Navigation Links
Mother Nature's oral antibiotics research gets $2.25 million help from NIH
Date:10/3/2011

Research from Case Western Reserve University School of Dental Medicine to study an isolated agent from common oral bacteria may hold the answer as to how human beta defensins (HBDs)nature's way of keeping oral microbes from entering the body and wreaking havoc with our healthcan be used to create new treatments to block bacteria from entering through the epithelial linings on and in the body.

Aaron Weinberg, professor and chair of the department of biological sciences at the Dental School, will lead the research group on a five-year, $2.25 million National Institutes of Health-funded project.

The new grant, Weinberg said, will continue the exploration of their discovery last year of an agent called Fusobacterium nucleatum-associated Beta-Defensin Inducer (FAD-I).

This agent triggers the expression and release of the HBD peptides from epithelial cells that make up the mucosal linings of the body, such as skin, the respiratory track and the gastrointestinal and urogenital tracks.

Weinberg and his research group reported FAD-I's discovery in the Journal of Biological Chemistry article, "Fusobacterium nucleatum-Associated Beta-Defensin Inducer (FAD-I)." The researchers described the identification, isolation and functions of FAD-I.

The new grant that continues FAD-I research has several foci: (1) isolating which strains of F. nucleatum bacteria have more potent FAD-I activity and why, (2) continued research to understand more about the biology and structure of FAD-I, and (3) using a mouse model to see how effective it is as a potential treatment.

In addition, the researchers are particularly interested in why FAD-I sets defensins to work without triggering inflammation, which can be a health risk if the inflammation is not abated by the normal defense system. In the mouth, it can cause gum disease and eventual tooth loss.

"It started with our observation that when the bacterium comes in c
'/>"/>

Contact: Susan Griffith
susan.griffith@case.edu
216-368-1004
Case Western Reserve University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Protein switches could turn cancer cells into tiny chemotherapy factories
2. Gene therapy kills breast cancer stem cells, boosts chemotherapy
3. Mothers poor health impairs childrens well-being, not only due to genetics
4. Mothers BMI linked to fatter babies
5. Popular herbal supplements may adversely affect chemotherapy treatment
6. Children of depressed mothers have a different brain
7. 51st Interscience Conference on Antimicrobial Agents and Chemotherapy
8. Trastuzumab and chemotherapy improved survival in HER2-postive breast and brain cancer patients
9. Your mother was right: Study shows good posture makes you tougher
10. A mothers salt intake could be key to prenatal kidney development
11. B vitamins in mothers diet reduce colorectal cancer risk in offspring
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/22/2014)... 2014) -- There are all sorts of signaling strategies ... their colorful tails; satin bowbirds build specialized stick structures, ... objects; and European bitterling males show off bright nuptial ... unique method to communicate with others. , ... can have profound fitness implications for individuals that are ...
(Date:4/22/2014)... University of Montana,s Wildlife Biology Program, co-wrote a research paper ... Academy of Sciences on how streamwater chemistry varies across ... Lowe and co-authors ... Washington, the Cary Institute of Ecosystem Studies, the University of ... 664 water samples collected every 10 meters along 32 tributaries ...
(Date:4/22/2014)... 22, 2014) Biotechnology scientists must be aware of ... and licensing guidelines, according to a new paper from ... in the current issue of the journal Regenerative ... 2013 U.S. Supreme Court ruling in the case Association ... occurring genes are unpatentable. The court case and rulings ...
Breaking Biology News(10 mins):Best practices in communication for the animal world 2Best practices in communication for the animal world 3New research focuses on streamwater chemistry, landscape variation 2New patenting guidelines are needed for biotechnology 2New patenting guidelines are needed for biotechnology 3
... April 30, 2012 It is often thought that starting ... they try to set a good example for their children. ... children into the home may affect parents, eating habits. ... a child,s eating preferences may influence how a family eats. ...
... Efforts to prevent obesity among low-income infants should focus not ... reasons behind unhealthy feeding practices, according to a study to ... (PAS) annual meeting in Boston. Adding cereal to bottles ... Academy of Pediatrics because it may lead to overfeeding and ...
... Calif. Avocado, a significant fruit crop grown in ... threatened by Phytophthora root rot (PRR), a disease that ... in Latin America and crippled production in Australia and ... estimated to cost avocado growers approximately $30-40 million a ...
Cached Biology News:Starting a family does not encourage parents to eat healthier 2Low-income moms under stress may overfeed infants 2New avocado rootstocks are high-performing and disease-tolerant 2New avocado rootstocks are high-performing and disease-tolerant 3
(Date:1/15/2014)... More than 5 million Americans are currently living ... will die with Alzheimer’s or another dementia, according to ... many Americans into looking for ways to improve their ... cognitive disorders. Jonathan Weisman, president of Biohack Pure, is ...
(Date:1/15/2014)... 2013 was a banner year of continued ... saw continued independent research led by the team at ... $1 million grant from the Susanne Marcus Collins Foundation, ... peer reviewed journal, Amy Grant highlighted Brainwave Optimization® in ...
(Date:1/14/2014)... January 14, 2014 Date: Friday, April 11, ... Warrington Country Club, 1360 Almshouse Road, Warrington, Pa. ... organization solely dedicated to finding a cure for hepatitis B ... will host its annual Crystal Ball on Friday, April 11 ...
(Date:1/14/2014)... 2014 As pet owners drew up their lists of New ... "Take better care of my furry companion." Nowadays there are pet ... carrying cases to take the little canine or feline darlings along ... to buy some pricey toys at the pet store. But anyone ...
Breaking Biology Technology:Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3Hepatitis B Foundation to Host Annual Crystal Ball Gala 2New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2
... NES-ZIONA, Israel, Sept. 21 PROLOR Biotech, Inc. (OTC ... of a Phase I clinical trial of its long-acting human ... hGH-CTP is being developed to provide growth hormone deficient adults ... per week that are currently required with a once-weekly or ...
... prolonged courses of stable disease and excellent, ... cancer, , , QUEBEC CITY, Sept. ... AEZS ) ("the Company"), a global biopharmaceutical company focused ... a Phase 1 study of its orally-active tubulin and topoisomerase ...
... ... most reliable and secure professional solution to inventory Ultra-low Freezer and Liquid Nitrogen Tank ... ... 21, 2009 -- RURO Inc. today announced the release of FreezerPro 2010, Frozen ...
Cached Biology Technology:PROLOR Biotech Announces Initiation of Phase I Clinical Trial for its Long-Acting Growth Hormone 2PROLOR Biotech Announces Initiation of Phase I Clinical Trial for its Long-Acting Growth Hormone 3PROLOR Biotech Announces Initiation of Phase I Clinical Trial for its Long-Acting Growth Hormone 4AEterna Zentaris Announces Completion of Phase 1 Study with Oral AEZS-112 in Cancer 2AEterna Zentaris Announces Completion of Phase 1 Study with Oral AEZS-112 in Cancer 3RURO Inc. Today Announced the Release of FreezerPro 2010, Frozen Sample Inventory and Information Management System 2
Human VEGF R Phycoerythrin Sampler (Cl 89106, 49560, 54733)...
ANTI ALPHA FSH:B...
... Dog serum is collected from fasted mixed breed, ... Available Anticoagulants: N-02: Citrate ... K2EDTA N-08: Potassium Oxalate N-10: ... N-05: ACD N-07: CPD ...
MOUSE ANTI BOVINE TROPONIN I...
Biology Products: