Navigation Links
More evidence that melanoma does not conform to the cancer stem cell model
Date:11/15/2010

bottom of the hierarchy can't," Morrison said. However, the Morrison laboratory was unable to find any subset of melanoma cells that lacked the ability to form tumors.

"In our model, all these cells can form tumors," he said. "And they're phenotypically different from each other not because they're hierarchically organized but because they're just turning these surface markers on and off."

The U-M team found that all tumor-forming melanoma cells gave rise to progeny with a variety of marker patterns, and that all of those sub-populations retained the ability to form tumors. The marker changes appeared to be reversible, rather than being associated with a transition from tumor-forming to non-tumor-forming states, as the cancer stem cell model would predict.

The Cancer Cell paper follows up on work reported by the Morrison lab in the Dec. 4, 2008, edition of the journal Nature. The Nature article demonstrated that tumor-forming melanoma cells are not rare, as predicted by the cancer stem cell model. The researchers determined that at least one-quarter of melanoma cells have the ability to form new tumors.

Melanoma kills more than 8,000 Americans each year. The human melanoma cells used in this study were provided---with the patients' permission---from the U-M's Multidisciplinary Melanoma Program, one of the country's largest melanoma programs and part of the U-M Comprehensive Cancer Center.

"These new findings significantly advance our understanding of melanoma," said cutaneous oncologist Dr. Timothy Johnson, director of the U-M melanoma program and a co-author of the Cancer Cell paper.

"This type of groundbreaking discovery achieves our core objective of combining clinical studies with laboratory research to develop new and better treatments for optimal patient care," Johnson said.


'/>"/>

Contact: Jim Erickson
ericksn@umich.edu
734-647-1842
University of Michigan
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Evidence is weak for tropical rainforest 65 million years ago in Africas low-latitudes
2. New evidence that fat cells are not just dormant storage depots for calories
3. Oldest evidence of dinosaurs found in Polish footprints
4. Researchers find first genetic evidence for loss of teeth in the common ancestor of baleen whales
5. Marine animals suggest evidence for a trans-Antarctic seaway
6. Animal bone markings show evidence that Lucy species used stone tools, ate meat
7. Scientists discover oldest evidence of human stone tool use and meat-eating
8. Scientists find new evidence of genetically modified plants in the wild
9. Scientists find the first evidence of genetically modified plants in the wild
10. Body of evidence: New fast, reliable method to detect gravesoil
11. Lack of access to evidence-based HIV prevention and care is a fundamental violation of human rights
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... 2014 Research and Markets ( ... "iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 ... their offering. http://photos.prnewswire.com/prnh/20130307/600769 ... in July 2012, Apple introduced the fingerprint reading ... the only device of Apple incorporating such a ...
(Date:12/19/2014)... 2014   LaunchKey , the first decentralized mobile ... Internet of Things era, today announced the close of ... was led by Metamorphic Ventures with participation from ENIAC ... and others.  LaunchKey has raised $4 million to date, ... team and bring LaunchKey to market in 2015. ...
(Date:12/17/2014)... Dec. 15, 2014  HITLAB SM announced ... (GCP) audit to confirm its adherence to current ... accomplishment enables HITLAB to conduct regulated smart device ... principles for patient safety and research quality. ... access, quality, and delivery with innovative technology," said ...
Breaking Biology News(10 mins):iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2
... the first time, demonstrated that mercury concentrations in fish respond ... The international teams research began in 2001 at the ... weeks Proceedings of the National Academy of Sciences. Up ... because of all the other factors that affect mercury levels ...
... have determined the three-dimensional structure of an unusual viral ... viruses. The Paramecium bursaria chlorella virus infects a ... cells. Once inside the chlorella, the virus DNA makes ... structural proteins that are assembled to create the outer ...
... smoking-cessation drug will enable you to quit smoking may ... from the Centre for Addiction and Mental Health (CAMH). ... journal Biological Psychiatry, found that the enzyme known to ... is highly genetically variable in all ethnicities and influences ...
Cached Biology News:International team shows mercury concentrations in fish respond quickly to increased deposition 2Scientists learn structure of enzyme in unusual virus 2New genetic research into nicotine addiction shows promise for personalized treatment 2
(Date:12/24/2014)... 2014 Earlier this year in a ... director of the Adult Stem Cell Technology Center, LLC ... and under appreciated unique property of adult tissue stem ... Cells: Misunderstood in the Past, Important for the Future,” ... He gave the address at the 4th World ...
(Date:12/24/2014)... Tenn. (PRWEB) December 23, 2014 Nashville ... was elected treasurer for the American Society for ... advancing knowledge and research in reproductive medicine. In ... a seat on the executive board and will have ... , Dr. Hill has actively supported ASRM since 1984 ...
(Date:12/24/2014)... PharmaBoardroom,s new report, , ... available for free download , digs deep into this ... in the sector today. One area where ... in developing a homegrown pharmaceutical manufacturing base, even if the ... some way off. A cursory comparison with neighboring ...
(Date:12/22/2014)... 22, 2014   Synthetic Biologics, Inc. ... pathogen-specific therapies for serious infections and diseases, ... today announced positive topline safety and tolerability ... of SYN-004, the Company,s investigational oral beta-lactamase ... difficile (C. difficile) infection, antibiotic-associated diarrhea ...
Breaking Biology Technology:Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 2Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 3Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 4Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 2Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 3PharmaBoardroom Releases New Algeria Pharmaceuticals Report 2PharmaBoardroom Releases New Algeria Pharmaceuticals Report 3Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 2Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 3Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 4Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 5
... Viragen, Inc. (OTC,Bulletin Board: VRAI) and its ... VRGE), today jointly announced,that Viragen International,s wholly-owned ... an application seeking protection under the,bankruptcy laws ... alpha interferon. The bankruptcy application was ...
... at 10:30 ET, 7:30 PT, EMERYVILLE, Calif., Sept. ... today announced its financial,results for its fiscal fourth quarter ... 1-for-7 reverse split of its common stock. For ... million, a,44% increase over last year,s revenue of $12.3 ...
... Germany, Sept. 14 Indivumed announces today,that a ... Within,this agreement Indivumed will apply its automated immunohistochemistry,service ... in the,area of oncology. Indivumed will provide for ... its tumor biobank as well as specifically,collected clinical ...
Cached Biology Technology:Viragen International's Subsidiary, ViraNative AB, Files to Seek Bankruptcy Protection in Sweden 2Neurobiological Technologies, Inc. Reports Fourth Quarter and Fiscal Year-End Financial Results for 2007 Announces 1-for-7 Reverse Stock Split 2Neurobiological Technologies, Inc. Reports Fourth Quarter and Fiscal Year-End Financial Results for 2007 Announces 1-for-7 Reverse Stock Split 3Neurobiological Technologies, Inc. Reports Fourth Quarter and Fiscal Year-End Financial Results for 2007 Announces 1-for-7 Reverse Stock Split 4Neurobiological Technologies, Inc. Reports Fourth Quarter and Fiscal Year-End Financial Results for 2007 Announces 1-for-7 Reverse Stock Split 5Neurobiological Technologies, Inc. Reports Fourth Quarter and Fiscal Year-End Financial Results for 2007 Announces 1-for-7 Reverse Stock Split 6