Navigation Links
Mount Sinai researchers develop first successful laboratory model for studying hepatitis C
Date:8/2/2013

By differentiating monkey stem cells into liver cells and inducing successful infection, researchers from the Icahn School of Medicine at Mount Sinai have shown for the first time that the hepatitis C virus (HCV) can replicate in monkeys, according to research published in the journal Gastroenterology. The new findings may lead to the first new animal model and provide new avenues for developing treatments and vaccines for this disease, which impacts more than three million people in the United States.

Scientists have tried for decades to develop animal models to study HCV, but the virus was incapable of infecting any species except for humans and chimpanzees. With a recent National Institutes of Health-imposed moratorium restricting chimpanzee research, the Mount Sinai research team turned to a close relative of chimpanzees and humansmacaques. Led by Matthew Evans, PhD, and Valerie Gouon-Evans, PhD, of Mount Sinai, the research team sought to find out why previous attempts to infect macaques with HCV failed.

Dr. Gouon-Evans, who is Assistant Professor of in the Department of Developmental and Regenerative Biology at Mount Sinai, worked with a team at the Fred Hutchison Cancer Research Center in Seattle to differentiate macaque stem cells into liver cells. Dr. Evans, who is an Assistant Professor in the Department of Microbiology, and his team then attempted to infect these cells with HCV in a petri dish. They found that these differentiated cells were able to support HCV infection and replication, although not as effectively as in human liver cells.

"Now that we know that HCV infection in macaque cells is possible, we wanted to find out why it only worked in liver cells that were derived from stem cells," said Dr. Gouon-Evans. "By identifying where in the viral life cycle the infection is dysfunctional, we can develop an effective animal model of HCV."

Dr. Evans and his team found that HCV was less efficient at enter
'/>"/>

Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. AMP concerned about the structure and application of gap fill payment amounts
2. Total amount of exercise important, not frequency, research shows
3. Earthquake swarms; marine Ediacaran fossil traces; Alca obsidian; Mammoth Mountain
4. Mount Sinai celebrates team science at second-annual SINAInnovations Conference Nov. 18-19, 2013
5. Mount Sinai discovers new liver cell for cellular therapy to aid in liver regeneration
6. Going green: Nation equipped to grow serious amounts of pond scum for fuel
7. Intermountain Medical Center reseachers develop new 3-D technology to treat atrial fibrillation
8. Mount Sinai Selects Exemplar LIMS for Genomics Core Facility
9. The right amount of vitamin D for babies
10. Mount Sinai study identifies new gene variations associated with heart rate
11. Mount Sinai leads global program using stem cells to accelerate cures for Alzheimers disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/26/2014)... sciences at New Jersey Institute of Technology (NJIT), is ... that sets the pace for daily life. , Evolution ... mammals with fundamental rhythms of life that include the ... with seasonal change. The brain,s circadian clock controls hormone ... when disrupted by experiences such as jet lag or ...
(Date:8/26/2014)... researchers at the University of Illinois at Urbana-Champaign ... design, paving the way for power-on-a-chip applications. ... microscopic scale that amplify light and produce ultra-narrowband ... of electrical and computer engineering (ECE) at Illinois. ... optical power on a chip containing both electronic ...
(Date:8/26/2014)... has recommended investing in dog owner education and facilities as ... obesity in both people and their pets. , In a ... that access to dog-friendly walking environments and better education about ... and take more exercise with their pets. , It is ... for a walk. In the UK, almost a quarter of ...
Breaking Biology News(10 mins):Researching fundamental rhythms of life 2Researching fundamental rhythms of life 3Symphony of nanoplasmonic and optical resonators produces laser-like light emission 2Education and dog-friendly neighbourhoods could tackle obesity 2
... by intestinal worms a condition that affects more than ... immune system is more versatile than has long been thought. ... exploration in the search for treatments against autoimmune diseases like ... tissues. The findings, reported by scientists who performed the ...
... Forest Service Southern Research Station (SRS) scientists and partners ... faster than expected in the southern Appalachians and rapidly ... and cooperators from the University of Georgia published the ... Ecosystems . "The study marks the ...
... has found that modern lifestyle habits may play a bigger ... A review of the scientific evidence over the ... good oral hygiene and health education, may override the effects ... online in a Supplement to the journal Obesity Reviews ...
Cached Biology News:A worm-and-mouse tale: B cells deserve more respect 2A worm-and-mouse tale: B cells deserve more respect 3Study finds hemlock trees dying rapidly, affecting forest carbon cycle 2
(Date:8/26/2014)... 2014   Lycera Corp ., a biopharmaceutical ... to treat autoimmune disease and cancer based on ... appointment of Harinder Singh , Ph.D., as ... Singh will lead the board,s efforts to provide ... research programs and pipeline of therapies targeting unmet ...
(Date:8/26/2014)... Vycom announced today that Modutek Corporation ... process equipment, has selected its Flametec materials for a ... Isotope Beams (FRIB). This involved the creation of ... Vycom’s Flametec PVC-C and Kytec PVDF material to clean ... FRIB’s linear accelerator (known as LINAC). ...
(Date:8/26/2014)...   Loveland Products, a subsidiary of Agrium and ... products and proprietary products provider for Agrium Retail ... a controlling interest in Agricen, a ... products for efficient and sustainable plant nutrition. Agricen ... nutrition brands, Accomplish ® LM and Titan ...
(Date:8/26/2014)... Albany Molecular Research Inc. (NASDAQ: ... , President and Chief Executive Officer at AMRI, will ... Monday, September 8, 2014 at 8:45 a.m. ET. ... can be accessed at AMRI,s Investor Relations web site at ... be archived for 90 days following the live presentation. ...
Breaking Biology Technology:Lycera Appoints Harinder Singh, Ph.D., as Chair of Scientific Advisory Board 2Lycera Appoints Harinder Singh, Ph.D., as Chair of Scientific Advisory Board 3Modutek Selects Vycom’s Flametec Materials for Michigan State University’s Superconductor Equipment 2Modutek Selects Vycom’s Flametec Materials for Michigan State University’s Superconductor Equipment 3Agrium, through Loveland Products, Acquires a Controlling Interest in Agricultural Biotechnology Company Agricen 2Agrium, through Loveland Products, Acquires a Controlling Interest in Agricultural Biotechnology Company Agricen 3Agrium, through Loveland Products, Acquires a Controlling Interest in Agricultural Biotechnology Company Agricen 4
... 2008 DaVita Inc., a,leading provider of kidney care ... today announced its former Chief Medical,Officer (CMO) Charles J. ... stepped down as CMO in July 2007, and has ... CMO., (Logo: http://www.newscom.com/cgi-bin/prnh/20020729/DAVITALOGO ), "Charlie has ...
... Kees Bald has demonstrated that hydrogen can be efficiently ... more easily used in mobile applications. Bald discovered that ... make the favourable extraction and storage of hydrogen possible. ... storage and transport medium for energy. Therefore many future ...
... Genaera,Corporation (Nasdaq: GENR ) today announced its financial ... net loss for the year ended,December 31, 2007 was $15.7 ... a net loss of $21.2 million, or $(1.46) per share,basic ... net loss for,the quarter ended December 31, 2007 was $5.8 ...
Cached Biology Technology:DaVita Announces Retirement of Former Chief Medical Officer Charles J. McAllister, M.D. 2Genaera Corporation Announces 2007 Financial Results 2Genaera Corporation Announces 2007 Financial Results 3Genaera Corporation Announces 2007 Financial Results 4Genaera Corporation Announces 2007 Financial Results 5Genaera Corporation Announces 2007 Financial Results 6
streptavidin, Alexa Fluor® 750–allophycocyanin conjugate (Alexa Fluor® 750–allophycocyanin streptavidin) *1 mg/mL*...
AedestaTM Animal Organ/Tissue Perfusion Soln....
Reusble. Uses in conjunction with the Apoptotic Cell Isolation Kit....
EGTA, 10 g. Ethylene glycol-O,O-bis-[2-amino-ethyl]-N,N,N,N,-tetraacetic acid.Assay: > 99.0%. Category: Nucleotides & Enzymes & Biochemicals, Ultrapure Biochemicals ....
Biology Products: