Navigation Links
Multiple myeloma study uncovers genetic diversity within tumors
Date:1/13/2014

ly at BRAF, a cancer gene for which several inhibitors, or drugs, exist. Previous studies indicated that around four percent of multiple myeloma patients may have mutations in this gene, and a recent report on a single multiple myeloma patient treated with drugs targeting BRAF showed promising results. BRAF inhibitors have also been used to treat patients with melanoma and other forms of cancer. In the lab, however, the research team found evidence that treating a tumor harboring subclonal BRAF mutations with one of these targeted drugs may at best kill a fraction of the cells, and at worst, stimulate another cancer cell subpopulation to grow.

"There's clearly potential for these drugs in some patients with multiple myeloma, but we show that there are also potential problems for others," said co-first author Jens Lohr an associated scientist at the Broad and a medical oncologist at Dana-Farber. "If a patient has a BRAF mutation in less than 100 percent of his cells, or if he has mutations in KRAS or NRAS at the same time, his oncologist would want to think through the potential pitfalls before giving the inhibitor."

Resistance or the ability for tumors to shrink and then grow back has become a major hurdle in treating patients with targeted therapies such as BRAF inhibitors. The new research suggests that subclonal populations could be one of the potential reasons many patients suffer relapse after treatment.

To take a genetic census of the populations of cancer cells that make up a tumor, the researchers used a computational technique known as ABSOLUTE, developed by the Broad's Cancer Genome Computational Analysis group, led by Broad associate member and co-senior author Gad Getz. In this study, ABSOLUTE was used to analyze information from many samples, but it's also feasible to use the algorithm to analyze information from a single patient. This could allow cancer researchers to examine a specific tumor and determine what fraction of
'/>"/>

Contact: Haley Bridger
hbridger@broadinstitute.org
617-714-7968
Broad Institute of MIT and Harvard
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Multiple mates worth the risk for female prairie dogs
2. Clinical ovarian cancers display extensive genetic heterogeneity, study suggests multiple treatment
3. Research reveals new understanding, warning signs, and potential treatments for multiple sclerosis
4. Research team uncovers root cause of multiple myeloma relapse
5. Carbon farming schemes should consider multiple cobenefits
6. Multiple sclerosis appears to originate in different part of brain than long believed
7. First study to investigate the human genome in multiple sclerosis
8. Novel approach to gene regulation can activate multiple genes simultaneously
9. Multiple genes manage how people taste sweeteners
10. Gene mutations caused by a fathers lifestyle can be inherited by multiple generations
11. Testing method promising for spinal cord injuries, multiple sclerosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... ALBANY, New York , July 7, 2014 /PRNewswire/ ... published by Transparency Market Research "Electronic Access Control Systems ... Analysis, 2014 - 2019," the global Electronic Access Control ... 2013 and is expected to grow at a CAGR ... estimated value of USD 31,187.8 million in 2019. ...
(Date:7/10/2014)... 2014  Acuity Market Intelligence today released forecasts from "The ... that the global market for National Electronic ID (eID) programs ... During this time, the number of National eID cards in ... Asia , with its vast population, will dominate ... issued, while Europe trails a distant ...
(Date:7/10/2014)... genus Axinaea belongs to the large, mainly tropical ... ca. 5000 species in the family rely on bees for ... by other insects or vertebrates. The flowers of Axinaea ... flowers and the petals of the different species are pink, ... out based on the contrasting colours of their bulbous appendages. ...
Breaking Biology News(10 mins):Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 2Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 3Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 4Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 5National Electronic ID Programs Generate $54 Billion Between 2013 and 2018 with 3.5 Billion National eID Card Holders Worldwide 2Novel type of bird pollination mechanism discovered in South America 2
... detection methods, researchers at the Saint Louis University Institute ... by which the HIV virus infects, or integrates, healthy ... for HIV. , Although scientists theorized that two ends ... healthy cell in order to infect it, until now, ...
... like other biological attributes, is shaped by evolution ... species that are in other ways very similar ... the visual world slightly differently, using photoreceptors that ... studying a special group of closely-related fish species ...
... stroke has taken a major step forward following promising results ... of Manchester have shown in laboratory studies that a naturally ... death. , The team, led by Professor Nancy Rothwell and ... first small trial of IL-1ra in patients, which are published ...
Cached Biology News:SLU researchers uncover direct evidence on how HIV invades healthy cells 2Multiple genes permit closely related fish species to mix and match their color vision 2Stroke treatment a step closer after trial 2
(Date:7/10/2014)... (PRWEB) July 10, 2014 OMICS Group’s ... techniques during 18-20 August, 2014 at Double Tree by ... the recent developments in Analytical & Bioanalytical research methods ... , Speaking on this occasion, Dr. Srinubabu Gedela, MD ... Acta conference is a remarkable one in bringing a ...
(Date:7/10/2014)... -- Kainos Capital, a firm specializing in acquiring and managing ... acquired the Slim-Fast brand from Unilever. Unilever will retain ... transaction were not disclosed. Slim-Fast is a ... ready-to-drink shakes, powders, bars and snacks to retail customers ... the United Kingdom and Ireland.  ...
(Date:7/10/2014)... the fight against terrorism with the creation of a ... the use of light and special glass fibres. , ... Chemical , the researchers describe a novel optical fibre ... as 6.3 ppm (parts per million). It requires an ... explosives detection has involved looking for metals that encase ...
(Date:7/10/2014)... that power our laptops and electric vehicles could store ... with the help of a sponge-like silicon material. ... graphite traditionally used in one of the battery,s electrodes, ... storage capacity of graphite. A paper describing the material,s ... in Nature Communications . , "Silicon has long ...
Breaking Biology Technology:A Critical Review of Analytical Techniques for Improved Living Standards 2A Critical Review of Analytical Techniques for Improved Living Standards 3A Critical Review of Analytical Techniques for Improved Living Standards 4Kainos Capital Acquires Slim-Fast From Unilever 2Detecting trace amounts of explosives with light 2Silicon sponge improves lithium-ion battery performance 2Silicon sponge improves lithium-ion battery performance 3
... , , , ... Board: SYMD), a biomaterials company engaged in the development ... the company,s bioresorbable adhesion barrier film for the reduction ... the Brazilian Ministry of Health for use in all ...
... DURHAM, N.C., Sept. 9 Oxygen Biotherapeutics, Inc. (OTC Bulletin Board: ... asks shareholders to approve a 1-for-15 reverse stock split at the ... "At last years, general annual meeting we explained the problems of ... promised to seek a listing change as soon as we can ...
... MUMBAI, India, September 9 , ... its First Domain-Specific Learning,and Consulting Solutions for Health Care ... Interactive Systems (TIS)-has,recently announced the launch of its first ... industry. TIS formally,launched this initiative with the appointment of ...
Cached Biology Technology:SyntheMed Receives Brazilian Regulatory Approval for REPEL-CV(TM) 2Oxygen Biotherapeutics, Inc. Seeks Shareholder Approval for Reverse Stock Split 2Tata Interactive Systems Initiates Vertical-Focused Learning Solutions for Health Care, Pharmaceutical, and Biotechnology 2Tata Interactive Systems Initiates Vertical-Focused Learning Solutions for Health Care, Pharmaceutical, and Biotechnology 3Tata Interactive Systems Initiates Vertical-Focused Learning Solutions for Health Care, Pharmaceutical, and Biotechnology 4
... is the major proteolytic system in ... it catalyzes the selective degradation of ... elimination of proteins with abnormal conformation ... The critical protease in this pathway ...
... [1320] to RFC1 Immunogen Recombinant protein ... Factor C expressed in E. coli. Reactivity ... cerevisiae. Not yet tested in other species. This ... Background Information Replication factor C is ...
... Bacterial DNA Isolation Kit provides a rapid ... genomic DNA from the various bacterial species ... the isolation of genomic DNA from both ... milk samples. ,Purification is based on ...
... Chemicon Select Tissue Arrays are intended for ... tissues were fixed in neutral buffered formalin ... and diagnosis was performed by certified pathologists. ... paraffin blocks and relocated into a new ...
Biology Products: