Two Mount Sinai School of Medicine researchers are among a select group of scientists from around the world who have been recognized by the National Cancer Institute (NCI) for their quest to answer the most pressing questions about cancer. Stuart Aaronson, MD, Professor and Chair of Oncological Sciences and Ross Cagan, PhD, Professor of Oncological Sciences at Mount Sinai, have received the NCI's new "Provocative Questions" grant, which was established to explore the important yet less obvious questions about cancer that may have been neglected in this era of significant discovery.
Provocative Question: Why do many cancer cells die when suddenly deprived of a protein encoded by an oncogene?
The grant will support Dr. Aaronson's research on signaling pathways responsible for a little-understood phenomenon called oncogene addiction. Oncogenes are mutant genes that scientists believe are key to tumor survival and progression. Disruption of the signaling pathway in these oncogenes has been shown to halt tumor growth or lead to tumor cell death. Dr. Aaronson's lab is exploring the signaling activity of one such pathway called Wnt, which plays a key role in regulating self-renewal of a variety of embryonic and adult stem cells and is a starting point for tumor development.
Dr. Aaronson's lab has found that inhibition of activated Wnt signaling can block growth and complement the effects of chemotherapy and radiation, leading to tumor cell death. The goals of this grant are to investigate the signaling pathways responsible for Wnt oncogene addiction, and discover its molecular basis.
"While increasing efforts are being made to develop effective inhibitors of Wnt signaling in tumors, to date, few, if any, have entered into clinical development," said Dr. Aaronson. "Our NCI grant will support our research to identify and characterize specific and potent Wnt-targeted drugs that can disrupt this oncogene addiction in tumor cell
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