Navigation Links
Mouse model developed at UT Southwestern mimics hyperglycemia, aids in diabetes research
Date:6/1/2008

mechanisms that allow beta cells to rebound in this environment could provide major insights in type 1 diabetes research. He and his colleagues are now developing a way to isolate the cell population that gives rise to the newly emerging beta cells.

About 1 million people, between 5 percent and 10 percent of all diagnosed cases of diabetes, in the U.S. are affected by type 1 diabetes, for which there is no cure or preventive measure.

"This model allows us to get a transcriptional signature, a fingerprint, of how beta cells fend off the pharmaceutical stimulus we provide to prompt cell death," Dr. Scherer said. "In other words, it provides a way to identify the most critical factors that protect against beta cell death and to potentially find ways to increase these factors in people with type 1 diabetes."

The key, Dr. Scherer said, is that the process researchers use to kill beta cells is very targeted.

"It creates very little inflammation, so we can eliminate specific cells with minimal collateral damage," he said. "The other nice aspect is that we can do it in a very dose-dependent way, so we can ablate, or kill, just a few cells, or we can ablate almost all of them."

Dr. Scherer said this model lends itself to studying conditions of temporary hyperglycemia such as gestational diabetes, a condition in which pregnant women who have never had diabetes develop hyperglycemia. Gestational diabetes usually disappears after pregnancy, but it is not clear whether these transient bouts of elevated glucose can cause permanent damage in the vasculature that persists even after normal glucose levels have been restored.

Dr. Zhao Wang, a postdoctoral researcher at UT Southwestern and lead author of the study, said the strength of the PANIC-ATTAC mouse as a research tool lies partly in the ability to test how specific pharmaceuticals impact beta-cell regeneration.

"We can test which drugs can more rapidly repa
'/>"/>

Contact: Kristen Holland Shear
kristen.hollandshear@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

0

GOOD

Page: 1 2 3

Related biology news :

1. Disabling mouse enzyme increases fertility
2. Mouse can do without mans most treasured genes
3. Mouse study: When it comes to living longer, its better to go hungry than go running
4. Negligent, attentive mouse mothers show biological differences
5. Scientists successfully treat new mouse model of inflammatory bowel disease
6. Book is the first high-resolution digital mouse brain atlas designed for Web applications
7. Dissecting the genetic components of adaptation of E. coli to the mouse gut
8. CSHL scientists identify and repress breast cancer stem cells in mouse tissue
9. New chimeric mouse model for human liver diseases, drug testing
10. Looking through the eyes of a mouse, scientists monitor circulating cells in its bloodstream
11. Cancer-resistant mouse discovered
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Mouse model developed at UT Southwestern mimics hyperglycemia, aids in diabetes research
(Date:6/19/2013)... further proof that the divergence of humans from chimpanzees ... profoundly influenced by mutations to DNA sequences that play ... study, published June 9 in Nature Genetics , ... genes must play an important role in evolution since ... the proteins produced by genes. Indeed, human and chimpanzee ...
(Date:6/18/2013)... University of Calgary,s Faculty of Medicine have discovered a ... harmful bacteria. Platelets, a component of blood typically associated ... bacteria, and upon detection, seal it off from the ... in Nature Immunology this week, provide the ... "The science community has known that platelets do participate ...
(Date:6/18/2013)... Laboratory of Molecular Biology, has been honored as ... Award. Torrent is being recognized for his outstanding ... predict antimicrobial regions in proteins. Luis Rivas, Centro ... this algorithm to interrogate full genomes in order ... appealing results." , Torrent obtained his Ph.D. ...
Breaking Biology News(10 mins):New research backs theory that genetic 'switches' play big role in human evolution 2New research backs theory that genetic 'switches' play big role in human evolution 3Immunity mechanism discovered 2The American Society for Microbiology honors Marc Torrent 2
... engine that could, the University of Nevada, Reno experiment ... along, dwarfed by the million-gallon tanks, pipes and pumps ... the plant,s electrical power could be supplied on-site by ... very pleased with the results of the demonstration testing ...
... from discoveries of ancient tools and artifacts may need ... finding suggested by a new study that for the ... and goats trampling artifacts into mud. In seeking ... new study documented how animal trampling in a water-saturated ...
... BOSTONDana-Farber Cancer Institute,s Belfer Institute of Applied ... and NYSE: SNY) announced today that they have ... to identify and validate novel oncology targets ... novel therapeutics agents directed to such targets and ...
Cached Biology News:University of Nevada, Reno, demonstrates successful sludge-to-power research 2University of Nevada, Reno, demonstrates successful sludge-to-power research 3Taking a new look at old digs: Trampling animals may alter Stone Age sites 2Taking a new look at old digs: Trampling animals may alter Stone Age sites 3Dana-Farber and sanofi-aventis establish cancer research alliance 2
(Date:6/19/2013)... June 19, 2013 Applied Rigaku Technologies, ... that details the measurement of sulfur in ultra-low sulfur ... high resolution benchtop EDXRF analyzer . The analysis detailed ... method ISO 13032. This International Standard specifies an ... determination of sulfur content in automotive gasoline. , Regulations ...
(Date:6/18/2013)... Santa Clara, CA (PRWEB) June 18, 2013 ... compared to standard size SEMs but have limited performance ... and lower resolution. Full size SEMs would normally provide ... require more knowledge to operate and have a higher ... SEMs address the gap between these two types ...
(Date:6/18/2013)... June 18, 2013 (PRWEB) June 18, 2013 ... and attendance system in North America, has introduced ... employee data and payroll records between ExakTime’s software ... automates ExakTime software setup and keeps employee ... employee data from a business’ current payroll software, ...
(Date:6/18/2013)... Wilmington, DE (PRWEB) June 18, 2013 ... teachers to the 11th annual DuPont National AgriScience Teachers ... Chesapeake Farms in Chestertown, Md. , ... sponsored by DuPont and is a special project of ... National Association of Agricultural Educators (NAAE) . The ...
Breaking Biology Technology:Rigaku Publishes New Application Note for Analysis of ULSD Per ISO 13032 2Nanounity Introduces the Pemtron Range of Compact Scanning Electron Microscopes 2Nanounity Introduces the Pemtron Range of Compact Scanning Electron Microscopes 3ExakTime Introduces AccountLinx Plus 2DuPont Sponsors National AgriScience Ambassador Academy 2DuPont Sponsors National AgriScience Ambassador Academy 3
... 20 CV Therapeutics, Inc. (Nasdaq: CVTX ... thoroughly reviewed and rejected the previously announced unsolicited proposal ... a price of $16.00 per share. After careful ... legal advisors, the CV Therapeutics board concluded that the ...
... AMSTERDAM, February 20 Elsevier announced today,that ... abstract and,citation (A&C) database, was chosen by ... in Research for Australia (ERA) initiative. , ... will assess research quality within Australia,s higher,education ...
... DUBLIN, February 20 Shire plc,(LSE: SHP, NASDAQ: ... it has signed an agreement with UCB to acquire ... (excluding the,USA, Canada and Barbados) used for the treatment ... EQUASYM XL is approved and marketed in 10 ...
Cached Biology Technology:CV Therapeutics' Board of Directors Rejects Astellas Unsolicited Proposal 2CV Therapeutics' Board of Directors Rejects Astellas Unsolicited Proposal 3CV Therapeutics' Board of Directors Rejects Astellas Unsolicited Proposal 4The Australian Research Council Selects Scopus for the Evaluation of the Australian Research Landscape 2The Australian Research Council Selects Scopus for the Evaluation of the Australian Research Landscape 3Shire to Enter European ADHD Market With the Acquisition of EQUASYM(R) IR and XL 2Shire to Enter European ADHD Market With the Acquisition of EQUASYM(R) IR and XL 3Shire to Enter European ADHD Market With the Acquisition of EQUASYM(R) IR and XL 4
AK6 Antibody...
Reacts with the 80 kDa fragment of the M-chain of human merosin....
Goat anti-mouse gamma chain-HRP...
mu Opioid Receptor splice variant Immunogen: Synthetic peptide corresponding to residues K S C M D R G M R N L L P D D G P R Q E of Mu Opioid Receptor. Storage: -20 C, Avoid Freeze/Thaw Cycle...
Biology Products: