Navigation Links
Moss protein plays role in Alzheimer's disease
Date:2/8/2008

ued Kopans interest: He saw the potential of looking at the role of presenilin independent of Notch. Khandelwal and Chandu took the phenotype, switched out a mammalian form of presenilin into the phenotype, and rescued it. Similarly, inserting the moss gene in mammalian cells resulted in reversing some of the losses experienced by animal cells lacking presenilin function, testifying that the human and moss proteins had an evolutionary conserved function.

In the moss, they were very nearly interchangeable, Quatrano said. This suggested that presenilin has a role outside the Notch pathway and may provide clues in mammalian systems as to its primary role, independent of its substrate in mammalian cells.

We were amazed to realize that genes from moss and humans were not only structurally conserved but also shared similar functions, Khandelwal said.

Moonlighting protein in mammals

We spent a lot of time trying to find an activity of PS to circumvent cleavage of APP, which has been very difficult, Kopan said. Importantly, the human protein acted in plant cells even if its enzymatic activity was removed by mutation. We stumbled upon an observation that presenilin proteins in mammals can perform other functions besides the enzymatic ones, that is, outside its role as gamma secretase. Were now looking closely to define this moonlighting functions and determine their contribution to disease.

In moss, the mutant phenotypes suggest presenilin might play a role in signal gathering, cytoskeleton organization and/or cell wall composition and organization. Quatrano and Khandelwal are checking that out. Kopan, Chandu and others are searching for presenilins moonlighting activities in mammalian cells.

As a developmental biologist, my job is to translate the genetic code as if it were a manufacturers manual, and that is accomplished by gaining detailed understanding of genes and protein function, Kopan said. Un
'/>"/>

Contact: Tony Fitzpatrick
tony_fitzpatrick@wustl.edu
314-935-5272
Washington University in St. Louis
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Protein chatter linked to cancer activation
2. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
3. Researchers identify proteins involved in new neurodegenerative syndrome
4. Low levels of key protein may indicate pancreatic cancer risk
5. Structure of 450 million year old protein reveals evolutions steps
6. Scientists retrace evolution with first atomic structure of an ancient protein
7. Specific brain protein required for nerve cell connections to form and function
8. NIH awards researcher $1.5 million new innovator grant for fruit-fly studies of prion proteins
9. Interacting protein theory awaits test from new neutron analysis tools
10. Depression, aging, and proteins made by a virus may all play role in heart disease
11. Census of protein architectures offers new view of history of life
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... A new study shows that some shark species may be ... that may come with rising temperatures. , The Arctic today ... but it wasn,t always like that. Roughly 53 to 38 ... epoch, the Arctic was more similar to a huge temperate ... life, including ancestors of tapirs, hippo-like creatures, crocodiles and giant ...
(Date:7/9/2014)... penguins shows that the population is 3.79 million ... estimated. Adlie penguins have long been considered a ... effects of climate change and fishing in the ... researchers from Stony Brook University and University of ... regular monitoring of Adlie penguins across their entire ...
(Date:7/9/2014)... is one of the amphibians with the highest distribution ... areas of water where it comes into contact with ... Research carried out by the Spaniard Germn Orizaola from ... of these frogs have developed a defensive response to ... larger bodies if they co-exist with the crayfish. , ...
Breaking Biology News(10 mins):Shark teeth analysis provides detailed new look at Arctic climate change 2Shark teeth analysis provides detailed new look at Arctic climate change 3New study finds that Adélie penguin population is on the rise 2New study finds that Adélie penguin population is on the rise 3Frogs have developed rapid defences against the red swamp crayfish 2Frogs have developed rapid defences against the red swamp crayfish 3
... NEW YORK An article released today ... Associated with Illegally Imported Wildlife Products, from a ... Disease Control and Prevention (CDC), identified evidence of ... confiscated at several U.S. international airports, including John ...
... of California, San Francisco (UCSF) has signed an alliance ... SNY) to share expertise in diabetes research and identify ... both type 1 and type 2 diabetes. The ... UCSF labs with deep understanding of the biology of ...
... limited and their combustion in vehicle motors increases atmospheric ... as an alternative is on the rise. In the ... his team at the Technische Universitaet Muenchen have now ... conversion of biopetroleum from microalgae into diesel fuels. ...
Cached Biology News:Study establishes importance of tracking diseases associated with illegal wildlife trade 2Study establishes importance of tracking diseases associated with illegal wildlife trade 3UCSF, Sanofi collaborate to find new diabetes cures 2UCSF, Sanofi collaborate to find new diabetes cures 3Algae for your fuel tank 2
(Date:1/15/2014)... , "The interface is the device," Nobel laureate ... properties to be found at the junctures where ... world of nanotechnology, the interfaces between layers of ... in such high-tech favorites as spintronics, high-temperature superconductors, ...
(Date:1/15/2014)... January 15, 2014 Cynvenio, a cancer ... through the genomic analysis of tumor cells in the ... a web-based cancer decision support application powered by CollabRx, ... Cynvenio’s ClearID™ genomic test, Therapy Finder will provide breast ...
(Date:1/15/2014)... More than 5 million Americans are currently living ... will die with Alzheimer’s or another dementia, according to ... many Americans into looking for ways to improve their ... cognitive disorders. Jonathan Weisman, president of Biohack Pure, is ...
(Date:1/15/2014)... (PRWEB) January 15, 2014 Freeslate, ... solutions, today announced that Lupin Limited, one of India’s ... CM Protégé PharmD System for high throughput ... India, is focused on a wide range of quality, ...
Breaking Biology Technology:A deeper look at interfaces 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3
... , Latest Trends and Research ... Biotech Industry Scientists , , NEW ... Discovery, hosted by the Alzheimer,s Drug Discovery Foundation ... and development of innovative drugs targeting Alzheimer,s disease and related dementias, ...
... September 1 , - ... Suggesting the Need to Reconsider Approach to Management of,Lipids ... initiative (R3i) Foundation Presents Early,Findings From Unique Global Investigation ... Low levels of high-density lipoprotein cholesterol ...
... , , , , ... NVAX ) announced today favorable results from a Phase II ... vaccine candidate. The vaccine was well tolerated and induced robust ... These results continue to support the planned study in elderly adults ...
Cached Biology Technology:Alzheimer's Drug Discovery Foundation Hosts 10th International Conference on Alzheimer's Drug Discovery - September 14-15 2Alzheimer's Drug Discovery Foundation Hosts 10th International Conference on Alzheimer's Drug Discovery - September 14-15 3New Insights Link Low HDL-Cholesterol and Elevated Triglycerides With Coronary Heart Disease and Microvascular Complications in Patients at Goal for LDL-Cholesterol 2New Insights Link Low HDL-Cholesterol and Elevated Triglycerides With Coronary Heart Disease and Microvascular Complications in Patients at Goal for LDL-Cholesterol 3New Insights Link Low HDL-Cholesterol and Elevated Triglycerides With Coronary Heart Disease and Microvascular Complications in Patients at Goal for LDL-Cholesterol 4New Insights Link Low HDL-Cholesterol and Elevated Triglycerides With Coronary Heart Disease and Microvascular Complications in Patients at Goal for LDL-Cholesterol 5New Insights Link Low HDL-Cholesterol and Elevated Triglycerides With Coronary Heart Disease and Microvascular Complications in Patients at Goal for LDL-Cholesterol 6New Insights Link Low HDL-Cholesterol and Elevated Triglycerides With Coronary Heart Disease and Microvascular Complications in Patients at Goal for LDL-Cholesterol 7New Insights Link Low HDL-Cholesterol and Elevated Triglycerides With Coronary Heart Disease and Microvascular Complications in Patients at Goal for LDL-Cholesterol 8NOVAVAX Announces Positive Results for the Second Phase II Clinical Trial of its Trivalent Seasonal Influenza Virus-like Particle (VLP) Vaccine Candidate 2NOVAVAX Announces Positive Results for the Second Phase II Clinical Trial of its Trivalent Seasonal Influenza Virus-like Particle (VLP) Vaccine Candidate 3NOVAVAX Announces Positive Results for the Second Phase II Clinical Trial of its Trivalent Seasonal Influenza Virus-like Particle (VLP) Vaccine Candidate 4NOVAVAX Announces Positive Results for the Second Phase II Clinical Trial of its Trivalent Seasonal Influenza Virus-like Particle (VLP) Vaccine Candidate 5
AM100 is an aqueous-based, permanent mounting media designed for use with alkaline phosphatase and immunoperoxidase stained tissue sections....
...
... Fixation Buffer, used in conjunction with ... can be used to fix and ... staining of cytokines and other cytoplasmic ... been specially formulated for reducing non-specific ...
... polyclonal to JMJD2D ( Abpromise for ... Synthetic peptide conjugated to KLH derived ... Human JMJD2D.(Note: the amino acid sequence is ... Entrez Gene ID: 55693 ...
Biology Products: