Navigation Links
Multi-institutional study identifies new form of inherited risk of cancer
Date:3/25/2008

NEW YORK (March 25, 2008) -- Like the subtext of a novel, the human genome sequence harbors more information than appears just in its "letters" of A, C, T and G. Since DNA is a data-packed molecule passed from generation to generation, comparing genome sequences among individuals also holds clues to ancestry.

So-called association studies that match unusual DNA sequence variations to diseases are very common nowadays. But a multi-institution group led by Dr. Francis Barany, professor of microbiology and immunology at Weill Cornell Medical College, has instead zeroed in on parts of the genome that are strikingly similar among people from a particular population group who have the same type of cancer. This "autozygosity" (identical copies of DNA inherited from both parents) might serve not only as a way to predict susceptibility to cancer in some people, but may lead researchers to novel cancer-causing genes. More broadly, the work suggests a new type of genetic signpost that clinicians might follow for a range of cancers, in many population groups.

In a paper "The Signatures of Autozygosity Among Patients with Colorectal Cancer," to be published online on March 28, and in print on April 15, in the journal Cancer Research, Dr. Barany and his colleagues report Identity by Descent (IBD) segments that are the same in sequence (autozygous) among individuals who have colorectal cancer. About half the cases are of Jewish heritage. The simplest explanation for their IBD segments is that they were inherited from a long-ago, shared ancestor. The investigators compared IBD regions among 74 colorectal cancer patients to two control groups, and found the segments to be twice as numerous and longer among the cancer patients.

Tellingly, the identical DNA stretches were more common among Jewish cancer patients. Scientifically, the power of this new approach derives from the common practice wherein individuals marry within the same ethnic or social background, known as "endogamy." (This custom carries no social stigma; on the contrary, it is a source of pride in most cultures.) Since the other half of patients with IBD are of Catholic or Protestant heritage, the results of such an analysis pertain to all populations. The IBD regions reveal where researchers should look for novel genes, which contribute to the overall risk for this cancer.

Colorectal cancer results in more than 52,000 deaths each year in the United States, with more than 153,000 new cases diagnosed. About a third of cases run in families, and some of them are caused by a handful of well-studied genes. The genetic underpinnings of most of the more than a million cases of colorectal cancer worldwide are not known. This new approach of following IBD regions may clear up some of that mystery -- and ultimately, many others.


'/>"/>

Contact: Andrew Klein
ank2017@med.cornell.edu
212-821-0560
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Source:Eurekalert

Related biology news :

1. Exposure to low levels of radon appears to reduce the risk of lung cancer, new study finds
2. Study finds pitching mound height affects throwing motion, injury risk
3. First study hints at insights to come from genes unique to humans
4. Community-intervention study links successful town makeover focused on boosting calcium and exercise
5. Study finds health professionals, public unprepared for genomic medicine
6. New study changes conditions for Spanish brown bears
7. Adolescent girls with ADHD are at increased risk for eating disorders, study shows
8. From the backyard to the ocean: New study shows streams act as key nitrogen filters
9. ORNL study finds rivers play part in removing nitrogen
10. US rush to produce corn-based ethanol will worsen dead zone in Gulf of Mexico: UBC study
11. Study suggests new way to screen infants for fetal alcohol syndrome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/20/2016)... Dec, 20, 2016   Valencell , the ... and STMicroelectronics (NYSE: STM), a global semiconductor ... applications, announced today the launch of a new, ... wearables that includes ST,s compact SensorTile ... biometric sensor system. Together, SensorTile and Benchmark ...
(Date:12/16/2016)...   IdentyTechSolutions America LLC , a leading ... and a cutting-edge manufacturer of software and hardware ... seamless, integrated solutions that comprise IDT biometric readers ... provide IdentyTech,s customers with combined physical identification and ... and theft. "We are proud to ...
(Date:12/16/2016)... , Dec. 16, 2016 The global wearable medical ... 12.14 billion by 2021 from USD 5.31 billion in 2016, at ... ... mainly driven by technological advancements in medical devices, launch of a ... preference for wireless connectivity among healthcare providers, and increasing focus on ...
Breaking Biology News(10 mins):
(Date:1/21/2017)... -- Bioptix, Inc. (Nasdaq: BIOP ... 14, 2017 the Board of Directors of the Company ... certain employees associated with the September 2016 acquisition of ... on January 16, 2017 and terminations are expected to ... severance benefits in certain circumstances of up to one ...
(Date:1/20/2017)... ... January 20, 2017 , ... The two newest companies to join the ... Vironika, a spin out from The Wistar Institute, and Sanguis, launched by a trio ... Market Street. , Vironika is developing a treatment for a chronic viral infection ...
(Date:1/20/2017)... NEW YORK , January 20, 2017 ... Health Organization, cancer is one of leading causes of ... in 2012. Although the number of cancer related deaths ... since 1990. Rising in incidence rate of various cancers ... According to a research report by Global Market Insights, ...
(Date:1/19/2017)... 19, 2017  Market Research Future has a half cooked research ... Biopsy is growing rapidly and expected to reach USD 450 Million ... ... Biopsy Market has been assessed as a swiftly growing market and ... in the coming future. There has been a tremendous growth in ...
Breaking Biology Technology: