alpha chain of high affinity IgE receptor, which plays a major role in controlling allergic responses. The team of scientists led by Dr. Stephan Weidinger from the Technische Universitt Mnchen and Dr. Thomas Illig from the Helmholtz Zentrum Mnchen found that certain variations of the FCER1A gene decisively influence the production of immunoglobulin E (IgE) antibodies. IgE antibodies are a particular type of antibody that is normally used to protect against parasites. In Western lifestyle countries with less contact, however, elevated IgE levels are associated with allergic disorders.

In genetically susceptible individuals the immune system becomes biased and produces IgE antibodies against harmless agents such as pollen, dust mites or animal hair. These IgE antibodies then work in conjunction with certain cells to get rid of the allergens, a process that gives rise to the symptoms of allergy such as allergic rhinitis (hay fever), atopic dermatitis or asthma.

"Most people with allergies are atopic - meaning they have a genetic tendency to develop allergies. To detect the genetic factors we examined the genomes of more than 10,000 adults and children from the whole of Germany" explained Stephan Weidinger.

Most of the persons examined for the study come from the population studies of the KORA (co-operative health research in the Augsburg region) research platform, which is led by Prof. Dr. H.-Erich Wichmann, the Director of the Institute of Epidemiology at the Helmholtz Zentrum Mnchen. The allergological examinations were carried by the Department for Dermatology and Allergy of the Technische Universitt Mnchen headed by Prof. Dr. Dr. Johannes Ring.

Although in its early stages, the new knowledge on the regulation of IgE production does have the potential to guide the development of new drugs.


'/>"/>

Contact: Heinz Joerg Haury
presse@helmholtz-muenchen.de
49-893-187-2460
Helmholtz Zentrum Mnchen - German Research Center for Environmental Health
Source:Eurekalert

Related biology news :

1. Rapid test for pathogens developed by K-State researchers
2. OU researchers isolate microorganisms that convert hydrocarbons to natural gas
3. UH researchers win top prize for research with humanitarian applications
4. Caltech researchers awarded $10M for molecular programming project
5. Researchers study facial structures, brain abnormalities to reveal formula for detection of autism
6. Mount Sinai researchers discover technology that silences genes
7. Researchers link cocoa flavanols to improved brain blood flow
8. Researchers create safer alternative to heparin
9. Researchers to study lyme-like illness in Texas
10. UNC researchers find MSG use linked to obesity
11. Monash researchers uncover cancer survival secrets
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/29/2016)... November 29, 2016 Nearly one billion matches per ... ... DERMALOG is ... an efficient Identity Management. (PRNewsFoto/DERMALOG Identification Systems) ... DERMALOG is Germany's largest Multi-Biometric supplier: The company's Fingerprint ...
(Date:11/22/2016)... 2016   MedNet Solutions , an innovative SaaS-based ... clinical research, is pleased to announce that the company ... Life Sciences Awards as "Most Outstanding in eClinical ... year of recognition and growth for MedNet, which has ... iMedNet ™ , MedNet,s flagship ...
(Date:11/17/2016)... INDUSTRY, Calif. , Nov. 17, 2016  AIC announces that it has just ... servers in organizations that require high-performance scale-out plus high speed data transfer storage solutions. ... ... ... Setting up a ...
Breaking Biology News(10 mins):
(Date:12/6/2016)... Dec. 6, 2016  The Texas Medical Center ... Australia (HISA) today announced the establishment of a ... between Australia and the Texas ... HISA and the Texas Medical Center, ... to create a global health innovation ecosystem where emerging ...
(Date:12/5/2016)... 2016 Research and Markets has announced ... Markets and Companies" to their offering. ... , , ... various -omics technologies such as proteomics and metabolomics. Molecular diagnostics technologies ... also based on biomarker. Currently the most important applications ...
(Date:12/5/2016)... 2016 /PRNewswire/ - Resverlogix Corp. ("Resverlogix" or the ... and Safety Monitoring Board (DSMB) for the Company,s ... (CVD) patients has completed a second planned safety ... as planned without any modifications. The DSMB reviewed ... or efficacy concerns were identified. The DSMB will ...
(Date:12/4/2016)... ... December 02, 2016 , ... A proposed five-year ... in federally funded research and development is welcome news for the photonics community, ... . , As part of the National Defense Authorization Act (NDAA) compromise agreement ...
Breaking Biology Technology: