Navigation Links
More than 200 genes identified for Crohn's Disease
Date:12/13/2012

ed UK data provided by the Wellcome Trust Case Control Consortium (WTCCC), which includes genetic information of 1698 CD patients. The team's results were also replicated using independent US data provided by the American National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), which contains genetic information of 813 patients with CD.

Dr Maniatis said: "The discovery of so many additional genes for Crohn's and much more precise locations within the gene-regions was partly because of the highly informative genetic maps of the human genome that we have used in our approach to locating the genes involved."

He added: "The success of our work was also attributable to the fact that we were able to subdivide patients by disease presentation. Data stratification can help sort out the genetics, and before long genetics will be able to sort out patients".

The team have provided the first clear evidence that some clinical sub-groups of patients are likely to carry different risk genes and their study shows how with a sufficiently powerful method more genes can be found in small groups of patients.

Professor Dallas Swallow, a collaborator and co-author also from the UCL Research Department of Genetics, Evolution & Environment, said: "Some genes are likely to have a large effect and some small, but not all genes will act the same way in all patients. We can combine all this information with that obtained by others from examining cellular and molecular changes to sort this out. This will ultimately lead to more personalised strategies for treatment".


'/>"/>

Contact: Clare Ryan
clare.ryan@ucl.ac.uk
44-020-310-83846
University College London
Source:Eurekalert

Page: 1 2

Related biology news :

1. Steroid hormone receptor prefers working alone to shut off immune system genes
2. Different genes behind same adaptation to thin air
3. METACARDIS: a European project that deciphers the genes of the gut microbiota
4. Corn: Many active genes - high yield
5. Algae held captive and genes stolen in crime of evolution
6. Mutations in genes that modify DNA packaging result in Facioscapulohumeral Muscular Dystrophy
7. Recent studies bring fossils and genes together to piece together evolutionary history
8. Honeybees harbor antibiotic-resistance genes
9. NIH researchers identify novel genes that may drive rare, aggressive form of uterine cancer
10. New genes discovered for adult BMI levels
11. Genes, depression and life satisfaction
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/19/2015)... Inc. (NASDAQ: NXTD ) ("NXT-ID" or the "Company"), ... market, announces its biometric payment technology, the Wocket® smart wallet ... on Washington DC,s Fox 5 News ... Next Great Thing", host Laura Evans calls the ... really big breakthrough in mobile payment.,  Award-winning ...
(Date:3/17/2015)... 2015 Emotient, the leader in facial ... general availability of Emotient Analytics , the ... of facial expressions. The system analyzes videos of ... and services. It delivers audience response metrics - ... as derived from facial evidence of emotional states. ...
(Date:3/12/2015)... 2015 IriTech, a leading iris based identity ... Texas Instruments Design Network, announced today that the Chief ... IriShield USB MK2120U device during a launching event of ... The iris scanner is manufactured by ... India through its Indian partner, ...
Breaking Biology News(10 mins):NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 2NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 3New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 2New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 3New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 4Indian States See IriTech's Scanner Bolstering Efficiency of Authentication for Aadhaar 2Indian States See IriTech's Scanner Bolstering Efficiency of Authentication for Aadhaar 3
... League Baseball pitchers indicates that the height of the pitchers ... lead to potential injuries because of stress on the shoulder ... William Raasch, M.D., associate professor of orthopaedic surgery at the ... head team physician for the Milwaukee Brewers. Major League Baseball ...
... Walker is taking on one of the biggest killers in ... battle to save lives, especially the lives of children., With ... Walker will lead a research team studying how insecticide-treated bed ... causes the deadly disease, as well as the mosquito that ...
... many researchers have believed women choose partners based ... a new study from The University of Texas ... by their own attractiveness. David Buss, psychology ... in Attractive Women Want it All: Good Genes, ...
Cached Biology News:Study finds pitching mound height affects throwing motion, injury risk 2Netting mosquitoes to prevent malaria 2Do attractive women want it all? 2
(Date:3/25/2015)... SHANGHAI , CAMBRIDGE, Mass. and ... -- WuXi NextCODE, which provides comprehensive capabilities for using the ... deCODE genetics on their publication of the largest studies of ... published today online in Nature Genetics ... date of sequence variation, authored by a team of deCODE ...
(Date:3/25/2015)... Fla. , March 25, 2015  Point-of-Care ... and management consulting firm, has launched the ePrescribing ... to simplify tracking of ePrescribing regulatory requirements in ... "The ePrescribing regulatory landscape continues to change rapidly, ... deliver what the industry, and ultimately patients, need," ...
(Date:3/25/2015)... Having added two International locations in Brisbane and ... Global proudly announced recently the organization’s expansion into Poland. ... in the United States, is one of the largest ... real estate. , Saltwood International is the ... advises occupiers of office space, ensuring that its corporate ...
(Date:3/25/2015)... LOUIS and the HAGUE, Netherlands ... of two-year results of LES Stimulation therapy for chronic ... the journal Surgery [ Surgery . ... efficacy of its minimally-invasive therapy. The ... average duration of 11 years and taking prescribed daily ...
Breaking Biology Technology:Landmark deCODE Studies Demonstrate the Power of Truly Big Genomics for Improving Medicine Worldwide 2Point-of-Care Partners Launches the ePrescribing State Law Capsule 2International Organization Expands its Global Reach to Warsaw, Poland 2EndoStim LES Stimulation therapy demonstrates long term safety and efficacy results in treating reflux patients 2EndoStim LES Stimulation therapy demonstrates long term safety and efficacy results in treating reflux patients 3
... EST, WALTHAM, Mass., Jan. 31 Repligen Corporation,(Nasdaq: ... and Chief,Executive Officer, Walter C. Herlihy, Ph.D., will host ... at 11:00 a.m. EST, to report,third quarter fiscal year ... the Company., This call is being webcast by ...
... siRNA, to Identify 273 Human Proteins Needed for Reproduction of ... ... AIDS, WALTHAM, Mass., Jan. 31 Thermo Fisher,Scientific Inc., the ... has enabled a groundbreaking study,at Harvard Medical School in Boston, which ...
... 8:30 a.m. EST at ... http://www.isispharm.com , ... ) announced today that Abbott is,investing up to $40 million in ... further develop the Ibis T5000(TM),Biosensor System, which offers a unique solution ...
Cached Biology Technology:Repligen Announces Conference Call of Third Quarter Fiscal Year 2008 Results 2Repligen Announces Conference Call of Third Quarter Fiscal Year 2008 Results 3Research Using Thermo Fisher Scientific RNA-Interference Technology Unveils Potential New Targets for HIV Drugs 2Research Using Thermo Fisher Scientific RNA-Interference Technology Unveils Potential New Targets for HIV Drugs 3Research Using Thermo Fisher Scientific RNA-Interference Technology Unveils Potential New Targets for HIV Drugs 4Research Using Thermo Fisher Scientific RNA-Interference Technology Unveils Potential New Targets for HIV Drugs 5Isis Announces Equity Investment in Ibis Biosciences Subsidiary by Abbott; Option Acquired to Purchase Remaining Ibis Equity 2Isis Announces Equity Investment in Ibis Biosciences Subsidiary by Abbott; Option Acquired to Purchase Remaining Ibis Equity 3Isis Announces Equity Investment in Ibis Biosciences Subsidiary by Abbott; Option Acquired to Purchase Remaining Ibis Equity 4
Special grade: for electrophoresis...
Collected from animals that are 16 to 18 months old. Sterile, Cell culture tested, ID clarifier: USA Origin...
This device is designed to run four simultaneous separations with the following StemSep ; column sizes: 0.3in., 0.5in., and 0.6in.. Depending on the column size, a range of 2x10 7 - 1.5 x 10 9 cell...
Contact us for more information...
Biology Products: