Navigation Links
Multiple species of bacteria may cause trachoma: Implications for treatment
Date:1/2/2008

In a study published in this weeks PLoS Medicine, researchers have found that more than one species of bacteria may be causing the infectious eye disease trachoma. Six million people most of whom live in crowded and unhygienic conditions in the developing world are blind because of the disease and many more are actively infected. The possibility that multiple strains of the Chlamydiceae family of bacteria are involved in trachoma would involve a re-evaluation of vaccines and treatment programmes.

It is accepted that Chlamydia trachomatis (C. trachomatis) causes trachoma. The bacteria, some strains of which are associated with sexually transmitted infections, can also pass between people on hands and clothing; successive infections cause scarring of the inside of the eyelid. As the eyelashes of the infected eyes turn inward they scar the cornea - the transparent tissue covering the front of the eye - leading eventually to blindness. To investigate whether other species of Chlamydiceae also cause human trachoma, Deborah Dean and colleagues from Childrens Hospital Oakland Research Institute and the University of California San Francisco conducted their research in the Lumbini Zone of south-western Nepal where the disease is endemic. Obtaining specimens from 146 individuals in 9 households, they found that a third of the people who had trachoma were infected with only C. trachomatis, including not only the type that is typically described in trachoma-infected eyes but also the type usually associated with sexually transmitted diseases. Also, participants with Chlamidiacae infections of the eye were infected only with species previously associated with lung infections: one in five showed Chlamydophilia psittaci (C. psittaci) and one in ten Chlamydophila pneumoniae (C. pneumoniae); infection with these strains was just as strongly linked with severe inflammation of the eyes as was infection with the C. trachomatis bacteria already known to cause trachoma. Additionally, one third of the individuals had a mixed infection with two or three species.

Interventions to prevent trachoma by improving personal hygiene such as the SAFE initiative promoted by the World Health Organization have had limited success, and an effective vaccine may also be needed to eliminate the disease. The findings and their distribution by household and age provide evidence that C. psittaci and C. pneumoniae, in addition to C. trachomatis, are involved with trachoma and that these infections are widespread rather than sporadic. The findings would also explain why some people with active trachoma do not have C. trachomatis in their eyes, and suggest that antibiotics used for trachoma may need to be changed or used for longer periods of time to be effective against all three species. If these findings are confirmed in other trachoma-endemic regions, then future vaccines and treatments w ill need to combat all these bacteria and not just C. trachomatis.


'/>"/>

Contact: Andrew Hyde
press@plos.org
44-122-346-3330
Public Library of Science
Source:Eurekalert

Related biology news :

1. Diverse genetic abnormalities lead to NF-κB activation in multiple myeloma
2. Nicotinic receptors may be important targets for treatment of multiple addictions
3. Emphasis on conifer forests places multiple species at risk
4. For honey bee queens, multiple mating makes a difference
5. Israeli scientists identify: Genes that affect responses of multiple sclerosis patients to copaxone
6. New magnetic separation technique might detect multiple pathogens at once
7. The power of multiples: Connecting wind farms can make a more reliable - and cheaper - power source
8. New continent and species discovered in Atlantic study
9. One species entire genome discovered inside anothers
10. How the plant immune system can drive the formation of new species
11. Student study bolsters case for adding a rare sunflower to the endangered species list
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2017)... a global expert in SoC-based imaging and computing solutions, has developed ... the company,s hybrid codec technology. A demonstration utilizing TeraFaces ® , ... showcased during the upcoming Medtec Japan at Tokyo Big Sight April ... Vegas Convention Center April 24-27. ... Click here for an image of the M820 ...
(Date:4/11/2017)... April 11, 2017 Crossmatch®, a globally-recognized ... solutions, today announced that it has been awarded ... Projects Activity (IARPA) to develop next-generation Presentation Attack ... "Innovation has been a driving force within ... will allow us to innovate and develop new ...
(Date:4/6/2017)... -- Forecasts by Product Type (EAC), Biometrics, ... (Transportation & Logistics, Government & Public Sector, Utilities / ... Facility, Nuclear Power), Industrial, Retail, Business Organisation (BFSI), Hospitality ... looking for a definitive report on the $27.9bn Access ... ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... 2017 , ... ComplianceOnline’s Medical Device Summit is back for its 4th year. ... San Francisco, CA. The Summit brings together current and former FDA office bearers, regulators, ... government officials from around the world to address key issues in device compliance, quality ...
(Date:10/11/2017)... 2017  VMS BioMarketing, a leading provider of patient support ... Nurse Educator (CNE) network, which will launch this week. The ... health care professionals to enhance the patient care experience by ... other health care professionals to help women who have been ... ...
(Date:10/11/2017)... Tbilisi, Georgia (PRWEB) , ... October 11, 2017 , ... ... disaster, taking the lives of over 5.5 million people each year. Especially those living ... the greenovative startup Treepex - based in one of the most pollution-affected countries globally ...
(Date:10/11/2017)... ... October 11, 2017 , ... Singh ... orphan drug designation to SBT-100, its novel anti-STAT3 (Signal Transducer and Activator of ... SBT-100 is able to cross the cell membrane and bind intracellular STAT3 and ...
Breaking Biology Technology: