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Mouse can do without man's most treasured genes
Date:5/14/2008

ur results will have some important implications," he said. "First, in many genome projects, people draw inferences about gene function by using information from other model organisms. We need to be careful doing this because we now know that a large fraction of the genes may have different functions or different importance in different species."

In addition, the results raise concerns about the widespread use of mouse models for studying human disease.

"Our study does not say that mouse models are useless," Zhang said. "Even for those genes that have changed essentiality, the mouse model may provide useful information. For example, it may tell us the molecular function of the gene, even if the gene's importance differs between species. But for some diseases, such as neurological diseases related to vacuole proteins, the phenotype is so different that it may be necessary to establish a primate model."


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Contact: Nancy Ross-Flanigan
rossflan@umich.edu
734-647-1853
University of Michigan
Source:Eurekalert

Page: 1 2 3

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