Navigation Links
More than a machine
Date:11/20/2012

be a useful way for us to think about targeting ribosomes for therapeutic purposes from an antiviral standpoint," said Whelan. "This is a way to think about interfering with rabies virus infection. There are no therapeutics for rabies infection."

The team screened protein constituents of the ribosome to see which ones might be involved in specialized protein synthesis. Studying the vesicular stomatitis virus, a rhabdovirus in the same family as the rabies virus, they found that its mRNAs depended on rpL40 but only 7 percent of host-cellular mRNAs did. Some of the cellular mRNAs that depend upon rpL40 were stress response genes.

Experiments in yeast and human cells revealed that a class of viruses, which includes rabies and measles, depended on rpL40 for replication.

"This work reveals that the ribosome is not just an automatic molecular machine but instead also acts as a translational regulator," said first author Amy Lee, who is now a post-doctoral researcher at the University of California, Berkeley.

The concept of targeting cellular functions such as protein synthesis for antiviral therapies is being explored by a number of research groups, but there are no drugs based on this.

"We think the principle is bigger than just this single protein," Whelan said. "Viruses have an uncanny way of teaching us new biology all the time."


'/>"/>
Contact: David Cameron
david_cameron@hms.harvard.edu
617-432-0441
Harvard Medical School
Source:Eurekalert

Page: 1 2

Related biology news :

1. These bots were made for walking: Cells power biological machines
2. New brain-machine interface moves a paralyzed hand
3. IU biologists offer clearer picture of how protein machine systems tweak gene expression
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/11/2015)... Curemark LLC, a privately held drug research ... Phase III double blind, randomized, placebo-controlled clinical trial to ... all children ages 3-8 with Autism. Previously, Curemark announced ... blinded clinical trial for CM-AT in children ages 3-8 ... enzyme chymotrypsin. This new trial will help determine whether ...
(Date:5/5/2015)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... mobile commerce market, reminds investors and media that  Mr. ...  at CARTES SECURE CONNEXIONS AMERICA 2015, held in ... The three-day conference is organized into a series of nine ... Global Fraud: Where is the Trust in Cyberspace? ...
(Date:4/20/2015)... Huntington Memorial Hospital is the first facility ... miniaturized, wireless monitoring sensor to manage heart failure (HF). ... FDA-approved heart failure monitoring device that has been proven ... to manage heart failure. The CardioMEMS HF ... pulmonary artery (PA) during a non-surgical procedure to directly ...
Breaking Biology News(10 mins):Curemark, LLC, Launches New Phase III Trial in Expanded Population of Children with Autism 2NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 2NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 3Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 2Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 3
... The founder of a public database that helps doctors ... decisions is the 2009 recipient of the March of ... field of genetic sciences. Roberta "Bonnie" Pagon, MD, ... of Medicine in Seattle, developed the Web site genetests.org ...
... have observed the initiation of a mass gathering and subsequent ... case, fish. The work, conducted using a novel imaging ... that vast oceanic fish shoals inhabit," the team writes in ... also confirms theories about the behavior of large groups of ...
... unveiled the evolutionary origin of the different chromosomal ... comprehensive comparison of the Agrobacterium sequence information with ... general model for how second chromosomes are formed ... Rhizobiaceae family, which also includes the benign, nitrogen-fixing ...
Cached Biology News:Roberta A. Pagon receives lifetime award in genetics from March of Dimes 2Team IDs genesis of mass migrations 2Team IDs genesis of mass migrations 3Evolutionary origin of bacterial chromosomes revealed 2
(Date:5/26/2015)... WORMS, GERMANY – May 26, ... GRA) announces that its manufacturing facility in Worms, ... from EXCiPACT™, an independent organization that certifies manufacturers, ... , All three Grace facilities that produce its ... gels have now received GMP certification, following the ...
(Date:5/26/2015)... May 26, 2015   Intrexon Corporation (NYSE: ... Gregory Frost , Ph.D., Senior Vice President and Head ... Global Healthcare Conference on Wednesday, June 3 rd , at ... New York City . About Intrexon ... Powering the Bioindustrial Revolution with Better DNA ™ to ...
(Date:5/26/2015)... , May 26, 2015   PDI , ... today announced that Oakwood Healthcare in ... the winning entry in Delivering the ... who display excellence in building collaborative relationships between ... in healthcare facilities.  Oakwood Healthcare,s ...
(Date:5/26/2015)... , May 26, 2015 Mr. Kevin ... family, thanks President Barack Obama and President ... the time of loss of Dr. Rongxiang Xu , ... and a leader ahead of his time, Dr. Xu,s commitment ... community leave a legacy that will not be forgotten. As ...
Breaking Biology Technology:CORRECTION: Grace European Facility Receives GMP Excipient Certification for SYLOID® FP Silica Gel 2Intrexon to Present at the Jefferies 2015 Global Healthcare Conference 2PDI Announces Winner in Delivering the Difference Contest 2PDI Announces Winner in Delivering the Difference Contest 3Dr. Rongxiang Xu, Beyond A Legend 2
... Board of Directors of the Pittsburgh Life Sciences Greenhouse ... formation and business growth services to the region,s life ... of Peter M. DeComo as the new Chairman of ... will replace Dr. D. Lansing Taylor who is stepping ...
... hair-like blood vessels in the back of our eyes, researchers ... those that bring blood to the heart respond to air ... otherwise healthy people exposed to high levels of air pollution ... of heart disease. Previous studies linked pollution to heart ...
... In 2008, experiments at The Fu Foundation School of ... graphene, a single layer of graphite only one atom ... raised a question for Chris Marianetti, Assistant Professor in ... how and why does graphene break? ...
Cached Biology Technology:The Pittsburgh Life Sciences Greenhouse Announces New Chairman of the Board 2Photos of tiny blood vessels in the eye link air pollution to heart disease 2Columbia engineering team discovers graphene's weakness 2
... Ready-to-use liquid controls for monitoring Aldolase ... & abnormal) with targeted manufacturing values ... 20 ± 3 IU/L. 30-day ... at 2-8 C. Level 1: 3 ...
Request Info...
One-step, microplate or cuvet, colorimetric, linear detection range 0.2 mg/dL to 20 mg/dL. Procedure: 20 min....
Recombinant Mouse Noggin...
Biology Products: