Navigation Links
Motor neuron disease and toxic substances: Possible link?
Date:3/20/2008

uron disorders, possibly including ALS. Motor neuron disease affects five per 100,000 people.

The findings are an exciting first step in uncovering a possible link between the environment and motor neuron disease, says Shirley Rainier, a research assistant professor at the U-M Department of Neurology and the first author of the study. Why does one person in a family get it, and another doesnt"

Piecing together a puzzle

In the 1930s, an estimated 50,000 people in the U.S. became lame or otherwise neurologically affected by neurotoxic organophosphates when they drank a contaminated batch of ginger jake, an alcohol-containing potion that was legal during Prohibition.

Ginger jake suppliers substituted a lubricating oil for the oil usually used, castor bean oil, when castor bean prices went up. A 2003 article in the New Yorker detailed the sad results, which led bands like the Mississippi Sheiks to write songs about the ginger jake blues.

More recently, there have been incidents in Fiji, India and Africa when accidental consumption of oils containing neurotoxic organophosphates (instead of cooking oil) caused death or nerve damage for tens of thousands of people. Although scientists dont yet know the exact manner in which toxic organophosphate exposure leads to progressive and permanent nerve damage, they have learned that this process involves disturbance of an enzyme, NTE, contained within nerves.

Fink examined members of two families who had progressive weakness and spasticity (tightness) in their legs, as well as muscle atrophy in their hands, shins and feet. James Albers, M.D., Ph.D., a U-M professor of neurology and an expert in neuromuscular disorders, studied nerve and motor function. Rainier performed genetic studies and determined that the gene for the condition was on a region of chromosome 19.

Mark Leppert, Ph.D., co-chair of human genetics at the University of Utah, and his team perfor
'/>"/>

Contact: Anne Rueter
arueter@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Silicon Valley Technology Leaders LaserCard Corporation and Tesla Motors Sign LaserPass Secure Access Deal
2. Weill Cornell team discovers how brains own tPA helps regulate blood flow to neurons
3. Overexcited neurons not good for cell health
4. Neuronal circuits able to rewire on the fly to sharpen senses
5. The birth and death of dopamine neurons: A new model for neurodegeneration
6. The accumulation of sugar in neurons may explain the origin of several neurodegenerative diseases
7. Neuronal conduction of excitation without action potentials based on ceramide production
8. Carnegie Mellon scientists investigate initial molecular mechanism that triggers neuronal firing
9. Mice use specialized neurons to detect carbon dioxide in the air
10. At home genomic tests for disease risk premature
11. European membrane expertise to focus on new treatments for human diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... ALBUQUERQUE, N.M. A credit-card-sized anthrax detection cartridge developed ... small business makes testing safer, easier, faster and cheaper. ... causes anthrax, is commonly found in soils all over ... illness in both humans and animals. The bacteria can ... to B. anthracis may occur through skin ...
(Date:4/17/2014)... bone marrow need to produce hydrogen sulfide in order ... a new study from the Center for Craniofacial Molecular ... USC. , Professor Songtao Shi, principal investigator on the ... the cells governs the flow of calcium ions. The ... results in osteogenesis, or the creation of new bone ...
(Date:4/17/2014)... and pathogens that devastate honeybees in Europe, Asia and ... do not appear to be impacting native honeybee populations ... researchers., The invasive pests include including Nosema microsporidia ... honeybees appear to be resilient to these invasive pests, ... control pests in Europe, Asia and the United States ...
Breaking Biology News(10 mins):Pocket-sized anthrax detector aids global agriculture 2Pocket-sized anthrax detector aids global agriculture 3East African honeybees are safe from invasive pests… for now 2East African honeybees are safe from invasive pests… for now 3
... March 21, 2011 Aware, Inc. (Nasdaq: AWRE ... that it will demonstrate several enhanced software modules for its ... at the upcoming IP&TV World Forum which will take place ... demonstrated include LDP,s DSL Service Predictor and Health Monitor. ...
... Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, have developed a ... gene as an informant. Published online today in Nature Genetics, ... systematically explore the very large part of our genome that ... large role in making each of us unique, by controlling ...
... mounds left by prehistoric humans might have driven the formation ... of exceptional ecological richness in the sprawling marsh that are ... of relatively high and dry ground that dot the marshes ... high, many of them are elevated enough to allow trees ...
Cached Biology News:Aware to Showcase DSL Test Solutions for IPTV Services at IP&TV World Forum 2Aware to Showcase DSL Test Solutions for IPTV Services at IP&TV World Forum 3The informant: a jumping gene 2Ancient trash heaps gave rise to Everglades tree islands 2
(Date:1/15/2014)... This webinar will focus on EMA and ... in biosimilars. , Regulatory frameworks are evolving many countries ... the complex nature of biopharmaceuticals makes the demonstration of ... challenging. Based on the specific aspects of biosimilar drug ...
(Date:1/15/2014)... Two champions of science, technology, engineering, ... an annual competition for middle and high school students ... STEM study. The competition presents students with real-world problems ... Aptitude, Mathematics, and Sciences is a program administered ...
(Date:1/15/2014)... Scottsdale, Arizona (PRWEB) January 15, 2014 ... growth for Scottsdale’s Brain State Technologies®. They saw continued ... University Medical Center who were awarded a $1 million ... papers published in “Brain and Behavior” a peer reviewed ...
(Date:1/15/2014)... Jan. 15, 2014 TaiGen Biotechnology Company, Limited ("TaiGen") ... with R-Pharm, a leading Russian pharmaceutical company, to develop ... Russian Federation , Turkey ... (CIS). Nemonoxacin is a novel antibiotic for the treatment of ...
Breaking Biology Technology:Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4
... Ltd. (Amex: SVA ), a,leading developer and provider of ... and nine-month periods ended,September 30, 2008. , , ... year-over-year to $34.1 million, -- Operating income year-to-date ... million, -- Net income year-to-date maintained at same ...
... experience in multi-GPU high-performance computing systems designed ... scientists, engineers and researchers with a GPU-based ... (PSC), which will be shown at the ... Conference, the top international conference for high ...
... Performance of Bioinformatics Application. Part of "Project GreenLight" Energy ... ... (PRWEB) November 17, 2008 -- Convey Computer Corporation today announced ... computer, the Convey HC-1, to the University of California, San ...
Cached Biology Technology:Sinovac Reports Third Quarter 2008 Unaudited Financial Results 2Sinovac Reports Third Quarter 2008 Unaudited Financial Results 3Sinovac Reports Third Quarter 2008 Unaudited Financial Results 4Sinovac Reports Third Quarter 2008 Unaudited Financial Results 5Sinovac Reports Third Quarter 2008 Unaudited Financial Results 6Sinovac Reports Third Quarter 2008 Unaudited Financial Results 7Sinovac Reports Third Quarter 2008 Unaudited Financial Results 8Sinovac Reports Third Quarter 2008 Unaudited Financial Results 9Sinovac Reports Third Quarter 2008 Unaudited Financial Results 10Sinovac Reports Third Quarter 2008 Unaudited Financial Results 11Sinovac Reports Third Quarter 2008 Unaudited Financial Results 12Sinovac Reports Third Quarter 2008 Unaudited Financial Results 13Sinovac Reports Third Quarter 2008 Unaudited Financial Results 14Sinovac Reports Third Quarter 2008 Unaudited Financial Results 15Sinovac Reports Third Quarter 2008 Unaudited Financial Results 16BOXX Personal Supercomputer for Research Scientists Featured at SC08 2Convey Computer™ Corporation Announces First Customer: University of California, San Diego at SC08 Conference 2Convey Computer™ Corporation Announces First Customer: University of California, San Diego at SC08 Conference 3Convey Computer™ Corporation Announces First Customer: University of California, San Diego at SC08 Conference 4Convey Computer™ Corporation Announces First Customer: University of California, San Diego at SC08 Conference 5
Evolutionarily conserved signaling intermediate in Toll pathway...
Amino-acids and Derivatives Rabbit Anti-conjugated L-isoleucine Polyclonal Antibody...
Phosphatidylinositol transfer protein beta isoform (PtdIns transfer protein beta) (PtdInsTP) (PI-TP-beta). [Source:Uniprot/SWISSPROT;Acc:P48739] Antigen: Recombinant Protein Epitope Signature Tag...
Anti-MMP-25 (Membrane-type MMP-6, Mt6MMP), hinge region; rabbit host...
Biology Products: