Navigation Links
Mount Sinai researchers awarded 'Provocative Questions' grant from National Cancer Institute
Date:9/20/2012

Two Mount Sinai School of Medicine researchers are among a select group of scientists from around the world who have been recognized by the National Cancer Institute (NCI) for their quest to answer the most pressing questions about cancer. Stuart Aaronson, MD, Professor and Chair of Oncological Sciences and Ross Cagan, PhD, Professor of Oncological Sciences at Mount Sinai, have received the NCI's new "Provocative Questions" grant, which was established to explore the important yet less obvious questions about cancer that may have been neglected in this era of significant discovery.

Provocative Question: Why do many cancer cells die when suddenly deprived of a protein encoded by an oncogene?

The grant will support Dr. Aaronson's research on signaling pathways responsible for a little-understood phenomenon called oncogene addiction. Oncogenes are mutant genes that scientists believe are key to tumor survival and progression. Disruption of the signaling pathway in these oncogenes has been shown to halt tumor growth or lead to tumor cell death. Dr. Aaronson's lab is exploring the signaling activity of one such pathway called Wnt, which plays a key role in regulating self-renewal of a variety of embryonic and adult stem cells and is a starting point for tumor development.

Dr. Aaronson's lab has found that inhibition of activated Wnt signaling can block growth and complement the effects of chemotherapy and radiation, leading to tumor cell death. The goals of this grant are to investigate the signaling pathways responsible for Wnt oncogene addiction, and discover its molecular basis.

"While increasing efforts are being made to develop effective inhibitors of Wnt signaling in tumors, to date, few, if any, have entered into clinical development," said Dr. Aaronson. "Our NCI grant will support our research to identify and characterize specific and potent Wnt-targeted drugs that can disrupt this oncogene addiction in tumor cell
'/>"/>

Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Studies shed light on how to reduce the amount of toxins in plant-derived foods
2. Increase in metal concentrations in Rocky Mountain watershed tied to warming temperatures
3. IdentiSys acquires the Identification, Security and Presentation Divisions of Mountainland Business Systems, a Utah based reseller
4. Mount Sinai researchers solve mystery surrounding the death of two sisters nearly 50 years ago
5. NCEAS DataONE streamlines search and analysis of massive amounts of ecological data
6. Nitrogen pollution changing Rocky Mountain National Park vegetation, says CU-Boulder-led study
7. Medbox Developing a Patent Pending Wall-Mounted Biometric Kiosk for Storage of Sensitive Medicine Samples and Supplies for Doctors Offices.
8. European mountain plant population shows delayed response to climate change
9. Global warming has driven Europes mountain plants to migrate 2.7 meters upwards in 7 years
10. Accelerating climate change exerts strong pressure on Europes mountain flora
11. CU research shows warming climate threatens ecology at mountain research site west of Boulder
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/18/2014)... 2014 Psychological stress and stress-related psychiatric disorders are ... but the molecular mechanisms underlying this relation ... to the development of targeted preventive strategies ... devastating diseases. This work is presented at ... Berlin., Now an international group of researchers ...
(Date:10/17/2014)... shown for the first time how bacteria can grow ... them the opportunity to get tremendous insights into bacteria ... also discovered the bacterial growth in chronic lung infections ... down by the immune cells. The researchers discovered the ... the bacteria, forcing the bacteria to switch to a ...
(Date:10/16/2014)... challenged conventional thinking on how the bowel lining develops ... how bowel cancer starts. , The researchers produced evidence ... the ,crypts, that are a feature of the bowel ... bowel cancer development, a controversial finding as scientists are ... 3D imaging technologies, Dr Chin Wee Tan and Professor ...
Breaking Biology News(10 mins):Researchers find why depression and aging linked to increased disease risk 2Scientists opens black box on bacterial growth in cystic fibrosis lung infection 2Cryptic clues drive new theory of bowel cancer development 2
... and misunderstandings frequently arise between individuals from different cultures. ... restrictive and another less so? A new international ... by the National Science Foundation,s Division of Behavioral and ... cultural differences and bridge the gaps between them. ...
... cause neurodegenerative prion diseases may require a genetic key, ... Chicago distinguished professor of biological sciences Susan Liebman. ... form. One prion in mammals promotes progressive neurodegenerative disorders ... how this process happens remains an open question for ...
... Calif., May 26, 2011 Epitomics, Inc. announced today ... Schering Pharma AG, Germany (Bayer HealthCare). Epitomics will use ... for Bayer HealthCare,s drug target identification and validation. ... Bayer HealthCare. This new agreement is a major expansion ...
Cached Biology News:World-wide assessment determines differences in cultures 2World-wide assessment determines differences in cultures 3Study finds 2 gene classes linked to new prion formation 2
(Date:10/25/2014)... 2014 Berkshire Corporation, the world ... announce the release of the ValuSeal® IonX™ cleanroom ... contamination containment in critical processing applications. , Recommended ... cleanroom environments, ValuSeal® IonX™ is a laser sealed ... that continues Berkshire’s innovative focus on meeting new ...
(Date:10/25/2014)... LONDON , October 24, 2014 ... CytRx Corporation (NASDAQ: CYTR ), Vertex Pharmaceuticals ... (NASDAQ: ALXN ), Peregrine Pharmaceuticals Inc. (NASDAQ: ... Free research on these five companies can be accessed ... on Thursday, October 23, 2014, ended on a positive ...
(Date:10/22/2014)... , Oct. 22, 2014 Research ... the "Global DNA Diagnostics Market (Product types, ... Share, Global Trends, Company Profiles, Demand, Insights, Analysis, ... 2020" report to their offering. ... (products, applications, techniques, end users and Geography) Global ...
(Date:10/22/2014)... Shimadzu Scientific Instruments introduces its Open Solution ... pain management and clinical markets. The software increases the ... allowing users to highlight and review results that are ... analysts to filter results by group or based on ... the need to sift through analytes of no interest. ...
Breaking Biology Technology:Ions Are Bygones, Berkshire Announces the Release of New Innovative Cleanroom Wipers 2Biotech Stocks Technical Data - CytRx, Vertex Pharma, Alexion Pharma, Peregrine Pharma, and StemCells 2Biotech Stocks Technical Data - CytRx, Vertex Pharma, Alexion Pharma, Peregrine Pharma, and StemCells 3Biotech Stocks Technical Data - CytRx, Vertex Pharma, Alexion Pharma, Peregrine Pharma, and StemCells 4Biotech Stocks Technical Data - CytRx, Vertex Pharma, Alexion Pharma, Peregrine Pharma, and StemCells 5Global DNA Diagnostics Market (Product types, Application, Technology, End User and Geography) - Forecast to 2020 2Global DNA Diagnostics Market (Product types, Application, Technology, End User and Geography) - Forecast to 2020 3Shimadzu Releases QuantAnalytics Open Access LCMS Software Package for Clinical Applications 2
... 2011 Neogen Corporation (Nasdaq: NEOG ) announced ... 2012, which ended Aug. 31, increased 6.5% to $45,697,000, from ... year,s revenue increase is almost entirely comprised of products available ... net income increased 3.1% from the prior year to $6,004,000, ...
... N.C. -- Copper nanowires may be coming to a little ... to drive down the costs of displaying information on cell ... build foldable electronics and improved solar cells, according to new ... have developed a technique to organize copper atoms in water ...
... ANNAPOLIS, Md., Sept. 26, 2011 PharmAthene, Inc. (NYSE ... medical countermeasures against biological and chemical threats, today announced ... Board of Directors, effective September 22, 2011. ... President and Chief Executive Officer for Nycomed U.S. which will be ...
Cached Biology Technology:Neogen Reports First Quarter Revenue and Net Income Increases 2Neogen Reports First Quarter Revenue and Net Income Increases 3Neogen Reports First Quarter Revenue and Net Income Increases 4Neogen Reports First Quarter Revenue and Net Income Increases 5Copper film could lower touch screen, led and solar cell costs 2PharmAthene Appoints Brian A. Markison to the Company's Board of Directors 2PharmAthene Appoints Brian A. Markison to the Company's Board of Directors 3
... Molecular Imaging Systems group announces the ... Digital Imaging Systems, featuring high resolution ... fluorescence, luminescence, radiographic and chromogenic imaging ... CCD and 10x optical zoom lens ...
Compound(s) tested through a broad panel of 38 ligand binding and enzyme assays targeting the Central Nervous System. Used to determine selectivity and potential GI liabilities of compounds....
... for the extraction of unwanted detergent ... macromolecules, Applications: ,Reducing octyl glucoside concentration ... of pure β-adrenergic receptor and pure ... in 6 M urea/0.05 mM Tris ...
... Proteolytic degradation is critical to ... short-lived and regulatory proteins as important ... cellular metabolism, heat shock and stress ... surface receptors and ion channels, cell ...
Biology Products: