Navigation Links
Mouse stem cell study offers new insights into body fat distribution
Date:7/11/2010

New research being presented today (12 July) at the UK National Stem Cell Network Annual Science Meeting in Nottingham shows that adding fat to mouse stem cells grown in the lab affects their response to the signals that push them to develop into one or other of the main types of fat storage cells subcutaneous (under the skin) or visceral (around the organs).

Visceral fat the so-called "pot-belly" indicates a much higher risk of cardiovascular disease and type 2 diabetes than subcutaneous fat. This discovery will help us to understand the fundamental biology underpinning these two major causes of obesity-related morbidity and mortality in the developed world.

During development, some groups of stem cells will go on to become adipose cells the large globular cells that store and metabolise fats from our diets. This research suggests that the distribution of visceral versus subcutaneous adipose cells is at least in part down to the nutrition available to stem cells during the early stages of development.

The study, led by Professor Kevin Docherty of the University of Aberdeen, found that adding palmitate (a major component in palm oil) to mouse stem cells affected how they responded to androgen and oestrogen - the sex hormones which normally control the types of fat cells that stem cells become.

Professor Docherty said "This finding is an important insight as it suggests that nutrition in early development can affect how and where fat is stored in later life. We've known for a while that having a pot-belly suggests someone's risk of developing type 2 diabetes and heart disease is high, but there is still a lot to learn about why body fat distribution varies so much between people. Our research helps by putting another small piece into the puzzle.

"Type 2 diabetes used to be a disease that struck people in later life, but in the UK and some other developed countries we're seeing a worrying increase of this problem amo
'/>"/>

Contact: Mike Davies
ukpo@uknscn.org
Biotechnology and Biological Sciences Research Council
Source:Eurekalert

Page: 1 2

Related biology news :

1. Anti-cancer drug prevents, reverses cardiovascular damage in mouse model of premature aging disorder
2. Multiple sclerosis research charges ahead with new mouse model of disease
3. Peering inside the skull of a mouse to solve meningitis mystery
4. Salk researchers develop novel glioblastoma mouse model
5. Diminuendo -- New mouse model for understanding cause of progressive hearing loss
6. A worm-and-mouse tale: B cells deserve more respect
7. Brain building: Study shows brain growth tied to cell division in mouse embryos
8. CSHL team develops mouse models of leukemia that predict response to chemotherapy
9. Mouse model provides a new tool for investigators of human developmental disorder
10. A new mouse model provides insight into genetic neurological disorders
11. Caffeic acid inhibits colitis in a mouse model -- is a drug-metabolizing gene crucial?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... the popular attention of both children and aquarium hobbyists ... as dehydrated eggs, these tiny brine shrimp readily hatch, ... of salt water. , Physicists, though, are interested ... vertically migrate in large groups in response to changing ... and retreating deeper during the day. , Two researchers ...
(Date:9/30/2014)... Medicine reports positive results of a phase 1 ... of lung cancer marked by rearrangement of the gene ... advanced non-small cell lung cancer testing positive for ROS1 ... 3 complete responses and 33 partial responses. Median progression-free ... to resume its growth after being slowed by treatment ...
(Date:9/30/2014)... Ludwig-Maximilians-Universitaet (LMU) in Munich report that a new ... sensitive to chemotherapeutic drugs. They have also pinpointed ... target for anti-tumor agents. , Researchers led ... Sieber of the Technische Universitt Mnchen have identified ... new weapon in the fight against malignant tumors. ...
Breaking Biology News(10 mins):Laser-guided sea monkeys show how zooplankton migrations may affect global ocean currents 2NEJM: Crizotinib effective in Phase 1 trial against ROS1 lung cancer 2Cancer therapy: Driving cancer cells to suicide 2
... engine is far from easy. Due to the turbulent ... are the same. Furthermore, the measurements are difficult to ... into the cylinder causes an extra source of turbulence. ... an engine adapted for this purpose. Laser Induced ...
... that a protein known as PEPT2 protects the brains ... toxic compound present in lead poisoning and in a ... neurological complications. Scientists at the University of ... 5-aminolevulinic acid (5-ALA), mice without the PEPT2 protein died ...
... United States Department of Agriculture (USDA) recently examined the ... production of packaged produce. The study, published in the ... learn more about how industry practices affect quality and ... Food Technologist at the United States Department of Agriculture,s ...
Cached Biology News:Fresh-cut produce washing practices can minimize food-borne illness risks 2
(Date:10/2/2014)... 2014  CSSi ( www.CSSiEnroll.com ), the leader ... industry, is pleased to announce its participation in ... October.  President Chris Trizna will be ... Clinical Trials New England conference sponsored by Arena ... annual Site Solutions Summit sponsored by the Society ...
(Date:10/2/2014)... and BRIDGEWATER, N.J. , ... , a leader in synthetic biology, and ... drug manufacturer by volume in the U.S., today ... Collaboration (ECC) for a target active pharmaceutical ingredient ... goal of the collaboration is to develop a ...
(Date:10/1/2014)... What: , Cambridge Semantics, the leading provider ... technology, today announced its participation in the 2014 Big ... Data solutions provide semantic linkage and meaning to Big ... and manage diverse data. Ben Szekely, vice president and ... a “life sciences data lake” and an approach for ...
(Date:10/1/2014)... 1, 2014  Discovery Laboratories, Inc. (Nasdaq: DSCO) ... a Phase II Small Business Innovation Research Grant ... the National Institute of Allergy and Infectious Diseases ... to support the development of the Company,s aerosolized ... to mitigate acute and chronic/late-phase radiation-induced lung injury. ...
Breaking Biology Technology:Patient Recruitment Expert CSSi to be Featured at Upcoming Industry Events 2Patient Recruitment Expert CSSi to be Featured at Upcoming Industry Events 3Intrexon and Amneal Expand Relationship with Second Product Collaboration 2Intrexon and Amneal Expand Relationship with Second Product Collaboration 3Cambridge Semantics to Present ‘A Useful Approach to Big Data’ at 2014 Big Data Leaders Forum 2Discovery Labs Receives SBIR Grant Valued up to $3.0 Million to Support Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 2Discovery Labs Receives SBIR Grant Valued up to $3.0 Million to Support Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 3
... 10 Beckman Coulter, Inc. (NYSE: BEC ... that simplify, automate, and innovate complex biomedical testing, will ... 2009, beginning at 10:00 a.m. (ET). The webcast ... www.beckmancoulter.com . To access the webcast select ...
... for the Treatment of EpilepsyBRANFORD, Conn., April 10 ... serious neurological and psychiatric disorders, today announced the close ... comes on the heels of the Company,s recent announcement ... adjunctive therapy in adults with partial onset seizures. The ...
... A University of California, San Diego bioengineer is the ... Science that provides insights on the "stickiness of ... organisms hailing from all limbs of the tree of ... example, the researchers outlined similar strategies across biology for ...
Cached Biology Technology:Marinus Pharmaceuticals Raises $20 Million in Series B Financing 2Marinus Pharmaceuticals Raises $20 Million in Series B Financing 3Marinus Pharmaceuticals Raises $20 Million in Series B Financing 4Marinus Pharmaceuticals Raises $20 Million in Series B Financing 5Life sticks: UC San Diego bioengineer's sticky insights published in journal Science 2Life sticks: UC San Diego bioengineer's sticky insights published in journal Science 3Life sticks: UC San Diego bioengineer's sticky insights published in journal Science 4
Bethyl Laboratories packages antibodies, conjugates and calibrators to provide quantitative ELISA kits. Each kit contains the following components, sufficient for 1000 single well assays....
Bethyl Laboratories packages antibodies, conjugates and calibrators to provide quantitative ELISA kits. Each kit contains the following components, sufficient for 1000 single well assays....
Bethyl Laboratories packages antibodies, conjugates and calibrators to provide quantitative ELISA kits. Each kit contains the following components, sufficient for 1000 single well assays....
Request Info...
Biology Products: