Navigation Links
Multiple sclerosis study reveals how killer T cells learn to recognize nerve fiber insulators
Date:1/11/2013

alitis originally mediated by CD4+ T cells. The membrane folds and protrusions of mature dendritic cells often look like branched tentacles or cupped petals well-suited to probing the surroundings.

The researchers proposed that the Tip dendritic cells can not only engulf myelin debris or dead oligodendrocytes and then present myelin peptides to CD4 + T cells, they also have the unusual ability to load a myelin peptide onto a specific type of molecule that also presents it to CD8+ T cells. In this way, the Tip dendritic cells can spread the immune response from CD4+ T cells to CD8+ T cells. This presentation enables CD8+ T cells to recognize myelin protein segments from oligodendrocytes, the cells that form the myelin sheath. The phenomenon establishes a second-wave of autoimmune reactivity in which the CD8+ T cells respond to the presence of oligodendrocytes by splitting them open and spilling their contents.

"Our findings are consistent," the researchers said, "with the critical role of dendritic cells in promoting inflammation in autoimmune diseases of the central nervous system." They mentioned that mature dendritic cells might possibly wait in the blood vessels of normal brain tissue to activate T-cells that have infiltrated the blood/brain barrier.

The oligodendrocytes, under the inflammatory situation of experimental autoimmune encephalitis, also present peptides that elicit an immune response from CD8+T cells. Under healthy conditions, oligodendrocytes wouldn't do this.

The researchers proposed that myelin-specific CD8+T cells might play a role in the ongoing destruction of nerve-cell endings in "slow burning" multiple sclerosis lesions. A drop in inflammation accompanied by an increased degeneration of axons (electrical impulse-conducting structures) coincides with multiple sclerosis leaving the relapsing-remitting stage of disease and entering a more progressive state.

Medical scientists are studying the roles
'/>"/>

Contact: Leila Gray
leilag@uw.edu
206-685-0381
University of Washington
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Nursing gerbils unravel benefit of multiple mothers in collective mammals
2. Medbox, Inc. Featured in Multiple Media Stories in Massachusetts and California
3. Combination of two pharmaceuticals proves effective in the treatment of multiple sclerosis
4. Multiple sclerosis immune exchange between brain and blood is uncovered
5. Under the right conditions, peptide blocks HIV infection at multiple points along the way
6. Researchers identify need to sample multiple tumor zones in breast cancer
7. New data improve understanding of breast cancers multiple varieties
8. Clinical trial launches to see whether vitamin D helps treat multiple sclerosis
9. New insights into how immune system fights atherosclerosis
10. Zebra fish point the way towards new therapies for amyotrophic lateral sclerosis
11. UMMS researchers isolate gene mutations in patients with inherited amyotrophic lateral sclerosis
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Multiple sclerosis study reveals how killer T cells learn to recognize nerve fiber insulators
(Date:1/22/2015)... DUBLIN , Jan. 22, 2015 Research and ... the addition of the "Global Wearable Technologies ... Growth, Share, Overview, Trends and Forecast 2014-2020" ... Wearable Technologies are smart devices that can be ...
(Date:12/22/2014)... , Dec. 22, 2014  NXT-ID, Inc. (NASDAQ: ... authentication company focused on the growing mobile commerce market, announces ... Apollo Robbins for the 2015 International CES debut of ... Robbins will be at the NXT-ID booth January 6th ...
(Date:12/19/2014)... Dec. 18, 2014 Research and Markets ( http://www.researchandmarkets.com/research/86ncd6/micro_market ... Monitor: North America Perimeter Security Systems Market" report to ... The North American perimeter security market is estimated to ... Although the U.S. market holds a larger share in this ...
Breaking Biology News(10 mins):Global Wearable Technologies Market and Applications, Opportunities, Industry Analysis, Segmentation, Size, Growth, Share, Overview, Trends and Forecast 2014-2020 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 4Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3
... Today, the New York Stem Cell Foundation (NYSCF) ... to identify genetic and environmental contributions to trait and ... genomic data and medical histories contributed by participants in ... and powerful resource to help researchers identify causes of ...
... PHILADELPHIA (December 8, 2013) According to Gertrude Stein, "A ... indicates that might not be the case when it comes ... collaborating institutions have found that as much as 30 percent ... any two individuals. This substantial variation is in turn reflected ...
... Hospital of Philadelphia have manipulated key biological events in ... normally absent after the newborn period. Because this fetal ... cell disease (SCD), the cell culture findings may open ... blood disorder. "Our study shows the power ...
Cached Biology News:New collaboration combines genomic sequencing and stem cell technology to understand disease 2New collaboration combines genomic sequencing and stem cell technology to understand disease 3Extensive variability in olfactory receptors influences human odor perception 2Flipping a gene switch reactivates fetal hemoglobin, may reverse sickle cell disease 2
(Date:1/22/2015)... RBJ today announces the firm brokered a long-term lease totaling ... biopharmaceutical company, at Two Ledgemont Center in Lexington, ... president, and Brian Cohen , senior vice president, represented ... 95 Hayden Ave. Photo - http://photos.prnewswire.com/prnh/20150122/170765 ...
(Date:1/22/2015)... Cambridge Semantics, the leading provider of smart data solutions driven ... record-breaking year across the board for the company. , ... and our Smart Data solutions, our customers were able to ... to record growth for the company in 2014,” said Alok ...
(Date:1/22/2015)... CO / Rootstown, OH (PRWEB) January 22, 2015 ... detection platform, announced today that it has received AOAC-PTM Certifications ... O45, O1O3, O111, O121, and O145; collectively referred to as ... coli) O157, at 1 colony forming unit (cfu) per 325 ...
(Date:1/22/2015)... Dr. Greg Leyer of UAS Labs recently was ... Pre-Conference seminar on probiotics in San Diego, CA. , ... conference for health care professionals. This year’s pre-conference seminar was ... in health. Dr. Leyer spoke about the emerging topics and ...
Breaking Biology Technology:Transwestern | RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Cambridge Semantics Announces Record Results for 2014 2Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 2
... BIKAM,pioneers in the discovery and development of ... eye diseases and ocular disorders and,Dalton Medicinal ... and agreement to discover and develop new ... Medicinal Chemistry will utilize their proprietary insights ...
... - Fuel Cell Technology On The Ground in Los Angeles and planned for New ... ... ... 3 Virgin Atlantic, one of,the world,s leading long-haul airlines, and General Motors, the world,s,largest ...
... Denmark and LELYSTAD, Netherlands, March 3, Genmab A/S ... a research collaboration aimed at identifying fully,human monoclonal ... that are difficult to address using,commonly available technologies ... These difficulties can for example be due to ...
Cached Biology Technology:BIKAM and Dalton Medicinal Chemistry Sign Collaborative Research Agreement 2Virgin Atlantic to Offer Zero-Emissions GM Hydrogen Fuel Cell Limousines to Upper Class Passengers 2Virgin Atlantic to Offer Zero-Emissions GM Hydrogen Fuel Cell Limousines to Upper Class Passengers 3Genmab and Pepscan to Identify Human Antibodies Against Intractable Targets 2Genmab and Pepscan to Identify Human Antibodies Against Intractable Targets 3
...
Mouse monoclonal [M2II-12] to MRP2 ( Abpromise for all tested applications). entrezGeneID: 1244 SwissProtID: Q92887...
Mouse monoclonal antibody to ANAPC2 - anaphase promoting complex subunit 2...
... POWER 500V Programmable Power Supply are ... can handle virtually any application from ... blotting. It is unique in offering ... MAX POWER Programmable Power Supply is ...
Biology Products: