Navigation Links
Multiple Sclerosis: new MRI contrast medium enables early diagnosis in animal model
Date:8/1/2008

In an animal model of multiple sclerosis (MS), neuroradiologists and neurologists of the University hospitals of Heidelberg and Wrzburg have been able to visualize inflammatory tissue damage, most of which had remained unrecognized up to now, with the aid of a new contrast medium, Gadofluorine M, in magnetic resonance imaging. The scientists have published their results in the online edition of the renowned medical journal Brain.

In particular at the early stage of the disease, drug treatment is effective. Up to now, how-ever, an early diagnosis is frequently not established with certainty, especially if no (or very few) inflammatory lesions are present on MRI. "With this new contrast medium, we were able to visualize five to ten times more foci of inflammation in comparison to conventional MRI images and contrast media", reports Professor Dr. Martin Bendszus, Medical Director of the Department of Neuroradiology at the University hospital of Heidelberg.

Previously unrecognized patches of demyelination visible in MRI

MS is a chronic inflammatory disease of the central nervous system of unknown cause. It usually begins in young adults, and women are affected more frequently. In Germany, ap-proximately 120,000 patients are afflicted. MS is characterized by multiple inflammatory le-sions in which nerve fibers lose their myelin sheath. These patches of demyelination cause neurological malfunctions that may regress upon remyelination. At later stages, MS may re-sult in a loss of nerve fibers, leading to irreversible damage and persistent neurological symptoms. MRI plays a crucial role in the early diagnosis of MS and monitoring of the dis-ease.

The scientists from Heidelberg and Wrzburg examined brains and spinal cords of animals at different stages of the disease with the new contrast medium and found significantly more inflammatory lesions than with conventional contrast media. Examinations of tissue sections f
'/>"/>

Contact: Dr. Martin Bendszus
martin_bendszus@med.uni-heidelberg.de
49-622-156-7566
University Hospital Heidelberg
Source:Eurekalert

Page: 1 2

Related biology news :

1. Fast AFM probes measure multiple properties of biomolecules or materials simultaneously
2. Potential new target for multiple sclerosis therapy
3. Multiple resource management is focus of new technical report
4. Multiple species of bacteria may cause trachoma: Implications for treatment
5. The power of multiples: Connecting wind farms can make a more reliable - and cheaper - power source
6. New magnetic separation technique might detect multiple pathogens at once
7. Israeli scientists identify: Genes that affect responses of multiple sclerosis patients to copaxone
8. For honey bee queens, multiple mating makes a difference
9. Emphasis on conifer forests places multiple species at risk
10. Nicotinic receptors may be important targets for treatment of multiple addictions
11. Diverse genetic abnormalities lead to NF-κB activation in multiple myeloma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/11/2015)... 2015   The Sync Project™ today ... measure and harness music to improve health. The ... objective measurements of physiology, enabling the study of ... large populations. It is designed for medical and ... rigorous studies and accelerate the discovery of the ...
(Date:3/10/2015)... , March 10, 2015 ... "Personalized Medicine in Human Space Flight" ... Thomas J. Goodwin , Ph.D. was recently featured ... the past two years. Specifically, "Personalized Medicine ... downloaded scientific papers published in 2013 and 2014 from ...
(Date:3/10/2015)... OXFORD, Conn. , March 10, 2015 /PRNewswire/ ... NXTDW) ("NXT-ID" or the "Company"), a biometric authentication ... reports the company,s Wocket™ smart wallet has been ... 2015" by Rethink Modern. Rethink Modern ... sharing modern and innovative items for your home and lifestyle that ...
Breaking Biology News(10 mins):Introducing The Sync Project, a Global Collaboration Harnessing the Scientific Potential of Music for Health 2Introducing The Sync Project, a Global Collaboration Harnessing the Scientific Potential of Music for Health 3"Personalized Medicine in Human Space Flight" Listed Among Most Influential Papers of 2013 and 2014 2NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 2NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 3NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 4
... to the Alps, have fascinated University of California, Berkeley, ... in a new book, " The Mountains of Saint ... a focus on Italian geologists and their groundbreaking - ... published this month by W. W. Norton & Company, ...
... Goldbergthe cartoonist who devised complex machines for simple taskswould have ... As Hinoi et al. show, the fat-derived hormone enlists the ... molecule that prods the pancreas to discharge insulin. The ... and in the December 29, 2008 print issue of The ...
... in Italy and Switzerland has shown that carbon nanotubes ... published December 21 in the advance online edition of ... step forward in the search to find ways to ... carbon nanotubes, which, like neurons, are highly electrically conductive, ...
Cached Biology News:Italy's geologic history becomes a personal tale in Walter Alvarez's new book 2Italy's geologic history becomes a personal tale in Walter Alvarez's new book 3Italy's geologic history becomes a personal tale in Walter Alvarez's new book 4Leptin's long-distance call to the pancreas 2New 'smart' materials for the brain 2
(Date:3/27/2015)... March 27, 2015 Governor Andrew M. ... period for 43North - the world’s largest business idea ... grand prize of $1 million, six $500,000 awards and ... the world to compete for prizes that will turn ... the Western New York region. , "Last year's ...
(Date:3/26/2015)... San Bruno, CA (PRWEB) March 26, 2015 ... organization (CRO), announced today several management and executive ... role of Chief Financial Officer (CFO) and member of ... Vice President of Business Operations, and Sue Dowden will ... Tony Taricco, co-founder and current Chief Operations Officer (COO), ...
(Date:3/26/2015)... 2015 The Market Element LLC, a ... alliance with Designing Gig LLC to provide website design, ... , “Forging this alliance with Designing Gig represents a ... extend a comprehensive, end-to-end, digital solution for our clients, ... said Chuck Miller, president of The Market Element. “For ...
(Date:3/26/2015)... and CINCINNATI , ... plc (LSE: SHP, NASDAQ: SHPG ) and ... three-year, broad research collaboration for rare diseases. The goal ... novel therapies to treat rare diseases with high ... capabilities with Cincinnati Children,s research expertise. As a ...
Breaking Biology Technology:Governor Andrew M. Cuomo Anounces Launch of Year Two of World's Largest Business Idea Competition and Opening of New Incubator Space in Buffalo, New York 2Governor Andrew M. Cuomo Anounces Launch of Year Two of World's Largest Business Idea Competition and Opening of New Incubator Space in Buffalo, New York 3Governor Andrew M. Cuomo Anounces Launch of Year Two of World's Largest Business Idea Competition and Opening of New Incubator Space in Buffalo, New York 4Governor Andrew M. Cuomo Anounces Launch of Year Two of World's Largest Business Idea Competition and Opening of New Incubator Space in Buffalo, New York 5PRC Clinical Announces Key Management Appointments and Launches East Coast Operations 2PRC Clinical Announces Key Management Appointments and Launches East Coast Operations 3The Market Element LLC and Designing Gig LLC Form Strategic Alliance 2Shire and Cincinnati Children's Establish Rare Disease Research Collaboration 2Shire and Cincinnati Children's Establish Rare Disease Research Collaboration 3Shire and Cincinnati Children's Establish Rare Disease Research Collaboration 4Shire and Cincinnati Children's Establish Rare Disease Research Collaboration 5
... Corporation, a,subsidiary of KV Pharmaceutical (NYSE: KVa/KVb), is ... January 26, 2009, a nationwide,voluntary recall of the ... at a wholesale or a retail level as ... under conditions that did not,sufficiently comply with current ...
... Scientific business of Thomson Reuters today announced the results ... of scientific research output continues to shrink while Asia-Pacific,s ... a healthy footing globally in the relative impact of ... Watch , Thomson Reuters analyzes 12 year,s worth of ...
... 28 Medarex, Inc. (Nasdaq: MEDX ) ... (IND) application filed with the U.S. Food & Drug ... (ADC) candidate generated from its proprietary technology. MDX-1203 is ... a fully human anti-CD70 antibody. CD70 is expressed in ...
Cached Biology Technology:ETHEX Corporation Issues Nationwide Voluntary Recall of Products 2ETHEX Corporation Issues Nationwide Voluntary Recall of Products 3ETHEX Corporation Issues Nationwide Voluntary Recall of Products 4ETHEX Corporation Issues Nationwide Voluntary Recall of Products 5ETHEX Corporation Issues Nationwide Voluntary Recall of Products 6Despite Decline in Share of Global Output, U.S. Science Impact Still Strong, Says Thomson Reuters 2Medarex Announces Allowance of Investigational New Drug Application for Company's First Antibody-Drug Conjugate, MDX-1203 2Medarex Announces Allowance of Investigational New Drug Application for Company's First Antibody-Drug Conjugate, MDX-1203 3
... 20 cm, is used for vertical slab gel ... gels. The cell is supplied without spacers and ... with gaskets, lower buffer chamber, lid with cables, ... upper buffer dam, casting stand with gaskets, leveling ...
CleanCut agarose is used to prepare genomic DNA plugs for use in pulsed field gel electrophoresis (PFGE) applications. Supplied as a 12 ml solution of 2% agarose....
... groove-binding probe for DNA. Binds to the ... AT rich DNA), forming a stable complex ... DAPI alone. DAPI is several times more ... in agarose gels. It may be used ...
...
Biology Products: