Navigation Links
Mouse study: Natural birth may strengthen the immune system
Date:7/9/2014

A number of studies suggest that children delivered by Caesarean section have a different intestinal flora than children delivered by natural birth. But it is still unknown why this is the case and what it means for the immune system. Researchers from the Faculty of Health and Medical Sciences therefore decided to scrutinise the impact of birth on the development of the immune system in a study of newborn mouse pups.

The study shows that pups delivered by Caesarean section had developed a lower number of cells that strengthen the immune system, says Camilla Hartmann Friis Hansen, Assistant Professor at the Department of Veterinary Disease Biology. The findings have recently been published in Journal of Immunology.

Mother's bacteria may be important

Newborns delivered by natural birth are exposed to more bacteria from the mother than those delivered by Caesarean section. According to a research hypothesis called the hygiene hypothesis, the newborn baby's immune system in this way learns to distinguish between its own harmless molecules and foreign molecules. In the experiment, pups delivered by Caesarean section showed a lower number of cells of a type that plays an important role in preventing reactive immune cells from responding to molecules from the body itself, from the diet and from harmless intestinal bacteria. Autoimmune diseases such as type 1 diabetes, Chrohn's disease and allergy are precisely characterised by an over-reaction by the immune system.

The researchers then looked for signs of development of type 1 diabetes in pups delivered by Caesarean section, but found none. The next step is therefore to study whether the pups are predisposed to other autoimmune diseases and then to test the theses in clinical trials.

The experiments on mice may give us an idea of what would be interesting to study in more detail in clinical trials, so that in the long term, we may be able to develop methods for strengthening the immune system in newborns who are predisposed to autoimmune diseases, says Professor Axel Kornerup Hansen, Department of Veterinary Disease Biology.


'/>"/>

Contact: Axel Kornerup Hansen
akh@sund.ku.dk
45-30-66-34-86
University of Copenhagen The Faculty of Health and Medical Sciences
Source:Eurekalert

Related biology news :

1. Mouse study points to potentially powerful tool for treating damaged hearts
2. New mouse model could revolutionize research in Alzheimers disease
3. From mouse ears to mans?
4. Mouse study shows gene therapy may be possible cure for Hurler syndrome
5. Dietary treatment shows potential in a mouse model of Alzheimers disease
6. The mouse that RORed
7. H. pylori vaccine shows promise in mouse studies
8. New book on mouse models of cancer from Cold Spring Harbor Laboratory Press
9. Mouse studies reveal promising vitamin D-based treatment for MS
10. Elevated levels of copper in amyloid plaques associated with neurodegeneration in mouse models of AD
11. New agent inhibits HCV replication in mouse models -- No resistance seen
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/2/2017)... JACKSONVILLE, Fla. , Feb. 2, 2017 /PRNewswire/ ... ), a clinical-stage immuno-oncology company specializing in the ... vaccines for the treatment of cancer and metastatic ... multi-gram scale-up and GMP manufacturing of a second ... T-cell vaccine targeting folate receptor alpha. The manufactured ...
(Date:1/31/2017)...  Spero Therapeutics, LLC, a biopharmaceutical company founded ... bacterial infections, today announced it has acquired a ... Bono Bio Ltd (PBB) to bolster its pipeline ... of Gram-negative bacteria.   The assets acquired have been ... group company. "The acquisition of these ...
(Date:1/25/2017)... , Jan. 25, 2017 The Elements ... Management (IAM) lifecycle is comprised of a comprehensive ... the purpose of maintaining digital identities and providing ... and applications. There are significant number of programs ... time to time by optimizing processes and changing ...
Breaking Biology News(10 mins):
(Date:2/22/2017)... 2017 Aethlon Medical, Inc. (Nasdaq: ... that validated the ability of the Aethlon Hemopurifier® to ... mortality in immune-suppressed sepsis patients and also contribute to ... objective of the study was to validate the ... (EBV) and Herpes Simplex virus 1 (HSV1) by the ...
(Date:2/22/2017)... and RESEARCH TRIANGLE PARK, N.C., Feb. 22, 2017 /PRNewswire/ ... today announced its financial results for the fourth ... "Our annual 2016 financial results reflect continued growth ... exceeded $700 million," said Martine Rothblatt, Ph.D., United ... results strengthen our ability to develop and advance ...
(Date:2/21/2017)... ... 21, 2017 , ... Vortex Biosciences announced the ... benchtop system for collecting intact circulating tumor cells (CTCs) that are shed by ... Tri Conference (Tri-Con) Annual Meeting 2017 (February 19–24 San Francisco). , The ...
(Date:2/21/2017)... IL (PRWEB) , ... February ... ... of the Life -Sciences division, Treximo will pair its $200M operational capacity ... results-based consulting and project management in areas affecting quality and operational management. ...
Breaking Biology Technology: