Navigation Links
Multiple sclerosis appears to originate in different part of brain than long believed
Date:9/10/2013

The search for the cause of multiple sclerosis, a debilitating disease that affects up to a half million people in the United States, has confounded researchers and medical professionals for generations. But Steven Schutzer, a physician and scientist at Rutgers New Jersey Medical School, has now found an important clue why progress has been slow it appears that most research on the origins of MS has focused on the wrong part of the brain.

Look more to the gray matter, the new findings published in the journal PLOS ONE suggest, and less to the white. That change of approach could give physicians effective tools to treat MS far earlier than ever before.

Until recently, most MS research has focused on the brain's white matter, which contains the nerve fibers. And for good reason: Symptoms of the disease, which include muscle weakness and vision loss, occur when there is deterioration of a fatty substance called myelin, which coats nerves contained in the white matter and acts as insulation for them. When myelin in the brain is degraded, apparently by the body's own immune system, and the nerve fiber is exposed, transmission of nerve impulses can be slowed or interrupted. So when patients' symptoms flare up, the white matter is where the action in the brain appears to be.

But Schutzer attacked the problem from a different direction. He is one of the first scientists to analyze patients' cerebrospinal fluid (CSF) by taking full advantage of a combination of technologies called proteomics and high-resolution mass spectrometry. "Proteins present in the clear liquid that bathes the central nervous system can be a window to physical changes that accompany neurological disease," says Schutzer, "and the latest mass spectrometry techniques allow us to see them as never before." In this study, he used that novel approach to compare the cerebrospinal fluid of newly diagnosed MS patients with that of longer term patients, as well as fluid ta
'/>"/>

Contact: Rob Forman
robert.forman@rutgers.edu
973-972-7276
Rutgers University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Clinical trial launches to see whether vitamin D helps treat multiple sclerosis
2. New data improve understanding of breast cancers multiple varieties
3. Researchers identify need to sample multiple tumor zones in breast cancer
4. Under the right conditions, peptide blocks HIV infection at multiple points along the way
5. Multiple sclerosis immune exchange between brain and blood is uncovered
6. Combination of two pharmaceuticals proves effective in the treatment of multiple sclerosis
7. Medbox, Inc. Featured in Multiple Media Stories in Massachusetts and California
8. Nursing gerbils unravel benefit of multiple mothers in collective mammals
9. Multiple sclerosis study reveals how killer T cells learn to recognize nerve fiber insulators
10. New research network for multiple sclerosis research
11. New research may aid treatment of multiple myeloma patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... scientists from 25 countries and 35 states will ... the Genetics Society of America (GSA) next week ... conference will feature close to 500 presentations (including ... including gene expression and regulation, functional genomics, chemical ... and a variety of diseases. , Of ...
(Date:7/25/2014)... at the University of Adelaide has opened the way for ... powdery mildew. , In Australia, annual barley production is second ... mildew is one of the most important diseases of barley. ... discovered the composition of special growths on the cell walls ... into the leaf. , The research, by the ARC Centre ...
(Date:7/25/2014)... After development of diffusion tensor tractography (DTT), which ... reconstruction and estimation for three motor tracts, such ... the corticoreticular pathway became possible. The corticospinal tract ... for motor function in the human brain. Several ... tract by transtentorial herniation. In addition, some studies ...
Breaking Biology News(10 mins):Yeast meeting to showcase latest breakthroughs in genetics and molecular biology 2New hope for powdery mildew resistant barley 2
... Mich.---In cells, as in cities, disposing of garbage and ... service. In both city and cell, health problems can ... research by University of Michigan cell biologist Haoxing Xu ... garbage dump and recycling center, the lysosome, functions. These ...
... 14, 2010 The Institute for Clinical & Translational ... five years from the National Institutes of Health to ... for patients. UCI is the first medical research ... to receive the competitive Clinical & Translational Science ...
... (July 13, 2010) -- The 52nd meeting of ... convenes from July18 - 22, 2010 in Philadelphia, ... medical physics, a broadly-based scientific and professional discipline ... biology. Its membership includes medical physicists who specialize ...
Cached Biology News:Opening the gate to the cell's recycling center 2UCI receives prestigious federal research award to hasten medical advances 2Nanotech medicine, tumor tracking, new technologies and more 2Nanotech medicine, tumor tracking, new technologies and more 3Nanotech medicine, tumor tracking, new technologies and more 4Nanotech medicine, tumor tracking, new technologies and more 5Nanotech medicine, tumor tracking, new technologies and more 6Nanotech medicine, tumor tracking, new technologies and more 7Nanotech medicine, tumor tracking, new technologies and more 8Nanotech medicine, tumor tracking, new technologies and more 9Nanotech medicine, tumor tracking, new technologies and more 10Nanotech medicine, tumor tracking, new technologies and more 11Nanotech medicine, tumor tracking, new technologies and more 12Nanotech medicine, tumor tracking, new technologies and more 13Nanotech medicine, tumor tracking, new technologies and more 14Nanotech medicine, tumor tracking, new technologies and more 15Nanotech medicine, tumor tracking, new technologies and more 16Nanotech medicine, tumor tracking, new technologies and more 17
(Date:7/25/2014)... Biotech Ltd. (Nasdaq: SVA ), a leading provider ... announced that it will release its unaudited financial results for ... on Thursday, August 14, 2014 EDT. The Company will host ... August 15, 2014, at 8:00 a.m. EDT (Friday, August 15, ... Company,s financial results and provide an update on recent corporate ...
(Date:7/24/2014)... , July 24, 2014  Asterias Biotherapeutics, Inc. ... emerging field of regenerative medicine, announced today that ... presentation to investors on Tuesday, July 29, 2014, ... presentation will include an overview of Asterias, business ... webcast, visit http://www.ustream.tv/channel/asterias-biotherapeutics at least 15 ...
(Date:7/24/2014)... Professor of Engineering at the University of Delaware, ... problems in energy engineering, environmental sustainability and electronics. ... porous rock with a well-defined, crystalline structure. At ... precisely decided that zeolites can separate molecules with ... angstrom (one-tenth of a nanometer), making them useful ...
(Date:7/24/2014)... 24, 2014 SRI International has been awarded ... Institute of Allergy and Infectious Diseases (NIAID), part of ... of potential therapies for HIV infection and AIDS. The ... and AIDS and the complications and opportunistic infections associated ... sexual transmission of HIV. According to ...
Breaking Biology Technology:Sinovac to Host Conference Call to Report Second Quarter 2014 Unaudited Financial Results 2Asterias Biotherapeutics Announces Live Investor Webcast 2Asterias Biotherapeutics Announces Live Investor Webcast 3Asterias Biotherapeutics Announces Live Investor Webcast 4University of Delaware researcher describes new approach for creating organic zeolites 2National Institute of Allergy and Infectious Diseases Awards SRI International Contract to Study New Therapies for HIV and AIDS 2National Institute of Allergy and Infectious Diseases Awards SRI International Contract to Study New Therapies for HIV and AIDS 3
... CONTINUE TO MANAGE ALS EAP IN ITALY AND ALL ... RESPONSIBILITY FOR REST OF WORLD , RICHMOND, Va., ... ), a biopharmaceutical company, today announced the signing of ... in the management of medicines on a named patient ...
... TorreyPines Therapeutics, Inc. (Nasdaq: TPTX ) ... the Southern District of New York dismissed proceedings filed ... ("Axonyx") against Axonyx and several of Axonyx,s former directors ... plaintiffs alleged that the defendants made misleading statements related ...
... Inverness Medical Innovations, Inc. (NYSE: IMA ), a ... health at home through the merger of rapid diagnostics and ... on its Series B Convertible Perpetual Preferred Stock (NYSE: IMA-PB). ... stock in an amount per share equal to the quotient ...
Cached Biology Technology:Insmed Announces Agreement With IDIS to Manage Expanded Access Programs for IPLEX(TM) 2Insmed Announces Agreement With IDIS to Manage Expanded Access Programs for IPLEX(TM) 3Insmed Announces Agreement With IDIS to Manage Expanded Access Programs for IPLEX(TM) 4Stockholder Suits Related to TorreyPines Therapeutics, Inc. Dismissed 2
Anti-human C5/C5b, Clone 568, Monoclonal Antibody...
Gentamicin sulfate, 5g...
... [EP282Y] to Asparagine synthetase ( ... applications). Antigen: ... residues in the C-terminus of ... Entrez GeneID: 440 ...
Anti-gamma Glutamyl Transferase (gammaGT) Host: mouse monoclonal Species Reactivity: human Applications: WB, IP, FC Storage: 4C...
Biology Products: