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More findings on gene involved in childhood asthma
Date:9/15/2008

Hospital network, the study team analyzed DNA from 807 white children with asthma, compared to 2,583 white children without the disease. Another cohort consisted of African American children, of whom 1,456 had asthma and 1,973 were healthy controls. The researchers used highly automated gene-scanning equipment at Children's Hospital's Center for Applied Genomics, the largest pediatric genotyping program in the world.

"Because asthma is a very heterogeneous disease, the genes involved in childhood-onset asthma may be very different from those involved in asthma that first appears in adults," said Hakonarson. "Furthermore, the biological mechanisms by which genetic variants contribute to asthma are not well understood. However, we will continue our investigations, to shed light on how we might use genetic knowledge to develop more effective treatments for this common disease. These treatments will be a form of personalized medicine, better tailored to the genetic makeup of the individual patient."


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Contact: John Ascenzi
Ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia
Source:Eurekalert

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