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Moss protein plays role in Alzheimer's disease
Date:2/8/2008

fortunately, were doing it one gene at a time, slowly building networks, figuring out what the context is. We cant think of all of it at once. We have to look at a small subset of genes and how they work with their friends, and hope that our observations will fit together in one coherent network.

Quatrano said the collaboration between the two labs is a reflection of what the Genomic Age can do.

Today, sitting at your computer, you can data mine genomes from hundreds of microorganisms, animals, fungi, insects and plants, and youre seeing more evidence of genes being conserved in widely different organisms, Quatrano said. This collaboration is a perfect example of bringing two labs together that on the surface have nothing in common other than one protein and two people who were aware of the interests of the other. Its led to a significant contribution that hopefully will lead to further clues as to the function of presenilin.

With this study, the Kopan and Quatrano labs and others could use this outstanding plant model not only to understand some of the off target affects during Alzheimers Disease therapy, but to unravel novel interactions and pathways in plants.


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Contact: Tony Fitzpatrick
tony_fitzpatrick@wustl.edu
314-935-5272
Washington University in St. Louis
Source:Eurekalert

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