Navigation Links
Montana State researcher discovers that bile sends mixed signals to E. coli
Date:3/31/2010

BOZEMAN, Mont. -- Bile secretions in the small intestine send signals to disease-causing gut bacteria allowing them to change their behavior to maximize their chances of surviving, Montana State University research associate Steve Hamner told the Society for General Microbiology during its spring meeting in Edinburgh, Scotland.

An SGM press release said the findings could allow us to better protect food from contamination by these harmful bacteria, as well as understand how they manage to cause disease.

Bile is secreted into the small intestine and exerts an antibacterial effect by disrupting bacterial membranes and damaging bacterial DNA, the release said. While bile is a human defense mechanism, Hamner and his colleagues at MSU and the University of New England found that some bacteria such as Escherichia coli O157:H7 -- an important food-borne pathogen known as E. coli -- have evolved to use the signal to their advantage. These bacteria use the presence of bile as a signal to tell them that they are in the intestine which allows them to adapt and prepare to cause disease.

Hamner's team found that bile causes the bacteria to switch on genes needed to increase iron uptake.

"This is useful in iron-scarce environments -- such as the small intestine -- as iron is an essential nutrient for bacterial growth. By increasing its chances of absorbing iron, the bacterium is maximizing its survival chances," Hamner explained.

E. coli O157:H7 primarily infects the large intestine, and this study provides one explanation why this is the case.

"We found that bile causes the bacteria to turn off genes that promote tight attachment to host cells. Bile may effectively prevent these bacteria from latching onto the epithelial cells that line the small intestine," Hamner suggested.

As bacteria move further down the digestive tract towards the large intestine, the concentration of bile decreases.

"The reduced concentration of bile in the large intestine may then be a signal for the bacteria to switch on their ability to attach to epithelial cells and to prepare to secrete toxins," Hamner said.

Studying the conditions that make these bacteria more likely to attach themselves to cells could help reduce outbreaks of food poisoning.

"By learning how the bacteria attach to food surfaces such as spinach leaves or to host tissues such as the lining of the intestine, we hope to better be able to protect food sources from contamination by these bacteria. Studying how these bacteria interact with hosts such as humans or cows could teach us how to interfere with the way that these bacteria cause disease," Hamner said.


'/>"/>

Contact: Evelyn Boswell
evelynb@montana.edu
406-994-5135
Montana State University
Source:Eurekalert

Related biology news :

1. New dinosaur species from Montana
2. Montana State grads work helps diagnose skin cancer without a biopsy
3. Montana State team finds Yellowstone alga that detoxifies arsenic
4. Montana State partnership receives $66.9M for carbon sequestration
5. Montana State researchers receive grant to study algae as a source of biofuel
6. Montana State University researchers find gene that regulates molds resistance to drugs
7. International experts collect alpine fungi in Beartooth Mountains of Montana
8. Sweets make young horses harder to train in Montana State study
9. Montana State researchers release guide to noninvasive carnivore research
10. Bird watchers, space technology come together in Montana State University study
11. Dinosaur diggers bring mobile lab, new techniques to Eastern Montana
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... , March 28, 2017 The ... Hardware (Camera, Monitors, Servers, Storage Devices), Software (Video Analytics, ... Region - Global Forecast to 2022", published by MarketsandMarkets, ... 2016 and is projected to reach USD 75.64 Billion ... and 2022. The base year considered for the study ...
(Date:3/24/2017)... 24, 2017 The Controller General of Immigration from ... Abdulla Algeen have received the prestigious international IAIR Award for the ... Continue Reading ... ... Controller Abdulla Algeen (small picture on the right) have received the IAIR ...
(Date:3/23/2017)... The report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based ... to 2022", published by MarketsandMarkets, the market is expected to be worth USD ... 2022. Continue Reading ... ... ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... and LAGUNA HILLS, Calif. , Oct. ... Cancer Research, London (ICR) and University ... SKY92, SkylineDx,s prognostic tool to risk-stratify patients with multiple myeloma ... MUK nine . The University of Leeds ... partly funded by Myeloma UK, and ICR will perform the ...
(Date:10/10/2017)... ... 2017 , ... San Diego-based team building and cooking events company, Lajollacooks4u, has ... The bold new look is part of a transformation to increase awareness, appeal to ... period. , It will also expand its service offering from its signature gourmet cooking ...
(Date:10/10/2017)... 10, 2017 International research firm Parks Associates announced ... at the TMA 2017 Annual Meeting , October 11 in ... residential home security market and how smart safety and security products impact ... Parks Associates: Smart Home ... "The residential security market has ...
(Date:10/9/2017)... DIEGO , Oct. 9, 2017  BioTech ... biological mechanism by which its ProCell stem cell ... critical limb ischemia.  The Company, demonstrated that treatment ... amount of limbs saved as compared to standard ... the molecule HGF resulted in reduction of therapeutic ...
Breaking Biology Technology: