Navigation Links
Mouse stem cell study offers new insights into body fat distribution
Date:7/11/2010

New research being presented today (12 July) at the UK National Stem Cell Network Annual Science Meeting in Nottingham shows that adding fat to mouse stem cells grown in the lab affects their response to the signals that push them to develop into one or other of the main types of fat storage cells subcutaneous (under the skin) or visceral (around the organs).

Visceral fat the so-called "pot-belly" indicates a much higher risk of cardiovascular disease and type 2 diabetes than subcutaneous fat. This discovery will help us to understand the fundamental biology underpinning these two major causes of obesity-related morbidity and mortality in the developed world.

During development, some groups of stem cells will go on to become adipose cells the large globular cells that store and metabolise fats from our diets. This research suggests that the distribution of visceral versus subcutaneous adipose cells is at least in part down to the nutrition available to stem cells during the early stages of development.

The study, led by Professor Kevin Docherty of the University of Aberdeen, found that adding palmitate (a major component in palm oil) to mouse stem cells affected how they responded to androgen and oestrogen - the sex hormones which normally control the types of fat cells that stem cells become.

Professor Docherty said "This finding is an important insight as it suggests that nutrition in early development can affect how and where fat is stored in later life. We've known for a while that having a pot-belly suggests someone's risk of developing type 2 diabetes and heart disease is high, but there is still a lot to learn about why body fat distribution varies so much between people. Our research helps by putting another small piece into the puzzle.

"Type 2 diabetes used to be a disease that struck people in later life, but in the UK and some other developed countries we're seeing a worrying increase of this problem amongst overweight teenagers and younger adults. In the UK, 30% of teenagers are overweight or obese so it's crucial that we understand the fundamental biology of weight-related diseases so that we can develop better ways of preventing, treating and managing this serious problem."

The researchers hope that this study might lead to new insights into how to combat type 2 diabetes and cardiovascular disease.

Professor Docherty concluded: "The number one way of reducing the number of overweight people is improving diet and encouraging exercise, but we hope our research might eventually offer insights that lead to new treatments including drugs to reduce these high-risk fat stores around organs."


'/>"/>

Contact: Mike Davies
ukpo@uknscn.org
Biotechnology and Biological Sciences Research Council
Source:Eurekalert

Related biology news :

1. Anti-cancer drug prevents, reverses cardiovascular damage in mouse model of premature aging disorder
2. Multiple sclerosis research charges ahead with new mouse model of disease
3. Peering inside the skull of a mouse to solve meningitis mystery
4. Salk researchers develop novel glioblastoma mouse model
5. Diminuendo -- New mouse model for understanding cause of progressive hearing loss
6. A worm-and-mouse tale: B cells deserve more respect
7. Brain building: Study shows brain growth tied to cell division in mouse embryos
8. CSHL team develops mouse models of leukemia that predict response to chemotherapy
9. Mouse model provides a new tool for investigators of human developmental disorder
10. A new mouse model provides insight into genetic neurological disorders
11. Caffeic acid inhibits colitis in a mouse model -- is a drug-metabolizing gene crucial?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/15/2016)... 15, 2016 Research and ... Biometrics Market 2016-2020,"  report to their offering.  , ... , ,The global gait biometrics market is expected ... the period 2016-2020. Gait analysis generates ... be used to compute factors that are not ...
(Date:3/31/2016)... March 31, 2016  Genomics firm Nabsys has completed ... Barrett Bready , M.D., who returned to the ... original technical leadership team, including Chief Technology Officer, ... Development, Steve Nurnberg and Vice President of Software and ... company. Dr. Bready served as CEO of ...
(Date:3/22/2016)... and SANDY, Utah , ... which operates the highest sample volume laboratory in ... Genomics and UNIConnect, leaders in clinical sequencing informatics and ... launch of a project to establish the informatics infrastructure ... NSO has been contracted by the Ontario ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... In a new case report published today in ... patient who developed lymphedema after being treated for breast cancer benefitted from an injection ... for dealing with this debilitating, frequent side effect of cancer treatment. , ...
(Date:6/23/2016)... June 23, 2016  Blueprint Bio, a company dedicated ... the medical community, has closed its Series A funding ... . "We have received a commitment from ... we need to meet our current goals," stated ... the runway to complete validation on the current projects ...
(Date:6/23/2016)... On Wednesday, June 22, 2016, the ... the Dow Jones Industrial Average edged 0.27% lower to finish ... 0.17%. Stock-Callers.com has initiated coverage on the following equities: Infinity ... NKTR ), Aralez Pharmaceuticals Inc. (NASDAQ: ... ). Learn more about these stocks by accessing their free ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... regulatory and technical consulting, provides a free webinar on Performing Quality ... 13, 2016 at 12pm CT at no charge. , Incomplete investigations are still ...
Breaking Biology Technology: