Navigation Links
Moss protein plays role in Alzheimer's disease
Date:2/8/2008

Preventing Alzheimers from developing is a goal of Raphael Kopan, Ph.D., professor of molecular biology and pharmacology at the Washington University School of Medicine. The moss plant (Physcomitrella patens) studied in the laboratory of Ralph S. Quatrano, Ph.D., Spencer T. Olin Professor and chair of the WUSTL biology department on the Danforth Campus, might inch Kopan toward that goal. Heres how.

The gene presenilin in mammals provides the catalytic activity for an enzyme called gamma secretase, which cleaves, or cuts, important proteins Notch, Erb4 and the amyloid precursor protein (APP), all key components of communication channels that cells use to arbitrate functions during development. Two genes occur in mammals in which mutations cause an earlier onset of Alzheimers. One is APP, where a fragment of the protein accumulates in amyloid plaques, associated with the disease. Another common site for mutations is found in presenilin (PS) proteins. The enzyme gamma secretase contains PS and works to dispose of proteins stuck in the cellular membrane.

This enzyme with PS at its core mediates two cellular decisions. One is to cut APP and as a byproduct, generate the bad peptide associated with Alzheimers; the other is to cut the Notch protein in response to specific stimuli. Notch is then free to enter the nucleus of cells where it partakes in regulating normal gene expression. Without Notch activity, a mammal has no chance of living.

Notch is a part of short-range mammalian communication channel, and for years it has been known to have a working relationship with PS. However, Notch is absent in plant cells, and presenilin function in plants remained mysterious until Quatranos post-doctoral researcher, Abha Khandelwal, Ph.D., arrived at Washington University and was interested in understanding signal transduction in plants.

When I searched the literature, the plant signal transduction pathways were not very well do
'/>"/>

Contact: Tony Fitzpatrick
tony_fitzpatrick@wustl.edu
314-935-5272
Washington University in St. Louis
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Protein chatter linked to cancer activation
2. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
3. Researchers identify proteins involved in new neurodegenerative syndrome
4. Low levels of key protein may indicate pancreatic cancer risk
5. Structure of 450 million year old protein reveals evolutions steps
6. Scientists retrace evolution with first atomic structure of an ancient protein
7. Specific brain protein required for nerve cell connections to form and function
8. NIH awards researcher $1.5 million new innovator grant for fruit-fly studies of prion proteins
9. Interacting protein theory awaits test from new neutron analysis tools
10. Depression, aging, and proteins made by a virus may all play role in heart disease
11. Census of protein architectures offers new view of history of life
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2014)... Journal of Nutrition Education and Behavior (JNEB) announces the ... awards, which were presented at the Society for Nutrition ... Local to Global," in Milwaukee, Wisconsin, June 28 ... authors of the best article and best GEM published ... the JNEB Journal Committee and Board of Editors. ...
(Date:8/1/2014)... -- LiveScan Service Provider Binary Biometrics is pleased to welcome Kevin ... will improve its mobile service capabilities and add more daily appointments, which will ... service several new cities such as, but not limited to, Daytona ... Deltona , Edgewater , Holly ... Beach , Oak Hill , Orange City ...
(Date:7/31/2014)... of bigeye tuna movements in the northwestern Atlantic Ocean ... Research Center at the University of Massachusetts Amherst, found ... geographical range with pronounced north-south movements from Georges Bank ... area off Cape Hatteras southwest of Bermuda for foraging. ... to study one of the most important commercial tuna ...
Breaking Biology News(10 mins):Binary Biometrics, Founded by James Timothy White, Expands Services to 13+ Locations With the Addition of Owner/Operator Kevin Morris 2Binary Biometrics, Founded by James Timothy White, Expands Services to 13+ Locations With the Addition of Owner/Operator Kevin Morris 3Study of bigeye tuna in Northwest Atlantic uses new tracking methods 2Study of bigeye tuna in Northwest Atlantic uses new tracking methods 3
... Nov. 12, 2013 One of the most comprehensive ... today, demonstrating an unprecedented level of genetic variation that ... ovarian cancer. The study highlights potential new pathways for ... multiple disease sites may be required for effective targeted ...
... as clear as glass, or why bakers use sugar, even ... in the American Chemical Society,s (ACS,) latest Bytesize Science ... . "Everything that happens in the kitchen is science," ... of it, you,re going to have more power over your ...
... protein, they tend to eat a small amount at ... at dinner. New research presented today at The ... eating high protein sausage and egg-based breakfasts curbed hunger ... and syrup) or skipping breakfast, in 18-55-year-old women., ...
Cached Biology News:Clinical ovarian cancers display extensive genetic heterogeneity, study suggests multiple treatment 2Clinical ovarian cancers display extensive genetic heterogeneity, study suggests multiple treatment 3
(Date:8/1/2014)... 01, 2014 Chantel Lee ’15 and Eli ... 10 40-hour weeks with Dr. Juan Rodriguez, Professor of Physics, ... a common diabetic eye disease caused by changes in the ... and Eli accomplished is quite remarkable,” said Rodriguez. “They took ... when they started, and together carried it to near completion ...
(Date:8/1/2014)... August 01, 2014 This is a ... the Ammonium Bicarbonate industry in Global and China. The ... definitions, applications and industry chain structure. Global market analysis ... focus on history, developments, trends and competitive landscape of ... situation is also offered. , The report also focuses ...
(Date:8/1/2014)... MD (PRWEB) August 01, 2014 ... RFID Solutions provider, today officially announces the opening ... prestigious Boji Science Park, Baoshan District in Shanghai, ... Shanghai is under the management of Mr. Shen ... , In the past three years, RURO’s has ...
(Date:8/1/2014)... CHICAGO , Aug. 1, 2014 AACC, ... better health through laboratory medicine, unveiled an updated brand ... laboratory professionals adapt to the changing healthcare environment and ... insight to physicians, so patients get the care they ... make up AACC,s membership play an essential role in ...
Breaking Biology Technology:Two Centenary College Students Tackle Diabetic Retinopathy Research 2Ammonium Bicarbonate Market in Internations & Chinese Regions Research Analysis Now Available at DeepResearchReports.com 2Ammonium Bicarbonate Market in Internations & Chinese Regions Research Analysis Now Available at DeepResearchReports.com 3RURO Opens Office in Shanghai, China 2AACC Debuts Refreshed Brand Identity 2
... BioMarin Pharmaceutical,Inc. (Nasdaq: BMRN ) today announced that ... on February 27, 2009. Dr. Kakkis has,decided to leave his ... more of his time to personal endeavors related to rare diseases. ... for the foreseeable,future. , "I ...
... ANN ARBOR, Mich., Nov. 21 MichBio, the ... professionals,and service providers to its fourth annual Expo ... Rock Financial ShowPlace in Novi, MI. The ... bioscience industry professionals.,In addition, this year,s event attracted ...
... Eli Lilly and,Company (NYSE: LLY ) and ImClone ... completion of the previously announced tender offer,by Lilly,s wholly-owned subsidiary, ... price of $70.00 per share in cash. The,offer expired ... The depositary for the ...
Cached Biology Technology:BioMarin Announces the Planned Retirement of Dr. Emil Kakkis, Chief Medical Officer 2BioMarin Announces the Planned Retirement of Dr. Emil Kakkis, Chief Medical Officer 3BioMarin Announces the Planned Retirement of Dr. Emil Kakkis, Chief Medical Officer 4MichBio Expo Draws Nearly 500 Professionals; Career Day Raises Profile 2MichBio Expo Draws Nearly 500 Professionals; Career Day Raises Profile 3Lilly Completes Cash Tender Offer for ImClone Systems 2Lilly Completes Cash Tender Offer for ImClone Systems 3
Anti-Human IFN-Gamma Receptor Chain 2 (beta chain) [CD119], Rabbit serum, NON-neutralizing polyclonal antibody...
Anti-BAR Immunogen: Peptide of aa 3-21 from human Bar Available Date: 38226...
... the HECT protein, E6-AP and ... suggests that this E2 is ... of non-""N-end rule"" protein substrates ... proteins as well as the ...
Anti-Mouse D011.10 TCR, Biotin (Clone KJ1-26) (mouse IgG2a)...
Biology Products: