Navigation Links
Multicolor quantum dots aid in cancer biopsy diagnosis
Date:7/6/2010

The tunable fluorescent nanoparticles known as quantum dots make ideal tools for distinguishing and identifying rare cancer cells in tissue biopsies, Emory and Georgia Tech scientists have demonstrated.

An article to be featured on the cover of the July 15 issue of Analytical Chemistry describes how multicolor quantum dots linked to antibodies can distinguish the Reed-Sternberg cells that are characteristic of Hodgkin's lymphoma.

"Our multicolor quantum dot staining method provides rapid detection and identification of rare malignant cells from heterogenous tissue specimens," says senior author Shuming Nie, PhD, the Wallace H. Coulter distinguished professor in the Coulter department of biomedical engineering at Georgia Tech and Emory University. "The clinical utility is not limited to Hodgkin's lymphoma but potentially could be extended to detect cancer stem cells, tumor-associated macrophages and other rare cell types."

Quantum dots are nanometer-sized semiconductor crystals that have unique chemical and physical properties due to their size and their highly compact structure. Quantum dots can be chemically linked to antibodies, which can detect molecules present on the surfaces or internal parts of cancer cells.

As a test of quantum dots' discriminatory power, the authors used four varieties at once -- white, red, green and blue each detecting a different protein, to stain lymph node biopsies. The goal was to distinguish six Hodgkin's lymphoma cases from two other types of lymphoma and samples from two patients with benign growths in their lymph nodes.

Reed Sternberg cells have a distinctive appearance, but in lymph node tissue, they are usually surrounded by other white blood cells. The authors describe identifying them as a task like "finding a needle in a haystack."

"We're excited about this technology," says Andrew Young, MD, PhD, associate professor of pathology and laboratory medicine at Emory University School of Medicine and director of clinical laboratories at Grady Health System. "We expect it could help guide the type of treatment a cancer patient gets and that it could be used with a wider variety of tumor types."

The most reliable way to assign cell identity is to look at more than one protein, Young says. With the standard methods in most pathology labs, staining cells with four different antibodies would require four separate slides a problem when the specimen is very small. Small diagnostic specimens are common today, because they minimize the burden on the patient. In addition, the images from multiple separate slides wouldn't depict exactly the same cells. The quantum dots allow "multiplexing": superimposing four colors on top of each other.

Hodgkin's lymphoma is usually treated with chemotherapy and radiation, and is notable among the subtypes of adult lymphoma because the survival rate is relatively high. Young says the quantum dot technique could be useful for other types of cancer, where distinguishing cancer cells based on surface or genetic markers can point oncologists towards "targeted therapies" designed for one particular type of tumor.


'/>"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University
Source:Eurekalert  

Related biology news :

1. Zeroing in on quantum effects
2. Untangling the quantum entanglement behind photosynthesis
3. Digging deep into diamonds, applied physicists advance quantum science and technology
4. Scientists find quantum mechanics at work in photosynthesis
5. Diamonds may be the ultimate MRI probe, say Quantum physicists
6. Covering the bases: Quantum effect may hold promise for low-cost DNA sequencing, sensor applications
7. Rice eyes risks of quantum dots
8. New technique is quantum leap forward in understanding proteins
9. Strained quantum dots show new optical properties
10. Study shows quantum dots can penetrate skin through minor abrasions
11. Europe gets together to harness quantum physics
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Multicolor quantum dots aid in cancer biopsy diagnosis
(Date:4/5/2017)... 2017 KEY FINDINGS The global ... a CAGR of 25.76% during the forecast period of ... factor for the growth of the stem cell market. ... MARKET INSIGHTS The global stem cell market is ... geography. The stem cell market of the product is ...
(Date:3/30/2017)... -- On April 6-7, 2017, Sequencing.com will host the world,s ... at Microsoft,s headquarters in Redmond, Washington ... health and wellness apps that provide a unique, personalized ... is the first hackathon for personal genomics and the ... the genomics, tech and health industries are sending teams ...
(Date:3/29/2017)... -- higi, the health IT company that operates the largest ... , today announced a Series B investment from BlueCross ... new investment and acquisition accelerates higi,s strategy to create ... health activities through the collection and workflow integration of ... and secures data today on behalf of over 36 ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... the three Winners and six Finalists of the 2017 Blavatnik Regional Awards for ... Blavatnik Family Foundation and administered by the New York Academy of Sciences to ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... multicenter, prospective clinical study that demonstrates the accuracy of the FebriDx® test, ... clinically significant acute bacterial and viral respiratory tract infections by testing the ...
(Date:10/12/2017)... ... October 12, 2017 , ... AMRI, a ... biotechnology industries to improve patient outcomes and quality of life, will now be ... are being attributed to new regulatory requirements for all new drug products, including ...
(Date:10/11/2017)... ... October 11, 2017 , ... At its ... announced Dr. Suneel I. Sheikh, the co-founder, CEO and chief research scientist of ... been selected for membership in ARCS Alumni Hall of Fame . ASTER ...
Breaking Biology Technology: