Navigation Links
Multi-institutional study identifies new form of inherited risk of cancer
Date:3/25/2008

NEW YORK (March 25, 2008) -- Like the subtext of a novel, the human genome sequence harbors more information than appears just in its "letters" of A, C, T and G. Since DNA is a data-packed molecule passed from generation to generation, comparing genome sequences among individuals also holds clues to ancestry.

So-called association studies that match unusual DNA sequence variations to diseases are very common nowadays. But a multi-institution group led by Dr. Francis Barany, professor of microbiology and immunology at Weill Cornell Medical College, has instead zeroed in on parts of the genome that are strikingly similar among people from a particular population group who have the same type of cancer. This "autozygosity" (identical copies of DNA inherited from both parents) might serve not only as a way to predict susceptibility to cancer in some people, but may lead researchers to novel cancer-causing genes. More broadly, the work suggests a new type of genetic signpost that clinicians might follow for a range of cancers, in many population groups.

In a paper "The Signatures of Autozygosity Among Patients with Colorectal Cancer," to be published online on March 28, and in print on April 15, in the journal Cancer Research, Dr. Barany and his colleagues report Identity by Descent (IBD) segments that are the same in sequence (autozygous) among individuals who have colorectal cancer. About half the cases are of Jewish heritage. The simplest explanation for their IBD segments is that they were inherited from a long-ago, shared ancestor. The investigators compared IBD regions among 74 colorectal cancer patients to two control groups, and found the segments to be twice as numerous and longer among the cancer patients.

Tellingly, the identical DNA stretches were more common among Jewish cancer patients. Scientifically, the power of this new approach derives from the common practice wherein individuals marry within the same ethnic or social background, known as "endogamy." (This custom carries no social stigma; on the contrary, it is a source of pride in most cultures.) Since the other half of patients with IBD are of Catholic or Protestant heritage, the results of such an analysis pertain to all populations. The IBD regions reveal where researchers should look for novel genes, which contribute to the overall risk for this cancer.

Colorectal cancer results in more than 52,000 deaths each year in the United States, with more than 153,000 new cases diagnosed. About a third of cases run in families, and some of them are caused by a handful of well-studied genes. The genetic underpinnings of most of the more than a million cases of colorectal cancer worldwide are not known. This new approach of following IBD regions may clear up some of that mystery -- and ultimately, many others.


'/>"/>

Contact: Andrew Klein
ank2017@med.cornell.edu
212-821-0560
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Source:Eurekalert

Related biology news :

1. Exposure to low levels of radon appears to reduce the risk of lung cancer, new study finds
2. Study finds pitching mound height affects throwing motion, injury risk
3. First study hints at insights to come from genes unique to humans
4. Community-intervention study links successful town makeover focused on boosting calcium and exercise
5. Study finds health professionals, public unprepared for genomic medicine
6. New study changes conditions for Spanish brown bears
7. Adolescent girls with ADHD are at increased risk for eating disorders, study shows
8. From the backyard to the ocean: New study shows streams act as key nitrogen filters
9. ORNL study finds rivers play part in removing nitrogen
10. US rush to produce corn-based ethanol will worsen dead zone in Gulf of Mexico: UBC study
11. Study suggests new way to screen infants for fetal alcohol syndrome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... GARDENS, Fla. , April 11, 2017 /PRNewswire/ ... management and secure authentication solutions, today announced that ... by Intelligence Advanced Research Projects Activity (IARPA) to ... IARPA,s Thor program. "Innovation has been ... and IARPA,s Thor program will allow us to ...
(Date:4/5/2017)... SEATTLE , April 5, 2017  The Allen ... the Allen Cell Explorer: a one-of-a-kind portal and dynamic ... large-scale 3D imaging data, the first application of deep ... edited human stem cell lines and a growing suite ... the platform for these and future publicly available resources ...
(Date:3/30/2017)... ANGELES , March 30, 2017  On April ... Hack the Genome hackathon at Microsoft,s ... exciting two-day competition will focus on developing health and ... Hack the Genome is the ... been tremendous. The world,s largest companies in the genomics, ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... Diego, CA (PRWEB) , ... ... ... (https://www.onramp.bio/ ) has launched Rosalind™, the first-ever genomics analysis platform specifically ... all bioinformatics complexity. Named in honor of pioneering researcher Rosalind Franklin, who ...
(Date:10/11/2017)... NJ (PRWEB) , ... October 11, 2017 , ... Personal eye wash is a basic ... one eye at a time. So which eye do you rinse first if a dangerous ... have Plum Duo Eye Wash with its unique dual eye piece. , “Whether ...
(Date:10/11/2017)... -- VMS BioMarketing, a leading provider of patient support solutions, has ... (CNE) network, which will launch this week. The VMS CNEs ... professionals to enhance the patient care experience by delivering peer-to-peer ... care professionals to help women who have been diagnosed and ... ...
(Date:10/11/2017)... ... 2017 , ... A new study published in Fertility and ... in vitro fertilization (IVF) transfer cycles. The multi-center matched cohort study ... comparing the results from the fresh and frozen transfer cohorts, the authors of ...
Breaking Biology Technology: