Navigation Links
Mount Sinai leads global program using stem cells to accelerate cures for Alzheimer's disease
Date:3/27/2013

have skin biopsies and will also undergo brain scans to detect the amount of amyloid plaque, the hallmark of AD, present in the brain. Samples will also be collected from a skin cell bank at the National Institutes of Health. The scans will be used to confirm AD, the risk for developing AD, and whether a brain is amyloid-free.

Dr. Noggle will reprogram these skin cells into the various cell types that make up the brain, employing the NYSCF Global Stem Cell Array, a breakthrough automated robotic technology that produces standardized stem cell lines. Results are specific to the patient's genetic makeup, allowing researchers to uncover Alzheimer's-related changes at an individual level and to track changes that might otherwise go undiscovered.

"Having all the cell types together in the same dish enables us to mimic as closely as possible the normal and the diseased adult human brain," said Dr. Gandy. "In these mixed cultures, we will study the roughly three-dozen genes that have been linked to AD to see if any are dysfunctional in such a way as to cause one or more known features of the disease."

To encourage international collaboration in Alzheimer's treatment, consortium researchers will create a stem cell bank that can be accessed globally to accelerate drug screening worldwide. This collaboration is an example of NYSCF's commitment to work with global collaborators to advance research.

"We can, for the first time, test drugs across a large, diverse population of Alzheimer's patients, using only their cells. This stem cell resource will embolden scientific investigations and accelerate bench to beside delivery of new treatments," said Dr. Noggle. "We're incredibly excited to be working with Dr. Gandy and fellow collaborators to find a cure for Alzheimer's disease."


'/>"/>

Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Intermountain study finds length of DNA strands can predict life expectancy
2. Antibacterial agent used in common soaps found in increasing amounts in freshwater lakes
3. Evidence mounts for role of mutated genes in development of schizophrenia
4. Mount Sinai grad student, 25, named to Forbes 30 Under 30 in Science and Healthcare
5. New book details the biological and cultural diversity of Khawa Karpo, sacred mountain of Tibet
6. MARC travel awards announced for the 2012 ISCB Rocky Mountain Bioinformatics Conference
7. From Mediterranean coasts to Tatra Mountains and beyond: Plant chromosome number variation
8. Mini-pig tale provides massive amount of genomic data for human health
9. Mongolia and the Altai Mountains: Origins of genetic blending between Europeans and Asians
10. Drought in 2001-2002 fueled Rocky Mountain pine beetle outbreak
11. 2001-2002 drought helped propel mountain pine beetle epidemic, says CU study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... A team of researchers at Louisiana ... for using affordable, consumer-grade 3D printers and ... can contain antibacterial and chemotherapeutic compounds for ... of doctoral students and research faculty from ... programs collaborated to create filament extruders that ...
(Date:8/20/2014)... Fox, a John and Rebecca Moores Professor of Biology and ... fellow in the International Society for the Study of the ... four members two from the U.S., one from France ... Fellows are elected every three years, and 36 have been ... than 20 countries, the ISSOL includes researchers from disciplines as ...
(Date:8/20/2014)... , Aug. 20, 2014 /CNW/ -  Issue ... and can quickly become life threatening for some children.    ... as 1.2 million Canadians have food allergies and this number ... cent of children are estimated to have food allergies.  ... mild skin irritations and hives to breathing difficulties and loss ...
Breaking Biology News(10 mins):Louisiana Tech University researchers use 3D printers to create custom medical implants 2Louisiana Tech University researchers use 3D printers to create custom medical implants 3UH professor named fellow by International Astrobiology Society 2Information Update - Allergens and food safety at school - What's in your child's lunch? 2Information Update - Allergens and food safety at school - What's in your child's lunch? 3
... at Albert Einstein College of Medicine of Yeshiva University ... from the Bill & Melinda Gates Foundation for their ... are Arturo Casadevall , M.D., Ph.D., who is working to ... , Ph.D., and Joan Berman , Ph.D., for their work ...
... Joseph G. Morse , a professor of entomology ... year,s recipient of the California Citrus Quality Council ... of "his steadfast dedication in the field of entomology ... For more than three decades, Morse has provided ...
... led by the University of Colorado Boulder has been awarded $9.2 ... research modifying E. coli to produce biofuels such as ... we have worked on for the past decade to the next ... and Sustainable Energy Institute, or RASEI. "In this project, we will ...
Cached Biology News:Einstein researchers receive 2 Grand Challenges Explorations grants to combat HIV and TB 2Einstein researchers receive 2 Grand Challenges Explorations grants to combat HIV and TB 3UC Riverside entomologist recognized for research in citrus entomology 2CU-led team receives $9.2 million DOE grant to engineer E. coli into biofuels 2
(Date:8/22/2014)... 22, 2014 Research and Markets ... Biology Enzymes, Kits, & Reagents (Cloning, Epigenetics, PCR, Restriction ... to their offering. The global molecular ... 2013, and is expected to grow at a CAGR ... biology enzymes, kits, & reagents find applications in a ...
(Date:8/22/2014)... Toronto, Canada (PRWEB) August 22, 2014 ... traits in model organisms can be accelerated by ... design and manufacturing technologies, the custom SeqCap EZ ... such research. , Mr. Watson will additionally present ... seen with commercially available human and mouse exome ...
(Date:8/21/2014)... 21, 2014 DNA vaccine pioneer ... its development of JRC-LAMP-vax, an innovative and safe potential ... IC studies began this month in Hawaii, moving the ... , The Japanese red cedar releases pollen that causes ... Mountain Cedar pollen wreaks similar havoc in Colorado, New ...
(Date:8/21/2014)... 21, 2014 2014 Deep ... is a professional and in-depth research report ... provides basic Seaweed Fertilizer information, including Seaweed ... structure as well as industry overview. This ... domestic market as well as global industry ...
Breaking Biology Technology:Global Molecular Biology Enzymes, Kits, & Reagents (Cloning, Epigenetics, PCR, Restriction Digestion, Sequencing) Market - Forecast to 2018 2Global Molecular Biology Enzymes, Kits, & Reagents (Cloning, Epigenetics, PCR, Restriction Digestion, Sequencing) Market - Forecast to 2018 3Efficient Identification of Protein-Coding Variants in a Model Organism Through Exome Sequencing, New Webinar Hosted by Xtalks 2Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 2Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 3Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 4Internationals Seaweed Fertilizer Industry 2014 Development Trend Analysis in New Research Study at DeepResearchReports.com 2Internationals Seaweed Fertilizer Industry 2014 Development Trend Analysis in New Research Study at DeepResearchReports.com 3
... Tech Coast Angels (TCA) today announced that Mike ... Board of Directors. Napoli has been a member of TCA ... Network Executive Committee for seven years, started the Inland Empire ... three years, and was chairman of two TCA Fast Pitch ...
... 2011 Cell Therapeutics, Inc. (CTI) (Nasdaq and MTA: ... WBBA Life Science Innovation Northwest Conference on Thursday, March ... of the Washington State Conference Center, Seattle, Washington. WBBA ... 201110:25 AM PST/1:25 PM EST/7:25 PM CETRoom 607, Washington ...
... of biomass to fuel requires several steps: chemical pretreatment ... acid, detoxification to remove the toxic chemicals required in ... to fuels. Virginia Tech researchers have discovered an enzyme ... infused liquid biomass (hydrolysate), meaning that the detoxification step ...
Cached Biology Technology:Mike Napoli Named New Chairman of Tech Coast Angels, Explains Enhanced Process for Entrepreneurs 2Mike Napoli Named New Chairman of Tech Coast Angels, Explains Enhanced Process for Entrepreneurs 3Enzyme cocktail could eliminate a step in biofuel process 2