Navigation Links
Mouse studies reveal promising vitamin D-based treatment for MS
Date:9/27/2013

MADISON -- A diagnosis of multiple sclerosis (MS) is a hard lot. Patients typically get the diagnosis around age 30 after experiencing a series of neurological problems such as blurry vision, wobbly gait or a numb foot. From there, this neurodegenerative disease follows an unforgiving course.

Many people with MS start using some kind of mobility aid -- cane, walker, scooter or wheelchair -- by 45 or 50, and those with the most severe cases are typically bed-bound by 60. The medications that are currently available don't do much to slow the relentless march of the disease.

In search of a better option for MS patients, a team of University of Wisconsin-Madison biochemists has discovered a promising vitamin D-based treatment that can halt -- and even reverse -- the course of the disease in a mouse model of MS. The treatment involves giving mice that exhibit MS symptoms a single dose of calcitriol, the active hormone form of vitamin D, followed by ongoing vitamin D supplements through the diet. The protocol is described in a scientific article that was published online in August in the Journal of Neuroimmunology.

"All of the animals just got better and better, and the longer we watched them, the more neurological function they regained," says biochemistry professor Colleen Hayes, who led the study.

MS afflicts around 400,000 people nationwide, with 200 new cases diagnosed each week. Early on, this debilitating autoimmune disease, in which the immune system attacks the myelin coating that protects the brain's nerve cells, causes symptoms including weakness, loss of dexterity and balance, disturbances to vision, and difficulty thinking and remembering. As it progresses, people can lose the ability to walk, sit, see, eat, speak and think clearly.

Current FDA-approved treatments only work for some MS patients and, even among them, the benefits are modest. "And in the long term they don't halt the disease process
'/>"/>

Contact: Colleen Hayes
cehayes@wisc.edu
608-263-6387
University of Wisconsin-Madison
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Elevated levels of copper in amyloid plaques associated with neurodegeneration in mouse models of AD
2. New agent inhibits HCV replication in mouse models -- No resistance seen
3. Cat and mouse: A single gene matters
4. New mouse viruses could aid hepatitis research
5. Omega-3s from fish vs. fish oil pills better at maintaining blood pressure in mouse model
6. UT Southwestern scientists make mouse model of human cancer, demonstrate cure
7. Researchers generate a mutant mouse model useful in the treatment of neuromuscular diseases
8. Transplanted neural stem cells slows als onset and progression in mouse models
9. Early menopause: A genetic mouse model of human primary ovarian insufficiency
10. NPointer from Neurotechnology Uses Hand Gestures to Control and Navigate Computer Programs Without a Mouse or Touchpad
11. Stem cell transplantation into mouse cochlea may impact future hearing loss therapies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... and other forms of dementia, but the research community ... of Washington bioengineers have a designed a peptide structure ... normal proteins into a state that,s linked to widespread ... diabetes and Lou Gehrig,s disease. The synthetic molecule blocks ... into an abnormally folded form by targeting a toxic ...
(Date:7/28/2014)... St. Jude Children,s Research Hospital study found that 73 ... doubled their risk of developing metabolic syndrome and related ... The results appear in the current issue of the ... the 1,598 adult survivors of childhood cancer in the ... risk factors like high blood pressure, abdominal obesity, elevated ...
(Date:7/28/2014)... Research and Markets has announced ... America 2014-2018" report to their offering. ... and analyze biological data. These systems capture biological traits ... patterns, and hand measurements from the subject and compare ... main purpose of a biometrics system is to identify ...
Breaking Biology News(10 mins):New protein structure could help treat Alzheimer's, related diseases 2New protein structure could help treat Alzheimer's, related diseases 3Unhealthy habits more than double risk of metabolic syndrome in childhood cancer survivors 2Unhealthy habits more than double risk of metabolic syndrome in childhood cancer survivors 3Biometrics Market in Latin America 2014-2018 2
... Research Institute,s Drs. Peter Cadieux and Hassan Razvi have ... $2.2 million grant from the National Institutes of Health ... explore the potential of novel coatings to significantly reduce ... The grant was awarded in collaboration with Nerites ...
... beginning of the Industrial Revolution, the concentration of carbon dioxide ... of fossil fuels. Increased absorption of this carbon by the ... how acidic or basic a substance is) and aragonite saturation ... the mineral form of calcium carbonate that is laid down ...
... a unique fish that lives on land and can leap ... complex social life, a new study has found., The odd lifestyle ... detailed for the first time in research findings that throw new ... The Pacific leaping blenny is a marine fish yet is terrestrial ...
Cached Biology News:Lawson researchers share in $2.2 million grant 2Scientist creates new hypothesis on ocean acidification 2Landlubber fish leap for love when tide is right 2
(Date:7/29/2014)... White papers by Clinovo on CDISC ... have been published by leading pharmaceutical publications Data Basics ... of white papers by Clinovo to have been featured ... Online, and OpenHealthNews. , At the request of SCDM ... Desgrousilliers, 'The Five Essentials of Cloud Computing for ...
(Date:7/28/2014)... VA (PRWEB) July 28, 2014 The ... nonprofit authority on the use of health IT to ... Health Plan Identifier (HPID) Workgroup has developed ... a Health Plan and Payer?” The HPID Workgroup, a ... closely with the Centers for Medicare and Medicaid Services ...
(Date:7/28/2014)... -   JOLT , a leading technology accelerator, announced ... growing portfolio of startups. Next-level tech and boundary-pushing innovation ... JOLT accelerator, and Cohort four is no exception, with ... Since its launch in July 2012, JOLT has produced ... Now at 23 investments, JOLT,s portfolio has an overall ...
(Date:7/28/2014)... 2014 Appistry, Inc. , a ... the power of genomics to next-generation medicine, announced today ... Challenge . , Two Appistry staff will be ... Center for Genome Resources, and Mr. Neil Miller, director ... Kansas City. Rounding out the panel are Appistry’s Dr. ...
Breaking Biology Technology:Clinovo White Papers Published in Summer 2014 Editions of Leading Medical Device & Pharmaceutical Publications 2Clinovo White Papers Published in Summer 2014 Editions of Leading Medical Device & Pharmaceutical Publications 3WEDI’s HPID Workgroup Announces Release of Issue Brief: “What is the Difference Between a Health Plan and Payer?” 2JOLT Announces the Next 6 Startups to Join its Summer 2014 Cohort 2JOLT Announces the Next 6 Startups to Join its Summer 2014 Cohort 3Appistry Names Industry Experts from the National Center for Genome Resources and Mercy Children's, Kansas City, to Judge Pipeline Challenge Competition 2
... 15, 2011 BioNeutral Group, Inc. (OTC Bulletin ... science technology-based company, today announced that it has ... with Raymond Associates LLC, a Service Connected Certified ... Under the terms of the agreement, Raymond Associates ...
... DIEGO, March 14, 2011 OncoSec Medical, Inc. (OTC ... appointment of Mr. Punit Dhillon as president and chief ... (Logo:   http://photos.prnewswire.com/prnh/20110314/MM64943LOGO ) Mr. Dhillon ... the biotech industry. He was recently VP Finance & ...
... Technology, Inc. ("ACT"; OTC Bulletin Board: ACTC ... announced today that Gary Rabin, the company,s interim chairman ... BIO-Europe Spring 2011 Conference, March 14-16, at the Milano ... scheduled for Wednesday, March 16, at 10:15 a.m. CET, ...
Cached Biology Technology:BioNeutral Enters into Global Sales and Distribution Agreement with Raymond Associates to Expand Market for Military-Grade Ygiene(TM) 2BioNeutral Enters into Global Sales and Distribution Agreement with Raymond Associates to Expand Market for Military-Grade Ygiene(TM) 3BioNeutral Enters into Global Sales and Distribution Agreement with Raymond Associates to Expand Market for Military-Grade Ygiene(TM) 4ACT Interim Chairman and CEO Gary Rabin to Present at BIO-Europe Spring 2011 Conference 2
... 2D polyacrylamide gel electrophoresis (2D-PAGE) with biological ... core technology platform for proteomic analysis. 2D-PAGE ... samples limited only in the dynamic range ... proteins. Quantitative image based analysis of separated ...
... is ideal for high-fidelity amplification of ... as cloning and mutagenesis. High ... enzyme preparation containing recombinant DNA polymerase ... Site5' exonuclease) activity. Platinum Anti-Pfx ...
... PLAU N-term Antibody This antibody is generated ... synthetic peptide selected within aa 50~150 of ... in PBS with 0.09% (W/V) sodium azide. ... G column and eluted out with both ...
...
Biology Products: