Navigation Links
More power to the cranberry: Study shows juice better than extracts at fighting infections
Date:10/28/2011

Worcester, Mass. -- With scientific evidence now supporting the age-old wisdom that cranberries, whether in sauce or as juice, prevent urinary tract infections, people have wondered if there was an element of the berry that, if extracted and condensed, perhaps in pill form, would be as effective as drinking the juice or eating cranberry sauce. A new study from researchers at Worcester Polytechnic Institute (WPI) helps to answer that question.

The study tested proanthocyanidins or PACs, a group of flavonoids found in cranberries. Because they were thought to be the ingredient that gives the juice its infection-fighting properties, PACs have been considered a hopeful target for an effective extract. The new WPI report, however, shows that cranberry juice, itself, is far better at preventing biofilm formation, which is the precursor of infection, than PACs alone. The data is reported in the paper "Impact of Cranberry Juice and Proanthocyanidins on the Ability of Escherichia coli to Form Biofilms," which will be published on-line, ahead of print on Oct. 31, 2011, by the journal Food Science and Biotechnology.

"What we have shown is that cranberry juice's ability to prevent biofilms is more complex than we may have originally thought," said Terri Camesano, professor of chemical engineering at WPI and senior author on the paper. "For a while, the field focused on these PACs, but the data shows that they aren't the silver bullet."

Camesano's lab explores the mechanisms that the virulent form of E. coli bacteria, the primary cause of most urinary tract infections (UTIs) in people, uses to form biofilms. This strain of E. coli is covered with small hair-like projections known as fimbriae that act like hooks and latch onto cells that line the urinary tract. When enough of the virulent bacteria adhere to cells, they form a biofilm and cause an infection. Previous work by Camesano's lab has shown that exposure to cranberry juice causes the fimbriae on E. coli to curl up, reducing their ability to attach to urinary tract cells.

In the new study, Camesano's team, which included graduate student Paola Andrea Pinzn-Arango and intern Kerrie Holguin, incubated two different strains of E. coli in the presence of two different mixtures of commercially available cranberry juice cocktail. They also incubated the bacteria separately in the presence of PACs, but not juice. While the juice cultures completely prevented biofilm formation, the PACs showed only limited ability to reduce biofilm formation, and only after extended exposure to the E. coli.

"Cranberries have been recognized for their health benefits for a number of years, especially in the prevention of UTIs," the authors write in the new paper. "While the mechanisms of action of cranberry products on bacterial adhesion and biofilm formation are not fully understoodthis study shows that cranberry juice is better at inhibiting biofilm formation than isolated A-type cranberry flavonoids and PACs, although the reasons for this are not yet clear."


'/>"/>
Contact: Michael Cohen
mcohen@wpi.edu
508-868-4778
Worcester Polytechnic Institute
Source:Eurekalert  

Related biology news :

1. Academy of Natural Sciences receives Green Power award
2. DigitalPersona Goes Mobile with New U.are.U 5100 Fingerprint Sensors for Battery-Powered Mobile ID Devices
3. NJIT alum, power expert, advisor during Exxon/Valdez clean-up, gets award
4. Researchers realize high-power, narrowband terahertz source at room temperature
5. Powerful antibody-based strategy suggests a new therapeutic approach to diabetes and obesity
6. The greatest human strength? Believe it or not, its willpower
7. Over the hump: Ecologists use power of network science to challenge long-held theory
8. Power corrupts, especially when it lacks status
9. More evidence that spicing up broccoli boosts its cancer-fighting power
10. New insight in how cells powerhouse divides
11. Powerful antioxidant resveratrol prevents metabolic syndrome in lab tests: U of A study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
More power to the cranberry: Study shows juice better than extracts at fighting infections
(Date:6/16/2016)... , June 16, 2016 ... size is expected to reach USD 1.83 billion ... Grand View Research, Inc. Technological proliferation and increasing ... applications are expected to drive the market growth. ... , The development of advanced multimodal ...
(Date:6/7/2016)... -- Syngrafii Inc. and San Antonio Credit Union (SACU) ... Syngrafii,s patented LongPen™ eSignature "Wet" solution into SACU,s ... in greater convenience for SACU members and operational ... document workflow and compliance requirements. Logo ... Highlights: ...
(Date:6/2/2016)... , June 2, 2016 Perimeter ... Platforms, Unmanned Systems, Physical Infrastructure, Support & Other Service  ... visiongain offers comprehensive analysis of the global ... market will generate revenues of $17.98 billion in 2016. ... DVTEL Inc, a leader in software and hardware technologies ...
Breaking Biology News(10 mins):
(Date:12/2/2016)... ... December 01, 2016 , ... Aerocom Healthcare ( http://www.aerocomhealthcare.com ), ... present its chain-of-custody solution for tracking and securing medications at booth 676 at ... 2016. , Aerocom has a proven solution for tracking medications via its system ...
(Date:12/2/2016)... ... December 02, 2016 , ... ... and biotechnology companies dedicated to collaboratively developing improved chemistry, manufacturing and control ... vendor-supported, portable online UHPLC, with robust, probe-based sampling. , Online liquid ...
(Date:11/30/2016)... ... November 30, 2016 , ... BEI Kimco, a brand of ... flexure design that ensures high alignment accuracy by preventing unwanted shaft rotation. The ... where extreme precision is required, such as in medical equipment, laboratory instrumentation, clean ...
(Date:11/30/2016)... Nov. 30, 2016  The Allen Institute for ... the first publicly available collection of gene edited, ... target key cellular structures with unprecedented clarity. Distributed ... powerful tools are a crucial first step toward ... understand what makes human cells healthy and what ...
Breaking Biology Technology: