Navigation Links
Mother's diet affects the 'silencing' of her child's genes
Date:4/29/2014

such effects also occur in humans.

Senior author Dr Branwen Hennig, Senior Investigator Scientist at the MRC Gambia Unit and the London School of Hygiene & Tropical Medicine, said: "Our results represent the first demonstration in humans that a mother's nutritional well-being at the time of conception can change how her child's genes will be interpreted, with a life-long impact."

The researchers found that infants from rainy season conceptions had consistently higher rates of methyl groups present in all six genes they studied, and that these were linked to various nutrient levels in the mother's blood. Strong associations were found with two compounds in particular (homocysteine and cysteine), and the mothers' body mass index (BMI) had an additional influence. However, although these epigenetic effects were observed, their functional consequences remain unknown.

Professor Andrew Prentice, Professor of International Nutrition at the London School of Hygiene & Tropical Medicine, and head of the Nutrition Theme at the MRC Unit, The Gambia, said: "Our on-going research is yielding strong indications that the methylation machinery can be disrupted by nutrient deficiencies and that this can lead to disease. Our ultimate goal is to define an optimal diet for mothers-to-be that would prevent defects in the methylation process. Pre-conceptional folic acid is already used to prevent defects in embryos. Now our research is pointing towards the need for a cocktail of nutrients, which could come from the diet or from supplements."

Dr Rob Waterland of Baylor College of Medicine in Houston, who conducted the epigenetic analyses said: "We selected these gene regions because our earlier studies in mice had shown that establishment of DNA methylation at metastable epialleles is particularly sensitive to maternal nutrition in early pregnancy."

The authors note that their study was limited by including only one blood sampling point during
'/>"/>

Contact: Joel Winston
joel.winston@lshtm.ac.uk
44-077-388-06614
London School of Hygiene & Tropical Medicine
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Abuse jeopardizes new mothers mental health
2. Innovations save lives of mothers and children
3. Expectant mothers periodontal health vital to health of her baby
4. Bright birds make good mothers
5. Offspring of mothers stressed during pregnancy with a passive stress coping style more prone to obesity
6. Female mice exposed to BPA by mothers show unexpected characteristics
7. Privacy a problem for mothers of newborns in neonatal intensive care units, CWRU study finds
8. Nursing gerbils unravel benefit of multiple mothers in collective mammals
9. Grant funded to improve mothers nutrition before pregnancy and impact on baby
10. Infants of overweight mothers grow more slowly
11. Montreal researchers repel mortality in Malian mothers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Mother's diet affects the 'silencing' of her child's genes
(Date:11/6/2014)... 6, 2014 - Insilico Medicine, Inc, a Baltimore-based ... age related diseases announced a research collaboration with ... Champions Oncology, Inc (OTC: CSBR). , "There are ... medicine, but Champions Oncology,s TumorGraft technology is unique ... chemotherapy regimen experimentally generating vast amounts of valuable ...
(Date:11/5/2014)... de Janeiro, Brazil -Individuals show great diversity in their ... males and females greatly differ in their perceptual evaluation ... of smell tests. , Sex differences in ... behaviors and may be connected to one,s perception of ... emotions. Thus, women,s olfactory superiority has been suggested to ...
(Date:11/4/2014)... Temple University School of Medicine announced today that ... initiative funded by the Bill & Melinda Gates ... Obstetrics, Gynecology and Reproductive Sciences; and Vice Chair ... School of Medicine will pursue an innovative global ... Biomarkers to Assess Fetal Neurodevelopment.", Grand Challenges Explorations ...
Breaking Biology News(10 mins):Insilico Medicine, Inc announces research collaboration with Champions Oncology, Inc 2The female nose always knows: Do women have more olfactory neurons? 2Temple University School of Medicine receives Grand Challenges Explorations grant 2
... have been identified as highly efficient generators of electricity. , ... high concentrations in the stratosphere orbiting the earth with the ... biofilm that has been engineered by a team of scientists ... from the Wear Estuary, Country Durham, UK, the team tested ...
... N.M Sandia National Laboratories researchers, using off-the-shelf ... on ways to improve amputees, control over prosthetics ... Organic materials chemist Shawn Dirk, robotics engineer Steve ... The goal is improved prosthetics with flexible nerve-to-nerve ...
... Researchers at The Pennsylvania State University College of ... integrity of the opioid growth factor receptor (OGFr), which ... on cell proliferation, is a key to understanding the ... of human ovarian cancer cells that were molecularly engineered ...
Cached Biology News:Superbugs from space offer new source of power 2Sandia seeks better neural control of prosthetics for amputees 2Sandia seeks better neural control of prosthetics for amputees 3Sandia seeks better neural control of prosthetics for amputees 4Sandia seeks better neural control of prosthetics for amputees 5A breakthrough in understanding the biology and treatment of ovarian cancer 2A breakthrough in understanding the biology and treatment of ovarian cancer 3
(Date:11/24/2014)... (PRWEB) November 24, 2014 The ... ” from METTLER TOLEDO demonstrates how to reduce ... Power analytics and sample panel design can be ... chemistry and protect against corrosion and deposition. Dedicated ... a significant amount of panel space. Additionally, installing ...
(Date:11/24/2014)... , November 24, 2014 Senior ... honored for dynamic leadership skills, business acumen ... and medical information products and services, congratulates Diane ... Clinical Reference and Workflow, Elsevier Clinical Solutions, for being ... Watching ® Awards issue of Profiles in ...
(Date:11/22/2014)... 21, 2014 Two new educational webinars hosted ... next for ALS research and how the pharmaceutical industry can ... Ice Bucket Challenge: Where Does the ALS Money Go? , ... December 2014, Time: 1:30pm ET, Register to attend ... Dr. Merit Cudkowicz, Julianne Dorn Professor of Neurology at Massachusetts ...
(Date:11/22/2014)... (PRWEB) November 21, 2014 Prominent ... investors will gather on December 3rd at Genetic ... Conferences series. GeneticRx will take place at the ... School and will discuss the present and future ... exon skipping, and gene editing—as well as the ...
Breaking Biology Technology:New Video Shows How to Simplify Cycle Chemistry Sample Panels to Save Time and Costs 2Elsevier Clinical Solutions' Diane Bartoli Featured In Profiles in Diversity Journal's 13th Annual Women Worth Watching Issue 2Elsevier Clinical Solutions' Diane Bartoli Featured In Profiles in Diversity Journal's 13th Annual Women Worth Watching Issue 3DrugDev Webinars in December to Explore What Comes Next for ALS Research and How We Can Make Life Easier for Clinical Sites 2Pioneering Academics and Key Industry Leaders to Discuss Rare Diseases and the Emergence of New Genetic Medicines at Genetic Rx on December 3rd 2
... March 7, 2012   Spherix Incorporated (NASDAQ: ... biotechnology for therapy in diabetes, metabolic syndrome and ... services to food, supplement, biotechnology and pharmaceutical companies ... candidates, SPX-106T, arrested development and reduced atherosclerotic plaque ...
... than 1,100 leaders from across California,s life sciences industry ... CALBIO2012: Driven by Patients on March 8-9. The conference ... through partnering and collaborative research. For the ... meeting for California,s life sciences companies. CALBIO2012: Driven by ...
... March 7, 2012  Today, Cobalt Technologies , ... the achievement of major progress toward commercial scale ... in cooperation with ANDRITZ , a globally ... the pulp and paper industry, tested its dilute ...
Cached Biology Technology:SPX-106T Arrests Development of Atherosclerotic Plaques in Mouse Model of Cardiovascular Disease 2SPX-106T Arrests Development of Atherosclerotic Plaques in Mouse Model of Cardiovascular Disease 3SPX-106T Arrests Development of Atherosclerotic Plaques in Mouse Model of Cardiovascular Disease 4First Statewide Biotech Meeting Focuses on Patient Access, Innovation 2Cobalt Technologies Hits Key Commercial Milestone with Pretreatment Process Demonstration 2Cobalt Technologies Hits Key Commercial Milestone with Pretreatment Process Demonstration 3
... 2 Detection System combines the indirect ... principle and Signets unique formulation of ... and reliablility. Signet reagents will achieve ... and automated protocols. ,Signets USA ...
Each bottle contains: Bromophenol Blue 0.25% w/v , Xylene Cyanol FF 0.25%, Glycerol solution 30% w/v...
Agarose Gel Loading Dye Mixture 6X...
...
Biology Products: