Navigation Links
Motor nerve targeting to limb muscles is controlled by ephrin proteins
Date:12/24/2008

Montral, December 24, 2008 A study from a team of researchers including Dr. Artur Kania, Director of the Neural Circuit Development Research Unit at the IRCM, and Dr. Dayana Krawchuk, postdoctoral fellow, shows how a family of proteins present in the developing limb control nerve targeting from the spinal cord to the muscles of the limb. This discovery, co-authored by scientists from Columbia University in New York City, is published on December 26, 2008 in the journal Neuron.

The nervous system is a highly precise and intricate nerve network whose major purpose is to analyze and respond to external stimuli through coordinated movement. Such precision stems from the accuracy of nerve connections formed between neurons and muscles. "To understand how this occurs," explains Dr. Kania, "we study a simple system in which nerves extend from the spinal cord to the limb to connect to either flexor muscles (i.e. biceps arm muscle) or extensor muscles (i.e. triceps arm muscle)." Previously, the researchers found that nerves connecting to extensor muscles were guided towards specific targets by a protein present in the developing limb (ephrin-A). Using chick and mouse embryos as models, the team of scientists now discovered that nerves connecting to the antagonist muscle group, the flexor muscles, are guided by a closely-related protein family, also present in the developing limb (ephrin-B). Together, these studies present a complete picture of how both limb nerves correctly connect the nervous system to muscles. Furthermore, by studying the wiring of a relatively simple nerve connection, the team of scientists has discovered a molecular strategy that is very likely widely used in the nervous system to wire much more complex neural circuits, such as those required for learning, memory and coordinated movement.

Miswiring of the nervous system is thought to be a factor in disorders such as epilepsy and mental retardation. By studying the process o
'/>"/>

Contact: Dr. Artur Kania
Artur.Kania@ircm.qc.ca
514-987-5526
Institut de recherches cliniques de Montreal
Source:Eurekalert

Page: 1 2

Related biology news :

1. Silicon Valley Technology Leaders LaserCard Corporation and Tesla Motors Sign LaserPass Secure Access Deal
2. Motor neuron disease and toxic substances: Possible link?
3. Motorola Biometric Identification System Selected by West Virginia State Police
4. Motorola Biometric Identification System Selected by West Virginia State Police
5. Motorola Introduces Mobile Biometric Identification for Handheld Computers
6. SAFRAN to Acquire Motorolas Biometrics Business
7. Specific brain protein required for nerve cell connections to form and function
8. Targeting nerve growth factor may cure liver cancer
9. West Nile virus spread through nerve cells linked to serious complication
10. Team of scientists develops non-invasive method to track nerve-cell development in live human brain
11. Salk scientists identify key nerve navigation pathway
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... Thanks to important discoveries in basic and clinical ... has mobilized into a complex offensive spanning multiple ... Alberta chemistry lab could help find new and ... a compound that targets a specific enzyme overexpressed ... in cells from brain tumours. , Chemistry professor ...
(Date:8/22/2014)... antioxidants and can reduce free radical damage. ... oxidative stress? Jianbo Zhao and co-workers from ... University, China discovered that green tea polyphenol ... apoptosis, indicating green tea polyphenols play a ... oxidative stress. The relevant study has been ...
(Date:8/22/2014)... the birds and the bees. But that old ... fertilized. The fertilization process for flowering plants is ... male and female reproductive cells. New research from ... Munich, and including Carnegie,s Wolf Frommer, David Ehrhardt, ... signaling process that guides flowering plant fertilization. It ...
Breaking Biology News(10 mins):New enzyme targets for selective cancer therapies 2New enzyme targets for selective cancer therapies 3Calcium and reproduction go together 2
... and philosophers across the nation are protesting a new ... a letter sent Monday to U.S. Secretary of the ... Public Works, and the House Committee on Natural Resources, ... legal opinion from the Solicitor of the U.S. Department ...
... to a new brain study, even people who seemed resilient but ... toppled on Sept. 11, 2001, have brains that are more reactive ... away. , That is the finding of a new Cornell study ... post-traumatic stress disorder (PTSD) or major depression. One of the first ...
... launched to try to boost the income of the world’s ... provide consumers with more nutritious, better tasting food. , New ... rice varieties that could fetch a higher price from consumers, ... The main aim of the new International Network for Quality ...
Cached Biology News:Legal ruling may put endangered species in danger 2Traumas like Sept. 11 make brains more reactive to fear 2New knowledge improves rice quality 2
(Date:8/22/2014)... The AMA is pleased to share ... Alaska that Alaska Governor Sean Parnell has signed House ... public use of Unmanned Aircraft Systems and the continuation ... 255states that it is, “An Act relating to unmanned ... unmanned aircraft system.” It defines State of Alaska laws ...
(Date:8/22/2014)... Canada (PRWEB) August 22, 2014 ... in model organisms can be accelerated by exome ... and manufacturing technologies, the custom SeqCap EZ Developer ... research. , Mr. Watson will additionally present how ... with commercially available human and mouse exome kits. ...
(Date:8/21/2014)... 21, 2014  BioSpecifics Technologies Corp. (NASDAQ: ... in class collagenase-based products marketed as XIAFLEX ® ... U.S. and XIAPEX ® in the EU, ... randomized, double-blind Phase 2a study of CCH for ... panniculopathy. The results showed that all three doses ...
(Date:8/21/2014)... A Finnish-Swedish research group at the Institute for ... Karolinska institutet, Stockholm, has developed a novel "man ... infection. This innovative diagnostic aid was described in ... August. The method is based on computer vision ... systems combined with visualization of only the diagnostically ...
Breaking Biology Technology:State of Alaska Signs Unmanned Aircraft Systems Bill 2Efficient Identification of Protein-Coding Variants in a Model Organism Through Exome Sequencing, New Webinar Hosted by Xtalks 2BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 2BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 3BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 4BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 5A novel 'man and machine' decision support system makes malaria diagnostics more effective 2
... Forecasts Growth of More Than 40%, NEW ... /Xinhua-PRNewswire-,FirstCall/ -- China Pharma Holdings, Inc. ("China Pharma") ... generic and brand,bio-pharmaceutical products in China, announced today ... to exceed 40%., According to recent sales ...
... Genome,Sciences, Inc. (Nasdaq: HGSI ) announced today that ... be webcast and may be accessed at, http://www.hgsi.com , ... of Human Genome Sciences, senior management team will present,a ... am Eastern,Time., Investors interested in listening to the ...
... physicians credentialed,to practice at the Texas Institute for Surgery ... at its annual Best Doctors event., "Texas Institute ... in the country and it is a tremendous honor ... this prestigious list. The physicians who,operate at TIS are ...
Cached Biology Technology:China Pharma Holdings, Inc. Projects 3rd Quarter 2008 Revenue Growth to Exceed 40% 2Annual List of 'Best Doctors in Dallas' Showcases Texas Institute for Surgery Physicians 2
This antibody detects cdc42 on SDS-PAGE immunoblots....
Goat polyclonal to DDDDK tag (FITC) ( Abpromise for all tested applications)....
Rabbit polyclonal to TRPM8 (rating: ****) ( Abpromise for all tested applications). entrezGeneID: 79054 SwissProtID: Q3YFM7...
...
Biology Products: