Navigation Links
Mounting a multi-layered attack on fungal infections
Date:9/7/2009

Unravelling a microbe's multilayer defence mechanisms could lead to effective new treatments for potentially lethal fungal infections in cancer patients and others whose natural immunity is weakened.

Although not as well known as bacterial infections, such as MRSA and E.coli, fungal infections such as that caused by the yeast Candida albicans can be more serious and lead to a higher death rate. Using mutant forms of the C. albicans yeast which lacked different parts of the yeast cell wall, Professor Neil Gow and his colleagues have uncovered a three-pronged mechanism by which the body's immune defences attack the invading fungus.

Presenting the work at the Society for General Microbiology's meeting at Heriot-Watt University, Edinburgh, today (8 September), Professor Gow explained that the yeast's cell wall consists of a skeleton-like structure made up of complex sugars called chitins and glucans, covered by an outer layer of proteins which are highly decorated with sugars. The white blood cells that form part of the human immune system have receptors on their surfaces which recognise specific parts of the yeast cell wall, enabling them to fasten on to the invading yeast cells, kill them and then break them down. However other components in the yeast cell wall were found that can damp down this immune response.

In addition, the immune system needs to attack the glucans in the yeast inner cell wall. In the early stages of infection when the white blood cells start to digest the outer cell wall of the yeast, the glucans become more exposed; the immune system is then able to mount a chemical attack on these molecules.

"We need to find out exactly what the body's immune systems detect and what receptors the defence cells have that recognise the yeast's cell wall components. However, fungi are clever enough to develop evasion strategies so we need to figure what these are too. If we can do this we may be able to stimulate the immune system to work more effectively in killing disease-causing fungi," said Professor Gow.

"In the longer term we may be able to treat patients with immunotherapy with agents that stimulate their immunity - as well as with anti-microbial drugs. In addition our work may also lead to new ways to detect fungal infections earlier. Too often the fungus has taken a hold and established itself so well that treatment becomes even more difficult".


'/>"/>

Contact: Dianne Stilwell
diannestilwell@me.com
07-957-200-214
Society for General Microbiology
Source:Eurekalert

Related biology news :

1. Mounting evidence shows health benefits of grape polyphenols
2. Mounting evidence shows red wine antioxidant kills cancer
3. Study finds women slightly more likely to die than men in the 30 days following a heart attack
4. Early detection and quick response are key to defense against anthrax attack
5. New drug may reduce heart attack damage
6. Heart attacks: The tipping point
7. Yale researchers uncover secrets of salmonellas stealth attack
8. Inhaling a heart attack: How air pollution can cause heart disease
9. Simple test helps predict heart attack risk
10. Shark attacks decline worldwide in midst of economic recession
11. International study identifies gene variants associated with early heart attack
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/10/2017)... 2017 Research and Markets has ... Medicine - Scientific and Commercial Aspects" to their offering. ... ... integrated with therapy for selection of treatment as well for ... prevention of disease in modern medicine. Biochip/microarray technologies and next ...
(Date:2/8/2017)... Inc. (NASDAQ: AWRE ), a leading supplier of ... quarter and year ended December 31, 2016. ... compared to $6.9 million in the same quarter last year. ... million compared to $2.6 million in the fourth quarter of ... $0.5 million, or $0.02 per diluted share, which compares to ...
(Date:2/8/2017)... -- Report Highlights The global biosurgery market ... in 2016 at a compound annual growth rate (CAGR) ... - An overview of the global market for biosurgery. ... 2015 and 2016, and projections of compound annual growth ... on the basis of product type, source, application, and ...
Breaking Biology News(10 mins):
(Date:2/18/2017)... 2017 Kurzlehrgang mit Fokus ... Zelltherapie-Studien, Poster legt metaproteomische Analyse des Darm-Mikrobioms bei Säuglingen ... ... Dr. Yoav Peretz , Scientific Director bei ImmuneCarta, ... Assays zum Nachweis intrazellulärer Zytokine bei adoptiven Zelltherapie-Studien im ...
(Date:2/18/2017)... 2017 Research and Markets has announced the ... report to their offering. ... The report provides separate comprehensive analytics for the US, ... Rest of World. Annual estimates and forecasts are provided for the ... for these markets. Market data and analytics are derived from primary ...
(Date:2/17/2017)... 17, 2017  If only one in every ... mutation-conferring resistance to chemotherapy, thousands of cancer cells ... focused on finding these mutations in ever-smaller subpopulations ... tumor DNA in blood — to guide treatment ... Unfortunately, however, detecting these genetic anomalies may ...
(Date:2/16/2017)... ... 16, 2017 , ... EIT Digital has launched work to develop ... Pilot studies are about to get under way for the framework, which is designed ... The concept is expected to be transferred eventually to other industries that also require ...
Breaking Biology Technology: