Navigation Links
Multicolor quantum dots aid in cancer biopsy diagnosis
Date:7/6/2010

The tunable fluorescent nanoparticles known as quantum dots make ideal tools for distinguishing and identifying rare cancer cells in tissue biopsies, Emory and Georgia Tech scientists have demonstrated.

An article to be featured on the cover of the July 15 issue of Analytical Chemistry describes how multicolor quantum dots linked to antibodies can distinguish the Reed-Sternberg cells that are characteristic of Hodgkin's lymphoma.

"Our multicolor quantum dot staining method provides rapid detection and identification of rare malignant cells from heterogenous tissue specimens," says senior author Shuming Nie, PhD, the Wallace H. Coulter distinguished professor in the Coulter department of biomedical engineering at Georgia Tech and Emory University. "The clinical utility is not limited to Hodgkin's lymphoma but potentially could be extended to detect cancer stem cells, tumor-associated macrophages and other rare cell types."

Quantum dots are nanometer-sized semiconductor crystals that have unique chemical and physical properties due to their size and their highly compact structure. Quantum dots can be chemically linked to antibodies, which can detect molecules present on the surfaces or internal parts of cancer cells.

As a test of quantum dots' discriminatory power, the authors used four varieties at once -- white, red, green and blue each detecting a different protein, to stain lymph node biopsies. The goal was to distinguish six Hodgkin's lymphoma cases from two other types of lymphoma and samples from two patients with benign growths in their lymph nodes.

Reed Sternberg cells have a distinctive appearance, but in lymph node tissue, they are usually surrounded by other white blood cells. The authors describe identifying them as a task like "finding a needle in a haystack."

"We're excited about this technology," says Andrew Young, MD, PhD, associate professor of pathology and laboratory medicine at E
'/>"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Zeroing in on quantum effects
2. Untangling the quantum entanglement behind photosynthesis
3. Digging deep into diamonds, applied physicists advance quantum science and technology
4. Scientists find quantum mechanics at work in photosynthesis
5. Diamonds may be the ultimate MRI probe, say Quantum physicists
6. Covering the bases: Quantum effect may hold promise for low-cost DNA sequencing, sensor applications
7. Rice eyes risks of quantum dots
8. New technique is quantum leap forward in understanding proteins
9. Strained quantum dots show new optical properties
10. Study shows quantum dots can penetrate skin through minor abrasions
11. Europe gets together to harness quantum physics
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Multicolor quantum dots aid in cancer biopsy diagnosis
(Date:7/11/2014)... near the City of Entiat on Tuesday, July 8, ... quickly grew to over 1,000 acres by evening. Three ... under investigation by the Washington Department of Natural Resources. ... resources in developing fire control strategies and tactics. Other ... Department of Natural Resources, (WA DNR), Bureau of Land ...
(Date:7/11/2014)... Institute of Standards and Technology (NIST) need a ... they often prove that necessity is truly the ... for M. Lorna De Leoz and Stephen Stein, ... glycomics. Glycomics is the study of the abundant, ... to proteins and lipids and influence cellular processes, ...
(Date:7/11/2014)... Researchers from Ume University, Sweden, have explored two ... the reaction sequence leading to the formation of ... been published in the scientific journal Nature ... improving present day synthetic catalysts for water oxidation, ... devices for the direct storage of solar energy ...
Breaking Biology News(10 mins):Molecular snapshots of oxygen formation in photosynthesis 2
... Steven Chu announced today the winners of the 2009 E.O. ... supporting the Department of Energy and its missions. The ... citation and $50,000. Winners will be honored at ... made by these researchers to advance the national, economic and ...
... short-term, seasonal exposure to pesticides in rivers and basins ... populations. In addition to the widespread deterioration of salmon ... pesticides may further inhibit the recovery of threatened or ... to restore Pacific salmon habitats in an effort to ...
... , , SUNNYVALE, Calif., Dec. 1 GestureTek ... 3.0 - a turnkey, portable, plug and play interactive ... promotions. GestureTek is the inventor and holder of dozens ... display, presentation and entertainment systems. , Guaranteed for quality, ...
Cached Biology News:Secretary Chu announces 2009 Ernest Orlando Lawrence Award winners 2Even at sublethal levels, pesticides may slow the recovery of wild salmon populations 2GestureTek Unveils The CUBE V3 Portable, Plug and Play Interactive Projection Display System for Advertising and Exhibits 2GestureTek Unveils The CUBE V3 Portable, Plug and Play Interactive Projection Display System for Advertising and Exhibits 3
(Date:7/10/2014)... July 10, 2014 Deep Knowledge ... Medicine Forum on ‘Commercialising Longevity Research’ and welcomed ... to the London Bioscience Innovation Center for the ... and Aging Analytics Ltd. The meeting highlighted the ... translational research for age-related disease, as well as ...
(Date:7/10/2014)... OMICS Group’s 5th International conference and exhibition ... at Double Tree by Hilton Beijing, China is all ... & Bioanalytical research methods only to facilitate improved living ... Dr. Srinubabu Gedela, MD of OMICS Group Inc has ... one in bringing a unique and international mix of ...
(Date:7/10/2014)... 10, 2014  Kainos Capital, a firm specializing in ... that it has acquired the Slim-Fast brand from Unilever. ... Terms of the transaction were not disclosed. ... business that markets ready-to-drink shakes, powders, bars and snacks ... and in the United Kingdom ...
(Date:7/10/2014)... the fight against terrorism with the creation of a ... the use of light and special glass fibres. , ... Chemical , the researchers describe a novel optical fibre ... as 6.3 ppm (parts per million). It requires an ... explosives detection has involved looking for metals that encase ...
Breaking Biology Technology:DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 2DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 3DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 4DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 5DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 6A Critical Review of Analytical Techniques for Improved Living Standards 2A Critical Review of Analytical Techniques for Improved Living Standards 3A Critical Review of Analytical Techniques for Improved Living Standards 4Kainos Capital Acquires Slim-Fast From Unilever 2Detecting trace amounts of explosives with light 2
... , COPENHAGEN, June 4 ... an inhibitor of HIF-1alpha, jointly developed by,Enzon Pharmaceuticals and ... signs of clinical benefit in previously treated cancer patients ... solid,tumors and lymphoma. The study data, which was presented ...
... June 4 Optimer Pharmaceuticals, Inc. (Nasdaq: OPTR ) today announced ... , , 8th ... Eastern Time at the New York Palace Hotel in New York City. , ... June 18, 2009 at 1:30 p.m. Eastern Time at the Mandarin Oriental Hotel ...
... Austria, June 4 EUCODIS Bioscience, a company,developing ... announced today that it has successfully launched its ... by EUCODIS,Bioscience and can be supplied in a ... antibiotics manufacturers to improve,quality control, to the diagnostics ...
Cached Biology Technology:LNA-Based HIF-1 Alpha Inhibitor Shows Early Signs of Clinical Benefit 2LNA-Based HIF-1 Alpha Inhibitor Shows Early Signs of Clinical Benefit 3Optimer Pharmaceuticals to Present at June 2009 Investor Conferences 2EUCODIS Bioscience Launches Beta-Lactamase for Antibiotics and Diagnostics Industries 2
The pCDF Expression System 1 plus Competent Cells contains 10 µg of pET-45b(+) DNA. pET-45b carries an N-terminal His•Tag ® coding sequence that is cleavable with enterokinase as well...
HIV-1 TAT (vN-21)...
Request Info...
Request Info...
Biology Products: