Navigation Links
Mother's diet affects the 'silencing' of her child's genes
Date:4/29/2014

such effects also occur in humans.

Senior author Dr Branwen Hennig, Senior Investigator Scientist at the MRC Gambia Unit and the London School of Hygiene & Tropical Medicine, said: "Our results represent the first demonstration in humans that a mother's nutritional well-being at the time of conception can change how her child's genes will be interpreted, with a life-long impact."

The researchers found that infants from rainy season conceptions had consistently higher rates of methyl groups present in all six genes they studied, and that these were linked to various nutrient levels in the mother's blood. Strong associations were found with two compounds in particular (homocysteine and cysteine), and the mothers' body mass index (BMI) had an additional influence. However, although these epigenetic effects were observed, their functional consequences remain unknown.

Professor Andrew Prentice, Professor of International Nutrition at the London School of Hygiene & Tropical Medicine, and head of the Nutrition Theme at the MRC Unit, The Gambia, said: "Our on-going research is yielding strong indications that the methylation machinery can be disrupted by nutrient deficiencies and that this can lead to disease. Our ultimate goal is to define an optimal diet for mothers-to-be that would prevent defects in the methylation process. Pre-conceptional folic acid is already used to prevent defects in embryos. Now our research is pointing towards the need for a cocktail of nutrients, which could come from the diet or from supplements."

Dr Rob Waterland of Baylor College of Medicine in Houston, who conducted the epigenetic analyses said: "We selected these gene regions because our earlier studies in mice had shown that establishment of DNA methylation at metastable epialleles is particularly sensitive to maternal nutrition in early pregnancy."

The authors note that their study was limited by including only one blood sampling point during
'/>"/>

Contact: Joel Winston
joel.winston@lshtm.ac.uk
44-077-388-06614
London School of Hygiene & Tropical Medicine
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Abuse jeopardizes new mothers mental health
2. Innovations save lives of mothers and children
3. Expectant mothers periodontal health vital to health of her baby
4. Bright birds make good mothers
5. Offspring of mothers stressed during pregnancy with a passive stress coping style more prone to obesity
6. Female mice exposed to BPA by mothers show unexpected characteristics
7. Privacy a problem for mothers of newborns in neonatal intensive care units, CWRU study finds
8. Nursing gerbils unravel benefit of multiple mothers in collective mammals
9. Grant funded to improve mothers nutrition before pregnancy and impact on baby
10. Infants of overweight mothers grow more slowly
11. Montreal researchers repel mortality in Malian mothers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Mother's diet affects the 'silencing' of her child's genes
(Date:7/31/2015)... , 31 de julio de 2015 ... (ICG-10,  www.icg-10.org ) del 22 al 25 de octubre ... La conferencia celebra su décimo aniversario este ... convertido en una de las reuniones anuales más influyentes ... es una de las conferencias científicas más dinámicas, entusiastas ...
(Date:7/31/2015)... 2015 La 10e Conférence internationale sur ... par le BGI du 22 au 25 octobre ... Chine. La conférence célèbre son 10e ... l,ICG est devenue l,une des réunions annuelles mondiales ... et c,est aussi la plus dynamique, la plus ...
(Date:7/31/2015)... , 31. Juli 2015 Die 10. internationale ... von BGI veranstaltet und findet vom 22. bis ... , statt. Die Konferenz ... ihrem Start 2006 ist die ICG weltweit zu ... geworden. Sie ist eines der dynamischsten, enthusiastischsten und ...
Breaking Biology News(10 mins):La 10ª Conferencia Internacional sobre Genómica (ICG-10) comienza en octubre 2La 10ª Conferencia Internacional sobre Genómica (ICG-10) comienza en octubre 3La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 2La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 3Die 10. internationale Konferenz zu Genomik (ICG-10) beginnt im Oktober 2Die 10. internationale Konferenz zu Genomik (ICG-10) beginnt im Oktober 3
... rubbed on the skin to reduce signs of aging and ... the first evidence of one of vitamin E,s normal body ... tears in the plasma membranes that protect cells from outside ... University researchers report in the journal Nature Communications ., ...
... is an adorable doe-eyed bat with a dark side it ... Tsang, a PhD student in ecology and evolutionary biology at The ... to a revolutionary way to help fund her research into how ... viruses can spread from flying foxes to humans by tracing the ...
... Researchers at the University of Delaware are examining tiny ... not only how these organisms adapt to the severe cold, ... The National Science Foundation study, led by Adam Marsh, ... Ocean, and Environment, also will compare the process of temperature ...
Cached Biology News:Scientists identify an innate function of vitamin E 2Crowdfunding science: Student raises cash online to follow a flying fox 2Crowdfunding science: Student raises cash online to follow a flying fox 3Will Antarctic worms warm to changing climate? 2Will Antarctic worms warm to changing climate? 3
(Date:9/1/2015)... ... September 01, 2015 , ... ... release of a groundbreaking new version of its flagship DNA design platform, which ... down complex DNA sequences into numerous genetic parts, which in turn can be ...
(Date:8/31/2015)... MabVax Therapeutics Holdings, Inc. (OTCQB: MBVX) aclinical ... lead antibody, HuMab 5B1, will be garnering major attention ... upcoming World Molecular Imaging Congress (WMIC) being held in ... from the Department of Radiology at Memorial Sloan Kettering ... of MabVax,s lead antibody as a PET imaging agent ...
(Date:8/31/2015)...  For people with Down syndrome, news from ... company, located in the Science + Technology Park at ... therapies yet for people with Down syndrome and other chromosome ... syndrome and Edwards syndrome aneuploidies in human cell cultures, ... Elixirgen plans to develop this technology into a treatment ...
(Date:8/31/2015)... 31, 2015 FLX Bio, Inc., a biopharmaceutical ... cancer immunotherapies, announced today that it has appointed ... and William Ho , M.D., Ph.D., as Chief ... management team led by veterans of Flexus Biosciences, Inc., ... Scientific Officer; Jay Powers , Ph.D., Vice President, ...
Breaking Biology Technology:GenoCAD Releases Combinatorial Design Tool to Optimize Protein Expression and Streamline DNA Synthesis Orders 2MabVax Therapeutics HuMab 5B1 Antibody Is Highlighted at Upcoming World Molecular Imaging Congress in Five Separate Presentations 2MabVax Therapeutics HuMab 5B1 Antibody Is Highlighted at Upcoming World Molecular Imaging Congress in Five Separate Presentations 3MabVax Therapeutics HuMab 5B1 Antibody Is Highlighted at Upcoming World Molecular Imaging Congress in Five Separate Presentations 4New Down syndrome therapy discovered 2FLX Bio Announces Senior Management Hires and Initiation of Phase 1 Trial of FLX925 2FLX Bio Announces Senior Management Hires and Initiation of Phase 1 Trial of FLX925 3FLX Bio Announces Senior Management Hires and Initiation of Phase 1 Trial of FLX925 4
... into why and how nanowires take the form they ... future electronic components. PhD student Peter Krogstrup from the ... the sensational new theoretical model, which is developed in ... One of the most important components in future electronic ...
... How would you like to store all the films ever ... Magnets made of just a few metallic atoms could make ... also recently been proposed as components for spintronics devices. There,s ... been seen to work at temperatures a few hairs above ...
... Group, Inc.  (OTC Bulletin Board: MDXG ), ... biomaterial-based products and bioimplants processed from human amniotic membrane, ... 31, 2010. Full Year 2010 ResultsIn ... with the calendar year. Its prior fiscal year was ...
Cached Biology Technology:Major advance in understanding how nanowires form 2Heavy metals open path to high temperature nanomagnets 2MiMedx Group Announces 2010 Results 2MiMedx Group Announces 2010 Results 3MiMedx Group Announces 2010 Results 4MiMedx Group Announces 2010 Results 5MiMedx Group Announces 2010 Results 6MiMedx Group Announces 2010 Results 7
Our Histology, Immunohistochemistry and tissue arrays services include samples processing, different type of staning, histollogical stains, image analysis, tissue arrays, immunohistochemistry, etc....
Mouse monoclonal antibody to PDK2 - pyruvate dehydrogenase kinase, isoenzyme 2...
... of an N-terminal FLAG® fusion and a ... from bicistronic mRNA. Two genes can ... transcription of a single message from the ... protein-protein interaction studies, multi-subunit proteins, and cloning ...
Mouse monoclonal antibody raised against a partial recombinant CALCOCO2. NCBI Entrez Gene ID = CALCOCO2...
Biology Products: