Navigation Links
Most-used diabetes drug works in different way than previously thought
Date:1/6/2013

PHILADELPHIA - A team, led by senior author Morris J. Birnbaum, MD, PhD, the Willard and Rhoda Ware Professor of Medicine, with the Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, found that the diabetes drug metformin works in a different way than previously understood. Their research in mice found that metformin suppresses the liver hormone glucagon's ability to generate an important signaling molecule, pointing to new drug targets. The findings were published online this week in Nature.

For fifty years, one of the few classes of therapeutics effective in reducing the overactive glucose production associated with diabetes has been the biguanides, which includes metformin, the most frequently prescribed drug for type 2 diabetes. The inability of insulin to keep liver glucose output in check is a major factor in the high blood sugar of type 2 diabetes and other diseases of insulin resistance.

"Overall, metformin lowers blood glucose by decreasing liver production of glucose," says Birnbaum. "But we didn't really know how the drug accomplished that."

Imperfectly Understood

Despite metformin's success, its mechanism of action remained imperfectly understood. About a decade ago, researchers suggested that metformin reduces glucose synthesis by activating the enzyme AMPK. But this understanding was challenged by genetic experiments in 2010 by collaborators on the present Nature study. Coauthors Marc Foretz and Benoit Viollet from Inserm, CNRS, and Universit Paris Descartes, Paris, found that the livers of mice without AMPK still responded to metformin, indicating that blood glucose levels were being controlled outside of the AMPK pathway.

Taking another look at how glucose is regulated normally, the team knew that when there is no food intake and glucose decreases, glucagon is secreted from the pancreas to signal the liver to produce glucose. Th
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2

Related biology news :

1. UCSB researchers perform pioneering research on Type 2 diabetes
2. NTU study finds ways to prevent muscle loss, obesity and diabetes
3. Notre Dame research may have important implications for combating diabetes
4. University of Chicagos Graeme Bell receives international diabetes prize
5. Joslin researchers increase understanding of genetic risk factor for type 1 diabetes
6. Arginine and proline enriched diet may speed wound healing in diabetes
7. Diabetes Management Provider ActiveCare Announces Cost Savings Of Over $4,000 Per Year Per Diabetic Member
8. Purple corn compound may aid in developing future treatments for Type 2 diabetes, kidney disease
9. Risk of developing diabetes higher in neighborhoods that arent walk-friendly: Study
10. Cystic fibrosis disrupts pancreas two ways in CF-related diabetes
11. Shedding new light on one of diabetes most dangerous complications
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Most-used diabetes drug works in different way than previously thought
(Date:4/14/2015)... OXFORD, Conn. , April 14, 2015 ... "Company"), a biometric authentication company focused on the growing ... has been nominated for the 2015 New York Design ... The Design100, New York City Design Awards are ... are based on over 2,500 ratings from the marketplace, ...
(Date:4/8/2015)... 8, 2015  Infinisource, a leading provider of SaaS-based ... Morpho, a leading supplier of biometric identification and ... market,s most advanced biometrically-enabled time clock, the companies ... clock is setting a bold, new standard for ... the small and mid-size employer. When connected to ...
(Date:4/2/2015)... GOTHENBURG, Sweden , April 2, 2015 ... for its touch fingerprint sensor FPC1025 from the distributor ... Deliveries will commence during Q2 2015 although the major ... 2015. The sensors will be used by smartphone manufacturers ... of 110 MSEK is included in the communicated revenue ...
Breaking Biology News(10 mins):NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 110 Million 2
... of Anthropology Jeffrey H. Schwartz and University of Salerno ... the New Anatomist journal, shows that the emerging understanding ... of evolution, originally explained in his seminal work, Sudden ... Wiley & Sons, 2000). , In that book, Schwartz ...
... simplest bacteria need almost twice as many genes to survive ... Nature (30 March 2006). , Bacteria are some of the ... trying to identify the smallest collection of genes ?or minimal ... scientists have done this by removing, or 'knocking out', a ...
... the 3-billion-base human genome play a vital role in ... the Wellcome Trust Sanger Institute and the Cambridge University's ... report in PLoS Genetics their detailed maps of differences ... unchanged in recent human history. , The Major ...
Cached Biology News:Pitt professor's theory of evolution gets boost from cell research 2Pitt professor's theory of evolution gets boost from cell research 3Minimal genome should be twice the size, study shows 2Minimal genome should be twice the size, study shows 3Researchers map of genetic variations implicated in disease 2Researchers map of genetic variations implicated in disease 3
(Date:4/21/2015)... Thornton Cleveleys (UK) (PRWEB) April 21, 2015 ... PEEK* technology and its clinical applications will ... Meeting. Participants include engineers, scientists, regulators and ... worldwide. The meeting is sponsored by Invibio ... PEEK polymer-based biomaterials, a specialist in manufacturing ...
(Date:4/20/2015)... , April 20, 2015 Stent retriever ... from vessels in the brain reduced disability after ... Tudor Jovin, MD, President of the Society of ... "This is a giant step forward that will ... of stroke patients," said Jovin, who is associate ...
(Date:4/20/2015)... 2015  Ardelyx, Inc. (NASDAQ: ARDX ), ... and metabolic diseases, today announced that Annalisa ... Board of Directors. Dr. Jenkins brings a wealth ... built and led teams advancing programs from scientific ... healthcare systems globally. "Annalisa brings ...
(Date:4/20/2015)... , April 20, 2015 ... Targeting Supramolecular Therapeutic Using the VOLVOX Platform - To ... -  Supramolecular Assembly of Antibody-drug Conjugates ... Payload - Presented on Sunday, Apr 19, 1:00 PM ... in supramolecular therapeutic program, today announced that the company,s ...
Breaking Biology Technology:2nd International PEEK Meeting: Invibio Biomaterial Solutions spearheads medical research for implantable PEEK polymer devices 22nd International PEEK Meeting: Invibio Biomaterial Solutions spearheads medical research for implantable PEEK polymer devices 3SVIN President Tudor Jovin, MD, Co-Leads Groundbreaking Stroke Study In The New England Journal Of Medicine 2SVIN President Tudor Jovin, MD, Co-Leads Groundbreaking Stroke Study In The New England Journal Of Medicine 3Ardelyx Appoints Dr. Annalisa Jenkins to Its Board of Directors 2Ardelyx Appoints Dr. Annalisa Jenkins to Its Board of Directors 3Ardelyx Appoints Dr. Annalisa Jenkins to Its Board of Directors 4Invictus Oncology Announces Two Posters to be Presented Describing its Platform Technology on Supramolecular Therapeutics at the American Association for Cancer Research Annual Meeting, 2015 2
... 33% more data than the previous product generation. ... of the 1.5 GB Cornice Storage Element (SE), ... Element. These storage devices are used in consumer ... amounts of reliable, inexpensive storage in a small space. ...
... of Silicon Valley has joined the doom of Y2K in ... to revisit the importance of technology to Northeast Wisconsin. After ... the so-called new economy, one fact remains: More money must ... , ,In this post-technology age, the only thing about technology ...
... Brookfield, Wis. - Fiserv Health, an operating group of ... Avidyn Health, a care management company targeting the self-funded ... provides independent health plan management, claims processing and administration ... With the addition of Avidyn Health, Fiserv Health now ...
Cached Biology Technology:With Larger Storage Capacity Comes Smaller Devices 2Look at the New Economy, Just Like the Old Economy 2Fiserv Launches Avidyn Health to Target Healthcare Costs 2
... are rigid macroporous hydrophilic media. The rigid ... moderate pressures, while the macroporous beads enhance ... matrix reduces nonspecific binding. Macro-Prep High Q ... with very high flow rates and resolution. ...
... --- a cocktail of 3 siRNAs specifically ... our most popular product. The siTrio reagent ... of your target gene when used under ... and confirmation of optimal transfection with one ...
... collection of phage display libraries, human ... and mouse tissues. All cDNA libraries ... size of cDNA inserts has been ... 1000bp by gel electrophoresis of DNA ...
... The IDS 25-Hydroxy Vitamin D kit ... quantitative determination of 25-hydroxyvitamin D (25-OH ... human serum or plasma. Our patented ... of solvent precipitation and centrifugation and ...
Biology Products: