Navigation Links
Motor nerve targeting to limb muscles is controlled by ephrin proteins
Date:12/24/2008

Montral, December 24, 2008 A study from a team of researchers including Dr. Artur Kania, Director of the Neural Circuit Development Research Unit at the IRCM, and Dr. Dayana Krawchuk, postdoctoral fellow, shows how a family of proteins present in the developing limb control nerve targeting from the spinal cord to the muscles of the limb. This discovery, co-authored by scientists from Columbia University in New York City, is published on December 26, 2008 in the journal Neuron.

The nervous system is a highly precise and intricate nerve network whose major purpose is to analyze and respond to external stimuli through coordinated movement. Such precision stems from the accuracy of nerve connections formed between neurons and muscles. "To understand how this occurs," explains Dr. Kania, "we study a simple system in which nerves extend from the spinal cord to the limb to connect to either flexor muscles (i.e. biceps arm muscle) or extensor muscles (i.e. triceps arm muscle)." Previously, the researchers found that nerves connecting to extensor muscles were guided towards specific targets by a protein present in the developing limb (ephrin-A). Using chick and mouse embryos as models, the team of scientists now discovered that nerves connecting to the antagonist muscle group, the flexor muscles, are guided by a closely-related protein family, also present in the developing limb (ephrin-B). Together, these studies present a complete picture of how both limb nerves correctly connect the nervous system to muscles. Furthermore, by studying the wiring of a relatively simple nerve connection, the team of scientists has discovered a molecular strategy that is very likely widely used in the nervous system to wire much more complex neural circuits, such as those required for learning, memory and coordinated movement.

Miswiring of the nervous system is thought to be a factor in disorders such as epilepsy and mental retardation. By studying the process of limb nerve development, this team of scientists contributes further to the development of new strategies for treatment of patients with a diseased and damaged nervous system. That is because knowing how nerves form is crucial in designing therapies that aim to rebuild damaged or diseased nerves.

"The study of the ephrin proteins should help us understand diseases such as autism, schizophrenia as well as a number of neurological disorders," says Dr. Rmi Quirion, a scientific director at the Canadian Institutes of Health Research (CIHR). "We are proud to support this important study and hope it will help to improve the lives of people with these health problems."


'/>"/>

Contact: Dr. Artur Kania
Artur.Kania@ircm.qc.ca
514-987-5526
Institut de recherches cliniques de Montreal
Source:Eurekalert

Related biology news :

1. Silicon Valley Technology Leaders LaserCard Corporation and Tesla Motors Sign LaserPass Secure Access Deal
2. Motor neuron disease and toxic substances: Possible link?
3. Motorola Biometric Identification System Selected by West Virginia State Police
4. Motorola Biometric Identification System Selected by West Virginia State Police
5. Motorola Introduces Mobile Biometric Identification for Handheld Computers
6. SAFRAN to Acquire Motorolas Biometrics Business
7. Specific brain protein required for nerve cell connections to form and function
8. Targeting nerve growth factor may cure liver cancer
9. West Nile virus spread through nerve cells linked to serious complication
10. Team of scientists develops non-invasive method to track nerve-cell development in live human brain
11. Salk scientists identify key nerve navigation pathway
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/29/2016)... LegacyXChange, Inc. (OTC: LEGX ... Protect are pleased to announce our successful effort to ... of writing instruments, ensuring athletes signatures against counterfeiting and ... athletes on LegacyXChange will be assured of ongoing proof ... Bill Bollander , CEO states, "By inserting ...
(Date:3/22/2016)... 2016 According to ... for Consumer Industry by Type (Image, Motion, Pressure, ... & IT, Entertainment, Home Appliances, & Wearable ... 2022", published by MarketsandMarkets, the market for ... USD 26.76 Billion by 2022, at a ...
(Date:3/21/2016)... March 22, 2016 Unique ... passcodes for superior security   ... provider of secure digital communications services, today announced it ... and offer enterprise customers, particularly those in the Financial ... and voice authentication within a mobile app, alongside, and ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... Charm Sciences, Inc. is ... has received AOAC Research Institute approval 061601. , “This is another AOAC-RI approval ... Bob Salter, Vice President of Regulatory and Industrial Affairs. “The Peel Plate methods ...
(Date:6/23/2016)... , June 23, 2016   EpiBiome , ... secured $1 million in debt financing from Silicon Valley ... up automation and to advance its drug development efforts, ... new facility. "SVB has been an incredible ... the services a traditional bank would provide," said Dr. ...
(Date:6/23/2016)... NC (PRWEB) , ... June 23, 2016 , ... In ... University Hospital in Denmark detail how a patient who developed lymphedema after being treated ... tissue. The results could change the paradigm for dealing with this debilitating, frequent side ...
(Date:6/23/2016)... Andrew D Zelenetz ... Published recently in Oncology ... touchONCOLOGY, Andrew D Zelenetz , discusses the ... is placing an increasing burden on healthcare systems ... With the patents on many biologics expiring, interest ...
Breaking Biology Technology: