Navigation Links
Mothers' sleep, late in pregnancy, affects offspring's weight gain as adults
Date:5/16/2014

d on males because their hormone levels are less complex and easier to track. By 24 weeks the sons of sleep-disturbed mothers weighed about 10 percent more than the sons of mice with uninterrupted sleep.

"This is not huge obesity," Gozal said, "just 10 percent, a little extra at this stage. This would amount to 15 extra pounds in a human adult." A few of these mice, however, "became morbidly obese at 18 months of age or so," he said. "They died long before their unexposed counterparts."

Offspring from mothers with fragmented sleep revealed health problems in addition to weight gain. They scored poorly on glucose-tolerance tests. They produced normal amounts of insulin but it was less effective, failing to lower glucose levels as expected. Insulin resistance is a hallmark of metabolic syndrome and type 2 diabetes.

They also had disproportionately high amounts of visceral white adipose tissue, the "bad fat," as well as elevated levels of low-density lipoproteins, the bad cholesterol. Plus, their fat cells produced less adiponectin.

Adiponectin is usually a "beneficial hormone," Gozal said. "It can reduce cholesterol, make you more sensitive to insulin, protect your heart." As adiponectin levels in adults go up, body-fat percentage tends to go down. Expression of the adiponectin gene was reduced in the offspring of sleep-fragmented mothers, especially in their visceral fat cells.

A closer look revealed epigenetic changes, such as methylation and histone modification, which shut down selected genes, often in response to environmental stresses.

"We found that the offspring of sleep-deprived mothers had largely inactivated AdipoQ, the adiponectin gene," Gozal said. "Such changes may affect other genes as well; we haven't studied all the potential targets yet. Even so, this is the first example of a perturbation during pregnancy that translates into a genetic risk, in midlife, for the next generation."

"Th
'/>"/>

Contact: John Easton
john.easton@uchospitals.edu
773-795-5225
University of Chicago Medical Center
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Montreal researchers repel mortality in Malian mothers
2. Infants of overweight mothers grow more slowly
3. Grant funded to improve mothers nutrition before pregnancy and impact on baby
4. Nursing gerbils unravel benefit of multiple mothers in collective mammals
5. Privacy a problem for mothers of newborns in neonatal intensive care units, CWRU study finds
6. Female mice exposed to BPA by mothers show unexpected characteristics
7. Offspring of mothers stressed during pregnancy with a passive stress coping style more prone to obesity
8. Bright birds make good mothers
9. Expectant mothers periodontal health vital to health of her baby
10. Innovations save lives of mothers and children
11. Abuse jeopardizes new mothers mental health
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Mothers' sleep, late in pregnancy, affects offspring's weight gain as adults
(Date:7/31/2015)... Den 10. internationale konference om Genomik (ICG-10, ... - 25. oktober i Shenzhen , ... i år. Siden starten i 2006 er ICB blevet ... og er en af de mest dynamiske, entusiastiske og ... nylige gennembrud og fremskridt inden for ,omik,-forskning, som yderligere ...
(Date:7/31/2015)... julio de 2015 BGI llevará a cabo la ... 22 al 25 de octubre de 2015, en ... celebra su décimo aniversario este año. Desde su inauguración ... las reuniones anuales más influyentes del mundo en los ... conferencias científicas más dinámicas, entusiastas y amenas. ...
(Date:7/31/2015)... 2015 A 10 a. Conferência Internacional ... BGI de 22-25 de outubro de 2015, em ... está celebrando seu 10 o. aniversário este ano. Desde ... das reuniões mais influentes do mundo no ramo das ... e prazerosos. A ICG-10 se concentra ...
Breaking Biology News(10 mins):Den 10. internationale konference om Genomics (ICG-10) åbner i oktober 2La 10ª Conferencia Internacional sobre Genómica (ICG-10) comienza en octubre 2La 10ª Conferencia Internacional sobre Genómica (ICG-10) comienza en octubre 3A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 3
... Carnivores in the Iberian Peninsula, such as the Iberian lynx, ... to changing climatic conditions and that can even survive in ... the innate ability of ticks to adapt according to climate. ... the climate, habitat or movement patterns of people and goods. ...
... bear. They may have to go months without eating. Their ... to that the melting of Arctic sea ice due to climate ... it,s easy to see why polar bears worldwide are in trouble. ... bright spot. In a study of PCBs in polar bear cubs ...
... chromosomal abnormality in children with a deadly form of ... survival, clinician scientists at The University of Nottingham have ... Children,s Brain Tumour Research Centre as part of a ... test to allow doctors to identify youngsters who are ...
Cached Biology News:Ticks can adapt to the Spain's climatic diversity 2PCBs levels down in Norwegian polar bears 2PCBs levels down in Norwegian polar bears 3Genetic abnormality offers diagnostic hope for children's cancer 2Genetic abnormality offers diagnostic hope for children's cancer 3
(Date:7/31/2015)... VEGAS , July 31, 2015 ... seek resources that help them drive positive health ... a vital source of patient care in their ... annual tradeshow and conference, AmerisourceBergen announced a ... its Pharmacy Services Administration Organization and help independent ...
(Date:7/31/2015)... ... July 31, 2015 , ... Global Resorcinol ... premium industry insights on the global resorcinol industry. The report highlights the various ... vivid market scenarios and analysis of primary and secondary inputs from the existing ...
(Date:7/31/2015)... , July 31, 2015 China Cord ... China,s leading provider of cord blood ... cell storage services, today announced that the Company has ... U.S. Securities and Exchange Commission. The filed Form 20-F ... March 31, 2015. The Form 20-F can be accessed ...
(Date:7/31/2015)... ... July 31, 2015 , ... ... and quantification of partially hydrolyzed gluten in foods, has been accepted by AOAC ... method “Partially Hydrolyzed Gluten in Fermented Cereal-Based Products by R5 Competitive ELISA,” based ...
Breaking Biology Technology:AmerisourceBergen Unveils Suite of Enhanced Capabilities for Independent Pharmacies at ThoughtSpot 2015 2AmerisourceBergen Unveils Suite of Enhanced Capabilities for Independent Pharmacies at ThoughtSpot 2015 3Resorcinol Market to Grow at 6% CAGR to 2019 Says New Research Report at ReportsnReports.com 2Resorcinol Market to Grow at 6% CAGR to 2019 Says New Research Report at ReportsnReports.com 3Resorcinol Market to Grow at 6% CAGR to 2019 Says New Research Report at ReportsnReports.com 4China Cord Blood Corporation Files Its Annual Report on Form 20-F 2RIDASCREEN® Competitve Gliadin Receives AOAC Official First Action Status 2
... , , , Multiporator / Electroporator 2510 , , , , ... Transformation Protocol , Protocol No. 4308 915.536 ... , , , , , ... fbd11, protoplasts, , , ...
... , , , , , Multiporator , , , , ... Transfection Protocol , Protocol No. 4308 915.040 11/2000 , ... , , , Cell line ... Transfection with , Plasmid pEGFP-C1 (in bidistilled H 2 O), ...
... , , Multiporator / Electroporator 2510 , , , , , , ... Transformation Protocol , Protocol No. 4308 915.534 01/2002 , , ... , , Microorganism , ... Cell type , Bacteria, gram positive, ...
Cached Biology Technology:Ustilago maydis 2Ustilago maydis 3U-266 2Staphylococcus epidermidis 2
... The Transcend Non-Radioactive Translation Detection Systems ... in vitro. Using these systems, biotinylated ... proteins during translation, eliminating the need ... radioactive amino acids. This biotinylated lysine ...
...
... Maximize the value of your microarray ... offer the support you need from ... the most up to date methods. ... the Gene Expression Profiling Service or ...
... your microarray data using Asuragens bioinformatics expertise. ... consultation to extensive data analysis using the ... expertise in combination with the Gene Expression ... experiments., ,Normalization and basic statistical analysis including ...
Biology Products: