Navigation Links
More than just a kinase: CDK6 in cancer
Date:8/13/2013

Cancer in humans is frequently associated with unusually high amounts of one or more proteins responsible for controlling the rate at which cells divide. As an example, excessive amounts of the cyclin-dependent kinase CDK6 are often found in types of cancer such as lymphoma. Together with a number of collaborators within Vienna and beyond, Karoline Kollmann of the University of Veterinary Medicine, Vienna (Vetmeduni) has now shown that CDK6 is part of a multiprotein complex that stimulates the production of one of the so-called INK4 family members (confusingly termed p16INK4a), which suppresses tumour growth. In other words, the cell has an inbuilt mechanism to help it cope with excessive amounts of CDK6.

The problems really start when p16INK4a is missing, as is frequently the case in lymphomas or leukaemias. Now the high levels of CDK6 are unchecked and so can lead directly to a stimulation of cell division. Furthermore, Kollmann and her colleagues showed that another CDK6-containing complex can also promote the production of an additional factor, known as VEGF-A, that increases the growth of blood vessels and thus ensures that the cells in the growing tumours are supplied with sufficient energy and oxygen to multiply. CDK6 is the first factor to be shown to be involved in regulating tumour growth while simultaneously helping to supply tumours with blood.

As its name implies, CDK6 is a kinase, i.e. it adds phosphate groups to other proteins and thereby alters their activity. In a further twist to the tail, the Vetmeduni scientists have shown that CDK6 can still exert its effects on p16INK4a and VEGF-A when it lacks its kinase activity: a mutant form of the CDK6 protein with the kinase function inactivated retains the ability to regulate expression of the p16INK4a and VEGF-A genes.

Veronika Sexl, Head of the Vetmeduni's Institute of Pharmacology and Toxicology, where the work was performed, notes the medical importance of her gr
'/>"/>

Contact: Susanna Kautschitsch
susanna.kautschitsch@vetmeduni.ac.at
43-125-077-1153
University of Veterinary Medicine -- Vienna
Source:Eurekalert

Page: 1 2

Related biology news :

1. Perception of fertility affects quality of life in young, female cancer survivors
2. New evidence that cancer cells change while moving throughout body
3. With early, obvious benefit of a targeted cancer drug, should expensive clinical testing continue?
4. Protein involved in nerve-cell migration implicated in spread of brain cancer
5. Breast cancer surgery linked to swollen arm syndrome
6. Cancer research implies future for personalized medicine, reduction in animal testing
7. Illinois scientists put cancer-fighting power back into frozen broccoli
8. Scientists learn how soy foods protect against colon cancer
9. Percentage of cancers linked to viruses potentially overestimated
10. Mechanism offers promising new approach for harnessing the immune system to fight cancer
11. HudsonAlpha and UAB researchers work to identify optimal treatments for ER+ breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2015)... 2015 Increasing adoption ... advancement to drive biometric systems market in ... According to a recently released TechSci ... ", biometric systems market in Saudi ... at CAGR of over 22% through 2020. The ...
(Date:4/13/2015)... 13, 2015 According to ... Biometrics Market Forecast & Opportunities, 2020", the global biometrics ... around 14% till 2020. The biometrics market is ... implementation and review of biometric management systems. The ... products with greater efficiency, are resulting in increasing ...
(Date:4/9/2015)... , April 9, 2015 Synaptics Inc. (NASDAQ: ... solutions, announced today that it will report financial results ... April 23, 2015, after the close of market. The ... and investors at 2:00 p.m. PT (5:00 p.m. ET), ... To participate on the live call, analysts and ...
Breaking Biology News(10 mins):Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2Synaptics to Report Third Quarter Results on April 23 2
... to two-thirds of Earth,s permafrost likely will disappear by ... quantities of carbon into the atmosphere, says a new ... for Research in Environmental Sciences. The ... to thaw in high latitudes from warming temperatures, which ...
... CHAMPAIGN, lll. University of Illinois animal sciences professor ... Prize in Agriculture. He shares the prize with James ... Wolf Prizes are awarded each year, with recipients in ... prize committee selected Lewin for his "highly significant discoveries" ...
... proteins in the blood of pregnant women that could be ... in discovery of biomarkers that seem to be specific enough ... a new study in ACS,s Journal of Proteome Research ... happens when an embryo does not attach normally inside the ...
Cached Biology News:Thawing permafrost likely will accelerate global warming 2Thawing permafrost likely will accelerate global warming 3Illinois professor awarded 2011 Wolf Prize in Agriculture 2
(Date:5/4/2015)... , May 4, 2015 /PRNewswire/ - The ... partners are pleased to announce the formation of ... on developing treatments for cancer that harness the ... represents a unique collaboration between the Children,s Hospital ... Research Institute, McMaster University, the Ontario Institute for ...
(Date:5/4/2015)... (PRWEB) May 04, 2015 Achieved primarily ... produces slides that boast 10 to 100x better detail ... the capabilities of all existing light microscopy methods, it ... micrographs were chosen as the frame of reference because ... , The goal from the earliest discovery days ...
(Date:5/4/2015)... 4, 2015 - New Massive ... students prepare for the United States Medical Licensing Examination ... scientific, technical and medical information products and services, announced ... Open Online Course) designed to help medical students prepare ... 1, the first and most daunting of the three ...
(Date:5/4/2015)... ALISO VIEJO, Calif. , May 4, 2015 /PRNewswire/ ... to eliminate preventable hospitalizations, has teamed with the ... effect of Sentrian technology on 1,000 patients with chronic ... nearly 13 million Americans and is the nation,s third ... plan members of CareMore Health System , a ...
Breaking Biology Technology:Turnstone Biologics Inc. to accelerate clinical and commercial translation of cancer immunotherapies 2Turnstone Biologics Inc. to accelerate clinical and commercial translation of cancer immunotherapies 3Elsevier's Free MOOC Prepares Med Students for Licensing Exam 2Elsevier's Free MOOC Prepares Med Students for Licensing Exam 3CareMore, Scripps Translational Science Institute, and Sentrian Launch Landmark Study of Remote Patient Monitoring for COPD Population 2CareMore, Scripps Translational Science Institute, and Sentrian Launch Landmark Study of Remote Patient Monitoring for COPD Population 3CareMore, Scripps Translational Science Institute, and Sentrian Launch Landmark Study of Remote Patient Monitoring for COPD Population 4CareMore, Scripps Translational Science Institute, and Sentrian Launch Landmark Study of Remote Patient Monitoring for COPD Population 5
... a three-year Phase II small business innovation research ... Institute for Environmental Health Sciences. , ,The grant ... for the measurement of low-dose, cumulative exposure to ... sensitive, inexpensive, rugged and suitable for studies involving ...
... heavy damage from Hurricane Charley, which threatened Tampa, Fla., ... Carolina. Source: Beau McCune. MADISON Insurance companies ... to speed claims processing for disaster victims. These companies ... process their portion of the $7.4 billion in losses ...
... argue about improvement. Motherhood, apple pie, the Packers, Badgers and ... apt to cause a fight after a few beers. Everyone ... things worse the next time. Einstein's theory of human nature ... defined insanity as doing the same things over and over ...
Cached Biology Technology:Wisconsins insurance companies use advanced IT to speed relief 2Wisconsins insurance companies use advanced IT to speed relief 3The Real World 2The Real World 3
... synthetic peptide whose sequence corresponds to residues 1-18 from rat rab ... terminus): M(1) - A - S - A - S - ... - R - D - A - A - D - ... neutralization and control experiments with the polyclonal antibody that reacts with ...
... RNA sequences from high throughput synthesis are new ... LC Sciences. These products provide a large number ... sequences delivered in a microtube as a mixture ... verified RNA sequence. This is a custom product ...
... gold standard for automated bioresearch: Developed ... applications • Based on decades of ... accessories designed for bioresearch • Holographic ... Versatility, reliability and ease-of-use • Pulsed ...
... Acuity is the complete enterprise microarray informatics platform ... analysis. Buy Acuity once and use it forever ... Tools for Quality Acuity has all the ... from your data, from quality control statistics and ...
Biology Products: