Navigation Links
Multi-disciplinary Penn research identifies protein required for cell movement
Date:8/12/2013

vesicles and then release important molecules such as hormones and neurotransmitters to travel elsewhere in the body. A structure made up several proteins, called the exocyst, helps mediate this process. Previous work by Guo and colleagues found that the exocyst is also involved in cell migration. Last year his lab published a paper, also with Liu and Zhao as lead authors, showing that Exo70, a component of the exocyst, stimulates actin structural changes at the leading edge of migrating cells.

In the current study, Zhao, Liu, Guo and colleagues wanted to more deeply examine what Exo70 was doing in the cell and how it was doing it. Using electron microscopy, they first found that Exo70 "bends" the membranes to generate high-curvature tubules. In addition, the presence of Exo70 in cells led to the creation of protrusions on the membranes. They also found that Exo70 formed complexes of at least two copies of the protein, known as oliogmers.

Using mathematical models, the researchers teamed with Ravi Radhakrishnan's group in Penn Engineering to study how the curvature of these protrusions formed. They confirmed that their simulations matched up with what they were observing Exo70 do under the microscope.

Then, using time-lapse microscopy, they found that Exo70 generated protrusions in the membrane that were later filled with actin.

"We call it the empty glove," Guo said. "Exo70 is the glove, and actin acts like fingers that push in and fill the empty pockets."

Exo70 proteins that were mutated so they couldn't form oligomers were unable to effectively migrate, the researchers discovered, underscoring the importance of the molecule in helping cells make directed movements.

"This gives us a new understanding of the mechanism of cell migration," Guo said. "Studies in the field have been very much focused on actin, but our findings emphasize the importance of the membrane component in cell motility."

Guo and
'/>"/>

Contact: Katherine Unger Baillie
kbaillie@upenn.edu
215-898-9194
University of Pennsylvania
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. ASU receives prestigious $6.25 million multi-disciplinary research award from Department of Defense
2. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
3. Research reveals first evidence of hunting by prehistoric Ohioans
4. Diabetes Research Institute develops oxygen-generating biomaterial
5. APS issues new policy requiring identification of sex or gender in reporting scientific research
6. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
7. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
8. U of Alberta researcher steps closer to understand autoimmune diseases
9. Research on flavanols and procyanidins provides new insights into how these phytonutrients may positively impact human health
10. A project to research biological and chemical aspects of microalgae to fuel approach
11. Scripps Research discoveries lead to newly approved drug for infant respiratory distress syndrome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2015)... --NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the "Company"), ... market, announces its biometric payment technology, the Wocket® smart wallet, ... March 30 th . The new ... York markets. Gino Pereira ... new ad campaign following the recent initial shipment of Wocket ...
(Date:3/20/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... growing mobile commerce market, announces its biometric payment technology, ... featured in 2015 "I Want That" International CES Special, ... the DIY Network.   DIY,s "I Want ... site of the 2015 International CES for a firsthand ...
(Date:3/18/2015)... 18, 2015 As mobile payments become ... smart wallets and apps continue to be introduced into the ... the mobile payment industry in focus today are:  NXT-ID, Inc. ... BABA ), Apple Inc. (NASDAQ: AAPL ... Inc. (NASDAQ: FB ) NXT-ID, Inc. ...
Breaking Biology News(10 mins):NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 2NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 3NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 2NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 3Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 2Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 3Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 4Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 5Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 6
... its food or wait for dinner to arrive is linked to ... revealed. Prof. Rob McLaughlin has discovered that foraging behaviour of ... in the fish,s brain. "We found that the fish that ... telencephalons than the fish that sit along the shoreline and wait ...
... available in Chinese . College Park, MD (August ... powerful tools in molecular biology today. The devices, which can ... or genetic sequences, are employed in everything from forensic analysis ... Li and colleagues at Simon Fraser University in Burnaby, Canada ...
... Malfunction of a protein has been linked to a form of ... males, says Nasser K. Yaghi, a Texas A&M University magna cum ... research project at Harvard that has been published in the journal ... the condition is detected early in fetal development a treatment could ...
Cached Biology News:Brain size determines whether fish hunters or slackers 2Texas A&M spring graduate contributes to mental retardation research published in Nature 2
(Date:4/1/2015)... FREMONT, Calif. , April 1, 2015  ValGenesis ... Software solutions, announced today that it has completed its ... Section 101, Attest Engagements (AICPA, Professional Standards) for the ... 31 st 2014.  ... The ...
(Date:4/1/2015)... , Apr. 1, 2015 Goldman Small ... the small cap and microcap sectors, announced today that ... Inc. (OTCQB – PMCB), a publicly traded clinical stage ... cancer and diabetes. To view the sponsored research article, ... in its entirety, please visit www.GoldmanResearch.com .  ...
(Date:4/1/2015)... /PRNewswire/ - Portage Biotech Inc. ("Portage") (OTC Market: ... announce that Biohaven Pharmaceutical Holding Company Limited (Biohaven), ... an agreement with inVentiv Health for the operational ... lead compound (BHV-0223). Biohaven is ... stage neuroscience compounds targeting the glutamatergic system. Clinical ...
(Date:4/1/2015)... April 1, 2015  EMD Serono, the U.S. biopharmaceuticals ... , announced today the appointment of Frederick E. ... and Immunology. In this capacity, he will lead the ... projects and collaborations for Rebif ® (interferon beta-1a) ... Dr. Munschauer joins EMD Serono from ...
Breaking Biology Technology:ValGenesis Inc. Successfully Completes Service Organization Controls 2 (SOC 2) Report under AT Section 101 2ValGenesis Inc. Successfully Completes Service Organization Controls 2 (SOC 2) Report under AT Section 101 3Flurry of Biotech Mergers and Acquisitions Bodes Well for PharmaCyte Biotech 2Flurry of Biotech Mergers and Acquisitions Bodes Well for PharmaCyte Biotech 3Flurry of Biotech Mergers and Acquisitions Bodes Well for PharmaCyte Biotech 4Portage's Biohaven Announces Agreement with inVentiv Health 2Portage's Biohaven Announces Agreement with inVentiv Health 3EMD Serono Appoints Frederick E. Munschauer M.D., FAAN to Vice President of Medical Affairs, Neurology and Immunology 2EMD Serono Appoints Frederick E. Munschauer M.D., FAAN to Vice President of Medical Affairs, Neurology and Immunology 3EMD Serono Appoints Frederick E. Munschauer M.D., FAAN to Vice President of Medical Affairs, Neurology and Immunology 4EMD Serono Appoints Frederick E. Munschauer M.D., FAAN to Vice President of Medical Affairs, Neurology and Immunology 5
... and flat federal funding of biomedical research, five,important actions ... cost --,can yield dramatic results for patients and the ... (NCI) in a commentary published today by "The,Oncologist." , ... , In the article, James ...
... 07/06 2008 08/07, ... millions millions, ... 14, Other EU Countries 9.7 22 17 11.3 ... 3 10 2.0 4 45, SLIT ...
... Jan. 15 Regado Biosciences, Inc., announced today ... to the position of Senior Vice President, Clinical ... immediately. He will report to David J. ... Officer.Dr. Mazzo stated, "Steven has led clinical programs ...
Cached Biology Technology:National Cancer Institute: Battling Cancer and a Recession 2National Cancer Institute: Battling Cancer and a Recession 3Stallergenes: 2008: Sales Up 16% - Excellent Performance - Guidance Exceeded 2Stallergenes: 2008: Sales Up 16% - Excellent Performance - Guidance Exceeded 3Dr. Steven L. Zelenkofske Joins Regado Biosciences as Senior Vice President, Clinical and Medical Affairs and Chief Medical Officer 2Dr. Steven L. Zelenkofske Joins Regado Biosciences as Senior Vice President, Clinical and Medical Affairs and Chief Medical Officer 3
... dye terminators, template DNA, primers, salts or ... products have proved critical for both standard ... to work with dye terminator cycle sequencing ... The unique uniformity of the magnetic paeticles ...
Enodgenous alkaline phosphotase inhibitor. Levamisole solution is supplied in concentrated form (20x). The final concentration of levamisole in the substrate solution will be 1 mM....
uncoupling protein 2 (mitochondrial, proton carrier), mRNA (cDNA clone MGC:19567 IMAGE:4335185), complete cds...
Catch and Release® v2.0 Reversible Immunoprecipitation System...
Biology Products: