Navigation Links
Mothers pass on disease clues to offspring
Date:1/5/2009

When there is a threat of disease during pregnancy, mothers produce less aggressive sons with more efficient immune systems, researchers at The University of Nottingham have discovered.

The study provides the first evidence for a transgenerational effect on immune response based on environmental cues with maternal perception of disease risk in the immediate environment potentially determining offspring disease resistance and social dominance. The results are published in Proceedings of the Royal Society B, the Royal Society's flagship biological research journal.

Pregnant female mice were housed next to males infected with Babesia microti, which is a mild blood parasite causing few symptoms, but some anaemia. The partitioned cages allowed the females to see, hear and smell their infected neighbours, but not touch them, ensuring that the disease did not spread. Researchers then measured the effect of these 'ambient cues' on maternal physiology and behaviour, along with the social behaviour and immune response to disease challenge in the adult offspring.

The dams (female mice that had given birth) were found to have increased blood serum levels of corticosterone after being housed next to the infected males double the amount found in dams housed next to a control group of males that were not infected. Corticosterone is a stress hormone known to have effects on foetal and new-born development.

The offspring of the dams exposed to infected neighbours were significantly less aggressive as adults than the control group offspring. In the final part of the experiment, all offspring were infected with B microti to see if the ambient exposure affected their immunity. The offspring which had developed in the diseased environment showed an earlier onset, peak and clearance of the infection than the offspring from the control dams.

The research group in the University's School of Biology have studied many populations o
'/>"/>

Contact: Dr. Olivia Curno
oliviacurno@hotmail.com
44-078-706-06563
University of Nottingham
Source:Eurekalert

Page: 1 2

Related biology news :

1. Vitamin D deficiency in infants and nursing mothers carries long-term disease risks
2. Mice mothers devote energies to offspring when life is threatened
3. Too much or too little weight gain poses risks to pregnant mothers, babies
4. Negligent, attentive mouse mothers show biological differences
5. Hungry mothers risk addiction in their adult children
6. Safer, more accurate radiation therapy for expecting mothers
7. Genetic variation may lead to early cardiovascular disease
8. Scientists make strides toward defining genetic signature of Alzheimers disease
9. Safe new therapy for genetic heart disease
10. Grazing animals help spread plant disease
11. Nutrigenomics -- developing personalized diets for disease prevention
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... Climate fiction, or simply cli-fi, is a newly coined term ... global warming. New research from University of Copenhagen shows how ... to simulate the potential consequences of climate change and imagine ... than scientific data on changes in the atmosphere; it is ... by the books we read and the films we see. ...
(Date:4/23/2014)... first cause of dementia and affects some 400,000 people ... been found. One of the reasons for this is ... cause alterations in nerve transmissions and the loss of ... from the Institute of Neuroscience at the Universitat Autnoma ... memory consolidation and were able to develop a gene ...
(Date:4/23/2014)... many social mammals, ravens form different types of social ... and they also form strict dominance relations. From a ... a key ability in daily social life ("knowing who ... group members have with each other sets the stage ... results of this study have been published in the ...
Breaking Biology News(10 mins):Fiction prepares us for a world changed by global warming 2Fiction prepares us for a world changed by global warming 3Loss of memory in Alzheimer's mice models reversed through gene therapy 2Ravens understand the relations among others 2
... Institute of Science and his colleagues caused a storm ... years back that tiny airborne particles, known as aerosols, ... change ?having, on a local scale, an even greater ... how these particles influence clouds have generated many uncertainties. ...
... sequencing of the chimpanzee genome last year, geneticists have spent ... closest evolutionary relative, looking for the differences that distinguish the ... human DNA sequence with the most dramatically increased rate of ... still unknown, but it appears to be directly involved in ...
... new study, published today in the current issue ... Sciences has significant implications for the design of ... in human biomedical research. The groundbreaking study, entitled, ... Quantum Dots", demonstrates that quantum dots can one ...
Cached Biology News:Tiny airborne particles are a major cause of climate change 2Tiny airborne particles are a major cause of climate change 3Researchers identify human DNA on the fast track 2Researchers identify human DNA on the fast track 3Connect the Quantum Dots 2
(Date:1/15/2014)... Vernon Hills, IL (PRWEB) January 15, 2014 ... Cole-Parmer to find hard-working items for the lab, from ... designated as Guaranteed-in-Stock (GIS)—ready to ship when you order. ... Masterflex® Peristaltic Pumps , from the L/S® model ...
(Date:1/15/2014)... California , January 15, 2014 Oxford ... today announced the appointment of Thomas C Reynolds MD, PhD ... years, development experience gained in the biotechnology industry, most recently ... am delighted to welcome Tom at this transformative time for ...
(Date:1/15/2014)... This webinar will focus on EMA and ... in biosimilars. , Regulatory frameworks are evolving many countries ... the complex nature of biopharmaceuticals makes the demonstration of ... challenging. Based on the specific aspects of biosimilar drug ...
(Date:1/15/2014)... TX (PRWEB) January 15, 2014 More ... disease, and about 1 in 3 seniors will die ... source ). These jaw-dropping figures have shocked many Americans ... and, hopefully, help prevent these tragic age-related cognitive disorders. ...
Breaking Biology Technology:Cole-Parmer Begins 2014 with the Release of Preferred Solutions 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 3Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2
... Proteon Therapeutics,( http://www.proteontherapeutics.com ), a privately ... address the,medical needs of patients with kidney ... Annual Meeting of the American Society of ... Dilates Outflow,Veins in a Preclinical Model of ...
... Dr. Brad Thompson, President,and CEO of Oncolytics Biotech Inc. ... the Company at the Acumen BioFin Rodman & Renshaw ... 3:20 p.m. ET.,The event will be held at the ... live audio webcast of the presentation will be available ...
... agency to provide free home caregiving to disabled ... has announced its,2007 We Care For Veterans campaign ... services to qualified disabled veterans. (Logo: ... the nation are,donating 20 hours each of free ...
Cached Biology Technology:Proteon Therapeutics to Present at Annual Meeting of American Society of Nephrology in San Francisco on November 2, 2007 2Media Advisory - Oncolytics Biotech Inc. to Present at Acumen BioFin Rodman & Renshaw 9th Annual Healthcare Conference 2Homewatch CareGivers Launches 2007 We Care For Veterans Campaign 2