Navigation Links
Mouse genome sequences reveal variability, complex evolutionary history
Date:9/15/2011

MADISON The genome of even a single organism is packed with information. A new paper, building on recent advances in sequencing capability, now reports the complete genomes of 17 different strains of mice, creating an unparalleled genetic resource that will aid studies ranging from human disease to evolution.

An international team of researchers, including University of WisconsinMadison geneticist Bret Payseur, describe in the Sept. 14 issue of the journal Nature the genome sequencing and comparison of 17 mouse strains, including several of the most common laboratory strains and four recently derived from wild populations. The resulting database, the largest for any vertebrate model organism, documents the range of genetic variation between mouse strains and its effects on phenotypes and gene regulation.

"Mice are the premier model organism for human disease. We've made a lot of progress in understanding the genetics of common human diseases by studying mice," says Payseur, an associate professor of medical genetics in the UWMadison School of Medicine and Public Health. "Although we've been able to map genomic regions that contribute to disease risk, we haven't known the full spectrum of mutations involved."

The new genetic compendium will help researchers more quickly find the subset of sequence differences responsible for disease and other characters, he adds. The new paper identifies mutations associated with more than 700 biological traits, including diabetes and heart disease.

"We are living in an era where we have thousands of human genomes at our fingertips," says David Adams from the Wellcome Trust Sanger Institute, who led the project. "The mouse, and the genome sequences we have generated, will play a critical role in understanding of how genetic variation contributes to disease and will lead us towards new therapies."

In addition to advancing the use of mice as a model for human disease, Payseur says the work also advances studies of evolution, his key interest. "We were interested in the history of mice how did mice evolve and come to be such an important organism for research?" he asks.

He and graduate student Michael White probed the evolutionary history of the lab mouse using sequences of four wild-derived mouse strains, including three common subspecies of house mice and a more distant relative. These strains represent a few million years of evolution, offering a window into the processes that drive genetic and phenotypic change.

They found that the mouse genomes do not reflect a single evolutionary story. Rather, different parts of the genome showed different patterns of relatedness. For the three wild house mouse subspecies in this study, Payseur and White found that nearly 40 percent of the sequence supported one evolutionary relationship, another 30 percent supported another and the remaining 30 percent of the DNA suggested yet a third relationship.

The complexity uncovered here should serve as a cautionary tale for studies of evolutionary relationships between organisms, which have often made inferences based on one or a few genes, Payseur says. "If you're looking at closely related species, don't expect to infer the species history just by looking at a handful of regions. You really have to look at a large fraction of the whole genome."

Payseur hopes to conduct similar analyses of the other sequenced laboratory strains to begin to fill in the large gaps in existing lab mouse pedigrees. Understanding the evolution of the lab mouse will provide important genetic context for mouse studies of human disease and help other researchers choose the strain most appropriate for their research questions.


'/>"/>

Contact: Bret Payseur
payseur@wisc.edu
608-890-0867
University of Wisconsin-Madison
Source:Eurekalert

Related biology news :

1. A mouse model brings new perspectives on Lafora disease
2. Mouse virus erroneously linked to chronic fatigue syndrome, UCSF collaborative study finds
3. Of mice and men: UNC-led team solves mouse genome dilemma
4. What is a laboratory mouse? Jackson, UNC researchers reveal the details
5. Better viewing through fluorescent nanotubes when peering into innards of a mouse
6. Birch mouse ancestor discovered in Inner Mongolia is new species of rare living fossil
7. UofL researchers replicate human kidney gene changes in mouse model
8. New mouse model may lead to new therapies for degenerative diseases
9. MARC travel awards announced for GSA Mouse Genetics Conference
10. Mutant mouse reveals new wrinkle in genetic code, say UCSF scientists
11. Freeway air bad for mouse brain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... No two people are believed to ... York University Tandon School of Engineering and Michigan ... partial similarities between prints are common enough that ... and other electronic devices can be more vulnerable ... in the fact that fingerprint-based authentication systems feature ...
(Date:4/5/2017)... Today HYPR Corp. , leading innovator ... of the HYPR platform is officially FIDO® Certified ... architecture that empowers biometric authentication across Fortune 500 enterprises ... over 15 million users across the financial services industry, ... product suites and physical access represent a growing portion ...
(Date:3/30/2017)... , March 30, 2017  On April 6-7, ... Hack the Genome hackathon at Microsoft,s headquarters ... two-day competition will focus on developing health and wellness ... Hack the Genome is the first ... tremendous. The world,s largest companies in the genomics, tech ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... Proscia Inc ... hosting a Webinar titled, “Pathology is going digital. Is your lab ready?” with ... adoption best practices and how Proscia improves lab economics and realizes an increase ...
(Date:10/11/2017)... HILLS, Calif. , Oct. 11, 2017  SkylineDx today ... (ICR) and University of Leeds ... risk-stratify patients with multiple myeloma (MM), in a multi-centric Phase ... University of Leeds is the sponsor ... and ICR will perform the testing services to include high-risk ...
(Date:10/11/2017)... ... October 11, 2017 , ... A new study published ... frozen and fresh in vitro fertilization (IVF) transfer cycles. The multi-center ... success. , After comparing the results from the fresh and frozen transfer cohorts, ...
(Date:10/10/2017)... DIEGO, CALIF. (PRWEB) , ... October 10, 2017 , ... ... as part of its corporate rebranding initiative announced today. The bold new look ... its reach, as the company moves into a significant growth period. , It will ...
Breaking Biology Technology: