Mouse study: When it comes to living longer, it's better to go hungry than ... (ere some elevated levels of heat shock p...)

Mouse study: When it comes to living longer, it's better to go hungry than go running

Date:5/13/2008

ere some elevated levels of heat shock proteins, a measure of oxidative stress and possible tissue damage among the exercising mice. But total protein carbonyls, another stress measure, were not significantly different.

Both exercise and caloric restriction moderated the level of 8-hydroxyguanosine (8-OHdG), a marker of DNA damage. Among the animals that ate all they wanted, those that did not exercise had the highest levels of 8-OHdG and those that exercised had much lower levels. The researchers concluded that DNA damage increases with age and is accelerated by obesity but could be slowed by caloric restriction and/or exercise. The researchers noted, however, that the results may differ if they had used older mice or subjected them to greater caloric restriction than the mild (9% fewer calories) or moderate (18%) restriction this study employed.

Overall, these findings indicate that the physiological stress of exercise did not produce enough damage to tissues or DNA to explain why exercise does not lengthen life span. Instead the study suggests that caloric restriction creates beneficial changes in the bodys hormone levels which exercise does not. The researchers concluded that these metabolic changes play a role in extending life.

A handful of studies comparing calorie restricted people to people who are avid exercisers, found similar hormonal benefits among those eating less. However, calorie restriction studies are difficult to carry out in people because participants often complain of feeling hungry, lethargic, and cold.

Huffman also emphasized that the benefits of exercise may be greater for humans than for mice because people are more prone to develop cardiovascular diseases, and exercise is particularly good at warding off those diseases. Mice tend to die of kidney disease and cancer, Huffman said.

I wouldnt say this study has direct implications for people right now, Huffman said. But it sho
'/>"/>

Contact: Christine Guilfoy
cguilfoy@the-aps.org
301-634-7253
American Physiological Society
Source:Eurekalert

1

GOOD

Page: 1 2 3 4
Related biology news :

1. Negligent, attentive mouse mothers show biological differences
2. Scientists successfully treat new mouse model of inflammatory bowel disease
3. Book is the first high-resolution digital mouse brain atlas designed for Web applications
4. Dissecting the genetic components of adaptation of E. coli to the mouse gut
5. CSHL scientists identify and repress breast cancer stem cells in mouse tissue
6. New chimeric mouse model for human liver diseases, drug testing
7. Looking through the eyes of a mouse, scientists monitor circulating cells in its bloodstream
8. Cancer-resistant mouse discovered
9. Immune cells promote blood vessel formation in mouse endometriosis
10. A computer for your mouse!
11. Smithsonian study: Sediment prediction tools off the mark

Post Your Comments:

Mouse study: When it comes to living longer, it's better to go hungry than ...(ere some elevated levels of heat shock p...)