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Multicolor quantum dots aid in cancer biopsy diagnosis
Date:7/6/2010

mory University School of Medicine and director of clinical laboratories at Grady Health System. "We expect it could help guide the type of treatment a cancer patient gets and that it could be used with a wider variety of tumor types."

The most reliable way to assign cell identity is to look at more than one protein, Young says. With the standard methods in most pathology labs, staining cells with four different antibodies would require four separate slides a problem when the specimen is very small. Small diagnostic specimens are common today, because they minimize the burden on the patient. In addition, the images from multiple separate slides wouldn't depict exactly the same cells. The quantum dots allow "multiplexing": superimposing four colors on top of each other.

Hodgkin's lymphoma is usually treated with chemotherapy and radiation, and is notable among the subtypes of adult lymphoma because the survival rate is relatively high. Young says the quantum dot technique could be useful for other types of cancer, where distinguishing cancer cells based on surface or genetic markers can point oncologists towards "targeted therapies" designed for one particular type of tumor.


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Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University
Source:Eurekalert  

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