Navigation Links
Mouse can do without man's most treasured genes
Date:5/14/2008

ANN ARBOR, Mich.---The mouse is a stalwart stand-in for humans in medical research, thanks to genomes that are 85 percent identical. But identical genes may behave differently in mouse and man, a study by University of Michigan evolutionary biologists Ben-Yang Liao and Jianzhi Zhang reveals.

Their results, which have implications for the use of mouse models in studying human disease, appear in the current issue of the journal Proceedings of the National Academy of Sciences (PNAS).

"Everyone assumes that deletion of the same gene in the mouse and in humans produces the same phenotype (an observable trait such as presence or absence of a particular disease). That's the basis of using the mouse to study human disease," said Zhang, an associate professor of ecology and evolutionary biology. "Our results show that may not always be the case."

Zhang and his graduate student Liao focused their study on so-called essential genes---genes which, through their effects on survival or fertility, are necessary for organisms to reach sexual maturity and reproduce. They then homed in on 120 essential human genes for which the mouse has an identical counterpart that also has been studied. Next they consulted a database that catalogs the results of experiments in which the mouse equivalents of human genes are deleted, or "knocked out."

If those 120 essential human genes are also essential in the mouse, deleting any of them should result in infertility or death before reproductive age. But the database showed an unexpected discrepancy.

"To our surprise, 22 percent of the 120 human essential genes are nonessential in the mouse," Zhang said. "I expected there would be some, but I never expected the percentage to be so high."

Intrigued, the researchers wanted to understand why the "essentiality" of some genes has changed in the time since human and mouse last shared a common ancestor. Looking more closely at the protein product
'/>"/>

Contact: Nancy Ross-Flanigan
rossflan@umich.edu
734-647-1853
University of Michigan
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Mouse study: When it comes to living longer, its better to go hungry than go running
2. Negligent, attentive mouse mothers show biological differences
3. Scientists successfully treat new mouse model of inflammatory bowel disease
4. Book is the first high-resolution digital mouse brain atlas designed for Web applications
5. Dissecting the genetic components of adaptation of E. coli to the mouse gut
6. CSHL scientists identify and repress breast cancer stem cells in mouse tissue
7. New chimeric mouse model for human liver diseases, drug testing
8. Looking through the eyes of a mouse, scientists monitor circulating cells in its bloodstream
9. Cancer-resistant mouse discovered
10. Immune cells promote blood vessel formation in mouse endometriosis
11. A computer for your mouse!
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... the first smartphone app that automatically reveals students, ... other words, your smartphone knows your state of ... how that affects you. , The StudentLife app, ... to their academic performance, also may be used ... monitor mental health, trigger intervention and improve productivity ...
(Date:9/18/2014)... have devastated algal forests in the eastern Mediterranean Sea ... if their distribution continues to expand as the climate ... international team of researchers led by Dr Adriana Vergs ... Mediterranean Institute for Advanced Studies in Spain, is published ... the team surveyed more than 1000 kilometres of coastline ...
(Date:9/18/2014)... ultimate form of camouflage: you don,t just blend in, ... not as uncommon as you might think. Kathryn Feller, ... that the larval life stages of many marine species ... anatomy that most creatures cannot make transparent. Feller explains ... each individual eye unit with an opaque pigment to ...
Breaking Biology News(10 mins):New Dartmouth smartphone app reveals users' mental health, performance, behavior 2New Dartmouth smartphone app reveals users' mental health, performance, behavior 3New Dartmouth smartphone app reveals users' mental health, performance, behavior 4Tropical fish a threat to Mediterranean Sea ecosystems 2Transparent larvae hide opaque eyes behind reflections 2
... Bruce J. Peterson, a senior scholar at the Marine ... for the Sciences of Limnology and Oceanography (ASLO) to ... The award honors the career achievements of an aquatic ... long-term influence. Dr. Peterson is being honored for "innovative ...
... at the University of Huddersfield aims to ensure that the risk ... of lead plumbing is reduced even further in line with ... 2013. The project is being conducted in collaboration with ... countries, such as European nations and the USA, have similar issues ...
... German . , Physicists of the ... of Natural Resources and Life Sciences Vienna developed nano-machines ... first versatile and modular example of a fully artificial ... (VSC), a high performance computing infrastructure. These "bionic proteins" ...
Cached Biology News:MBL scientist Bruce Peterson wins ASLO Lifetime Achievement Award 2MBL scientist Bruce Peterson wins ASLO Lifetime Achievement Award 3Research with Yorkshire Water to reduce lead in water supplies 2Nano-machines for 'bionic proteins' 2
(Date:9/19/2014)... NYU Langone Medical Center have found a way to ... turning adult cells into so-called pluripotent stem cells by ... new technique in mice, the researchers increased the number ... more than 20-fold compared with the standard method. They ... should generally accelerate research aimed at using stem cells ...
(Date:9/19/2014)... 2014  Nektar Therapeutics (NASDAQ: NKTR ... the analgesic profiles of a series of the ... molecules. The preclinical research candidates were created using ... The analgesic properties of kappa receptor agonism ... Kappa opioid receptors are expressed in the ...
(Date:9/19/2014)... , September 19, 2014 ... and Markets ( http://www.researchandmarkets.com/research/b2jxhs/micro_market ) has announced the addition ... Chromatography Columns"  report to their offering.  ... market is one of the fastest-growing segments in ... $1.2 billion in 2013, and expected to reach ...
(Date:9/18/2014)... About POCT POCT, ... clinical laboratory. It helps in making fast clinical ... medication. POCT is gaining popularity due to the ... as diabetes, heart disease, and obesity. It is ... to minimize errors during the diagnosis of patients. ...
Breaking Biology Technology:NYU Langone scientists report reliable and highly efficient method for making stem cells 2NYU Langone scientists report reliable and highly efficient method for making stem cells 3Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 2Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 3Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 4Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 5Micro Market Monitor : Global Pre-packed Chromatography Columns 2POCT Market in China 2014-2018 2
... NOVATO, Calif., Sept. 29, 2011 BioMarin Pharmaceutical ... that Jean-Jacques Bienaime, Chief Executive Officer of BioMarin, ... Thursday, October 27, at 5:00 p.m. ET to ... Dial-in Number: 877.299.4454International Dial-in Number: 617.597.5447Participant Code: 74745522Replay ...
... Orexigen® Therapeutics, Inc. (Nasdaq: OREX ), ... abstracts accepted for poster presentations and an oral presentation ... Obesity Society. This meeting will be held October 1-5, ... Marriott. Details on the presentation times ...
... you think about your immune system, you probably think about ... University of Adelaide suggests that immune cells in your brain ... amazing to think that despite 10,000 years of using alcohol, ... affects the nerve cells in our brain, we are still ...
Cached Biology Technology:BioMarin to Host Third Quarter 2011 Financial Results Conference Call and Webcast on Thursday, October 27 at 5:00 p.m. ET 2Orexigen® Therapeutics Announces Multiple Contrave® Data Presentations at the 29th Annual Scientific Meeting of The Obesity Society 2Alcohol-related behavior changes -- blame your immune system 2
... Analyzer for General Chemistries, Specialty Chemistries, QC, Reagent Development, Pharmaceutical Development, Physician Owned Labs, Drugs ... user-selectable wavelengths. ... ... ...
Recorder REC-111 single-channel, 1. Category: Chromatography Systems & Accessories, Systems....
2,4,6, Trinitrophenyl hapten is conjugated to lipopolysaccharide (LPS)....
For the quantitative determination of cyclic AMP (cAMP) concentrations in cell culture supernates, serum, plasma, saliva, urine and cell lysates....
Biology Products: