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More than 200 genes identified for Crohn's Disease
Date:12/13/2012

ed UK data provided by the Wellcome Trust Case Control Consortium (WTCCC), which includes genetic information of 1698 CD patients. The team's results were also replicated using independent US data provided by the American National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), which contains genetic information of 813 patients with CD.

Dr Maniatis said: "The discovery of so many additional genes for Crohn's and much more precise locations within the gene-regions was partly because of the highly informative genetic maps of the human genome that we have used in our approach to locating the genes involved."

He added: "The success of our work was also attributable to the fact that we were able to subdivide patients by disease presentation. Data stratification can help sort out the genetics, and before long genetics will be able to sort out patients".

The team have provided the first clear evidence that some clinical sub-groups of patients are likely to carry different risk genes and their study shows how with a sufficiently powerful method more genes can be found in small groups of patients.

Professor Dallas Swallow, a collaborator and co-author also from the UCL Research Department of Genetics, Evolution & Environment, said: "Some genes are likely to have a large effect and some small, but not all genes will act the same way in all patients. We can combine all this information with that obtained by others from examining cellular and molecular changes to sort this out. This will ultimately lead to more personalised strategies for treatment".


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Contact: Clare Ryan
clare.ryan@ucl.ac.uk
44-020-310-83846
University College London
Source:Eurekalert

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