Navigation Links
Montreal Heart Institute and Mount Sinai Hospital researchers contribute to Crohn's disease study
Date:6/30/2008

Twenty-one new genetic risk factors associated with Crohn's disease have been discovered, more than doubling the amount of genetic information about the disease. An international consortium of Crohn's disease researchers combined efforts, including major contributions from Canadian researchers Dr. John D. Rioux from Montreal Heart Institute and Universit de Montral and Drs. Mark Silverberg and Hillary Steinhart from Mount Sinai Hospital in Toronto to publish this breakthrough study in Nature Genetics.

"This greatly increases our knowledge of the genetic architecture of Crohn's and gives us more detailed insight into the biological underpinnings of the disease," says Mark J. Daly, PhD, of the Massachusetts General Hospital Center for Human Genetic Research and the Broad Institute of MIT and Harvard, the report's senior author.

In 2007, three studies compared the genomes of patients with Crohn's disease to those of healthy individuals a North American-based study, led by Dr. John D. Rioux PhD, Associate Professor of Medicine at the Montreal Heart Institute (MHI) and the Universit de Montral and director of the Laboratory in Genetic and Genomic Medicine at the MHI, and input from colleagues at five other institutions, including contributions from Dr. Mark Silverberg, Staff Gastroenterologist, Mount Sinai Hospital and Assistant Professor of Medicine and Surgery at the University of Toronto, and Dr. Hillary Steinhart, Chief of Gastroenterology, Mount Sinai Hospital; a U.K. study supported by the Wellcome Trust; and a study by a group of French and Belgian investigators identified a total number of Crohn's-associated genes to 11. Those explained only a small proportion of the heritability of Crohn's, which affects over a half a million people in the U.S and Canada.

The three teams combined their data in the current study that involved more than 3,200 Crohn's patients with more than 4,800 controls. This study not only confirmed the 11 previously identified genetic risk factors, but it also identified 21 new ones. These new discoveries continue to build a picture of factors leading to the inappropriate immune-system activation that characterizes the disorder.

"Given the fact that prior to 2007 we only knew of three genetic risk factors for Crohn's disease truly represents tremendous progress in our ability to understand Crohn's disease. Specifically this study is indicating which biological pathways specifically lead to Crohn's disease as well as which of these pathways are in common with other immune mediated diseases such as autoimmune diabetes, lupus and rheumatoid arthritis," says Dr. Rioux, co-author of the current study.

"This is breakthrough research for patients with Crohn's disease and one of the most significant advances in our understanding of this disease, to date," says Dr. Silverberg, co-author of the study.

"Our research was successful because of the international collaborative approach."

Finally, Rioux stated that "the hope is that the identification of the biological paths that lead to Crohn's disease can be translated into useful clinical tools for improved diagnosis, classification and treatment of this chronic disease."

In total, the effort constituted a collaboration between clinical genetic researchers from 25 institutions across North America including Yale University, University of Pittsburgh, Universit de Montral, University of Toronto, Johns Hopkins University, and Cedars-Sinai Medical Center in Los Angeles the United Kingdom, Belgium and France. The team is committed to further advancing these results in collaboration with investigators from additional countries. Support for the study came from several organizations, including the National Institute of Diabetes and Digestive and Kidney Diseases, through the Inflammatory Bowel Disease Genetic Consortium.


'/>"/>

Contact: Doris Prince
doris.prince@icm-mhi.org
514-376-3330
University of Montreal
Source:Eurekalert

Related biology news :

1. NASA keeps eye on ozone layer amid Montreal Protocols success
2. Abnormal fat metabolism underlies heart problems in diabetic patients
3. High blood pressure, low energy -- a recipe for heart failure
4. Human derived stem cells can repair rat hearts damaged by heart attack
5. Geron Demonstrates hESC-derived cardiomyocytes improve heart function after myocardial infarction
6. Heart of Herschel to be presented to media
7. Minimally invasive heart surgery research wins NIH award
8. A step toward tissue-engineered heart structures for children
9. Research explains link between cholesterol and heart disease
10. Eating competence may lower risk of heart disease
11. Cardiologists and heart surgeons meet for Controversies and Advances conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/12/2016)... WearablesResearch.com , a brand of Troubadour Research & ... Q1 wave of its quarterly wearables survey. A particular ... a program where they would receive discounts for sharing ... "We were surprised to see that so many ... CEO of Troubadour Research, "primarily because there are segments ...
(Date:4/26/2016)... and LONDON , April 26, ... of EdgeVerve Systems, a product subsidiary of Infosys ... announced a partnership to integrate the Onegini mobile ...      (Logo: http://photos.prnewswire.com/prnh/20151104/283829LOGO ) ... customers enhanced security to access and transact across ...
(Date:4/14/2016)... Israel , April 14, 2016 ... Authentication and Malware Detection, today announced the appointment of ... assumed the new role. Goldwerger,s leadership appointment ... on the heels of the deployment of its platform ... BioCatch,s behavioral biometric technology, which discerns unique cognitive and ...
Breaking Biology News(10 mins):
(Date:5/23/2016)... Zimmer Biomet Holdings, Inc. (NYSE and SIX: ZBH), ... Board of Directors has approved the payment of a quarterly ... The cash dividend of $0.24 per share ... stockholders of record as of the close of business on ... approval of the Board of Directors and may be adjusted ...
(Date:5/22/2016)... ... May 22, 2016 , ... Doctors in Rome say micronutrients found ... cancer, malignant mesothelioma. Surviving Mesothelioma has just posted an article on the new research. ... Rome’s Department of Clinical Sciences and Translational Medicine evaluated more than 150 studies on ...
(Date:5/19/2016)... ... May 19, 2016 , ... Anton Paar USA, located in Ashland, Virginia ... is complete. The new structure adds a third office building to the current facilities. ... purchased 2.4 acres of land, along with office space adjacent to the previous main ...
(Date:5/19/2016)... MADRID , May 19, 2016 ... di una sessione orale durante il 52 ° ... (abstract n. 8006)    - Le conclusioni ... quanto riguarda i pazienti trattati, di cui il 90% presenta ... di sei mesi o più. Il settantadue per cento dei ...
Breaking Biology Technology: