Navigation Links
Montana State researcher discovers that bile sends mixed signals to E. coli
Date:3/31/2010

BOZEMAN, Mont. -- Bile secretions in the small intestine send signals to disease-causing gut bacteria allowing them to change their behavior to maximize their chances of surviving, Montana State University research associate Steve Hamner told the Society for General Microbiology during its spring meeting in Edinburgh, Scotland.

An SGM press release said the findings could allow us to better protect food from contamination by these harmful bacteria, as well as understand how they manage to cause disease.

Bile is secreted into the small intestine and exerts an antibacterial effect by disrupting bacterial membranes and damaging bacterial DNA, the release said. While bile is a human defense mechanism, Hamner and his colleagues at MSU and the University of New England found that some bacteria such as Escherichia coli O157:H7 -- an important food-borne pathogen known as E. coli -- have evolved to use the signal to their advantage. These bacteria use the presence of bile as a signal to tell them that they are in the intestine which allows them to adapt and prepare to cause disease.

Hamner's team found that bile causes the bacteria to switch on genes needed to increase iron uptake.

"This is useful in iron-scarce environments -- such as the small intestine -- as iron is an essential nutrient for bacterial growth. By increasing its chances of absorbing iron, the bacterium is maximizing its survival chances," Hamner explained.

E. coli O157:H7 primarily infects the large intestine, and this study provides one explanation why this is the case.

"We found that bile causes the bacteria to turn off genes that promote tight attachment to host cells. Bile may effectively prevent these bacteria from latching onto the epithelial cells that line the small intestine," Hamner suggested.

As bacteria move further down the digestive tract towards the large intestine, the concentration of bile decreases.

"The redu
'/>"/>

Contact: Evelyn Boswell
evelynb@montana.edu
406-994-5135
Montana State University
Source:Eurekalert

0

GOOD

Page: 1 2

Related biology news :

1. New dinosaur species from Montana
2. Montana State grads work helps diagnose skin cancer without a biopsy
3. Montana State team finds Yellowstone alga that detoxifies arsenic
4. Montana State partnership receives $66.9M for carbon sequestration
5. Montana State researchers receive grant to study algae as a source of biofuel
6. Montana State University researchers find gene that regulates molds resistance to drugs
7. International experts collect alpine fungi in Beartooth Mountains of Montana
8. Sweets make young horses harder to train in Montana State study
9. Montana State researchers release guide to noninvasive carnivore research
10. Bird watchers, space technology come together in Montana State University study
11. Dinosaur diggers bring mobile lab, new techniques to Eastern Montana
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2013)... Pacific Northwest National Laboratory honored more than 165 ... intellectual property at PNNL,s annual Intellectual Property Commercialization ... Department of Energy national laboratory named materials scientist ... work developing battery materials that can store large ... grid, and reduce the time it takes to ...
(Date:5/23/2013)... The tight wrapping of genomic DNA around nucleosomes ... gene expression. A team of Ludwig-Maximilians-Universitaet (LMU) in ... DNA to be locally displaced from nucleosomes for ... is stored in the cell nucleus, wrapped around ... pairs of four different histone proteins and accommodating ...
(Date:5/23/2013)... have succeeded in treating cerebral palsy with autologous cord ... a 2.5 year old boy had been in a ... Just two months after treatment with the cord blood ... following months, the child learned to speak simple sentences ... a Korean study, dispel the long-held doubts about the ...
Breaking Biology News(10 mins):PNNL staff recognized for scientific accomplishments, moving technologies into the marketplace 2Biochemistry: Unspooling DNA from nucleosomal disks 2First successful treatment of pediatric cerebral palsy with autologous cord blood 2
... inventions are birthed at a bar, their futures scribbled ... technological change in X-rays in more than a century, ... It was 2000. Otto Zhou was the principal investigator ... Naval Research to find applications for carbon nanotubes. Zhou ...
... atmospheric mercury emissions should quickly reduce mercury levels in ... week in the Proceedings of the National Academy of ... loading at rates relevant to atmospheric deposition resulted in ... fish in only three years. This is ...
... and ... terminal solutions, WALL, N.J., Sept. 18 ... in finger-based biometric,identification and wireless public safety solutions, ... technology to the hospitality and,retail industries, announced today ...
Cached Biology News:UNC nanotech spin-off forms new venture with Siemens 2UNC nanotech spin-off forms new venture with Siemens 3New study shows fish respond quickly to changes in mercury deposition 2New study shows fish respond quickly to changes in mercury deposition 3Radiant Systems Selects BIO-key(R) Biometric Software for POS Solution 2Radiant Systems Selects BIO-key(R) Biometric Software for POS Solution 3
(Date:5/25/2013)... Dennis R. HIll M.D. Radiation Oncologist at the ... recently there has been a promotion of the idea that ... seed, or low dose rate, brachytherapy for prostate cancer. The ... a shorter half life, and gives a higher biologically effective ... has a higher average energy than the other commonly used ...
(Date:5/24/2013)... 24, 2013 Senomyx , Inc. (NASDAQ: ... science technologies to discover, develop, and commercialize novel flavor ... , Ph.D., the Company,s Vice President, Biology and ... & Corporate Communications, will present an overview of Senomyx,s ... a.m. Eastern Time (7:25 a.m. Pacific Time) during the ...
(Date:5/24/2013)... Madison, WI (PRWEB) May 24, 2013 ... to the discovery and development of calcium-binding proteins ... publication of safety assessment study of apoaequorin ... an international journal published for the British Industrial ... the study was to investigate potential adverse effects, ...
(Date:5/23/2013)... Can economic incentives such as gift ... of the public to increase their donations of blood? ... Carey Business School Assistant Professor Mario Macis says ... large body of recent research that supports their argument, ... issue of Science that the World Health Organization and ...
Breaking Biology Technology:Dennis R. Hill MD HDR Prostate Brachytherapy Specialist Compares Prostate Cancer Treatment Options: Not All Low Dose Rate Brachytherapy Isotopes Are the Same 2Dennis R. Hill MD HDR Prostate Brachytherapy Specialist Compares Prostate Cancer Treatment Options: Not All Low Dose Rate Brachytherapy Isotopes Are the Same 3SENOMYX TO WEBCAST CORPORATE PRESENTATION AT THE CITI 2013 GLOBAL CONSUMER CONFERENCE 2Safety Assessment Study of Apoaequorin Published in Food and Chemical Toxicology 2Offering Economic Incentives to Attract Blood Donations Should Be Encouraged, Research Team writes in Science 2Offering Economic Incentives to Attract Blood Donations Should Be Encouraged, Research Team writes in Science 3
... Feb. 9 Celsis In Vitro Technologies (Celsis,IVT), ... life science,products and laboratory services company, and Wisconsin-based ... of ADME-Tox testing in primary,hepatocytes. Celsis IVT ... use with Promega,s bioluminescent ADME-Tox assays, including,the P450-Glo(TM) ...
... of Pharmaceuticals in a New U.S. Political AdministrationPHILADELPHIA, ... start of the first annual conference on Managed ... at the Loews Philadelphia Hotel. The conference ... needed to prepare for future changes in health ...
... Measuring Prevalence of Sleep Apnea Among Insomnia PatientsALBUQUERQUE, N.M., ... (SHHI) was awarded a grant to study one of ... connects insomnia to psychological factors -- stress, racing thoughts, ... pills or talk therapy. Pitted against the CW ...
Cached Biology Technology:Celsis In Vitro Technologies and Promega to Offer Fast, Reliable Solutions for ADME-Tox Testing With Primary Hepatocytes 2Celsis In Vitro Technologies and Promega to Offer Fast, Reliable Solutions for ADME-Tox Testing With Primary Hepatocytes 3ExL Pharma Presents The Pharmaceutical Managed Markets Insight & Marketing for the Pharmaceutical Industry Conference 2ExL Pharma Presents The Pharmaceutical Managed Markets Insight & Marketing for the Pharmaceutical Industry Conference 3Controversial Study to Test Link Between Insomnia and Sleep Apnea 2
...
BD Primaria 35 mm Cell Culture Dish with Easy-Grip design, surface-modified polystyrene for enhanced cell culture. (20/sp, 200/ca) Packaging: 20 / sleeve, 500 / case ...
...
BD Falcon insert HTS 96 well, square A-bottom with lid. PET membrane, sterile. (5/ca) Packaging: 5 / pack, 5 / case ...
Biology Products: