Navigation Links
Mounting evidence shows health benefits of grape polyphenols
Date:10/28/2008

Philadelphia, PA, October 28, 2008 A growing body of research data suggests that consuming foods rich in polyphenols from grapes, including red wine, helps reduce the risk of heart disease, according to a review article in the November issue of Nutrition Research.

"Consumption of grape and grape extracts and/or grape products such as red wine may be beneficial in preventing the development of chronic degenerative diseases such as cardiovascular disease," write Wayne R. Leifert, Ph.D., and Mahinda Y. Abeywardena, Ph.D., of Commonwealth Scientific and Industrial Research Organisation in Adelaide, Australia.

The authors review the accumulating evidence that grape polyphenols work in many different ways to prevent cardiovascular and other "inflammatory-mediated" diseases. Polyphenols are natural antioxidants found in grapes and some other plant foods. Their types and actions vary, depending on where in the grape they are found. Grape seeds, grape skin, and grape juice contain several types of polyphenols, including resveratrol, phenolic acids, anthocyanins, and flavonoids.

Through their antioxidant effects, grape polyphenols help to slow or prevent cell damage caused by oxidation. Polyphenols decrease oxidation of low-density lipoprotein cholesterol ("bad" cholesterol)a key step in the development of atherosclerosis (hardening of the arteries). Grape polyphenols also have other protective effects on the heart and blood vessels, including actions to reduce blood clotting, abnormal heart rhythms, and blood vessel narrowing. It's not yet clear exactly how these benefits of polyphenols occur, although there is evidence of effects on cellular signaling and on the actions of certain genes. The wide range of health-promoting effects suggests that several different, possibly interrelated mechanisms may be involved.

So far, most of the evidence on grape polyphenols comes from laboratory experiments and animal studies. However, a few studies support the disease-preventing benefits of grapes in humans. Studies in patients treated with grape seed extracts have shown improvements in blood flow and cholesterol levels. In other studies, drinking Concord grape juice has improved measures of blood flow in patients with coronary artery disease and lowered blood pressure in patients with hypertension.

Studies investigating the lower rates of heart disease in Francethe so-called "French paradox"first raised the possibility that red wine might have health benefits. The subsequent research reviewed by Drs. Leifert and Abeywardena helps build the case that grapes and grape products might be a useful part of strategies to lower the high rate of death from cardiovascular disease.

At a time of growing interest in the use of "functional foods and nutraceuticals" to promote heart health, grapes and grape polyphenols are "attractive candidates" for use in such supplements, Drs. Leifert and Abeywardena believe. "Therefore," they conclude, "supplementation with grape seed, grape skin or red wine products may be a useful adjunct to consider for a dietary approach in the prevention of cardiovascular diseases, although additional research is required to support such a strategy."


'/>"/>
Contact: Jayne Dawkins
ja.dawkins@elsevier.com
215-239-3674
Elsevier
Source:Eurekalert

Related biology news :

1. Mounting evidence shows red wine antioxidant kills cancer
2. A private bandwidth for communication in bats: Evidence from insular horseshoe bats
3. Comet probes reveal evidence of origin of life, scientists claim
4. Evidence of a relationship between swimming babies and infections
5. Researchers find evidence linking stress caused by the Sept. 11 disaster with low birth weights
6. Fossil record supports evidence of impending mass extinction
7. New evidence for female control in reproduction
8. RAND study finds evidence disease management programs
9. CWRU School of Medicine has evidence vaccine against malaria will reduce disease
10. There is powerful evidence of evolution in human DNA
11. Scientific evidence supporting evolution continues to grow
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/6/2016)... 6, 2016  Zimmer Biomet Holdings, Inc. (NYSE and SIX: ... offering of €500.0 million principal amount of its 1.414% senior ... its 2.425% senior unsecured notes due 2026. ... December 13, 2016, subject to the satisfaction of customary closing conditions.  ... The Company intends to use the ...
(Date:12/2/2016)... , Dec. 1, 2016   SoftServe , ... BioLock , an electrocardiogram (ECG) biosensor analysis ... a key IoT asset. The smart system ensures ... vehicle,s steering wheel and mobile devices to easily ... As vehicle technology advances, so too ...
(Date:11/29/2016)... Nearly one billion matches per second with DERMALOG,s high-speed AFIS    ... ... DERMALOG is Germany's largest Multi-Biometric supplier: The ... Identification Systems) ... Germany's largest Multi-Biometric supplier: The company's Fingerprint Identification System is part of ...
Breaking Biology News(10 mins):
(Date:12/6/2016)... ... December 06, 2016 , ... ... 1, 2016 asking the Federal Drug Administration (FDA) to consider OA as a ... OARSI is concerned about the growing population of OA patients, many of whom ...
(Date:12/6/2016)... Colorado (PRWEB) , ... December 06, 2016 , ... ... dynamic aqueous plasma technology platforms, announced today that the company has engaged in ... Research and Development Agreement (MRDA) with the CSU Office of the Vice President ...
(Date:12/6/2016)... , Dec. 6, 2016  Creative Medical Technology ... , MD, PhD, FANA, FAAN to the Company,s Scientific ... and clinical trials to assist the Company,s clinical development ... AmnioStem product is a universal donor stem cell derived ... in animal models of stroke 1 .  ...
(Date:12/6/2016)... Australia , Dec. 6, 2016  The ... Informatics Society of Australia (HISA) today announced the ... startup exchange program between Australia ... in the world. HISA and the ... initiating a program to create a global health innovation ...
Breaking Biology Technology: