Navigation Links
Motor nerve targeting to limb muscles is controlled by ephrin proteins

Montral, December 24, 2008 A study from a team of researchers including Dr. Artur Kania, Director of the Neural Circuit Development Research Unit at the IRCM, and Dr. Dayana Krawchuk, postdoctoral fellow, shows how a family of proteins present in the developing limb control nerve targeting from the spinal cord to the muscles of the limb. This discovery, co-authored by scientists from Columbia University in New York City, is published on December 26, 2008 in the journal Neuron.

The nervous system is a highly precise and intricate nerve network whose major purpose is to analyze and respond to external stimuli through coordinated movement. Such precision stems from the accuracy of nerve connections formed between neurons and muscles. "To understand how this occurs," explains Dr. Kania, "we study a simple system in which nerves extend from the spinal cord to the limb to connect to either flexor muscles (i.e. biceps arm muscle) or extensor muscles (i.e. triceps arm muscle)." Previously, the researchers found that nerves connecting to extensor muscles were guided towards specific targets by a protein present in the developing limb (ephrin-A). Using chick and mouse embryos as models, the team of scientists now discovered that nerves connecting to the antagonist muscle group, the flexor muscles, are guided by a closely-related protein family, also present in the developing limb (ephrin-B). Together, these studies present a complete picture of how both limb nerves correctly connect the nervous system to muscles. Furthermore, by studying the wiring of a relatively simple nerve connection, the team of scientists has discovered a molecular strategy that is very likely widely used in the nervous system to wire much more complex neural circuits, such as those required for learning, memory and coordinated movement.

Miswiring of the nervous system is thought to be a factor in disorders such as epilepsy and mental retardation. By studying the process of limb nerve development, this team of scientists contributes further to the development of new strategies for treatment of patients with a diseased and damaged nervous system. That is because knowing how nerves form is crucial in designing therapies that aim to rebuild damaged or diseased nerves.

"The study of the ephrin proteins should help us understand diseases such as autism, schizophrenia as well as a number of neurological disorders," says Dr. Rmi Quirion, a scientific director at the Canadian Institutes of Health Research (CIHR). "We are proud to support this important study and hope it will help to improve the lives of people with these health problems."


Contact: Dr. Artur Kania
Institut de recherches cliniques de Montreal

Related biology news :

1. Silicon Valley Technology Leaders LaserCard Corporation and Tesla Motors Sign LaserPass Secure Access Deal
2. Motor neuron disease and toxic substances: Possible link?
3. Motorola Biometric Identification System Selected by West Virginia State Police
4. Motorola Biometric Identification System Selected by West Virginia State Police
5. Motorola Introduces Mobile Biometric Identification for Handheld Computers
6. SAFRAN to Acquire Motorolas Biometrics Business
7. Specific brain protein required for nerve cell connections to form and function
8. Targeting nerve growth factor may cure liver cancer
9. West Nile virus spread through nerve cells linked to serious complication
10. Team of scientists develops non-invasive method to track nerve-cell development in live human brain
11. Salk scientists identify key nerve navigation pathway
Post Your Comments:
(Date:10/12/2015)... 2015 NXTD ) ("NXT-ID" or the ... commerce market, reports on the recent SNS Future in Review ... --> NXTD ) ("NXT-ID" or the "Company"), a biometric ... on the recent SNS Future in Review Conference in ... Inc. (NASDAQ: NXTD ) ("NXT-ID" or the "Company"), a ...
(Date:10/8/2015)... LAKE CITY , 8. Oktober 2015 ... TRCK), ein global tätiges Unternehmen des Bereiches ... einem Vertrag mit der Gefängnisbehörde Virginias (Department ... dessen Rahmen elektronische Überwachungsdienste für alle Strafen ... Derek Cassell , Präsident für den ...
(Date:10/6/2015)... 6, 2015 Track Group, Inc. (OTCQX: TRCK), ... has signed a contract with the Virginia Department of ... range of sentences under the Department,s oversight. ... "This contract with the Virginia DOC will expand our ... advances our position as a trusted leader in offender ...
Breaking Biology News(10 mins):
(Date:10/12/2015)... /PRNewswire/ - Aeterna Zentaris Inc. (NASDAQ:  AEZS) (TSX: AEZ) ... and commercializing novel treatments in oncology, endocrinology and women,s ... , the Company,s former Senior Vice President, Chief Financial ... Quebec City office.  David ... of the Company commented, "After a comprehensive review, the ...
(Date:10/12/2015)... , Belgium , Oct. 12, 2015 /PRNewswire/ ... that full results from a completed clinical study of its ... have been published in the online issue of Clinical ... The peer-reviewed study was conducted in collaboration with ... led by Roland Andersson , MD, PhD, Professor of ...
(Date:10/11/2015)... ... October 11, 2015 , ... Intelligent Implant Systems, LLC is ... multiple surgeries have been completed with this new posterior thoracolumbar spinal fusion system. ... Center of the Carolinas. The Revolution™ Spinal System pioneers a new approach ...
(Date:10/9/2015)... 9, 2015 Governor Tom Wolf ... company focused on developing T-cell receptor cancer immunotherapy treatments, ... a new expansion project. Pennsylvania ... commonwealth as 110 new, high-paying jobs will be created ... "My budget proposal includes sustained funding for the life ...
Breaking Biology Technology: