Navigation Links
Motor Neurone Disease Association study identifies MND biomarker
Date:11/4/2010

A study funded by the Motor Neurone Disease (MND) Association, in collaboration with the Medical Research Council (MRC), has identified a common signature of nerve damage in the brains of MND patients.

The study's exciting findings have been published in the prestigious journal Neurology (2 November 2010). These are the first results to be published from the ongoing Oxford Study for Biomarkers in MND/ALS (BioMOx).

MND research is being held back by the lack of an early diagnostic test and predictable markers of the progression of the disease biomarkers. Patients still wait too long for a certain diagnosis of MND and clinical trials are hampered by lengthy study times and variability of the disease between people living with MND. If MND biomarkers can be identified then they could dramatically improve the speed and accuracy with which MND can be diagnosed, and how future treatments are assessed.

This study used an advanced magnetic resonance imaging (MRI) technique, to look for areas of the brain that are universally damaged in patients with MND as compared to healthy controls. From this, Dr Martin Turner and colleagues at the University of Oxford found a unique similarity of nerve damage in a region of the brain that connects the motor neurones to the brain as well as damage to a region that acts as a connection between the left and right sides of the brain known as the 'corpus callosum'.

Talking about the study findings, Dr Martin Turner says: "The finding of a common pattern of nerve pathway damage in a varied group of MND patients holds the promise of a much needed biomarker.

"This study confirms the ability of advanced MRI techniques to sensitively detect nerve damage in a wide range of people living with MND. It builds on a decade of international work, and shows that MRI is now a frontrunner in the quest to generate biomarkers of disease activity in MND."

Dr Brian Dickie, director of research development at the Motor Neurone Disease Association, adds: "MRI scanning provides an exciting 'window on the brain', allowing researchers to link the changes occurring in the central nervous system with the 'real world' symptoms of motor neurone disease. Understanding these changing events is going to be central to the development of future treatments."

Dr Martin Turner was awarded the Association's first joint-funded MRC/MND Association Lady Edith Wolfson Clinical Research Fellowship in 2008 for his proposed BioMOx study.

The BioMOx study aims to develop a biomarker for MND by following changes in the brain, in the blood and in spinal cord fluid of people living with MND, every six months. People living with MND have made, and continue to make, a significant contribution in giving their time and effort to make this research project possible.

Dr Dickie continues: "The BioMOx study is one of the largest biomarker studies for motor neurone disease in the world. It's very encouraging to hear the first exciting results emerging from this four-year initiative."

The Lady Edith Wolfson Fellowships aim to attract and develop outstanding young clinicians in MND research, in order to create future scientific leaders in the field. Good researchers are fundamental to good research and developing the MND research workforce is a key element of the Association's research strategy.

The fellowships are an exciting development in MND research as they are allowing the MND Association to attract the best young clinicians, help develop their scientific expertise and place them at the heart of translating knowledge from the lab to the MND clinic.


'/>"/>

Contact: Louise Coxon
louise.coxon@mndassociation.org
01-604-611-843
Motor Neurone Disease Association
Source:Eurekalert

Related biology news :

1. Motorola Introduces Mobile Biometric Identification for Handheld Computers
2. SAFRAN to Acquire Motorolas Biometrics Business
3. Motor nerve targeting to limb muscles is controlled by ephrin proteins
4. Biologists learn structure, mechanism of powerful molecular motor in virus
5. Microbot motors fit to swim human arteries
6. UCLA stem cells scientists make electrically active motor neurons from iPS cells
7. First neuroimaging study examining motor execution in children with autism reveals new insights
8. Researchers design first model motor nerve system thats insulated and organized like the human body
9. Atomic-level snapshot catches protein motor in action
10. New study possibly links cognitive and motor delays with flat head syndrome in young babies
11. Lifes smallest motor, cargo carrier of the cells, moves like a seesaw
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/15/2017)... , Aug. 15 2017   ivWatch LLC , a medical ... (IV) therapy, today announced receipt of its ISO 13485 Certification, the ... the International Organization for Standardization (ISO®). ... ivWatch Model 400 Continuous Monitoring device for the early detection ... "This is an important ...
(Date:6/23/2017)... ITHACA, N.Y. , June 23, 2017 ... a leader in dairy research, today announced a new ... help reduce the chances that the global milk supply ... this dairy project, Cornell University has become the newest ... Food Supply Chain, a food safety initiative that includes ...
(Date:5/16/2017)... N.J. , May 16, 2017  Veratad Technologies, ... provider of online age and identity verification solutions, announced ... K(NO)W Identity Conference 2017, May 15 thru May 17, ... Regan Building and International Trade Center. ... the globe and in today,s quickly evolving digital world, ...
Breaking Biology News(10 mins):
(Date:9/21/2017)... SAN DIEGO, CALIF. (PRWEB) , ... September 21, 2017 , ... ... kitchen earlier this month. The organization, a worldwide society of professional women with ... a venue to hold its annual dinner. , Twelve members began with ...
(Date:9/20/2017)... ... , ... Diversity focused business accelerator, The Refinery , announced today they ... the top technology-driven, women-led startups in Boston, MA, New Haven/Hamden, CT, and Newark, NJ. ... going on that week – in Boston, it will be part of the City ...
(Date:9/20/2017)... ... 20, 2017 , ... From industry leaders, sports stars, and Hollywood icons to ... of these people had lost all hope. Their stories are told here. ... , “Neil takes readers on a riveting journey through the past, present ...
(Date:9/19/2017)... ... 2017 , ... Participants of this educational webinar will learn ... with the advantages and disadvantages of ductless, filtered fume hoods, they will also ... , Attendees will learn from an industry expert about the different types of ...
Breaking Biology Technology: