Navigation Links
Multiple myeloma study uncovers genetic diversity within tumors
Date:1/13/2014

ly at BRAF, a cancer gene for which several inhibitors, or drugs, exist. Previous studies indicated that around four percent of multiple myeloma patients may have mutations in this gene, and a recent report on a single multiple myeloma patient treated with drugs targeting BRAF showed promising results. BRAF inhibitors have also been used to treat patients with melanoma and other forms of cancer. In the lab, however, the research team found evidence that treating a tumor harboring subclonal BRAF mutations with one of these targeted drugs may at best kill a fraction of the cells, and at worst, stimulate another cancer cell subpopulation to grow.

"There's clearly potential for these drugs in some patients with multiple myeloma, but we show that there are also potential problems for others," said co-first author Jens Lohr an associated scientist at the Broad and a medical oncologist at Dana-Farber. "If a patient has a BRAF mutation in less than 100 percent of his cells, or if he has mutations in KRAS or NRAS at the same time, his oncologist would want to think through the potential pitfalls before giving the inhibitor."

Resistance or the ability for tumors to shrink and then grow back has become a major hurdle in treating patients with targeted therapies such as BRAF inhibitors. The new research suggests that subclonal populations could be one of the potential reasons many patients suffer relapse after treatment.

To take a genetic census of the populations of cancer cells that make up a tumor, the researchers used a computational technique known as ABSOLUTE, developed by the Broad's Cancer Genome Computational Analysis group, led by Broad associate member and co-senior author Gad Getz. In this study, ABSOLUTE was used to analyze information from many samples, but it's also feasible to use the algorithm to analyze information from a single patient. This could allow cancer researchers to examine a specific tumor and determine what fraction of
'/>"/>

Contact: Haley Bridger
hbridger@broadinstitute.org
617-714-7968
Broad Institute of MIT and Harvard
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Multiple mates worth the risk for female prairie dogs
2. Clinical ovarian cancers display extensive genetic heterogeneity, study suggests multiple treatment
3. Research reveals new understanding, warning signs, and potential treatments for multiple sclerosis
4. Research team uncovers root cause of multiple myeloma relapse
5. Carbon farming schemes should consider multiple cobenefits
6. Multiple sclerosis appears to originate in different part of brain than long believed
7. First study to investigate the human genome in multiple sclerosis
8. Novel approach to gene regulation can activate multiple genes simultaneously
9. Multiple genes manage how people taste sweeteners
10. Gene mutations caused by a fathers lifestyle can be inherited by multiple generations
11. Testing method promising for spinal cord injuries, multiple sclerosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... celebrated tonight at the third annual Golden Goose Award ... premature infants and in paving the way for the ... supported by the National Science Foundation, the National Institutes ... be honored at a ceremony at the Library of ... of Congress will be on hand to help present ...
(Date:9/18/2014)... of the fish world, are the ideal animal in ... They,ve moved from the ocean into tens of thousands ... time changing their skeleton to adapt to the new ... of sticklebacks now have turned up one of the ... simple change in that gene,s regulation in a freshwater ...
(Date:9/17/2014)... were instrumental in the creation of the Santa Ana ... the fire threat potential of the powerful, hot, dry ... an inferno. The index was introduced Sept. 17 by ... San Diego Gas and Electric. , The index includes ... will be used to help fire agencies and other ...
Breaking Biology News(10 mins):3rd annual Golden Goose award ceremony honors 8 researchers; Unusual work had big results 2Counting fish teeth reveals regulatory DNA changes behind rapid evolution, adaptation 2Counting fish teeth reveals regulatory DNA changes behind rapid evolution, adaptation 3UCLA scientists play key role in developing new Santa Ana Wildfire Threat Index 2
... 15, 2011 -- Sing it with us: What lives in the ... new species of mushroom almost as strange as its cartoon namesake. ... Francisco State University researcher Dennis Desjardin, suggests that even some of ... be identified. Shaped like a sea sponge, S. squarepantsii ...
... research papers that have been recently published in ... (GRL), Journal of Geophysical Research-Atmospheres (JGR-D), ... Geophysical Research-Oceans (JGR-C). In this release:, ... Surge in North Atlantic hurricanes due to better detectors, ...
... press conference on Monday 11 July at University of Edinburgh ... the world meet next month in Edinburgh (11-15 July) to ... the first time in over 20 years, the Scientific Committee ... Symposium of Antarctic Earth Sciences (ISAES) in the UK. ...
Cached Biology News:'SpongeBob' mushroom discovered in the forests of Borneo 2'SpongeBob' mushroom discovered in the forests of Borneo 3AGU journal highlights -- June 15, 2011 2AGU journal highlights -- June 15, 2011 3AGU journal highlights -- June 15, 2011 4AGU journal highlights -- June 15, 2011 5AGU journal highlights -- June 15, 2011 6AGU journal highlights -- June 15, 2011 7AGU journal highlights -- June 15, 2011 8AGU journal highlights -- June 15, 2011 9AGU journal highlights -- June 15, 2011 10AGU journal highlights -- June 15, 2011 11AGU journal highlights -- June 15, 2011 12
(Date:9/18/2014)... LOUIS , Sept. 18, 2014  U.S. biotech ... by signing an exclusive license for technology developed by ... control gene expression in plants, including for applications in ... The technology was developed under the ... officer at Kultevat and former president of the Danforth ...
(Date:9/18/2014)...  Neogen Corporation (Nasdaq: NEOG ) announced ... with Merck Animal Health to market Neogen,s Igenity ® ... Dairy Heifer Program consists of genomic tests that offer ... of replacement dairy heifers. The genomic tests can be ... an excellent tool in the decision-making process for breeding ...
(Date:9/18/2014)... YARDLEY , Pennsylvanie, 18 septembre 2014 ... Lyon en 1974, a été ... à compléter les évaluations cliniques traditionnelles par ... Reported Outcomes) et sur les impacts économiques ... http://photos.prnewswire.com/prnh/20140618/119365 A cours ...
(Date:9/18/2014)... OMICS Group International invites researchers, authors and ... ‘Open Access Week’ by actively contributing their research ... Journals from 20-26th October, 2014. , Pharmaceutical ... accelerating with a tremendous speed to provide improved ... industry is gearing with innovation and technological revolution ...
Breaking Biology Technology:Kultevat obtains license of gene switch technology 2Merck Animal Health to market Neogen's dairy genomic program 21974 - 2014 - Mapi fête ses 40 ans 2Pharma and Omics Journals to Address Global Challenges during Open Access Week 2Pharma and Omics Journals to Address Global Challenges during Open Access Week 3
... University of Wisconsin-Madison faculty have created a new dual-degree ... students how to apply such knowledge to problems in ... and aggression," says Clark Miller, a professor of science ... the new program. "Or what about brain mechanisms that ...
... agricultural equipment manufacturer Gehl Co. has developed a ... boom functions using a compact, wireless remote control pendant from ... The hand-held pendant can be used to raise, lower, extend ... , ,"Our goal was to add a new dimension ...
... -- Thomas Record, a biophysical chemist at the University ... Society Fellows by the Biophysical Society, a 7,000-member U.S. ... professor of chemistry and biochemistry, Record hopes that the ... students and extramural funding for his research. , ,A ...
Cached Biology Technology:UW offers new program in neuroscience and public policy 2
...
Agarose for baculovirus plaque assays which allow optimal growth of plated insect cells....
BD BaculoGold Max-XP Insect Cell Medium 1 Liter...
Mycoplasma and virus tested...
Biology Products: