Navigation Links
Mount Sinai researchers discover new mechanism behind cellular energy conversion
Date:8/18/2010

Researchers from Mount Sinai School of Medicine have enhanced our understanding of the mechanism by which cells achieve energy conversion, the process in which food is converted into the energy required by cells. This groundbreaking research helps scientists gain atomic-level insight into how organisms synthesize their major form of chemical energy. The researchers' findings were published in the August issue of PLoS Biology.

Cells use the enzyme ATP synthase to generate a chemical called ATP, the form of energy cells use to function. Structurally, ATP synthase is a nano-machine, a cellular "motor" that consists of proton turbines, or rotor rings, with the output being ATP. The investigators wanted to find out more about how these ATP synthase rotors work.

David Hicks, PhD, Assistant Professor of Pharmacology & Systems Therapeutics and Terry Krulwich, PhD, Sharon & Frederick A. Klingenstein-Nathan G. Kase, MD Professor of Pharmacology & Systems Therapeutics, led the Mount Sinai-based part of the effort. They and their co-investigators, Thomas Meier, PhD, and two members of his research team at the Max Planck Institute of Biophysics in Germany, grew three-dimensional protein crystals of an unusually stable rotor found in bacteria called Bacillus pseudofirmus and evaluated them using X-ray technology.

The researchers were surprised to find that these ATP synthase rotor rings use a water molecule as part of the rotary mechanism of ATP synthesis, providing a clearer understanding of how these nano-machines function. Previous studies of a rotor from a blue-green alga, the only other proton-moving rotor observed at this atomic level, showed that it did not use a water molecule.

With this new insight, they were able to infer how ATP synthase captures the protons that drive the rotation of the "motor" and visualize how those protons remain bound to the rotor. This discovery has added interest because the rotor structure of
'/>"/>

Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Ecologists to discuss impacts of mountaintop mining at special ESA symposium
2. For pandas, there is a mountain high enough, there is a valley low enough
3. Mount Sinai researchers discover new way diseases develop
4. Predicting amount of oil in contaminated soils
5. Amount of dust, pollen matters for cloud precipitation, climate change
6. Climate change and mountain building led to mammal diversity patterns
7. Large amounts of nitrogen stored beneath selected agricultural areas
8. Scientists identify seamounts as significant, unexplored territory
9. Mount Sinai researchers discover potential treatment for bone death in the hip from osteonecrosis
10. Topography of mountains could complicate rates of global warming
11. A thesis characterizes marine conditions of Aralar mountain range of 120 million years ago
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... linked to dandruff, eczema and other itchy, flaky maladies ... global reachesincluding Hawaiian coral reefs and the extreme environments ... review in the scientific journal PLOS Pathogens ... of the genus Malassezia in light of ... around the world. , University of Hawai,i at Mānoa ...
(Date:8/21/2014)... Juliane Mller the Fram Strait is a key region in ... passage between Greenland and Svalbard warm Atlantic water flows to ... side cold Arctic water masses and sea ice push their ... considerable portion of the Atlantic water cools here on its ... circulation of the water caused in this manner drives the ...
(Date:8/21/2014)... RUSTON, La. A team of researchers ... innovative method for using affordable, consumer-grade 3D ... implants that can contain antibacterial and chemotherapeutic ... team comprised of doctoral students and research ... nanosystems engineering programs collaborated to create filament ...
Breaking Biology News(10 mins):From dandruff to deep sea vents, an ecologically hyper-diverse fungus 2Arctic sea ice influenced force of the Gulf Stream 2Arctic sea ice influenced force of the Gulf Stream 3Louisiana Tech University researchers use 3D printers to create custom medical implants 2Louisiana Tech University researchers use 3D printers to create custom medical implants 3
... builder. Using a bottom-up approach, nature takes tiny atoms ... silicon and even table salt. In all of them, ... and arrangement of atoms within the crystalline lattice. ... learned how to top nature by building crystalline materials ...
... ARLINGTON, Va.R&D Magazine honored Office of Naval Research ... "R&D 100" award on Oct. 13 for the development ... The special high-tech surface technology, HybridSil Fire/Blast, acts ... type of surface, making it blast-, ballistic- and fire-resistant. ...
... 2011 Researchers have shown for the first time that ... in cats. The research was conducted at the WALTHAM Centre ... such as WHISKAS and ROYAL CANIN. The research demonstrated ... daily water intake to a level that cannot be achieved ...
Cached Biology News:Emulating -- and surpassing -- nature 2Emulating -- and surpassing -- nature 3Spray-on protective coating wins 'R&D 100' Award 2
(Date:8/21/2014)... His Majesty Willem-Alexander, King of the Netherlands ... His Majesty Willem-Alexander, King of the Netherlands, has announced ... POET-DSM Advanced Biofuels’ Project LIBERTY cellulosic ethanol plant in ... will take part in the Grand Opening Ceremony to ... p.m. and tour the plant. POET-DSM is a joint ...
(Date:8/21/2014)... , Aug. 21, 2014  Decision Resources ... Brazil and Mexico ... uptake of several newly approved agents, the anticipated ... indication and the launch of emerging biologics will ... In particular, the emerging IL-5 inhibitors will introduce ...
(Date:8/21/2014)... -- China Cord Blood Corporation (NYSE: CO ) ... results for the first quarter of fiscal year 2015 ... the US.  The Company will host ... August 29, 2014 to discuss its financial performance and ... followed by a question and answer session.  Interested parties ...
(Date:8/21/2014)... 2014 Ontotext S4 , The ... Ontotext . Now the same enterprise hardened text ... and unstructured data is available to start-ups and mid-size ... technology. Organizations that do not have resources to evaluate ... use S4 since there is no need for on ...
Breaking Biology Technology:His Majesty Willem-Alexander, King of the Netherlands, to Attend Project LIBERTY opening 2His Majesty Willem-Alexander, King of the Netherlands, to Attend Project LIBERTY opening 3Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 2Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 3China Cord Blood Corporation to Report First Quarter of Fiscal 2015 Financial Results 2Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 2Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 3Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 4
... WEST BRIDGEWATER, Mass., Aug. 30 Pressure,BioSciences, ... announced that it has been,issued its first ... "Pressure-Mediated Binding of Biomolecular Complexes" (Number,2,259,318), this ... pressure,cycling technology (PCT) patents previously issued in ...
... ITMN ) today announced that Daniel G. Welch, ... the Thomas Weisel,Healthcare Conference in Boston on September 5, ... at the Bear Stearns 20th Annual Healthcare,Conference in New ... EDT. To access a live audio webcast of ...
... 30 VaxGen,Inc. (Pink Sheets: VXGN) announced today ... Commission (SEC) its Annual Report on Form 10-K ... Reports on Form 10-Q for the,first three quarters ... the link titled,"SEC Filings" in the Investor Relations ...
Cached Biology Technology:Pressure BioSciences, Inc. Issued First Patent in Canada 2Pressure BioSciences, Inc. Issued First Patent in Canada 3InterMune to Present at Thomas Weisel and Bear Stearns Healthcare Conferences 2VaxGen Files 2006 Financial Statements and Provides Cash Update 2
... Purity is >95%NEN Radiolabeled Ligands\n\nReceptor-related research has ... of new radiolabeled ligands selected to keep ... wide range of products and services for ... 400 state-of-the-art radioligands. If you do not ...
Request Info...
... (patent pending) was developed using a protein engineering ... DNA binding pocket of wild-type DNase I. These ... for DNA. The result is a versatile enzyme ... and an ability to maintain at least 50% ...
Request Info...
Biology Products: