Navigation Links
More evidence that melanoma does not conform to the cancer stem cell model
Date:11/15/2010

Sciences Institute, and Mark Shackleton, formerly with the Morrison lab and now at the Peter MacCallum Cancer Center in Melbourne, Australia.

The study found that tumor-forming melanoma cells have the ability to throw a genetic switch that changes the types of proteins expressed on the cells' surface. The study is the first to present evidence for this type of pervasive "phenotypic plasticity" among melanoma cells from patients.

Patterns of surface proteins are used to identify different cell types and are commonly called cell surface markers.

"The fact that these markers are turned on and off by melanoma cells raises the possibility that melanoma cells may also turn on and off genes that regulate clinically important characteristics like drug resistance and metastatic ability," Morrison said. "The ability to transition between various states may make melanoma more difficult to treat."

The authors stress that while their results argue against a cancer stem cell model for melanoma, their findings do not invalidate the model. In fact, certain leukemias and other cancers appear to follow the model.

"It will be critical to determine which cancers follow a stem cell model and which do not, so therapies designed to target rare sub-populations of cells are not inappropriately tested in patients whose disease is driven by many diverse cancer cells," Quintana said.

The cancer stem cell model assumes that cells differing in marker expression also differ in function, and that only a very small subset of cancer cells displaying the critical marker pattern---less than 1 percent of cancer cells---can form tumors. The model proposes that most of the cancer cells that compose tumors have little or no capacity to proliferate or to contribute to disease progression.

"The cancer stem cell model says that tumor cells are organized hierarchically, and that only the cells at the top of the hierarchy form tumors. Cells at the
'/>"/>

Contact: Jim Erickson
ericksn@umich.edu
734-647-1842
University of Michigan
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Evidence is weak for tropical rainforest 65 million years ago in Africas low-latitudes
2. New evidence that fat cells are not just dormant storage depots for calories
3. Oldest evidence of dinosaurs found in Polish footprints
4. Researchers find first genetic evidence for loss of teeth in the common ancestor of baleen whales
5. Marine animals suggest evidence for a trans-Antarctic seaway
6. Animal bone markings show evidence that Lucy species used stone tools, ate meat
7. Scientists discover oldest evidence of human stone tool use and meat-eating
8. Scientists find new evidence of genetically modified plants in the wild
9. Scientists find the first evidence of genetically modified plants in the wild
10. Body of evidence: New fast, reliable method to detect gravesoil
11. Lack of access to evidence-based HIV prevention and care is a fundamental violation of human rights
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/11/2014)... 10, 2014  Data Sciences International (DSI), the ... a new series of digital telemetry implants to ... M series, part of the PhysioTel™ Digital platform, ... possible physiologic data when incorporating functional endpoints into ... to toxicology studies has evolved from short ECG ...
(Date:12/10/2014)... DIEGO , Dec. 9, 2014 CIE ... collaboration catalyst that provides the connective tissue that enhances ... enabling them to easily share client-level information; earned a ... to expand to organizations serving seniors aging in community ... Diego" partner on December 11 th 4-6p. ...
(Date:12/5/2014)... , Dec. 4, 2014  Tute Genomics, a ... $2.3 million in Series A1 funding led by UK-based ... also participated in the investment round. "We ... healthcare community adopts next-generation sequencing and seeks new approaches ... Reid Robison , MD MBA, and CEO of ...
Breaking Biology News(10 mins):New telemetry implants expected to change how large animal toxicology studies are conducted 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 4Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 2Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 3
... at four major genomics and plant pathology laboratories in ... causative agent of "black rot" disease, which is the ... which represents the largest comparative and functional genomics screen ... is published online today in the journal Genome Research. ...
... the toxins that cause paralytic shellfish poisoning (PSP), but scientists ... protection. PSP toxins interfere with nerve function, and the mutation, ... makes nerves less sensitive to those toxins. , The discovery ... Nature. The authors suggest that it has wide ranging implications ...
... especially when it comes to the vaccine description; be sure ... want to understand what the vaccine is about. , ... The European Vaccine Effort against HIV/AIDS today announced that a ... and NYVAC-HIV-C for the prevention of HIV infection has started ...
Cached Biology News:Scientists identify genes responsible for 'black rot' disease in vegetables 2Mutation in clams protects against paralytic shellfish poisoning but raises human health risk 2'EuroVacc 02' HIV Vaccine Trial Begins 2'EuroVacc 02' HIV Vaccine Trial Begins 3
(Date:12/22/2014)... Dec. 22, 2014  Alternative Energy & Environmental ... has signed a letter of intent to acquire ... and patented a nanotechnology-based development platform used to ... enable rapid on-site collection and testing to identify ... issues in an immediate, non-invasive and cost-effective manner. ...
(Date:12/22/2014)...  ( www.competitivehealth.com ) — Competitive Health is pleased ... and advocacy service, has signed an agreement to become ... health services marketplace. 63% of Americans have ... expected to pay. As part of an ongoing effort ... is pleased to offer medical bill review and negotiation ...
(Date:12/22/2014)... 22, 2014 ITRA Global, one of ... of commercial real estate, has further expanded its global ... Perth and Brisbane, Western Australia, reports Mylinda Vick, CCIM, ... ITRA Global / ACORPP (Australian Corporate Property and ... company providing property services to a wide range of ...
(Date:12/19/2014)... Hershey, PA (PRWEB) December 19, 2014 ... a leading developer and manufacturer of needle-free injection ... an agreement with Immunomic Therapeutics, Inc. (“ITI”) for ... injection device with its LAMP™ vaccine platform. ... for an exclusive Worldwide license to the Biojector®-2000 ...
Breaking Biology Technology:ALNE Announces Intention To Acquire BioTechPharma 2WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2ITRA Global Continues International Expansion in Perth and Brisbane, Australia 2Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 2Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 3
... Economic Summit served its purpose by fading away. , ... place between 2000 and 2003 were unsuccessful; on the ... state's growth. But once those general themes were pinpointed, ... them, the Wisconsin Economic Summit needed to give way ...
... - There is nothing that could have been done ... Thursday. But thanks to technology, warning systems for such storms ... F3-grade tornadoes that swept through the south central and western ... of tornadoes here in one day and, undoubtedly, took many ...
... rules, the manufacturer's product going straight to the lap of the ... a roofer or a big business, a single-item purchase is sufficient. ... no costly structures, no bureaucracies and no extra hoards of people ... cheap -- it just takes one call and one quick delivery. ...
Cached Biology Technology:Forum builds on the work of the Wisconsin Economic Summit 2Forum builds on the work of the Wisconsin Economic Summit 3Tornadoes put technology to work 2Tornadoes put technology to work 3Tornadoes put technology to work 4Move over B2B, B2C -- it's M2E time 2Move over B2B, B2C -- it's M2E time 3
...
... of systems provide fast and reliable scalable ... proteomics and drug development laboratories. Staccato systems ... Workstation Series, Application Series and Custom Systems ... a remarkably compact system for performing ELISA ...
... low-vibration filter/fan unit provides continuous vertical flow ... 100 (ISO 5) cleanliness standards , ... clean and disinfect , Large, ... to allow insertion of filling machines or ...
... provides a safe, clean environment for ... accord with USP-797 requirements. HEPA filtration ... cleanliness conditions in the work area. ... tilt-up front panel for easy access ...
Biology Products: