Navigation Links
Multiple sclerosis 'immune exchange' between brain and blood is uncovered
Date:11/19/2012

DNA sequences obtained from a handful of patients with multiple sclerosis at the University of California, San Francisco (UCSF) Medical Center have revealed the existence of an "immune exchange" that allows the disease-causing cells to move in and out of the brain.

The cells in question, obtained from spinal fluid and blood samples, are called B cells, which normally help to clear foreign infections from the body but sometimes react strongly with the body itself. One of the current theories of multiple sclerosis, which strikes hundreds of thousands of Americans and millions more worldwide, holds that the disease manifests when self-reactive B cells in the brain become activated and cause inflammation there.

The apparent exchange of the cells between the brain and the blood may be a key to unlocking better treatments and diagnostics, because the activated B cells causing problems in the brain may be accessible when they move from the brain to the periphery.

"The hope is that if we can identify culprit B cells, using precise tools, we will be able to better diagnose multiple sclerosis and monitor disease activity. In addition, in ways that may have to be tailored for each patient, this may also allow us to develop therapies that directly target disease-causing B cells," said UCSF neurologist Hans Christian von Bdingen, MD, who led the research.

Described this week in the Journal of Clinical Investigation, the work is the latest from the UCSF Multiple Sclerosis Center, part of the UCSF Department of Neurology and one of the leading programs in multiple sclerosis research and patient care worldwide.

Since 2008, a UCSF team led by the chair of the Department of Neurology, Stephen Hauser, MD, has completed two clinical trials that showed, in essence, that blocking B cells may stop the attacks, or flare-ups, that occur in people with multiple sclerosis. These trials used Rituximab and Ocrelizumab, both of which targ
'/>"/>

Contact: Jason Socrates Bardi
jason.bardi@ucsf.edu
415-502-6397
University of California - San Francisco
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Under the right conditions, peptide blocks HIV infection at multiple points along the way
2. Researchers identify need to sample multiple tumor zones in breast cancer
3. New data improve understanding of breast cancers multiple varieties
4. Clinical trial launches to see whether vitamin D helps treat multiple sclerosis
5. Zebra fish point the way towards new therapies for amyotrophic lateral sclerosis
6. UMMS researchers isolate gene mutations in patients with inherited amyotrophic lateral sclerosis
7. Groundbreaking discovery of mechanism that controls obesity, atherosclerosis
8. Research breakthrough selectively represses the immune system
9. Immune system fighters speak in patterns of proteins, prefer squishy partners
10. Chain reaction in the human immune system trapped in crystals
11. UCLA researchers discover missing link between stem cells and immune system
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Multiple sclerosis 'immune exchange' between brain and blood is uncovered
(Date:4/23/2014)... today announced Sophie Martin of the University of Lausanne, ... Medal. The award acknowledges her work to understand the ... the cell. , Martin has been working for the ... the way in which the spatial organization of cells ... last 11 years, she has been using fission yeast, ...
(Date:4/23/2014)... form different types of social relationships they may ... strict dominance relations. From a cognitive perspective, understanding one,s ... daily social life ("knowing who is nice or not"). ... each other sets the stage for "political" maneuvers ("knowing ... have been published in the scientific journal Nature ...
(Date:4/22/2014)... 21, 2014) -- There are all sorts of signaling ... spread their colorful tails; satin bowbirds build specialized stick ... shiny objects; and European bitterling males show off bright ... a unique method to communicate with others. , ... "Signaling can have profound fitness implications for individuals that ...
Breaking Biology News(10 mins):EMBO Gold Medal 2014 awarded to Sophie Martin 2Ravens understand the relations among others 2Best practices in communication for the animal world 2Best practices in communication for the animal world 3
... food, air and water pathogens may get a lot easier ... University researcher and his team. , Syed Hashsham, an ... and the Center for Microbial Ecology, is developing a portable, ... agents in air, water and food. , "This ...
... patients living with heart failure and other health conditions, blood ... their condition. Often, though, chemical or physiologic changes silently cause ... what if in the future a tiny device, one the ... in the patient to monitor and detect abnormalities, and could ...
... in the thymus, where the immune system's T cells develop, ... body's thousands of proteins as "self." The research confirms ... of the immune system, and not only at the sites ... case of type 1 diabetes, or the joints in rheumatoid ...
Cached Biology News:Professors to develop hand-held pathogen testing device 2Cardiologist's 'living chip' changes science of disease monitoring 2Cardiologist's 'living chip' changes science of disease monitoring 3Cardiologist's 'living chip' changes science of disease monitoring 4Proteins anchor memories in our brain 2Proteins anchor memories in our brain 3
(Date:1/15/2014)... A study has been launched to test whether ... could help to tackle the problem of obesity.  This unique ... surgery based in Stowmarket) and academics at University Campus Suffolk ... technology, which is inspired by equipment used to collect data ...
(Date:1/15/2014)... 2013 was a banner year of ... They saw continued independent research led by the team ... a $1 million grant from the Susanne Marcus Collins ... a peer reviewed journal, Amy Grant highlighted Brainwave Optimization® ...
(Date:1/14/2014)... Carahsoft and CDS Federal Services have scheduled a ... EST (11am PST), “Natural Language Processing: Converting Raw Data ... can turn raw, heterogeneous data into actionable knowledge to ... webinar will last approximately one hour. , Synopsis: Big ...
(Date:1/14/2014)... Jan. 14, 2014 The largest international professional ... plants and therapeutic derivatives thereof has endorsed an ... researchers about the challenges of adulterated herb and ... The Society for Medicinal Plant ...
Breaking Biology Technology:Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 4World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 5World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 6World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 7World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 8
... home of innovation for entrepreneurs, as its liberal climate and productive ... roots. With over 120 technology companies founded in Madison over the ... Magazine to place it first on the list of best ... a major project in mind when they start, such as ...
... Recently the Wisconsin Technology Network sat down with ... Council , to discuss the basic tenants and initiatives ... technology space grow. This is the first portion of ... and how the Wisconsin Technology Council is working to ...
... Inc . has introduced two new AV-ready Mediasite ... for a variety of uses. The new products, ... technology, are intended to enable customers to record ... communications, Web-based education, online training, product marketing and ...
Cached Biology Technology:The NeuronFarm works to increase reading comprehension 2The NeuronFarm works to increase reading comprehension 3The NeuronFarm works to increase reading comprehension 4WTN exclusive interview with Tom Still, Wisconsin Technology Council 2WTN exclusive interview with Tom Still, Wisconsin Technology Council 3WTN exclusive interview with Tom Still, Wisconsin Technology Council 4WTN exclusive interview with Tom Still, Wisconsin Technology Council 5Sonic Foundry announces new Mediasite products 2