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Montana State researcher discovers that bile sends mixed signals to E. coli
Date:3/31/2010

BOZEMAN, Mont. -- Bile secretions in the small intestine send signals to disease-causing gut bacteria allowing them to change their behavior to maximize their chances of surviving, Montana State University research associate Steve Hamner told the Society for General Microbiology during its spring meeting in Edinburgh, Scotland.

An SGM press release said the findings could allow us to better protect food from contamination by these harmful bacteria, as well as understand how they manage to cause disease.

Bile is secreted into the small intestine and exerts an antibacterial effect by disrupting bacterial membranes and damaging bacterial DNA, the release said. While bile is a human defense mechanism, Hamner and his colleagues at MSU and the University of New England found that some bacteria such as Escherichia coli O157:H7 -- an important food-borne pathogen known as E. coli -- have evolved to use the signal to their advantage. These bacteria use the presence of bile as a signal to tell them that they are in the intestine which allows them to adapt and prepare to cause disease.

Hamner's team found that bile causes the bacteria to switch on genes needed to increase iron uptake.

"This is useful in iron-scarce environments -- such as the small intestine -- as iron is an essential nutrient for bacterial growth. By increasing its chances of absorbing iron, the bacterium is maximizing its survival chances," Hamner explained.

E. coli O157:H7 primarily infects the large intestine, and this study provides one explanation why this is the case.

"We found that bile causes the bacteria to turn off genes that promote tight attachment to host cells. Bile may effectively prevent these bacteria from latching onto the epithelial cells that line the small intestine," Hamner suggested.

As bacteria move further down the digestive tract towards the large intestine, the concentration of bile decreases.

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Contact: Evelyn Boswell
evelynb@montana.edu
406-994-5135
Montana State University
Source:Eurekalert

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