Navigation Links
Montreal researchers find a link between pollutants and certain complications of obesity
Date:2/27/2014

Montral, February 27, 2014 A team of researchers at the IRCM in Montral led by Rmi Rabasa-Lhoret, in collaboration with Jrme Ruzzin from the University of Bergen in Norway, found a link between a type of pollutants and certain metabolic complications of obesity. Their breakthrough, published online this week by the Journal of Clinical Endocrinology & Metabolism, could eventually help improve the prevention, diagnosis, and treatment of cardiometabolic risk associated with obesity, such as diabetes, hypertension and cardiovascular disease.

Although obesity is strongly linked to insulin resistance and type 2 diabetes, a subset of obese individuals, termed "metabolically healthy but obese", appears relatively protected from the development of such cardiometabolic complications. IRCM researchers are studying the factors that seem to protect obese individuals who remain metabolically healthy, in an attempt to find therapeutic avenues to prevent complications for others who are at risk.

"Recently, persistent organic pollutants (POPs) have been found to accelerate the development of prediabetes and obesity in mice, thereby mimicking the unfavourable cardiometabolic profile characteristic of certain obese individuals," says Rmi Rabasa-Lhoret, MD, PhD, endocrinologist and Director of the Metabolic Diseases research unit at the IRCM. "As a result, the aim of our study was to test whether metabolically healthy but obese individuals have lower circulating levels of POPs than obese individuals with cardiometabolic complications."

Persistent organic pollutants are man-made chemicals used in agricultural, industrial and manufacturing processes. Due to their toxicity, POPs have been strictly and internationally regulated to ensure public health. However, because they have the ability to resist environmental degradation, POPs can still be found all around the world, even in areas where they have never been used, and remain omnipresent in our environment and food products. Thus, virtually all humans are exposed to POPs daily.

"Exposure to POPs comes primarily from the environment and the consumption of food such as fatty fish, meat and milk products," explains Jrme Ruzzin, PhD, expert in the field of research on POPs. "One important characteristic of POPs is their lipid solubility, meaning they accumulate in the body's fatty tissues. As their name suggests, they are also persistent so the body cannot easily eliminate them. POPs can therefore have significant impacts on human health, and have been shown to affect reproduction, promote cancer, and be involved in the development of metabolic diseases."

IRCM researchers conducted a study of 76 obese women of similar age, body mass index and fat mass index, in which they analyzed the concentration of 21 POPs, as well as cardiometabolic risk factors. Among 18 detectable pollutants, the women with cardiometabolic complications had higher concentrations of 12 POPs.

"Remarkably, close to 70 per cent of the detectable POPs were significantly higher in individuals with cardiometabolic complications compared to metabolically healthy but obese subjects," adds Marie-Soleil Gauthier, PhD, co-first author of the study and research associate at the IRCM. "Our study confirms that the two groups have distinct POP profiles, and that metabolically healthy but obese individuals have significantly lower circulating levels of various classes of POPs than patients with complications. A better understanding of the role of POPs could lead to new directions for the prevention, diagnosis, and treatment of cardiometabolic risk associated with obesity."

"Although this study does not show a causal link, it suggests that pollutants found abundantly in our environment could promote the development of cardiometabolic diseases like diabetes," concludes Dr. Rabasa-Lhoret. "If future studies confirm this increased risk, such observations could have a significant impact on public health decisions because we will need to dramatically reduce our exposure to these pollutants."


'/>"/>

Contact: Julie Langelier
julie.langelier@ircm.qc.ca
514-987-5555
Institut de recherches cliniques de Montreal
Source:Eurekalert

Related biology news :

1. Montreal researchers repel mortality in Malian mothers
2. University of Montreal researchers discover how drug prevents aging and cancer progression
3. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
4. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
5. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
6. UNH researchers find African farmers need better climate change data to improve farming practices
7. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
8. Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
9. Researchers print live cells with a standard inkjet printer
10. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
11. Researchers reveal how a single gene mutation leads to uncontrolled obesity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2016)... , May 24, 2016 Ampronix facilitates superior patient care by providing ...  3D medical LCD display is the latest premium product recently added to the range ... ... ... Sony 3d Imaging- LCD Medical Display- Ampronix News ...
(Date:5/3/2016)... , May 3, 2016  Neurotechnology, a ... the MegaMatcher Automated Biometric Identification System (ABIS) ... large-scale multi-biometric projects. MegaMatcher ABIS can process multiple ... using any combination of fingerprint, face or iris ... MegaMatcher SDK and MegaMatcher Accelerator , ...
(Date:4/19/2016)... The new GEZE SecuLogic access ... "all-in-one" system solution for all door components. It can ... door interface with integration authorization management system, and thus ... minimal dimensions of the access control and the optimum ... offer considerable freedom of design with regard to the ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... Md. , June 23, 2016 A person ... from the crime scene to track the criminal down. ... the U.S. Food and Drug Administration (FDA) uses DNA evidence ... Sound far-fetched? It,s not. The FDA ... sequencing to support investigations of foodborne illnesses. Put as simply ...
(Date:6/23/2016)... Cancer Foundation (PCF) is pleased to announce 24 new Young Investigator (YI) ... of the Class of 2016 were selected from a pool of 128 applicants ... the Class of 2016 PCF Young Investigators ... ... ...
(Date:6/23/2016)... ... June 23, 2016 , ... Supplyframe, the Industry Network for ... Design Lab . Located in Pasadena, Calif., the Design Lab’s mission is to ... are designed, built and brought to market. , The Design Lab is Supplyframe’s ...
(Date:6/23/2016)... June 23, 2016 Apellis Pharmaceuticals, Inc. ... clinical trials of its complement C3 inhibitor, APL-2. ... multiple ascending dose studies designed to assess the ... subcutaneous injection in healthy adult volunteers. ... as a single dose (ranging from 45 to ...
Breaking Biology Technology: