Navigation Links
Mosquito parasite may help fight dengue fever
Date:4/30/2009

Dengue fever is a terrible viral disease blighting many of the world's tropical regions. Carried by mosquitoes, such as Aedes aegypti, 40% of the world's population is believed to be at risk from the infection. What is more, previous exposure to other strains of the fever does not confer protection. In fact, subsequent infections are significantly worse, and can result in fatal dengue haemorrhagic fever. The lack of a functioning vaccine forced Scott O'Neill and Elizabeth McGraw to look for a more creative form of defence. Knowing that a parasite, Wolbachia pipientis, shortens the lifespan of host insects and could restrict dengue fever transmission by killing the insects before they can pass the infection on, O'Neill and his team successfully infected Ae. aegypti with a strain of the Wolbachia bacterium and shortened the mosquitoes' lifespan. But before insects carrying the bacterium can be released into the environment, the O'Neill and McGraw teams have to convince international governments that mosquitoes carrying the Wolbachia parasite could successfully limit transmission of the virus. McGraw and O'Neill had to find out how the bacterium affects the mosquito's physiology and behaviour and publish their results in the Journal of Experimental Biology on May 1 2009 at http://jeb.biologists.org.

Knowing that Wolbachia slows down some insects' activity and speeds up others, the team decided to test how the parasite affects Ae. aegypti as they age and the infection takes hold. Working with uninfected and infected mosquitoes produced by Conor McMeniman, Oliver Evans and Eric Caragata used a system designed by Craig Williams to film the activities of male and female mosquitoes as they aged to find how the bacteria affected the insects' activity levels. According to McGraw, the experiments generated a huge amount of video data, so Evans teamed up with Megan Woolfit and David Green to pipe the data to a cluster of workstations to track the insects' movements and analyse their activity levels.

After a year of experimental design, data collection and analysis, it was clear that the infected mosquitoes were more active than the uninfected insects. Most surprisingly, as the mosquitoes aged and the infection took hold, it did not increase their activity levels further.

Having found that the insects became more active in response to their bacterial lodgers, Craig Franklin joined the team to help measure the insects' CO2 production to find how their metabolic rates respond to the parasite. Again, the insects' metabolic rates were higher than those of the uninfected mosquitoes.

So why are the infected insects more active than the uninfected insects? McGraw says there are three possible explanations; the insects are living fast and dying young; the insects are hungrier and consume more energy in their constant search for food; or the bacteria somehow affect the insects' tissues to change their behaviour and increase their metabolic rate. McGraw suspects that the last explanation is the most likely.

Having shown that the activity levels of Wolbachia infected mosquitoes respond to the bacterium, McGraw and O'Neill are continuing to test how the infection affects the insects' biting behaviour and whether a Wolbachia infection can become established in Ae. aegypti populations to limit their lifespans. Ultimately, McGraw and O'Neill hope to release infected mosquitoes into afflicted regions of the world to limit dengue fever transmission, but only once they are sure that the insects will do no harm to the environment.


'/>"/>

Contact: Kathryn Knight
kathryn@biologists.com
44-122-342-5525
The Company of Biologists
Source:Eurekalert

Related biology news :

1. Advance in effort to fight malaria by tricking the mosquitos sense of smell
2. USDA Cooperative Agreement funds mosquito project at Rutgers
3. Earlier bites by uninfected mosquitoes boost West Nile deaths in lab mice
4. Researchers put the bite on mosquitoes
5. Netting mosquitoes to prevent malaria
6. Ayurvedic nightshade deadly for dengue mosquito
7. Pathway found that lets mosquitoes fatten up, slow down for winter
8. No more big stink: scent lures mosquitoes, but humans cant smell it
9. Mosquitoes create harmonic love song before mating, study finds
10. Hoarding rainwater could dramatically expand range of dengue-fever mosquito
11. Malaria immunity trigger found for multiple mosquito species
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/9/2016)... leader in attendance control systems is proud to announce the introduction of fingerprint attendance ... the right employees are actually signing in, and to even control the opening of ... ... ... Photo - ...
(Date:6/2/2016)... The Department of Transport Management (DOTM) of ... project, for the , Supply and Delivery of ... Infrastructure , to Decatur , ... Management Solutions. Numerous renowned international vendors participated in the tendering ... selected for the most compliant and innovative solution. The contract ...
(Date:5/24/2016)... Ampronix facilitates superior patient care by providing unparalleled technology to leaders of ... the latest premium product recently added to the range of products distributed by Ampronix. ... ... ... Medical Display- Ampronix News ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... ... its second eBook, “Clinical Trials Patient Recruitment and Retention Tips.” Partnering with experienced ... this eBook by providing practical tips, tools, and strategies for clinical researchers. , ...
(Date:6/23/2016)... Mass. , June 23, 2016   ... development of novel compounds designed to target cancer ... napabucasin, has been granted Orphan Drug Designation from ... the treatment of gastric cancer, including gastroesophageal junction ... stemness inhibitor designed to inhibit cancer stemness pathways ...
(Date:6/23/2016)... A person commits a crime, and the detective ... the criminal down. An outbreak of foodborne illness ... (FDA) uses DNA evidence to track down the bacteria that ... It,s not. The FDA has increasingly used a complex, cutting-edge ... illnesses. Put as simply as possible, whole genome sequencing is ...
(Date:6/23/2016)... Lawrence, MA (PRWEB) , ... June 23, 2016 ... ... the Peel Plate® YM (Yeast and Mold) microbial test has received AOAC Research ... test platform of microbial tests introduced last year,” stated Bob Salter, Vice President ...
Breaking Biology Technology: