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Mothers pass on disease clues to offspring
Date:1/5/2009

When there is a threat of disease during pregnancy, mothers produce less aggressive sons with more efficient immune systems, researchers at The University of Nottingham have discovered.

The study provides the first evidence for a transgenerational effect on immune response based on environmental cues with maternal perception of disease risk in the immediate environment potentially determining offspring disease resistance and social dominance. The results are published in Proceedings of the Royal Society B, the Royal Society's flagship biological research journal.

Pregnant female mice were housed next to males infected with Babesia microti, which is a mild blood parasite causing few symptoms, but some anaemia. The partitioned cages allowed the females to see, hear and smell their infected neighbours, but not touch them, ensuring that the disease did not spread. Researchers then measured the effect of these 'ambient cues' on maternal physiology and behaviour, along with the social behaviour and immune response to disease challenge in the adult offspring.

The dams (female mice that had given birth) were found to have increased blood serum levels of corticosterone after being housed next to the infected males double the amount found in dams housed next to a control group of males that were not infected. Corticosterone is a stress hormone known to have effects on foetal and new-born development.

The offspring of the dams exposed to infected neighbours were significantly less aggressive as adults than the control group offspring. In the final part of the experiment, all offspring were infected with B microti to see if the ambient exposure affected their immunity. The offspring which had developed in the diseased environment showed an earlier onset, peak and clearance of the infection than the offspring from the control dams.

The research group in the University's School of Biology have studied many populations o
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Contact: Dr. Olivia Curno
oliviacurno@hotmail.com
44-078-706-06563
University of Nottingham
Source:Eurekalert

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