Navigation Links
Mouse can do without man's most treasured genes
Date:5/14/2008

s of the individual genes that are essential in humans but nonessential in the mouse, they discovered that a much higher than expected percentage are located in the vacuole, a sac-like cellular structure that functions as a garbage dump---but a highly important garbage dump.

"The main function of the vacuole is to contain and degrade cellular wastes and toxins," Zhang said. "In humans, the absence of vacuole proteins causes those wastes and toxins to accumulate, often leading to fatal neurological diseases."

The same thing happens in the mouse, but at a much later stage of life, often past reproductive age. As a result, "many of these vacuole proteins are not so 'essential' to the mouse," Zhang said. "Even without the proteins, the mouse can survive long enough to reproduce."

The researchers speculated that in the course of primate evolution, as life span increased and reproductive age was delayed, efficient waste management became increasingly important.

Additional results of their analysis support the idea. By developing an index that incorporated metabolic rate (a measure of how fast cellular waste products are generated) and reproductive age, and then using that index to compare human and mouse, the researchers determined that the total amount of waste produced per gram of body mass from birth to reproductive age is about 18 times higher for humans than for the mouse.

"Hence, waste management is much more important in humans than in the mouse for maintaining proper cellular functions until the time of reproduction," Zhang said. "And when a biological process becomes more important to a species, the genes involved in that process tend to become essential."

Zhang acknowledges that the study involved a relatively small number of genes, and he hopes that other researchers will be able to confirm the results as more information on human and mouse genes becomes available.

"If our sample is unbiased, o
'/>"/>

Contact: Nancy Ross-Flanigan
rossflan@umich.edu
734-647-1853
University of Michigan
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Mouse study: When it comes to living longer, its better to go hungry than go running
2. Negligent, attentive mouse mothers show biological differences
3. Scientists successfully treat new mouse model of inflammatory bowel disease
4. Book is the first high-resolution digital mouse brain atlas designed for Web applications
5. Dissecting the genetic components of adaptation of E. coli to the mouse gut
6. CSHL scientists identify and repress breast cancer stem cells in mouse tissue
7. New chimeric mouse model for human liver diseases, drug testing
8. Looking through the eyes of a mouse, scientists monitor circulating cells in its bloodstream
9. Cancer-resistant mouse discovered
10. Immune cells promote blood vessel formation in mouse endometriosis
11. A computer for your mouse!
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... news release is available in German . ... is a method that uses the refraction of X-rays ... The images produced with this method are often of ... scientists in the team of Prof. Franz Pfeiffer are ... imaging and therapy including X-ray phase-contrast imaging. One ...
(Date:7/11/2014)... 10, 2014---A team of researchers from The Chinese University ... a gene of wild soybean linked to salt tolerance, ... in saline soil. This study published online in ... novel genomic information for crop improvement. , Soybean is ... and human selection, cultivated soybeans have less genetic diversities ...
(Date:7/11/2014)... international team of researchers, including scientists from the Max ... a reported a major step in understanding photosynthesis, the ... maintains the oxygen in its atmosphere and which is ... earth. , The researchers report the first direct ... namely the step in which a specific protein complex, ...
Breaking Biology News(10 mins):New simple setup for X-ray phase contrast 2BGI reports a novel gene for salt tolerance found in wild soybean 2A first direct glimpse of photosynthesis in action 2
... that causes plaque buildup in Alzheimer,s disease is the focus ... Georgia Health Sciences University graduate student. In Alzheimer,s, the ... eliminated by the body,s natural defenses, nestling between the neurons ... gets there could be targets for a new vaccine. ...
... Sept. 26, 2011 -A compound tested by UT Southwestern Medical ... that killed an estimated 30 million people in the worldwide ... by increasing the levels of a human antiviral protein - ... the flu, a virus that tends to mutate into strains ...
... Scientists have for the first time discovered sixteen new sections ... opening up the possibility for better prevention as well ... 175 scientists from 126 centres in Europe, the USA and ... human lung. Their discovery sheds new light on the ...
Cached Biology News:Award-winning research points toward Alzheimer’s vaccine 2Compound kills highly contagious flu strain by activating antiviral protein 2New discoveries in genetics of lung health 2
(Date:7/10/2014)... Senior supply chain management executives from over ... challenges of “Reducing Cost, Lead Time, & Defects in ... Describing the partnership of the Bio Supply Management Alliance ... ( SCMI) of the University of San Diego ... Kroc Institute of Peace and Justice in San Diego, ...
(Date:7/10/2014)... DUBLIN , July 10, 2014 ... the addition of the "International Photonic Integrated ... - Forecasts to 2019" report to their ... The concept of photonic integration traces ... twentieth century. The promise of photonic integration went ...
(Date:7/10/2014)... study published today in the journal PNAS (Proceedings ... that time of day and sleep deprivation have a ... crucial when looking at the best time of day ... disease, and for administering medicines effectively. , Researchers from ... Research, London, investigated the links between sleep deprivation, body ...
(Date:7/10/2014)... shelled out for crude 3-D glasses, polarized glasses, ... These basic devices, used to trick the brain ... be rendered obsolete with the introduction of new ... , TAU doctoral students Yuval Yifat, Michal Eitan, ... based on nanoantennas that could be used for ...
Breaking Biology Technology:Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 2Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 4International Photonic Integrated Circuit (Monolithic Integration, Hybrid Integration, Module Integration) Market - Forecasts to 2019 2Time of day crucial to accurately test for diseases, new research finds 2Projecting a 3-dimensional future 2Projecting a 3-dimensional future 3
... ... WILMINGTON, Del., April 22 , Highlights -- First quarter 2008 ... year. Excluding a significant item charge in the prior year, earnings ... 6 percent higher local selling prices and 5 percent currency benefit, ...
... Step to Tap Alternative Energy Business in China, ... Technology,Company Ltd ("JIC" or "the Company") to be ... 987), a wholly-owned subsidiary of HKC,(Holdings) Limited ("HKC ... invest in three alternative energy projects at the ...
... Ortho Evra is an adhesive,transdermal birth control patch. It ... of ethinyl estradiol into the bloodstream per 24,hours. It is ... is worn,during the fourth week. Ortho Evra was approved by ... used Ortho Evra since its approval.,Ortho Evra continues to be ...
Cached Biology Technology:DuPont Reports First Quarter Earnings Growth of Over 20 Percent 2DuPont Reports First Quarter Earnings Growth of Over 20 Percent 3DuPont Reports First Quarter Earnings Growth of Over 20 Percent 4DuPont Reports First Quarter Earnings Growth of Over 20 Percent 5DuPont Reports First Quarter Earnings Growth of Over 20 Percent 6DuPont Reports First Quarter Earnings Growth of Over 20 Percent 7DuPont Reports First Quarter Earnings Growth of Over 20 Percent 8DuPont Reports First Quarter Earnings Growth of Over 20 Percent 9DuPont Reports First Quarter Earnings Growth of Over 20 Percent 10DuPont Reports First Quarter Earnings Growth of Over 20 Percent 11DuPont Reports First Quarter Earnings Growth of Over 20 Percent 12DuPont Reports First Quarter Earnings Growth of Over 20 Percent 13DuPont Reports First Quarter Earnings Growth of Over 20 Percent 14DuPont Reports First Quarter Earnings Growth of Over 20 Percent 15DuPont Reports First Quarter Earnings Growth of Over 20 Percent 16DuPont Reports First Quarter Earnings Growth of Over 20 Percent 17DuPont Reports First Quarter Earnings Growth of Over 20 Percent 18JIC Invests in Three New Alternative Energy Projects 2JIC Invests in Three New Alternative Energy Projects 3JIC Invests in Three New Alternative Energy Projects 4JIC Invests in Three New Alternative Energy Projects 5Ortho Evra Patch Makers Settling Cases 2
RayBio Human Atherosclerosis Antibody Array 1.1 (4) with Accessory, detects 40 inflammatory factors (for lysate) Class: Antibody Array Products Product Group: Antibody Array...
Ultra Pure Grade. Used in conjunction with IPTG to identify bacterial colonies that contain recombinant plasmids by blue/white selection. X-Gal forms an intense blue precipitate in the presence of be...
Request Info...
4-Hydroxy-3-nitrophenylacetyl hapten is conjugated to SSA (Sheep serum albumin) lysine through amide bonds. This product is homologous to NP-BSA....
Biology Products: