Navigation Links
Mount Sinai researchers discover new way diseases develop
Date:7/8/2010

Researchers from Mount Sinai School of Medicine have identified a previously unknown mechanism by which cells direct gene expression, the process by which information from a gene is used to direct the physical and behavioral development of individuals. The research, which may help scientists gain insight into how muscle and heart diseases develop, is published in the July 8th issue of Nature.

Using a combined approach of structural and molecular biology, a team of researchers led by Ming-Ming Zhou, PhD, Professor and Chair, Structural and Chemical Biology, Mount Sinai School of Medicine, determined that the molecular interactions between proteins are very different than previously thought, and that they play an essential role in the initiation of gene transcription of muscle and the heart. Gene transcription is the first step to gene expression, a cellular process that occurs in response to physiological and environmental stimuli, and is dictated by chemical modifications of the DNA and histones, which are the proteins responsible for packaging the DNA.

Dr. Zhou's team found a new fundamental mechanism in gene transcription through a protein called DPF3b. They learned that DPF3b recognizes gene-activating chemical marks in these histones in a very different way. DPF3b plays a critical role in the copying of genesa crucial part of the transcription processfor muscle growth and heart development.

"This discovery opens new doors in genome biology research, and has broad implications in the field of epigenetics of human biology of health and disease," said Martin Walsh, PhD, Associate Professor, Pediatrics, and Structural and Chemical Biology at Mount Sinai who is also a co-author of the study. "Knowing that there is an additional way our genome is regulated will allow us to understand the molecular basis of certain human disorders that result from dysregulation of gene expression."

Dr. Zhou said that bromodomains, which are housed in proteins, read off cell signals that turn on genes that determine genetic makeup. "This study uncovers that nature has an alternative to bromodomains for gene expression to initiate, providing a new mechanism to help us understand how our muscles and heart grow properly, and what might cause them to grow abnormally," Dr. Zhou said.


'/>"/>

Contact: Mount Sinai Press Office
newsnow@mountsinai.org
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Related biology news :

1. White Mountain Research Station to host climate change conference
2. Tropical rainforest and mountain species may be threatened by global warming
3. Missouri Botanical Garden mounts milestone 6 millionth herbarium specimen
4. Mounting evidence shows health benefits of grape polyphenols
5. Escherichia coli bacteria transferring between humans and mountain gorillas
6. Mountain caribous ancient ancestry revealed
7. Will large amounts of soil carbon be released if grasslands are converted to energy crops?
8. Mount Sinai Hospital researcher makes stem cell breakthrough
9. Mountain on Mars may answer big question
10. UC Davis launches One Health care for wild mountain gorillas and human neighbors
11. Geoscientists meet to discuss Rocky Mountain geology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/4/2017)... , Jan. 4, 2017  CES 2017 – ... biometric sensor technology, today announced the launch of ... sensor systems, the highly-accurate biometric sensor modules that ... biometric technology, experience and expertise. The two new ... designed specifically for hearables, and Benchmark BW2.0, a ...
(Date:12/20/2016)... N.C. and GENEVA, Dec, 20, 2016 /PRNewswire/ ... biometric data sensor technology, and STMicroelectronics ... the spectrum of electronics applications, announced today the ... development kit for biometric wearables that includes ST,s ... with Valencell,s Benchmark™ biometric sensor system. ...
(Date:12/15/2016)... BADEN-BADEN, Germany , December 15, 2016 /PRNewswire/ ... services provider, today announced an agreement with NuData Security, ... join forces. The partnership will enable clients to focus on ... with local data protection regulation. ... In order to provide a one-stop ...
Breaking Biology News(10 mins):
(Date:1/24/2017)... ... January 24, 2017 , ... Amendia, Inc., designer, developer, ... F. McAllister as Executive Vice President and Chief Financial Officer. , Steve has ... markets. Beginning his career at Howmedica, Inc., he has since served in various ...
(Date:1/24/2017)... LAVAL, QC , Jan. 24, 2017 /PRNewswire/ - ProMetic ... the "Corporation") announced today that its orally active lead ... Medicine ("PIM") designation by the UK Medicines and Healthcare ... Syndrome ("AS"). A PIM designation is ... promising candidate for the Early Access to Medicines Scheme ...
(Date:1/24/2017)... , January 23, 2017 ... Model Market by Type (Genetic, Cell-based (CD34, PBMC, BLT)), ... End User (Pharmaceutical & Biotech Companies, CRO) - Global ... the global Humanized Mouse Model Market for the forecast ... to reach USD 116.0 Million by 2021 from USD ...
(Date:1/23/2017)... NEW YORK , Jan. 23, 2017  Spherix ... development company committed to the fostering of technology and ... its active patent infringement lawsuits. Anthony ... we enter 2017, we will continue to communicate with ... Equitable IP and our due diligence on other patent ...
Breaking Biology Technology: