Navigation Links
Mouse model developed at UT Southwestern mimics hyperglycemia, aids in diabetes research
Date:6/1/2008

DALLAS June 2, 2008 UT Southwestern Medical Center researchers have genetically engineered a laboratory mouse in which pancreatic beta cells can regenerate after being induced to die. The new animal model's regenerative ability may provide future insights into improved treatments of diabetes, which affects millions of Americans.

The model, named the PANIC-ATTAC mouse, mimics what occurs in humans with type 1 diabetes, a condition that develops when the body's immune system destroys pancreatic beta cells, as well as in type 2 diabetes, where beta cells die from working overtime.

After inducing death in the beta cells which make and release the hormone insulin the researchers found that the engineered mice's beta-cell populations can regenerate, which makes the animal useful for studying conditions such as type 1 diabetes, hyperglycemia (high blood sugar) and gestational diabetes.

The animal model is described online and in a future print issue of the journal Diabetes.

"The ability to induce cell death is not novel. The fact that the beta cells regenerate after we kill them is really the new aspect of the model," said Dr. Philipp Scherer, professor of internal medicine, director of the Touchstone Center for Diabetes Research at UT Southwestern and senior author of the study. "It enables us to see what kind of event or pharmacological intervention might stimulate or enhance the regeneration."

In the study, the researchers genetically manipulated mature, insulin-positive pancreatic beta cells in the PANIC-ATTAC mice so that these cells would die when they came in contact with a drug. When the researchers stopped administering the drug and allowed the animals to recover, they found that the animals' beta cells had regenerated and their blood glucose levels returned to normal after two months.

Dr. Scherer said it's unclear what caused the pancreatic beta cells to regenerate, but uncovering the
'/>"/>

Contact: Kristen Holland Shear
kristen.hollandshear@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Disabling mouse enzyme increases fertility
2. Mouse can do without mans most treasured genes
3. Mouse study: When it comes to living longer, its better to go hungry than go running
4. Negligent, attentive mouse mothers show biological differences
5. Scientists successfully treat new mouse model of inflammatory bowel disease
6. Book is the first high-resolution digital mouse brain atlas designed for Web applications
7. Dissecting the genetic components of adaptation of E. coli to the mouse gut
8. CSHL scientists identify and repress breast cancer stem cells in mouse tissue
9. New chimeric mouse model for human liver diseases, drug testing
10. Looking through the eyes of a mouse, scientists monitor circulating cells in its bloodstream
11. Cancer-resistant mouse discovered
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Mouse model developed at UT Southwestern mimics hyperglycemia, aids in diabetes research
(Date:8/27/2014)... when it only requires nerve cells to rearrange existing ... to generate new patterns, a study of monkeys has ... through recordings of electrical activity of brain cell networks. ... of Health. , "We looked into the brain and ... outside the box," said Aaron Batista, Ph.D., an assistant ...
(Date:8/27/2014)... neural circuits in the brain of mice, scientists ... The research, led by Howard Hughes Medical Institute ... Technology (MIT), reveals that the connections between the ... about an experience and the part of the ... experience are malleable. , Altering those connections ...
(Date:8/27/2014)... 2014 University of Utah biologist agan Sekercioglu, who ... won that nation,s highest science prize, which is similar ... is among five researchers picked for 2014 the top ... of Turkey. Three researchers won the Science Award and ... which is equivalent to the Science Award but for ...
Breaking Biology News(10 mins):Scientists plug into a learning brain 2Scientists plug into a learning brain 3Researchers change the emotional association of memories 2Researchers change the emotional association of memories 3Researchers change the emotional association of memories 4University of Utah biologist wins Turkey's top science prize 2
... has only been in Spain for a short time. Far away ... north of Europe where it has already crossed the Alps. Amongst ... of fruit is suitable for it to lay its eggs. This ... more European countries. "Out of the 3,000 known species of ...
... YORK (March 16, 2012)A rapid increase in shipping ... a significant increase in risk to the region,s marine ... for food security and cultural identity, according to an ... convened at a recent workshop. , The workshopwhich ...
... Office of Naval Research (ONR) will bring its technologically ... the 2012 Pacific Operational Science & Technology (S&T) Conference ... a key strategic area for the Navy and Marine ... research. "Gathering worldwide leaders in S&T at this event ...
Cached Biology News:An invasive Asian fly is taking over European fruit 2Increase in Arctic shipping poses risk to marine mammals 2Increase in Arctic shipping poses risk to marine mammals 3Increase in Arctic shipping poses risk to marine mammals 4ONR outreach focuses on Pacific total force 2
(Date:8/27/2014)... mysteries is how plants survive impact by the ... rays, while using this energy for photosynthesis. The ... plant,s blades quickly dissipate the energy throughout the ... at DTU Physics have now managed to successfully ... bacteria contain light-absorbing proteins which play a role ...
(Date:8/27/2014)... , Aug. 27, 2014 Research ... "Global Lactic Acid  (Biodegradable Polymer, Food & ... & Forecasts to 2019" report to their ... hydroxyl-carboxylic acid with an asymmetrical carbon atom. The ... biodegradable polymer, food and beverage, personal care product, ...
(Date:8/27/2014)... “We are honored to be named to this ... of Radiant Sage. “We are offering truly ground-breaking clinical ... market to a different level. We are enabling ... and effectively manage the massive amounts of medical imaging ... read by trained physicians. Being recognized by technology industry ...
(Date:8/27/2014)... August 27, 2014 Flagship Biosciences LLC, ... services to the pharmaceutical and medical device industries, has ... The fast growing company has consolidated its histology and ... Boulder to Westminster, CO, just north of Denver. ... 7575 W. 103rd Ave., Suite 100, Westminster, CO 80021 ...
Breaking Biology Technology:DTU researchers film protein quake for the first time 2Global Lactic Acid (Biodegradable Polymer, Food & Beverage, Personal Care & Pharmaceutical) Market - Trends & Forecasts to 2019 2Radiant Sage Named to CIOReview List of 100 Most Promising Technology Companies 2Flagship Biosciences Announces Relocation and Expansion 2
... Verenium,Corporation (Nasdaq: VRNM ), a leading developer ... development of high-performance specialty,enzymes, announced today that John ... Financial Officer, will present at the upcoming,Piper Jaffray ... to begin at 10:00 a.m. ET on Wednesday, ...
... and Reduce the ... Conn., Feb. 13 VION,PHARMACEUTICALS, INC. (Nasdaq: VION ) ... Omni Hotel in New Haven, Connecticut today at,10:00 Eastern Time., ... the,Company,s Restated Certificate of Incorporation to:, -- effect ...
... Company Posts Fourth Quarter EPS of $0.37, Up 16% -, - For ... Up 41%; Total Revenues and Product ... Income Growth in Four Years, ... $1.72 -, SAN DIEGO, Feb. 13 Gen-Probe Incorporated,(Nasdaq: GPRO ...
Cached Biology Technology:Verenium Corporation to Present at Piper Jaffray Clean Technology & Renewables Conference 2Verenium Corporation to Present at Piper Jaffray Clean Technology & Renewables Conference 3Vion Pharmaceuticals Holds Special Meeting of Stockholders 2Vion Pharmaceuticals Holds Special Meeting of Stockholders 3Gen-Probe Reports Strong Financial Results for Fourth Quarter and Full Year 2007 2Gen-Probe Reports Strong Financial Results for Fourth Quarter and Full Year 2007 3Gen-Probe Reports Strong Financial Results for Fourth Quarter and Full Year 2007 4Gen-Probe Reports Strong Financial Results for Fourth Quarter and Full Year 2007 5Gen-Probe Reports Strong Financial Results for Fourth Quarter and Full Year 2007 6Gen-Probe Reports Strong Financial Results for Fourth Quarter and Full Year 2007 7Gen-Probe Reports Strong Financial Results for Fourth Quarter and Full Year 2007 8Gen-Probe Reports Strong Financial Results for Fourth Quarter and Full Year 2007 9Gen-Probe Reports Strong Financial Results for Fourth Quarter and Full Year 2007 10Gen-Probe Reports Strong Financial Results for Fourth Quarter and Full Year 2007 11Gen-Probe Reports Strong Financial Results for Fourth Quarter and Full Year 2007 12Gen-Probe Reports Strong Financial Results for Fourth Quarter and Full Year 2007 13Gen-Probe Reports Strong Financial Results for Fourth Quarter and Full Year 2007 14Gen-Probe Reports Strong Financial Results for Fourth Quarter and Full Year 2007 15Gen-Probe Reports Strong Financial Results for Fourth Quarter and Full Year 2007 16
... Polyoxyethylene Lauryl Ether ... 0.02% Kathon Preservative. Surfactant. ... in immunohistochemistry is 1 ... 35 solution added to ...
Request Info...
PGC-1 (H-300)...
Mouse VEGF R1/Flt-1 Allophycocyanin MAb (Clone 141522) Keywords: Receptor Tyrosine Kinase, RTK, VEGFR1, VEGF Receptor 1 Protein Family: Receptor Tyrosine Kinases, VEGF/PDGF Family...
Biology Products: