Navigation Links
Mouse genome sequences reveal variability, complex evolutionary history
Date:9/15/2011

MADISON The genome of even a single organism is packed with information. A new paper, building on recent advances in sequencing capability, now reports the complete genomes of 17 different strains of mice, creating an unparalleled genetic resource that will aid studies ranging from human disease to evolution.

An international team of researchers, including University of WisconsinMadison geneticist Bret Payseur, describe in the Sept. 14 issue of the journal Nature the genome sequencing and comparison of 17 mouse strains, including several of the most common laboratory strains and four recently derived from wild populations. The resulting database, the largest for any vertebrate model organism, documents the range of genetic variation between mouse strains and its effects on phenotypes and gene regulation.

"Mice are the premier model organism for human disease. We've made a lot of progress in understanding the genetics of common human diseases by studying mice," says Payseur, an associate professor of medical genetics in the UWMadison School of Medicine and Public Health. "Although we've been able to map genomic regions that contribute to disease risk, we haven't known the full spectrum of mutations involved."

The new genetic compendium will help researchers more quickly find the subset of sequence differences responsible for disease and other characters, he adds. The new paper identifies mutations associated with more than 700 biological traits, including diabetes and heart disease.

"We are living in an era where we have thousands of human genomes at our fingertips," says David Adams from the Wellcome Trust Sanger Institute, who led the project. "The mouse, and the genome sequences we have generated, will play a critical role in understanding of how genetic variation contributes to disease and will lead us towards new therapies."

In addition to advancing the use of mice as a model for human disease, Payseur says
'/>"/>

Contact: Bret Payseur
payseur@wisc.edu
608-890-0867
University of Wisconsin-Madison
Source:Eurekalert

Page: 1 2

Related biology news :

1. A mouse model brings new perspectives on Lafora disease
2. Mouse virus erroneously linked to chronic fatigue syndrome, UCSF collaborative study finds
3. Of mice and men: UNC-led team solves mouse genome dilemma
4. What is a laboratory mouse? Jackson, UNC researchers reveal the details
5. Better viewing through fluorescent nanotubes when peering into innards of a mouse
6. Birch mouse ancestor discovered in Inner Mongolia is new species of rare living fossil
7. UofL researchers replicate human kidney gene changes in mouse model
8. New mouse model may lead to new therapies for degenerative diseases
9. MARC travel awards announced for GSA Mouse Genetics Conference
10. Mutant mouse reveals new wrinkle in genetic code, say UCSF scientists
11. Freeway air bad for mouse brain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... 2014 /PRNewswire-iReach/ -- The Geneva Healthcare Suite, an innovative ... cut emergency room wait times by an average of ... Center, according to a recent study published in the ... using the suite to access data from incoming patients, ... "Using Geneva,s technology platform we have been able ...
(Date:7/24/2014)... by 45% on average over a 35 year period ... on the impact of humans on declining animal numbers. ... such as insects, spiders, crustaceans, slugs and worms bring ... for crops, decomposition for nutrient cycling, water filtration and ... and led by UCL, Stanford and UCSB, focused ...
(Date:7/24/2014)... Imagine a smog-free Los Angeles, where electric cars ply ... run on heat from beneath the earth, from howling ... new Stanford study finds that it is technically and ... one powered by clean, renewable energy. Published in ... sustainable, inexpensive and reliable energy supply in California that ...
Breaking Biology News(10 mins):UC San Diego Medical Center Cuts Average ER Wait Time by 92 Minutes using the Geneva Healthcare Suite 2UC San Diego Medical Center Cuts Average ER Wait Time by 92 Minutes using the Geneva Healthcare Suite 3Invertebrate numbers nearly halve as human population doubles 2Invertebrate numbers nearly halve as human population doubles 3Stanford study shows how to power California with wind, water and sun 2Stanford study shows how to power California with wind, water and sun 3Stanford study shows how to power California with wind, water and sun 4
... is showing multiple benefits from restoration efforts, newly published ... increased the abundance and diversity of submerged aquatic vegetation ... during the 18-year field study. Since 1990, the ... doubled, the area covered by native SAV has increased ...
... prominent speakers have been added to the slate ... Military Medicine Symposium: Advancing Public-Private Partnerships, on September ... Washington, D.C. The event is a premier opportunity ... to come together to discuss medical partnerships to ...
... than a health hazard according to scientists from The University ... Medicine and Science have discovered powerful antibiotic properties in the ... treatments for multi-drug resistant bacterial infections. They found that the ... were able to kill more than 90 per cent of ...
Cached Biology News:Potomac River: 10-fold increase in native submerged vegetation reflects improved water quality 2Sutherland and Berglass to keynote USU-HJF Military Medicine Symposium 2Sutherland and Berglass to keynote USU-HJF Military Medicine Symposium 3Cockroach brains could be rich stores of new antibiotics 2
(Date:7/24/2014)... -- ECC West Africa, LLC (ECC) signed a contract in ... Hospital (UCH) Ibadan Board of Management for the first ... and operate and maintain a new, state-of-the-art Cancer Institute ... first of the 4-phase project, ECC will conduct feasibility ... Ibadan intends to finance and develop the Cancer Institute ...
(Date:7/24/2014)... natural and synthetic processes prefer to settle into ... energyit is within the realm of non-equilibrium conditions ... changes in energy and phases, such as temperature ... allow humans to regulate their body temperature, airplanes ... seismic activity. , But even though these ...
(Date:7/24/2014)... , July 24, 2014  CorMedix Inc. ... developing and commercializing therapeutic products for the prevention ... announces receipt of notice on July 18, 2014 ... NYSE-MKT has accepted the CorMedix plan to regain ... As a result, the NYSE-MKT is continuing the ...
(Date:7/24/2014)... 2014 1000 balances – 4 steps ... customers’ weighing needs and expertly narrows down the mass ... scales or even terminals. , First, select the ... (or select readability instead) and define the accuracy – ... criteria narrows down the list to models that fit ...
Breaking Biology Technology:ECC Signs a Contract for the Finance, Design, and Construction of a Premier Cancer Institute in Ibadan, Nigeria 2New approach to form non-equilibrium structures 2CorMedix, Inc. Granted Extension of NYSE-MKT Listing 2CorMedix, Inc. Granted Extension of NYSE-MKT Listing 3
... than a year after Chippewa Valley Technical College ... Administration has approved a $1.5 million grant to help ... ,The grant will cover part of the cost of ... create an estimated 650 jobs and generate $30 million ...
... Day birthing of new products, or simply the last rush to ... busy day for product news. In fact, two DEMO alumni - ... - are delivering significant new functionality to their faithful customers. ... smart phone. The newest member of the Treo family is based ...
... - By several measures, these should be heady days ... manufacturing jobs were lost, the economy is back, manufacturing revenue ... there is a sense of unease linked to withering competitive ... of what their American counterparts earn, where manufacturers have a ...
Cached Biology Technology:Two DEMO alumni make big product splashes 2Two DEMO alumni make big product splashes 3Manufacturers advised to redesign customer relations 2Manufacturers advised to redesign customer relations 3
... The Zero Blunt ... for Sequencing is designed ... sequencing of blunt-end PCR ... provides 5-minute TOPO Cloning ...
Recommend to use at 1000X dilutions for cell culture (e.g. Add 1 ul to 1 ml of culture medium.)...
Recombinant Human CCL21/6Ckine (Mucin Stalk Chimera)...
One-step, microplate or cuvet, colorimetric, detection range 0.78 ug/dL to 65 ug/dL Zn in serum, plasma, urine, saliva etc. Procedure: 10 min....
Biology Products: