Navigation Links
Mouse study: Natural birth may strengthen the immune system
Date:7/9/2014

A number of studies suggest that children delivered by Caesarean section have a different intestinal flora than children delivered by natural birth. But it is still unknown why this is the case and what it means for the immune system. Researchers from the Faculty of Health and Medical Sciences therefore decided to scrutinise the impact of birth on the development of the immune system in a study of newborn mouse pups.

The study shows that pups delivered by Caesarean section had developed a lower number of cells that strengthen the immune system, says Camilla Hartmann Friis Hansen, Assistant Professor at the Department of Veterinary Disease Biology. The findings have recently been published in Journal of Immunology.

Mother's bacteria may be important

Newborns delivered by natural birth are exposed to more bacteria from the mother than those delivered by Caesarean section. According to a research hypothesis called the hygiene hypothesis, the newborn baby's immune system in this way learns to distinguish between its own harmless molecules and foreign molecules. In the experiment, pups delivered by Caesarean section showed a lower number of cells of a type that plays an important role in preventing reactive immune cells from responding to molecules from the body itself, from the diet and from harmless intestinal bacteria. Autoimmune diseases such as type 1 diabetes, Chrohn's disease and allergy are precisely characterised by an over-reaction by the immune system.

The researchers then looked for signs of development of type 1 diabetes in pups delivered by Caesarean section, but found none. The next step is therefore to study whether the pups are predisposed to other autoimmune diseases and then to test the theses in clinical trials.

The experiments on mice may give us an idea of what would be interesting to study in more detail in clinical trials, so that in the long term, we may be able to develop methods for strengthening the immune system in newborns who are predisposed to autoimmune diseases, says Professor Axel Kornerup Hansen, Department of Veterinary Disease Biology.


'/>"/>

Contact: Axel Kornerup Hansen
akh@sund.ku.dk
45-30-66-34-86
University of Copenhagen The Faculty of Health and Medical Sciences
Source:Eurekalert

Related biology news :

1. Mouse study points to potentially powerful tool for treating damaged hearts
2. New mouse model could revolutionize research in Alzheimers disease
3. From mouse ears to mans?
4. Mouse study shows gene therapy may be possible cure for Hurler syndrome
5. Dietary treatment shows potential in a mouse model of Alzheimers disease
6. The mouse that RORed
7. H. pylori vaccine shows promise in mouse studies
8. New book on mouse models of cancer from Cold Spring Harbor Laboratory Press
9. Mouse studies reveal promising vitamin D-based treatment for MS
10. Elevated levels of copper in amyloid plaques associated with neurodegeneration in mouse models of AD
11. New agent inhibits HCV replication in mouse models -- No resistance seen
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... , March 28, 2017 ... Biometrics), Hardware (Camera, Monitors, Servers, Storage Devices), Software (Video ... and Region - Global Forecast to 2022", published by ... in 2016 and is projected to reach USD 75.64 ... 2017 and 2022. The base year considered for the ...
(Date:3/23/2017)... The report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based ... to 2022", published by MarketsandMarkets, the market is expected to be worth USD ... 2022. Continue Reading ... ... ...
(Date:3/22/2017)... 2017 Vigilant Solutions , a vehicle ... agencies, announced today the appointment of retired FBI special ... safety business development. Mr. Sheridan brings more ... a focus on the aviation transportation sector, to his ... Mr. Sheridan served as the Aviation Liaison Agent Coordinator ...
Breaking Biology News(10 mins):
(Date:6/23/2017)... ... June 23, 2017 , ... ... of a redesigned, easier-to-navigate website for all six of their healthcare job ... nurses, dentists, pharmacists, physical and occupational therapists, and biotechnicians, DocCafe.com and the ...
(Date:6/22/2017)... ... June 21, 2017 , ... Building on the success of the inaugural ... on the very latest developments in radical life extension. RAADfest combines cutting edge science ... the empowerment of personal development, making it the largest most comprehensive and inclusive super ...
(Date:6/22/2017)... , ... June 22, 2017 , ... ... results to clients throughout the biopharma and life sciences industries, continue to be ... is seeing. Tunnell’s Kip Wolf will be speaking on “The State of Information ...
(Date:6/20/2017)... ... 20, 2017 , ... CTNext , Connecticut’s go-to resource ... a Higher Education Entrepreneurship Advisory Committee to implement the recommendations of the master ... representatives from 35 higher education institutions across the state over the past six ...
Breaking Biology Technology: