Navigation Links
Mother Nature's oral antibiotics research gets $2.25 million help from NIH
Date:10/3/2011

Research from Case Western Reserve University School of Dental Medicine to study an isolated agent from common oral bacteria may hold the answer as to how human beta defensins (HBDs)nature's way of keeping oral microbes from entering the body and wreaking havoc with our healthcan be used to create new treatments to block bacteria from entering through the epithelial linings on and in the body.

Aaron Weinberg, professor and chair of the department of biological sciences at the Dental School, will lead the research group on a five-year, $2.25 million National Institutes of Health-funded project.

The new grant, Weinberg said, will continue the exploration of their discovery last year of an agent called Fusobacterium nucleatum-associated Beta-Defensin Inducer (FAD-I).

This agent triggers the expression and release of the HBD peptides from epithelial cells that make up the mucosal linings of the body, such as skin, the respiratory track and the gastrointestinal and urogenital tracks.

Weinberg and his research group reported FAD-I's discovery in the Journal of Biological Chemistry article, "Fusobacterium nucleatum-Associated Beta-Defensin Inducer (FAD-I)." The researchers described the identification, isolation and functions of FAD-I.

The new grant that continues FAD-I research has several foci: (1) isolating which strains of F. nucleatum bacteria have more potent FAD-I activity and why, (2) continued research to understand more about the biology and structure of FAD-I, and (3) using a mouse model to see how effective it is as a potential treatment.

In addition, the researchers are particularly interested in why FAD-I sets defensins to work without triggering inflammation, which can be a health risk if the inflammation is not abated by the normal defense system. In the mouth, it can cause gum disease and eventual tooth loss.

"It started with our observation that when the bacterium comes in contact with human epithelial cells, it promotes the induction of these HBD peptides," said Weinberg.

HBDs put up a defense when challenged by oral bacteria and block the invasion of the more than 700 species of bacteria in the mouth from entering the body. Oral bacteria have been linked to pre-term labor, fetal death, heart disease, diabetes and other health conditions.

The researcher and his team have studied the link between the mouth's bacteria and the induction of HBDs for more than a decade, and in a step-by-step process have unraveled the symbiotic relationship between this common oral bacterium and the peptides.

In the process of understanding HBDs and oral bacteria by focusing on F. nucleatum, they discovered FAD-I on the surface of the outer membrane of this bacterium. Even when the outer membrane portion containing FAD-I was separated from the main bacterium, FAD-I continued to induce HBD action in vitro. In addition, when researchers genetically expressed FAD-I in other bacteria that didn't induce HBD expression and release from epithelial cells, the bacteria were then able to induce HBD expression and release, Weinberg explained.

So,the idea is to promote nature's own antibiotics in sites where they would come in contact with FAD-I, Weinberg said.

"The possibility exists that FAD-I can induce defensins in other parts of the body where they are found. Wouldn't it be neat if we could promote the expression of Mother Nature's own antibiotics in vulnerable sites by intentionally challenging the sites with FAD-I and thereby protecting the sites from microbial challenges?"


'/>"/>

Contact: Susan Griffith
susan.griffith@case.edu
216-368-1004
Case Western Reserve University
Source:Eurekalert

Related biology news :

1. Protein switches could turn cancer cells into tiny chemotherapy factories
2. Gene therapy kills breast cancer stem cells, boosts chemotherapy
3. Mothers poor health impairs childrens well-being, not only due to genetics
4. Mothers BMI linked to fatter babies
5. Popular herbal supplements may adversely affect chemotherapy treatment
6. Children of depressed mothers have a different brain
7. 51st Interscience Conference on Antimicrobial Agents and Chemotherapy
8. Trastuzumab and chemotherapy improved survival in HER2-postive breast and brain cancer patients
9. Your mother was right: Study shows good posture makes you tougher
10. A mothers salt intake could be key to prenatal kidney development
11. B vitamins in mothers diet reduce colorectal cancer risk in offspring
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/15/2016)... 15, 2016 Transparency Market ... Recognition Market by Application Market - Global Industry Analysis Size ... to the report, the  global gesture recognition market ... and is estimated to grow at a CAGR ... 2024.  Increasing application of gesture recognition ...
(Date:6/7/2016)... 7, 2016  Syngrafii Inc. and San Antonio ... that includes integrating Syngrafii,s patented LongPen™ eSignature "Wet" ... collaboration will result in greater convenience for SACU ... while maintaining existing document workflow and compliance requirements. ... Highlights: ...
(Date:6/2/2016)... 2, 2016   The Weather Company , an IBM ... an industry-first capability in which consumers will be able to ... ask questions via voice or text and receive relevant information ... Marketers have long sought an advertising solution that ... be personal, relevant and valuable; and can scale across millions ...
Breaking Biology News(10 mins):
(Date:11/30/2016)... Nov. 30, 2016  GenomOncology today announced the appointment of ... Medical Affairs.  Dr. Coleman will oversee clinical ... proprietary knowledge-enabled platform. The GenomOncology software suite empowers molecular pathologists ... data and clinical decision support, from quality control through reporting. ... , , ...
(Date:11/30/2016)... VANCOUVER , Nov. 30, 2016 /PRNewswire/ -  Equicare ... coordination solutions, has been recognized as one of the ... 100, an annual international listing that distinguishes the top ... "We,ve pushed a great step forward this year continually ... growing our own customer base and team," says ...
(Date:11/30/2016)... 30, 2016   Merck , a leading science ... into a set of agreements with Evotec AG, whereby ... of genetic reagents such as CRISPR and shRNA libraries. ... offers an accelerated pathway to explore and identify new ... identification of new targets, a process that can be ...
(Date:11/30/2016)... ... 2016 , ... With growth rates averaging more than 30% each year, Random42 ... to continuing their expansion in their new office space. The new office has a ... by the creative industries, so Random42 Scientific Communication will fit right in. , ...
Breaking Biology Technology: