Navigation Links
Mount Sinai researchers discover new way diseases develop
Date:7/8/2010

Researchers from Mount Sinai School of Medicine have identified a previously unknown mechanism by which cells direct gene expression, the process by which information from a gene is used to direct the physical and behavioral development of individuals. The research, which may help scientists gain insight into how muscle and heart diseases develop, is published in the July 8th issue of Nature.

Using a combined approach of structural and molecular biology, a team of researchers led by Ming-Ming Zhou, PhD, Professor and Chair, Structural and Chemical Biology, Mount Sinai School of Medicine, determined that the molecular interactions between proteins are very different than previously thought, and that they play an essential role in the initiation of gene transcription of muscle and the heart. Gene transcription is the first step to gene expression, a cellular process that occurs in response to physiological and environmental stimuli, and is dictated by chemical modifications of the DNA and histones, which are the proteins responsible for packaging the DNA.

Dr. Zhou's team found a new fundamental mechanism in gene transcription through a protein called DPF3b. They learned that DPF3b recognizes gene-activating chemical marks in these histones in a very different way. DPF3b plays a critical role in the copying of genesa crucial part of the transcription processfor muscle growth and heart development.

"This discovery opens new doors in genome biology research, and has broad implications in the field of epigenetics of human biology of health and disease," said Martin Walsh, PhD, Associate Professor, Pediatrics, and Structural and Chemical Biology at Mount Sinai who is also a co-author of the study. "Knowing that there is an additional way our genome is regulated will allow us to understand the molecular basis of certain human disorders that result from dysregulation of gene expression."

Dr. Zhou said that bromodomains, which are housed in proteins, read off cell signals that turn on genes that determine genetic makeup. "This study uncovers that nature has an alternative to bromodomains for gene expression to initiate, providing a new mechanism to help us understand how our muscles and heart grow properly, and what might cause them to grow abnormally," Dr. Zhou said.


'/>"/>

Contact: Mount Sinai Press Office
newsnow@mountsinai.org
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Related biology news :

1. White Mountain Research Station to host climate change conference
2. Tropical rainforest and mountain species may be threatened by global warming
3. Missouri Botanical Garden mounts milestone 6 millionth herbarium specimen
4. Mounting evidence shows health benefits of grape polyphenols
5. Escherichia coli bacteria transferring between humans and mountain gorillas
6. Mountain caribous ancient ancestry revealed
7. Will large amounts of soil carbon be released if grasslands are converted to energy crops?
8. Mount Sinai Hospital researcher makes stem cell breakthrough
9. Mountain on Mars may answer big question
10. UC Davis launches One Health care for wild mountain gorillas and human neighbors
11. Geoscientists meet to discuss Rocky Mountain geology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/30/2016)... 2016  higi SH llc (higi) announced today ... national brands, industry thought-leaders and celebrity influencers looking ... for taking steps to live healthier, more active ... higi has built the largest self-screening health station ... people who have conducted over 185 million biometric ...
(Date:11/24/2016)... , Nov. 23, 2016 Cercacor today introduced ... and their trainers non-invasively measure hemoglobin, Oxygen ... Rate, and Respiration Rate in approximately 30 seconds. Smaller ... easy and immediate access to key data about their ... a training regimen. Hemoglobin carries oxygen ...
(Date:11/17/2016)... Global Market Watch: Primarily supported by ownership types; ... Academics) market is to witness a value of US$37.1 billion ... Compounded Annual Growth Rate (CAGR) of 10.75% is foreseen from ... 2014-2020. North America is not way ... Europe at 9.56% respectively. Report Focus: ...
Breaking Biology News(10 mins):
(Date:12/9/2016)... 2016 China Cord Blood Corporation (NYSE: ... leading provider of cord blood collection, laboratory testing, hematopoietic ... the results of its 2016 Annual General Meeting, which was ... China . At the Annual ... of KPMG Huazhen LLP as the independent auditors of the ...
(Date:12/8/2016)... ... December 08, 2016 , ... Lajollacooks4u, San Diego’s premier team building ... team building events, new program offerings and company expansion. , This is ... to include groups of over 30 people. Ever since, Lajollacooks4u has seen significant demand ...
(Date:12/8/2016)... , Dec. 8, 2016  Renova™ Therapeutics, ... congestive heart failure and type 2 diabetes, announced ... a novel adeno-associated virus (AAV) vector developed in ... M.D., Ph.D., at Stanford University. The company plans ... paracrine gene therapy product pipeline. ...
(Date:12/8/2016)... OXFORD, England , December 8, 2016 ... Company, has expanded its customisable SureSeq™ NGS panel range with ... - allowing fast and cost-effective study of variants in familial ... copy number variation (CNV) detection on a single small panel ... and hotspot content. This includes all exons for LDLR ...
Breaking Biology Technology: