Navigation Links
More than a machine
Date:11/20/2012

be a useful way for us to think about targeting ribosomes for therapeutic purposes from an antiviral standpoint," said Whelan. "This is a way to think about interfering with rabies virus infection. There are no therapeutics for rabies infection."

The team screened protein constituents of the ribosome to see which ones might be involved in specialized protein synthesis. Studying the vesicular stomatitis virus, a rhabdovirus in the same family as the rabies virus, they found that its mRNAs depended on rpL40 but only 7 percent of host-cellular mRNAs did. Some of the cellular mRNAs that depend upon rpL40 were stress response genes.

Experiments in yeast and human cells revealed that a class of viruses, which includes rabies and measles, depended on rpL40 for replication.

"This work reveals that the ribosome is not just an automatic molecular machine but instead also acts as a translational regulator," said first author Amy Lee, who is now a post-doctoral researcher at the University of California, Berkeley.

The concept of targeting cellular functions such as protein synthesis for antiviral therapies is being explored by a number of research groups, but there are no drugs based on this.

"We think the principle is bigger than just this single protein," Whelan said. "Viruses have an uncanny way of teaching us new biology all the time."


'/>"/>
Contact: David Cameron
david_cameron@hms.harvard.edu
617-432-0441
Harvard Medical School
Source:Eurekalert

Page: 1 2

Related biology news :

1. These bots were made for walking: Cells power biological machines
2. New brain-machine interface moves a paralyzed hand
3. IU biologists offer clearer picture of how protein machine systems tweak gene expression
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... racial and ethnic groups describe losing eyesight as ... life, more so than other conditions including: loss ... African-Americans, 49% of non-Hispanic whites, 43% of Asians ... or ailment is the worst that could happen ... by AIDS/HIV. Hispanics and Asians ranked cancer ...
(Date:9/18/2014)... Eight researchers from several disciplines will be celebrated tonight ... their roles in improving the health of premature infants ... supercomputing revolutions. The researchers, whose work was supported by ... and the former Atomic Energy Commission, will be honored ... Washington, DC. A bipartisan group of Members of Congress ...
(Date:9/18/2014)... of carbon and nitrogen comprise all spheres of ... systems have caused imbalances and perturbations that resulted ... Increased GHGs result in climate changes which influence ... and the atmosphere. Understanding these feedback mechanisms has ... environmental science during the past three decades. , ...
Breaking Biology News(10 mins):Americans rate losing eyesight as having greatest impact on their lives 2Americans rate losing eyesight as having greatest impact on their lives 33rd annual Golden Goose award ceremony honors 8 researchers; Unusual work had big results 2Greenhouse gas research enters a new era 2
... 19, 2010 -- A five-year follow up study in Bangladesh ... health for themselves, their families and even their neighbors. ... only the household from cholera, but reduces the incidence of ... results of this study appear in the inaugural issue of ...
... shows that nearly 1 in 5 cases of infection with ... by not one but multiple strains of the pathogen. ... Medical School report their findings today in the inaugural issue ... by the American Society for Microbiology. "Koch,s postulates are ...
... Center, researchers are working to provide solutions in developing countries ... Director David Sabatini, 1 billion people in the world do ... million deaths a year. Located within OU,s School of ... on Sabatini,s expertise in physiochemical processes for water treatment and ...
Cached Biology News:Sari cloth a simple sustainable protector from cholera 2Unexpectedly high rate of multiple strains in fungal infection 2OU WaTER Center researchers providing solutions in developing countries 2
(Date:9/18/2014)...  Neogen Corporation (Nasdaq: NEOG ) announced ... with Merck Animal Health to market Neogen,s Igenity ® ... Dairy Heifer Program consists of genomic tests that offer ... of replacement dairy heifers. The genomic tests can be ... an excellent tool in the decision-making process for breeding ...
(Date:9/18/2014)... , Sept. 18, 2014   Sigma-Aldrich ... it has entered into a new gene editing ... School,s Vector Core. Under the partnership, Sigma-Aldrich will ... experimental design consultation, and dedicated gene editing bioinformaticians. ... gene editing-based research at the U-M Medical School. ...
(Date:9/18/2014)... group of rare diseases that afflict skeletal growth ... hits at the fetal stage and is caused ... encoding fibroblast growth factor receptor 3 (FGFR3) has ... thanatophoric dysplasia (TD), a skeletal dysplasia that cause ... lethal, and achondroplasia (ACH), which causes stunted growth ...
(Date:9/18/2014)... microscopy technology that allows them to view single ... Dubbed "Complementation Activated Light Microscopy" (CALM), the new ... of magnitude finer than conventional optical microscopy, providing ... the nanometer scale. , In a paper published ... the researchers behind CALM used it to study ...
Breaking Biology Technology:Merck Animal Health to market Neogen's dairy genomic program 2Sigma-Aldrich, University of Michigan Medical School Establish CRISPR Core Lab Partnership 2Sigma-Aldrich, University of Michigan Medical School Establish CRISPR Core Lab Partnership 3Sigma-Aldrich, University of Michigan Medical School Establish CRISPR Core Lab Partnership 4Researchers use iPS cells to show statin effects on diseased bone 2Researchers use iPS cells to show statin effects on diseased bone 3Scientists pioneer microscopy technique that yields fresh data on muscular dystrophy 2
... Inc. (OTC Bulletin Board: RGIN ) a ... of regenerative cell therapies to restore the health of ... will be represented by former U.S. Congressman Curt Weldon ... Summit, January 20-22, 2011, at the Renaissance Mumbai Convention ...
... group announced today preclinical results showing that MEDI-573, a ... shown to play a critical role in the development ... in the February 1 issue of Cancer Research ... Research), suggests that MEDI-573 inhibits multiple biological pathways related ...
... PITTSBURGH, Jan. 20, 2011 / PRNewswire / -- ... molecule disease-modifying treatments for Alzheimer,s, has closed on a $2.5 ... or more of its compounds to Investigational New Drug (IND) ... of the nation,s largest angel investing groups, and was syndicated ...
Cached Biology Technology:Former U.S. Congressman Curt Weldon to Represent Regenicin at 2011 Future of Financial Markets Conference in Mumbai 2Former U.S. Congressman Curt Weldon to Represent Regenicin at 2011 Future of Financial Markets Conference in Mumbai 3Investigational Compound Offers Novel Anti-IGF Approach To Inhibit Growth of Cancer Cells 2Investigational Compound Offers Novel Anti-IGF Approach To Inhibit Growth of Cancer Cells 3Cognition Therapeutics Completes $2.5M in Series A1 Financing to Advance Alzheimer's Disease Drug Treatment Program 2Cognition Therapeutics Completes $2.5M in Series A1 Financing to Advance Alzheimer's Disease Drug Treatment Program 3
... Alkaline Phosphatase, Calf Intestinal (CIAP), catalyzes the ... and ribo- and deoxyribonucleoside triphosphates. This enzyme ... of linearized cloning vector DNA by removing ... also be used for the dephosphorylation of ...
Trypsin (Pig Pancreas) (TPCK Treated, Highly Purified)...
100 adhesive strips....
Homo sapiens palladin...
Biology Products: