Navigation Links
Mouse stem cell study offers new insights into body fat distribution
Date:7/11/2010

New research being presented today (12 July) at the UK National Stem Cell Network Annual Science Meeting in Nottingham shows that adding fat to mouse stem cells grown in the lab affects their response to the signals that push them to develop into one or other of the main types of fat storage cells subcutaneous (under the skin) or visceral (around the organs).

Visceral fat the so-called "pot-belly" indicates a much higher risk of cardiovascular disease and type 2 diabetes than subcutaneous fat. This discovery will help us to understand the fundamental biology underpinning these two major causes of obesity-related morbidity and mortality in the developed world.

During development, some groups of stem cells will go on to become adipose cells the large globular cells that store and metabolise fats from our diets. This research suggests that the distribution of visceral versus subcutaneous adipose cells is at least in part down to the nutrition available to stem cells during the early stages of development.

The study, led by Professor Kevin Docherty of the University of Aberdeen, found that adding palmitate (a major component in palm oil) to mouse stem cells affected how they responded to androgen and oestrogen - the sex hormones which normally control the types of fat cells that stem cells become.

Professor Docherty said "This finding is an important insight as it suggests that nutrition in early development can affect how and where fat is stored in later life. We've known for a while that having a pot-belly suggests someone's risk of developing type 2 diabetes and heart disease is high, but there is still a lot to learn about why body fat distribution varies so much between people. Our research helps by putting another small piece into the puzzle.

"Type 2 diabetes used to be a disease that struck people in later life, but in the UK and some other developed countries we're seeing a worrying increase of this problem amongst overweight teenagers and younger adults. In the UK, 30% of teenagers are overweight or obese so it's crucial that we understand the fundamental biology of weight-related diseases so that we can develop better ways of preventing, treating and managing this serious problem."

The researchers hope that this study might lead to new insights into how to combat type 2 diabetes and cardiovascular disease.

Professor Docherty concluded: "The number one way of reducing the number of overweight people is improving diet and encouraging exercise, but we hope our research might eventually offer insights that lead to new treatments including drugs to reduce these high-risk fat stores around organs."


'/>"/>

Contact: Mike Davies
ukpo@uknscn.org
Biotechnology and Biological Sciences Research Council
Source:Eurekalert

Related biology news :

1. Anti-cancer drug prevents, reverses cardiovascular damage in mouse model of premature aging disorder
2. Multiple sclerosis research charges ahead with new mouse model of disease
3. Peering inside the skull of a mouse to solve meningitis mystery
4. Salk researchers develop novel glioblastoma mouse model
5. Diminuendo -- New mouse model for understanding cause of progressive hearing loss
6. A worm-and-mouse tale: B cells deserve more respect
7. Brain building: Study shows brain growth tied to cell division in mouse embryos
8. CSHL team develops mouse models of leukemia that predict response to chemotherapy
9. Mouse model provides a new tool for investigators of human developmental disorder
10. A new mouse model provides insight into genetic neurological disorders
11. Caffeic acid inhibits colitis in a mouse model -- is a drug-metabolizing gene crucial?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/15/2016)... , June 15, 2016 ... report titled "Gesture Recognition Market by Application Market - Global Industry ... - 2024". According to the report, the  global gesture ... in 2015 and is estimated to grow at ... billion by 2024.  Increasing application of ...
(Date:6/2/2016)... The Department of Transport Management (DOTM) of ... Dollar project, for the , Supply and Delivery ... IT Infrastructure , to Decatur ... Identity Management Solutions. Numerous renowned international vendors participated in the ... was selected for the most compliant and innovative solution. The ...
(Date:5/20/2016)... May 20, 2016  VoiceIt is excited to ... VoicePass. By working together, VoiceIt and ... VoiceIt and VoicePass take slightly different approaches to ... both security and usability. ... this new partnership. "This marketing and ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... DIEGO , June 24, 2016 ... more sensitively detects cancers susceptible to PARP inhibitors ... circulating tumor cells (CTCs). The new test has ... HRD-targeted therapeutics in multiple cancer types. ... targeting DNA damage response pathways, including PARP, ATM, ...
(Date:6/23/2016)... Mass. , June 23, 2016   ... development of novel compounds designed to target cancer ... napabucasin, has been granted Orphan Drug Designation from ... the treatment of gastric cancer, including gastroesophageal junction ... stemness inhibitor designed to inhibit cancer stemness pathways ...
(Date:6/23/2016)... June 23, 2016  The Prostate Cancer Foundation (PCF) is pleased ... and faster cures for prostate cancer. Members of the Class of 2016 were ... Read More About the Class of 2016 PCF Young ... ... ...
(Date:6/23/2016)... ... June 23, 2016 , ... In a new case ... Denmark detail how a patient who developed lymphedema after being treated for breast cancer ... could change the paradigm for dealing with this debilitating, frequent side effect of cancer ...
Breaking Biology Technology: